Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: The study of vascular permeability is important for understanding the mechanism that maintains the exchange between blood, tissues, and organs. Recent research has provided a better understanding of vascular cell functions and interactions between blood vessels. The identification of endothelial cell receptors and mediators and their role in homeostasis and disease has shed light on the maintenance of vascular permeability. Additionally, drugs and specific antibodies have been found to reduce the severity and mortality of diseases with enhanced vascular permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Baalachandran Ramasubramanian, Junghyun Kim, Yunbo Ke, Yue Li, Chen-Ou Zhang, Kamoltip Promnares, Kenichi A. Tanaka, Konstantin G. Birukov, Pratap Karki, Anna A. Birukova
Summary: This study investigates the effects of different histone subunits on pulmonary endothelial cells and identifies H3 and H4 histones as key subunits that can increase cell permeability and induce inflammation. The Toll-like receptor 4 signaling pathway plays a significant role in mediating the deleterious effects of H3 and H4 histones.
Article
Cardiac & Cardiovascular Systems
Min Ji Cho, Dong Gwang Lee, Jeong Woong Lee, Byungtae Hwang, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Seung-Ho Park, Hee Gu Lee, Yong-Hoon Kim, Chul-Ho Lee, Jangwook Lee, Nam-Kyung Lee, Tae-Su Han, Hyun-Soo Cho, Jeong Hee Moon, Ga Seul Lee, Kwang-Hee Bae, Geum-Sook Hwang, Sang-Hak Lee, Sang J. Chung, Sungbo Shim, Jaehyung Cho, Goo Taeg Oh, Young-Guen Kwon, Jong-Gil Park, Jeong-Ki Min
Summary: This study investigates the role of protein tyrosine phosphatase type IVA1 (PTP4A1) in the negative regulation of the NF-kappa B signalling pathway in endothelial cells (ECs). The findings suggest that PTP4A1 regulates NF-kappa B inactivation through the USF1/A20 axis, and its expression or activation in ECs may be useful for the treatment of vascular inflammatory diseases.
CARDIOVASCULAR RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah
Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Parasitology
Y. Falcon-Cordon, A. Tvarijonaviciute, J. A. Montoya-Alonso, A. Munoz-Prieto, A. Caro-Vadillo, E. Carreton
Summary: This study evaluated the serum concentrations of acute phase proteins (APP) in dogs infected with heartworm disease and examined their usefulness as diagnostic biomarkers for vascular damage and pulmonary hypertension (PH). The study found that vascular inflammation may persist up to 7 months after treatment, and persistent PH could be a clinical manifestation of severe vascular alterations.
VETERINARY PARASITOLOGY
(2022)
Article
Medicine, Research & Experimental
Mandy Otto, Laura Brabenec, Melanie Mueller, Sebastian Kintrup, Katharina E. M. Hellenthal, Richard Holtmeier, Sophie Charlotte Steinbuch, Ole Sonken Karsten, Heorhii Pryvalov, Jan Rossaint, Eric R. Gross, Nana-Maria Wagner
Summary: The study suggests that 12-HETE may serve as a biomarker for endothelial dysfunction and HFpEF in patients with type 2 diabetes. Antagonizing 12-HETE is a potent way to control the development and progression of HFpEF in type 2 diabetes by preserving vascular function.
