Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jingying Chen, Xiuhua Li, Rui Ni, Qi Chen, Qifen Yang, Jianbo He, Lingfei Luo
Summary: The study in zebrafish cerebrovascular injury models reveals that the earliest regenerated blood vessels originate from lymphatic transdifferentiation via Notch activation. This process only occurs in stand-alone lymphatic vessels, while late-regenerated blood vessels form through a different mechanism.
DEVELOPMENTAL CELL
(2021)
Review
Physiology
Fumiko Itoh, Tetsuro Watabe
Summary: Transforming growth factor (TGF)-beta and its family members play a crucial role in the development and maintenance of the lymphatic vascular system, which is involved in various physiological and pathological processes such as immune cell trafficking and tumor metastasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Tomohiro Shiiya, Masanori Hirashima
Summary: During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. This review discusses the chemotactic factors, LEC-extracellular matrix interactions, and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels, providing insights into the molecular mechanisms underlying physiological lymphatic vascular development and lymphangiogenesis associated with pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Konstantin I. Ivanov, Olga V. Samuilova, Andrey A. Zamyatnin Jr
Summary: Recent advancements in RNA sequencing technology have allowed for the exploration of the complex and versatile world of long noncoding RNAs (lncRNAs) in the human genome. Once thought to be transcriptional noise, lncRNAs are now recognized as essential regulators of gene expression networks that control development, homeostasis, and disease progression. The regulatory functions of lncRNAs are diverse, acting at various levels within the cell, and there is growing evidence for their involvement in lymphatic vascular development and disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Article
Biology
Deepti Sharma, Shivantika Bisen, Geetika Kaur, Eric C. Van Buren, Gadiparthi N. Rao, Nikhlesh K. Singh
Summary: This study discovered that genetic deletion or siRNA-mediated downregulation of IL-33 can reduce pathological neovascularization in a mouse model of oxygen-induced retinopathy without affecting normal retinal repair. It was also found that IL-33 induces angiogenesis through the NFkappaB-Jagged1-Notch1 signaling pathway. Additionally, IL-33 interacts with BRCA1-associated protein 1 (BAP1) and Numb to enhance the de-ubiquitination and stabilization of Notch1 intracellular domain.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Chuanghua Luo, Haofan Yin, Tianxiao Gao, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao, Xia Yang, Ti Zhou
Summary: PEDF is lowly expressed in human NPC tissues and negatively correlated with lymphatic vessel density, inhibiting lymphangiogenesis and lymphatic metastasis by targeting lymphatic endothelial cells and NPC cells. It also reduces the expression and secretion of VEGF-C in NPC cells through the NF-kappa B signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shuai-Jun Xu, Bin Jin, Wei-Jun Zhao, Xue-Xian Chen, Ying-Ying Tong, Xiao-Fei Ding, Ying-Yuan Chen, Dong-Hao Wang, Zhi-Ming Wang, Bing-Qing Dai, Sai Chen, Yong Liang, Guang Chen, Su-Jiao Pan, Ling-Long Xu
Summary: The study found that the expression of specifically androgen-regulated gene (SARG) is up-regulated in papillary thyroid carcinoma (PTC) and down-regulated in follicular thyroid cancer (FTC). SARG can promote lymphatic metastasis in PTC through the VEGF-C/VEGFR-3 signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song
Summary: This study demonstrates that nicotine promotes lymphatic metastasis by preventing mRNA decay of VEGF-C mRNA through downregulating OTUD3 and ZFP36. The interaction between OTUD3 and ZFP36 stabilizes ZFP36 and inhibits VEGF-C mRNA decay, highlighting their crucial role in nicotine addiction-induced lymphatic metastasis in esophageal cancer.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsaeter, Michael Vanlandewijck, Bojana Jakic, Eulalia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Maekinen
Summary: Researchers have identified a new subtype of lymphatic endothelial cells called iLECs, which are positive for Ptx3 and are involved in PI3K-driven lymphatic malformations. These cells recruit pro-lymphangiogenic macrophages and promote pathological lymphatic vessel growth. Understanding the specific disease pathogenesis of different vessel types could lead to the development of more efficient therapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Editorial Material
Oncology
Yuqing Zhang, Rolf A. Brekken
Summary: The study challenges the functional significance of Tie2-expressing macrophages in tumor angiogenesis and relapse after chemotherapy, highlighting the need for reconsideration of Tie2 as a therapeutic target or prognostic indicator.
