Review
Chemistry, Multidisciplinary
Yifeng Shi, Xuyao Han, Shuang Pan, Yuhao Wu, Yuhan Jiang, Jinghao Lin, Yihuang Chen, Haiming Jin
Summary: As the population ages and bone/cartilage diseases become more prevalent, bone/cartilage tissue engineering has emerged as a potential therapeutic technique. The use of gold nanomaterials, especially gold nanoparticles, in this field has attracted significant attention due to their excellent biocompatibility and characteristics.
FRONTIERS IN CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Abigail Herrera-Ruiz, Benjamin Betancourt Tovar, Ruben Gutierrez Garcia, Maria Fernanda Leal Tamez, Narsimha Mamidi
Summary: GelMA-based composites have wide-ranging applications in biomedical field due to their exceptional properties, but their potential in bone tissue engineering is still limited. Further research and development are needed to design more efficient composites for bone regeneration, although challenges remain.
Review
Nanoscience & Nanotechnology
Mingyu Lee, Min Chul Kim, Jae Young Lee
Summary: Cardiovascular disease is a leading cause of death, and biomaterial-based tissue engineering approaches have shown promise in cardiac repair. This review focuses on the use of nanomaterial-incorporated conductive hydrogels for improving cardiac function post-myocardial infarction.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Vijay Bhooshan Kumar, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, Ehud Gazit
Summary: Tissue engineering is focused on restoring or replacing damaged tissues, and peptide self-assembly, particularly RGD peptides, is an effective method for developing tissue structures and functionalities. This review summarizes the progress of RGD application in tissue and organ development, examines its impact on TE efficacy in clinical and preclinical studies, and outlines recent advancements in the use of RGD functionalized biomaterials for tissue regeneration.
Review
Chemistry, Multidisciplinary
Jie Qiu, Xiang-Ju Liu, Bei-An You, Na Ren, Hong Liu
Summary: Cardiovascular disease is a leading cause of disability and death worldwide. Stem cell-based therapies, although promising, face challenges such as low transplantation efficiency. Nanomaterials play a crucial role in improving cardiac repair and regeneration through regulating stem cell differentiation. This study discusses the current status, limitations, and recent advances in nanomaterials used in cardiac therapy, as well as the potential clinical applications and future research directions.
Review
Medicine, Research & Experimental
Bin Lv, Li Lu, Liangcong Hu, Peng Cheng, Yiqiang Hu, Xudong Xie, Guandong Dai, Bobin Mi, Xin Liu, Guohui Liu
Summary: Increasing data reveals the involvement of methacrylated gelatin in various physiologic processes for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel, with its good biocompatibility, low cost, and photo-cross-linking structure, is an attractive bioink for cell survivability and monitoring. GelMA has extensive biomedical applications and recent advances focus on integrating bioactive nanomaterials to improve its properties. GelMA shows promise for musculoskeletal disorders and has been investigated for applications in osteoarthritis, intervertebral disc degeneration, bone regeneration, and tendon disorders.
Article
Biophysics
Zhiwei Jiang, Jin He, Xueting Wang, Danji Zhu, Na Li, Lingfei Ren, Guoli Yang
Summary: Nanomaterial-based cell sheet technology has significant potential in regenerative medicine and tissue engineering. Different types of nanomaterials have been used to harvest cell sheets, categorized by mechanisms such as light-induced, thermo-responsive, magnetic-controlled, and ROS-induced. Studies have demonstrated successful outcomes in the regeneration of bone, skeletal muscle, cardiac tissue, tendon, angiogenesis, and osseointegration. However, challenges remain in terms of comprehensive preparation, safety, and cell quality.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Ye Qi, Conger Wang, Qiuyu Wang, Fang Zhou, Tao Li, Bo Wang, Weidong Su, Dawei Shang, Shaohua Wu
Summary: The study reports on a simple, quick, and cost-effective method to produce nanofiber-constructed yarns (NYs) using a combination of electrospinning, hand winding, and stretching post-treatment. The NYs demonstrated improved surface hydrophilicity and wettability with increasing silk fibroin (SF) content. Cells were able to sense and respond to the nanofibrous morphology and orientation of the NYs and SF promoted cell growth and proliferation. This research provides a simple and feasible method for fabricating PCL/SF NYs and NY-based biotextiles with great potential for tissue engineering and regenerative medicine applications.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Debora F. Silva, Ailime L. P. Melo, Ana F. C. Uchoa, Graziela M. A. Pereira, Alisson E. F. Alves, Maria C. Vasconcellos, Francisco H. Xavier-Junior, Marcele F. Passos
Summary: Nanotechnology plays a crucial role in biomedical engineering, with applications in tissue engineering, drug release systems, biosensors, and imaging diagnosis. Understanding and applying nanomaterials in these fields are of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Seyyed Mojtaba Mousavi, Khadije Yousefi, Seyyed Alireza Hashemi, Marzie Afsa, Sonia Bahrani, Ahmad Gholami, Yasmin Ghahramani, Ali Alizadeh, Wei-Hung Chiang
Summary: Dental tissue engineering is being significantly impacted by carbon-based nanomaterials, which have extraordinary properties and are ideal for biomedical applications, especially in the dental field.