Article
Hematology
Toshiaki Iba, Jerrold H. Levy, Jecko Thachil, Sophie Susen, Marcel Levi, Ecaterina Scarlatescu
Summary: Disseminated intravascular coagulation (DIC) is a pathomechanistic process that accompanies various underlying diseases, characterized by systemic coagulation activation and endothelial injury. However, current diagnostic criteria for DIC do not include biomarkers for vascular endothelial injury.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Md Zahid Akhter, Jagdish Chandra Joshi, Vijay Avin Balaji Ragunathrao, Mark Maienschein-Cline, Richard L. Proia, Asrar B. Malik, Dolly Mehta
Summary: The study demonstrates the generation of a population of S1PR1(+) EC is crucial for mediating endothelial repair and restoring vascular homeostasis in inflammatory vascular injury states. This transition of cells is induced by S1P and involves key genes such as SPHK1 and SPNS2, which are regulated by transcription factors EGR1 and STAT3.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, Atsushi Yamauchi, Keisuke Migita
Summary: This study investigated the effect of bortezomib (BTZ) on vascular permeability and expression of cell-cell junction molecules in human pulmonary microvascular endothelial cells. The findings showed that clinically relevant concentrations of BTZ increased the permeability of endothelial cell monolayers and downregulated the expression of claudin-5, occludin, and VE-cadherin at both protein and mRNA levels. This suggests that BTZ-induced pulmonary toxicity may be mediated by increased vascular permeability caused by the downregulation of these cell-cell junction molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Ha-Hyeon Shin, Hyun-Seung Rhyu, So-Hee Kim, Eun-Seok Jeon, Byung-Kwan Lim
Summary: Research has shown that Coxsackievirus and adenovirus receptor (CAR) plays a crucial role in vascular endothelial cell junctions, with CAR deletion leading to increased vascular permeability and inflammatory cell infiltration. However, in a mouse model, CAR deletion did not significantly increase CVB3-induced myocarditis, although tissue virus titers were higher in CAR-eKO compared to WT mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jay Rollins, Tyler Worthington, Allison Dransfield, Jordan Whitney, Jordan Stanford, Emily Hooke, Joseph Hobson, Jacob Wengler, Sandra Hope, Dario Mizrachi
Summary: Cell-adhesion molecules (CAMs) are responsible for various cell interactions. In this study, the expression of CLDN proteins in E. coli is investigated and its consequences are discussed. The iCLASP method is introduced as a high-throughput screening approach for identifying paracellular modulators for CLDN2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Zhiqiang Lei, Xiang Hu, Yaoqi Wu, Longsheng Fu, Songqing Lai, Jing Lin, Xiaobing Li, Yanni Lv
Summary: The vascular endothelial niche is a rapidly growing field in vascular biology, which not only responds to external stimuli but also has decisive effects on neighboring tissues and circulating cells. Intervention through the vascular niche is meaningful for improving the treatment of various diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Roman Roy, Joshua Wilcox, Andrew J. Webb, Kevin O'Gallagher
Summary: Nitric oxide (NO) plays important roles in regulating various functions in the cardiovascular system. Different isoforms of nitric oxide synthase (NOS) have distinct functions and localizations, and may have different pathophysiological roles. Modulating NOS activity is a potential therapeutic approach for cardiovascular diseases. This review summarizes recent advances in understanding the physiological role of NOS isoforms and discusses the possibility of targeting NO and NOS activity for novel cardiovascular therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Parasitology
Elena Carreton, Rodrigo Morchon, Yaiza Falcon-Cordon, Jorge Matos, Noelia Costa-Rodriguez, Jose A. Montoya-Alonso
PARASITES & VECTORS
(2020)
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Alicia Diosdado, Fernando Simon, Rodrigo Morchon, Javier Gonzalez-Miguel
Summary: The larvae of Ascaris suum can control host blood coagulation by inhibiting blood clot formation, which may facilitate their migration and survival within the host.
Article
Agriculture, Dairy & Animal Science
Rodrigo Morchon, Jose Alberto Montoya-Alonso, Jose angel Sanchez-Agudo, Juan de Vicente-Bengochea, Xiomara Murcia-Martinez, Elena Carreton
Summary: Canine angiostrongylosis, caused by Angiostrongylus vasorum, affects domestic and wild canids, with an emerging presence in Europe, particularly in red foxes. A study in Spain analyzed the presence of A. vasorum antigens in 1475 dogs, with a prevalence of 0.75%, mainly outdoors and living in mild climates close to water bodies. More comprehensive epidemiological studies are needed in Spain and Europe to effectively control this disease in both domestic and wild animals.
Editorial Material
Veterinary Sciences
Rodrigo Morchon, Ruben Bueno-Mari, Laura Rinaldi, Elena Carreton
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Oscar Otalora, Guillermo Couto, Julio Benavides, Carlos Mucha, Rodrigo Morchon
Summary: This study investigated the prevalence of cardiopulmonary dirofilariosis, anaplasmosis, ehrlichiosis, and Lyme borreliosis in dogs in Barranquilla and Puerto Colombia, finding the highest percentage of dogs positive for Ehrlichia spp. It is suggested that veterinarians should routinely implement prophylactic programmes for these diseases, particularly for dogs that reside outdoors.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Jose Alberto Montoya-Alonso, Rodrigo Morchon, Sara Nieves Garcia-Rodriguez, Yaiza Falcon-Cordon, Noelia Costa-Rodriguez, Jorge Isidoro Matos, Ivan Rodriguez Escolar, Elena Carreton
Summary: Canine heartworm disease is prevalent in Spain, with higher infection rates in northwestern and southern provinces, as well as in the Balearic and Canary Islands. Positive cases were also reported in provinces and islands where no infected dogs were previously reported. Given its zoonotic nature, further studies and prevention programs are necessary.