Review
Orthopedics
M. Cao, M. T. Y. Ong, P. S. H. Yung, R. S. Tuan, Y. Jiang
Summary: This review discusses the function and potential regulatory pathways of the synovial lymphatic system (SLS) in osteoarthritis (OA) and aims to provide a knowledge framework for the development of OA treatments targeting lymphatic structure and functions. The SLS is located in the subintima layer of the synovium and consists of lymphatic capillaries and lymphatic collecting vessels. Impairment of lymphatic endothelial cells and nitric oxide production-induced damage to lymphatic muscle cells may contribute to drainage dysfunction. Preclinical evidence suggests that promoting lymphatic drainage may help restore intra-articular homeostasis and attenuate the progression of OA.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Dermatology
Andrea Luengas-Martinez, Anna Kamaly-Asl, Iskander H. Chaudhry, Paul E. C. Brenchley, Helen S. Young
Summary: This study assessed the cutaneous vascular structure and perfusion in patients with chronic plaque psoriasis, and found that blood flow, mean blood vessel area, and number of blood and lymphatic vessels was significantly higher in psoriasis plaques than in uninvolved skin. Expression of vascular endothelial growth factor (VEGF)-A(121,) VEGF-A(165) and VEGF-D was also significantly increased in plaques, and the number of blood vessels in uninvolved skin was associated with the VEGF-A (rs833061) genotype.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Otorhinolaryngology
Kwang Jae Cho, Jun Ook Park, Young Hoon Joo, Inn Chul Nam
Summary: This study found that local flap reconstruction is effective in preventing soft tissue necrosis (STN) after transoral robotic surgery (TORS) in patients with tonsillar cancer. Factors such as mucositis grade, radiation therapy dose, and secondary intention healing were identified as predictors of STN.
AURIS NASUS LARYNX
(2023)
Article
Engineering, Mechanical
Pratap Anbalagan, Young Hoon Joo
Summary: This study investigates a dissipative-based fuzzy sampled-data control scheme for stabilizing a variable-speed wind turbine system and enhancing its dynamic performance using a fragmented-delayed state looped functional framework.
NONLINEAR DYNAMICS
(2023)
Article
Green & Sustainable Science & Technology
Raghul Venkateswaran, Balasubramani Natesan, Seong Ryong Lee, Young Hoon Joo
Summary: This study proposes a Q-learning MPPT algorithm with FTC scheme for maximum power extraction in a PMVG-based WECS. A model-free sensorless reinforcement Q-learning algorithm-based MPPT method is firstly introduced, followed by the construction of an optimal speed-power curve using the proposed learning algorithm. Additionally, a wind-speed change detection algorithm and FTC method are implemented to ensure the adaptability and stability of the PMVG-based WECS.
IEEE TRANSACTIONS ON SUSTAINABLE ENERGY
(2023)
Article
Engineering, Marine
Dongran Song, Jiaqi Yan, Hongda Zeng, Xiaofei Deng, Jian Yang, Xilong Qu, Rizk M. Rizk-Allah, Vaclav Snasel, Young Hoon Joo
Summary: This paper proposes a hybrid optimization method to optimize the topological structure of an offshore-wind-farm power collection system. The proposed method integrates cable investment, energy loss, and line construction to design the cable connection, cable selection, and substation location optimally. The novel hybrid optimization, named PSAO, combines the advantages of particle swarm optimization (PSO) and aquila optimization (AO) algorithms to intensify the searching capability. The results demonstrate that the PSAO algorithm outperforms GA, AO, and PSO algorithms in terms of total cost reduction and optimization efficiency.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Automation & Control Systems
Kumarasamy Palanimuthu, Ganesh Mayilsamy, Seong Ryong Lee, Sang Yong Jung, Young Hoon Joo
Summary: This article investigates fault ride-through capability for a grid-connected permanent magnet vernier generator (PMVG)-based wind turbine system (WTS) using coordinated active and reactive power control strategy. The proposed control methods demonstrate their superiority through simulations on 5-kW PMVG, 1.5 MW PMSG-based WTS, and its application potential is shown through the experimental prototype of a 5-kW PMVG-based WTS.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Computer Science, Information Systems
Dinesh Elayaperumal, Young Hoon Joo
Summary: This work proposes a multi-expert deep feature fusion method based on the learning spatial variance-key surrounding-aware correlation filter (LSVKSCF) to address various problems in continuous object tracking. By extracting surrounding samples, introducing selective spatial information, and utilizing spatial variance information, this method effectively handles scale changes, occlusion, and boundary effects, achieving good tracking performance on multiple datasets.
INFORMATION SCIENCES
(2023)
Article
Automation & Control Systems
Shanmugam Lakshmanan, Young Hoon Joo
Summary: This article investigates the robust stability of PMSG-based WT systems with ROUs under a fuzzy sampled-data control scheme. The uncertainties in the d-q inductance, system inertia, and stator resistance are considered and modeled as ROUs using white noise sequences. A fuzzy-based sampled-data control is designed to achieve stability against uncertainties and disturbances. Linear matrix inequalities based on looped-Lyapunov functionals are derived to ensure the stability of the T-S fuzzy model for the nonlinear PMSG-based WTs. The derived conditions are validated and compared to show their less conservative nature.
INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING
(2023)
Article
Automation & Control Systems
Shanmugam Lakshmanan, Young Hoon Joo
Summary: This paper presents a decentralized observer-based control scheme for large-scale interconnected systems using the integral sliding mode control (ISMC) approach. A novel decentralized observer is designed to estimate the unmeasured states. Sufficient conditions for the asymptotic stability of the interconnected system and the ultimate boundedness of estimation errors are derived using matrix inequality. Numerical simulations validate the theoretical conditions and demonstrate the effectiveness of the proposed control scheme in an interconnected power system with a DFIG-based wind farm.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Automation & Control Systems
Ramasamy Subramaniyam, Young Hoon Joo
Summary: This manuscript presents a method for stabilizing discrete-time Takagi-Sugeno (T-S) fuzzy systems with additive time-varying delay components. By constructing a fuzzy Lyapunov-Krasovskii functional (LKF) with membership functions, the stability criteria for the systems with additive time-varying delays are established. The extended version of Wirtinger's inequality is used to bound the forward differences of the LKF. A fuzzy controller is designed to ensure the H-infinity performance of the closed-loop system formulated in terms of linear matrix inequalities (LMIs). Numerical simulations are conducted to validate the theoretical findings.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Mathematics, Applied
Chendrayan Dineshkumar, Young Hoon Joo
Summary: This article primarily investigates the approximate controllability outcomes for the Atangana-Baleanu fractional neutral stochastic integro-differential equation with infinite delay. The existence of mild solutions for the fractional stochastic evolution equations is demonstrated using stochastic analysis, fractional calculus, and Krasnoselskii fixed point techniques. A sufficient condition that ensures the approximate controllability of the stochastic evolution equations is then presented. The findings are further applied to nonlocal conditions, and an example is provided to define the primary results.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Subramanian Kuppusamy, Young Hoon Joo
Summary: This paper proposes novel stabilization criteria for a nonlinear permanent magnet synchronous generator (PMSG)-based wind turbine system (WTS) with sampled-data information under uncertainty and controller gain variations. The nonlinearity in the PMSG-based WTS is modeled using Takagi-Sugeno (T-S) fuzzy systems. A novel looped-type asymmetric augmented Lyapunov-Krasovskii functional (LKF) is developed by taking advantage of the variable characteristic related to the sampling pattern. The dynamic delay partition method is used for the non-fragile sampled-data control design of the T-S fuzzy systems, and the less conservative stabilization criteria are obtained in the form of linear matrix inequality.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Automation & Control Systems
Sathiyamoorthi Arthanari, Young Hoon Joo
Summary: This study presents a memory sampled-data control design for the Takagi-Sugeno (T-S) fuzzy-based permanent magnet synchronous generator (PMSG) via an improved looped functional (ILF). The proposed method models the nonlinear PMSG as a T-S fuzzy system and introduces a novel ILF to derive the sufficient criteria. The stabilizsation conditions expressed as linear matrix inequalities (LMIs) ensure the asymptotic stability of the closed-loop system.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Automation & Control Systems
Gandhi Velmurugan, Young Hoon Joo
Summary: In this study, a coupled fuzzy controller design was proposed for stabilizing a continuous nonlinear system with external perturbations represented by Takagi-Sugeno fuzzy systems. The controller was developed using non-parallel distributed compensation techniques and a non-quadratic Lyapunov functional was utilized. Stabilization conditions were formulated as linear matrix inequalities using the time derivatives of the non-QLF and Jensen's inequality techniques, ensuring stochastic asymptotic stability of the system with $H_{\infty}$ perturbation damping criterion. Two simulation results were presented to validate the proposed methodologies.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Automation & Control Systems
G. Narayanan, M. Syed Ali, Young Hoon Joo, R. Perumal, Bashir Ahmad, Hamed Alsulami
Summary: In this article, an adaptive fractional sliding-mode control (AFSMC) method is proposed to solve the Mittag-Leffler synchronization (MLS) problem in a fractional-order permanent magnet synchronous generator (FOPMSG)-based wind turbine system. The AFSMC method incorporates a fractional-order term into the new law for reaching the sliding mode, improving the control signal chattering and reducing the time required for the system to reach the sliding-mode surface. The robust MLS for the sliding-mode dynamics is ensured by the designed robust controller.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Automation & Control Systems
Girija Panneerselvam, Manivannan Annamalai, Young Hoon Joo, Prakash Mani
Summary: The aim of this study is to propose a theoretical framework for investigating the stability properties of PMSMs considering stochastic disturbances and parameter uncertainties in the fractional domain. The research focuses on the aerodynamics of PMSM as stochastic disturbances and the inherent parameter uncertainties in voltage equations. A nonlinear PMSM model is derived and equivalent linear submodels are obtained through Takagi-Sugeno fuzzy approach. The proposed approach is validated through numerical experiments.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