Review
Chemistry, Multidisciplinary
Keerti Jain, Rahul Shukla, Awesh Yadav, Rewati Raman Ujjwal, Swaran Jeet Singh Flora
Summary: Three-dimensional (3D) printing is advancing in the manufacturing of nanomedicines for personalized treatment, using a variety of natural biomaterials and engineered polymers. This technology has the potential to revolutionize biomedical applications and contribute to precision medicine.
Article
Engineering, Biomedical
Kaveh Roshanbinfar, Maria Kolesnik-Gray, Miriam Angeloni, Stefan Schruefer, Maren Fiedler, Dirk W. Schubert, Fulvia Ferrazzi, Vojislav Krstic, Felix B. Engel
Summary: Cardiac tissue engineering is a promising strategy to prevent heart failure, but several issues remain unsolved. This study develops a biohybrid hydrogel that enhances the beating properties of engineered cardiac tissues and allows for concurrent drug release.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Hamid Esmaeili, Alejandra Patino-Guerrero, Masoud Hasany, Mohammad Omaish Ansari, Adnan Memic, Alireza Dolatshahi-Pirouz, Mehdi Nikkhah
Summary: Myocardial infarction (MI) remains a major cause of death worldwide, with the use of electroconductive biomaterials showing promise in improving cardiac tissue engineering. This review article discusses the recent advancements in the application of electroconductive biomaterials for cTE and explores potential avenues for enhanced cardiac tissue engineering.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Hussein M. El-Husseiny, Eman A. Mady, Walaa A. El-Dakroury, Moataz B. Zewail, Mina Noshy, Amr M. Abdelfatah, Ahmed S. Doghish
Summary: Bone tissue engineering plays a crucial role in repairing bone defects by combining biomolecules, biomimetic scaffolds, and cells to provide smart and complex platforms that enhance the limited self-healing capacity.
APPLIED MATERIALS TODAY
(2022)
Review
Engineering, Biomedical
Itsasne Erezuma, Tatiane Eufrasio-da-Silva, Nasim Golafshan, Kaivalya Deo, Yogendra Kumar Mishra, Miguel Castilho, Akhilesh K. Gaharwar, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Nanoclay-reinforced biomaterials have the potential to revolutionize the treatment of musculoskeletal defects by providing enhanced mechanical performance and bioactive properties. Incorporating nanoclays into biomaterials is a feasible way to mimic the important properties of native tissues for optimal tissue integration and regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Rodica Ana Ungur, Adriana Muresan, Diana Elena Olteanu, Adrian Florea, Viorela Mihaela Ciortea, Laszlo Irsay, Ileana Monica Borda, Razvan Andrei Codea, Ciprian Andrei Ober, Stefana Balici, Simona Cainap, Eleonora Dronca, Georgiana Smaranda Martis (Petrut), Ioana Anamaria Onac, Soimita Mihaela Suciu
Summary: This study aimed to evaluate the effects of therapeutic ultrasound on oxidative stress-induced changes in human chondrocytes. The results showed that ultrasound could protect chondrocytes from oxidative stress and stimulate the development of autophagosomes.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Codruta Varodi, Maria Coros, Florina Pogacean, Alexandra Ciorita, Alexandru Turza, Stela Pruneanu
Summary: Nitrogen-doped graphene (NGr) was synthesized using urea as a reducing and doping agent for graphene oxide (GO) in a hydrothermal method. The graphene structure was transformed and the nitrogen concentration in the NGr sample was found to be 6 wt%. The NGr /GC electrode showed significantly better performance in piroxicam detection compared to the bare GC electrode, with higher peak values and lower potentials.