Article
Biology
Josune Garcia-Sanmartin, Judit Narro-Iniguez, Alicia Rodriguez-Barbero, Alfredo Martinez
Summary: Hereditary hemorrhagic telangiectasia (HHT) is a rare disease characterized by vascular malformations and profuse bleeding. Recent research has found that HHT patients have higher levels of adrenomedullin (AM) in their blood. However, a study using mutant mice showed that the mutations responsible for HHT did not consistently affect the expression of AM. Some organs had no changes in AM levels, while others had lower or higher expression. These findings suggest that the genes and molecules related to HHT may have yet-to-be-investigated functions.
Article
Agriculture, Dairy & Animal Science
Elena Carreton, Rodrigo Morchon, Sara Nieves Garcia-Rodriguez, Ivan Rodriguez-Escolar, Jorge Isidoro Matos, Noelia Costa-Rodriguez, Jose Alberto Montoya-Alonso
Summary: The overall prevalence of canine angiostrongylosis in Spain was 1.39%, with infected domestic dogs reported in most provinces. Coastal provinces had higher prevalence compared to inland provinces, indicating a possible influence of climatic factors on parasite establishment. This study contributes to the epidemiological map of A. vasorum in dogs in Spain and highlights the need for awareness and prevention campaigns for this emerging disease.
Review
Microbiology
Rodrigo Morchon, Jose Alberto Montoya-Alonso, Ivan Rodriguez-Escolar, Elena Carreton
Summary: This review provides an update on the epidemiological situation of heartworm disease in Europe and analyzes the factors contributing to its continuous spread. The disease has extended to Eastern European countries and the prevalence continues to increase in southern countries where it was traditionally endemic. Factors such as climate changes, presence of new vectors, movement of pets from endemic countries, urbanization of rural areas, and expansion of irrigated crops have influenced the distribution trends and changes in this disease.
Article
Agriculture, Dairy & Animal Science
Ivan Rodriguez-Escolar, Ricardo E. Hernandez-Lambrano, Jose Angel Sanchez-Agudo, Manuel Collado, Patricia Perez-Perez, Rodrigo Morchon
Summary: A new model confirms the high risk of vector-borne dirofilariosis in the Iberian Peninsula and Balearic Islands, providing a valuable tool for its management and control.
Editorial Material
Microbiology
Rodrigo Morchon, Ruben Bueno-Mari, Daniel Bravo-Barriga
Article
Agriculture, Dairy & Animal Science
Rodrigo Morchon, Ivan Rodriguez-Escolar, Ricardo E. Hernandez Lambrano, Jose angel Sanchez Agudo, Jose Alberto Montoya-Alonso, Irene Serafin-Perez, Carolina Fernandez-Serafin, Elena Carreton
Summary: In this study, a more accurate transmission risk model for heartworm disease in the Canary Islands was developed. By calculating different variables and using an ecological niche model, potential areas of infection risk were identified, and the model also predicted future transmission patterns under different climatic conditions. The results showed that all islands had a risk of transmission, with higher risk in coastal areas, moderate risk in midland areas, and lower risk in higher altitude areas.
Article
Biology
Raquel Del Pozo-Valero, Jose Angel Martin-Oterino, Alicia Rodriguez-Barbero
Summary: Ambulatory blood pressure monitoring is valuable in diagnosing and managing hypertension, as it reveals discrepancies between office blood pressure measurement and sleep-time blood pressure values. The presence of nocturnal hypertension is high, and may serve as a significant indicator of cardiovascular risk.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Parasitology
T. Zueva, R. Morchon, E. Carreton, C. Ollauri-Ibanez, M. Pericacho, A. Rodriguez-Barbero, F. Simon
JOURNAL OF HELMINTHOLOGY
(2020)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)