Article
Psychiatry
Mihaela Elvira Vuscan, Andrei Buciuta, Mihaela Laura Vica, Stefana Balici, Sergiu Ionica Rusu, Costel Vasile Siserman, Horia George Coman, Horea Vladi Matei
Summary: A study in Cluj County, Romania, analyzed the changes in the number of suicides and suicide attempts during the first year of the COVID-19 pandemic. Overall, the suicide rate did not change significantly, but there was an increase in suicides related to mild cognitive disorders and dementia, while suicides related to substance use disorders decreased. The long-term effects of the pandemic on mental health and the importance of taking measures to prevent suicides are still unknown.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Chemistry, Analytical
Codruta Varodi, Florina Pogacean, Maria Coro, Alexandra Ciori, Stela Pruneanu
Summary: In this study, a graphene sample (EGr) was synthesized through electrochemical exfoliation method. Scanning electron microscopy (SEM) was used to observe the morphology of the graphene material. The graphene modified electrode exhibited higher sensitivity and lower detection limit in L-tyrosine detection compared to the bare glassy carbon electrode, demonstrating the advantages of using graphene in electrochemical sensing.
Article
Biochemical Research Methods
Raluca-Ioana Stefan-van Staden, Mihaela Iuliana Bogea, Ruxandra-Maria Ilie-Mihai, Damaris-Cristina Gheorghe, Hassan Y. Aboul-Enein, Maria Coros, Stela Maria Pruneanu
Summary: Arginine plays an important role in the metabolomics of gastric cancer. Two 3D enantioselective needle stochastic sensors were designed for the enantiomer analysis of arginine, and showed good selectivity and sensitivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Psychiatry
Mihaela Elvira Vuscan, Cristina Faludi, Andrei Buciuta, Mihaela Laura Vica, Stefana Balici, Costel Vasile Siserman, Horia George Coman, Horea Viadi Matei
Summary: This study aims to explore the socio-demographic and medical characteristics of psychiatric patients with a history of suicidal behavior and identify the main risk factors underlying their suicidal ideation and acts. The study uses a mixed methodological design and investigates 65 hospitalized psychiatric patients who have committed at least one non-lethal suicide attempt. The findings reveal that family disruptions, social problems, economic burdens, and a mixture of psychiatric pathologies are major risk factors for non-lethal suicidal attempts. This study is the first to explore suicide triggers in a clinical environment in the Balkan region.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Mihai Lupu, Camelia Alexandra Coada, Diana -Valentina Tudor, Ioana Baldea, Adrian Florea, Vlad -Alexandru Toma, Ana Lupsor, Remus Moldovan, Nicoleta Decea, Gabriela Adriana Filip
Summary: Iron dysmetabolism is common in heart failure patients, especially those with reduced ejection fraction. Chronic hypertension, a common risk factor for heart failure and death, is associated with iron deficiency. Iron deposition in organs can cause oxidative stress and cell death. In a rat model of cardiac hypertrophy induced by pressure overload, iron chelation with deferiprone reduced inflammation, lipid peroxidation, mitochondrial iron levels, and hypertrophy. This suggests that iron redistribution, particularly in mitochondria, may have beneficial effects in the cardiovascular system.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Analytical
Lidia Magerusan, Florina Pogacean, Bogdan Ionut Cozar, Stela Pruneanu
Summary: Food safety has become a concern due to the increase in living standards. To address this, a highly sensitive method for detecting Sunset Yellow was proposed, using a glassy carbon electrode modified with few-layer graphenes. The modified electrode showed good linearity, selectivity, and sensitivity, and was successfully applied in quantification of Sunset Yellow. The research provides an effective approach for rapid testing of food additives.
Article
Pharmacology & Pharmacy
Diana Harfmann, Adrian Florea
Summary: Bee stings are a public health concern, but the mechanisms of bee venom toxicity are still not fully understood. In this study, the reactions of adrenocortical cells to two components of honeybee venom, melittin and phospholipase A2, were investigated. The results showed that both melittin and phospholipase A2 had toxic effects on cellular structures, particularly the mitochondria.
Article
Chemistry, Multidisciplinary
Remus Moldovan, Daniela-Rodica Mitrea, Adrian Florea, Luminita David, Laura Elena Muresan, Irina Camelia Chis, Soimita Mihaela Suciu, Bianca Elena Moldovan, Manuela Lenghel, Liviu Bogdan Chiriac, Irina Ielciu, Daniela Hanganu, Timea Bab, Simona Clichici
Summary: In this study, gold nanoparticles functionalized with bioactive compounds from Cornus mas fruit extract (AuNPsCM) were orally administered to rats with a high-fat diet and diabetes mellitus. The investigation of the aorta using imaging techniques showed that the oral administration of AuNPsCM significantly increased aorta volume, decreased blood flow velocity, and caused ultrastructural disorganization of the aorta wall. These findings suggest that the oral administration of AuNPsCM can alter the aorta wall and affect blood flow.
Article
Chemistry, Multidisciplinary
Florina Pogacean, Codruta Varodi, Lidia Magerusan, Stela Pruneanu
Summary: This article presents the development of an electrochemical sensor based on graphene/glassy carbon electrode for trace level detection of nitrite in water samples. The sensor exhibits remarkable enhanced sensing response towards nitrite compared to the bare electrode (three orders of magnitude higher). It also demonstrates excellent operational stability, repeatability, and interference capability, and shows excellent results in the practical application test in commercially available waters.
Article
Chemistry, Multidisciplinary
Ioana Baldea, Anca Petran, Adrian Florea, Alexandra Sevastre-Berghian, Iuliana Nenu, Gabriela Adriana Filip, Mihai Cenariu, Maria Teodora Radu, Cristian Iacovita
Summary: We synthesized a core-shell magnetic structure using magnetite nanoclusters (MNC) with a magnetite core and polymer shell. The MNCs showed good biocompatibility and induced apoptosis in tumor cells through magnetic hyperthermia treatment (MH).
Article
Microbiology
Alexandra Ciorita, Maria Suciu, Maria Coros, Codruta Varodi, Florina Pogacean, Lidia Magerusan, Valentin Mirel, Raluca-Ioana Stefan-van Staden, Stela Pruneanu
Summary: Bacterial infections pose a major threat due to antibiotic resistance, driving the need for new drugs or improved resources. Nanomaterials with high surface area and bactericidal properties show promise in combatting microbial infections. In this study, graphene decorated with silver nanoparticles (5 wt% Ag) exhibited inhibitory capacity against S. aureus and E. coli. The hybrid material was incubated with a high-efficiency particulate air (HEPA) filter, resulting in a modified filter with enhanced antibacterial properties, particularly against Gram-negative bacteria. The modified HEPA filter significantly affected the colony forming unit capacity of bacteria, suggesting its potential to improve existing technology.
Review
Food Science & Technology
Alina Mihaela Baciu, Razvan Vlad Opris, Gabriela Adriana Filip, Adrian Florea
Summary: The socioeconomic burden of Alzheimer's Disease (AD) is caused by its multifactorial etiology and the difficulties associated with its treatment. Nutraceuticals and functional foods derived from fermented sources have shown therapeutic outcomes and cognitive benefits in animal models of AD. Fermentation processes can enhance the phytochemical content of food, leading to improved functional and health-related properties.
Article
Medicine, Research & Experimental
Mihaela Elvira Vuscan, Mihaela Laura Vica, Stefana Balici, Gheorghe Zsolt Nicula, Sergiu Ionica Rusu, Costel Vasile Siserman, Horia George Coman, Horea Vladi Matei
Summary: The study revealed that HLA-DQB1*02, *03, and *06 alleles and genotypes were more common in individuals with suicidal behavior, while HLA-DQB1*04 and *13 alleles and genotypes were less frequent in this group. Similarly, the HLA-DRB1 alleles DRB1*12/*15 and DRB1*07/*13 were associated with a possible risk for suicidal behavior. The findings contribute to a better understanding of the mechanisms underlying suicidal behavior.
REVISTA ROMANA DE MEDICINA DE LABORATOR
(2023)