Article
Chemistry, Multidisciplinary
Esteban Rodriguez-Arce, Eric Gavrilov, Ximena Alvite, Nazia Nayeem, Ignacio E. Leon, Michelle C. Neary, Lucia Otero, Dinorah Gambino, Claudio Olea Azar, Maria Contel
Summary: This work reports the synthesis and stability study of four gold(I) [AuClL] compounds containing chloro and biologically active protonated thiosemicarbazones based on 5-nitrofuryl (L=HSTC). The cytotoxicity of these compounds was evaluated against cancer cell lines, and one compound showed significant antimigratory and anti-angiogenic properties on a renal cancer cell line (Caki-1), along with preferential accumulation in the cell nuclei. Its mode of action seems to involve interaction with DNA and induction of apoptosis.
Review
Chemistry, Multidisciplinary
Beata Miksa
Summary: Phenazine derivatives are important bactericidal antibiotics and antiparasitic compounds that can be used with anticancer drugs to improve chemotherapy. The introduction of chemical variations at the phenazine core, which has fluorescent properties, provides advanced theranostic agents for optical bioimaging techniques and photodynamic anticancer therapy. This review summarizes the structural modifications of phenazine derivatives and their evaluations as anticancer drugs for the development of new chemotherapeutic and bio-imaging reagents.
HELVETICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Tanja V. Soldatovic, Biljana Smit, Emina M. Mrkalic, Sanja Lj. Matic, Ratomir M. Jelic, Marina Cendic Serafinovic, Nevenka Gligorijevic, Milena Cavic, Sandra Arandelovic, Sanja Grguric-Sipka
Summary: Novel Pt-Zn complexes were synthesized and characterized. The complexes showed strong binding to DNA through groove binding, hydrogen bonds, and hydrophobic or electrostatic interaction. Among them, C2 exhibited highly selective cytotoxicity and induced cell cycle arrest and expression of apoptotic related genes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Microbiology
Stefan L. Debbert, Mikaela J. Hintz, Christian J. Bell, Kenya R. Earl, Grant E. Forsythe, Cecile Haeberli, Jennifer Keiser
Summary: Some quinoxaline compounds showed promising activity against Schistosoma mansoni in vitro, but exhibited only moderate activity in vivo, indicating the need for optimization of their pharmacokinetic properties to improve in vivo efficacy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Organic
Huda K. Mahmoud, Sobhi M. Gomha, Thoraya A. Farghaly, Hanem M. Awad
Summary: The study synthesized four new series of thiazolylimidazothiazole derivatives and characterized their structures, evaluating their activity against human cancer cells in vitro. The promising results suggest the potential for further investigation into these novel compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Daniela Meco, Giorgio Attina, Stefano Mastrangelo, Pierluigi Navarra, Antonio Ruggiero
Summary: Repurposing approved non-antitumor drugs, such as Mebendazole, offers a promising and affordable strategy to increase the number of effective anticancer drugs. Mebendazole has demonstrated anticancer properties and can target multiple cancers. It shows potential as both a monotherapy and in combination with standard chemotherapeutics and radiotherapy. Its repurposing could reduce medical care costs and optimize existing cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Reza Ghiasi, Alireza Valizadeh
Summary: The interaction between a cycloplatinated thiosemicarbazone and B12N12 nano-cage was investigated using LC-wPBE functional. The study found that the solvent had an effect on the interaction energy and dipole moment values. ETS-NOCV and EDA analysis provided insights into the nature and strength of the interaction. CDA analysis demonstrated charge transfer between the drug and B12N12 nanocage.
RESULTS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kerong Guo, Jian Li, Yingdong Jia, Xiaojuan Yang, Xiqing Yan, Liqiang Wu
Summary: In this study, novel quinolinedione-linked sulfonylpiperazine derivatives were investigated as NQO1-directed antitumor agents. Most of the compounds showed higher effectiveness in inhibiting cancer cell proliferation compared to 5-Fu and TSA. Among them, compound 22r exhibited significant anti-proliferative activity against NQO1-rich cancer cells and was recognized as an excellent substrate for NQO1. Mechanistic studies revealed that 22r induced ROS production, DNA damage, and apoptosis in HepG2 cells. Remarkably, compound 22r also showed excellent anticancer activity in HepG2 xenograft models. Overall, this study demonstrated that compound 22r could be a promising strategy for the treatment of malignant tumors.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
John A. Gilleran, Xin Yu, Alan J. Blayney, Anthony F. Bencivenga, Bing Na, David J. Augeri, Adam R. Blanden, S. David Kimball, Stewart N. Loh, Jacques Y. Roberge, Darren R. Carpizo
Summary: A new class of metal ion chelators was identified to reactivate mutant p53 by shuttling zinc into cells, demonstrating similar efficacy to traditional TSCs. These chelators showed reduced toxicity and equivalent growth inhibition in rodents, with C85 functioning as a chemotherapy and radiation sensitizer. This study indicates the potential of benzothiazolyl, benzoxazolyl, and benzimidazolyl hydrazones as zinc metallochaperones in restoring mutant p53.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ilaria D'Agostino, Githa Elizabeth Mathew, Paola Angelini, Roberto Venanzoni, Giancarlo Angeles Flores, Andrea Angeli, Simone Carradori, Beatrice Marinacci, Luigi Menghini, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Bijo Mathew, Claudiu T. Supuran
Summary: The COVID-19 pandemic has highlighted the urgent need for new antimicrobials to combat cross-resistance. Thiosemicarbazones (TSCs) have emerged as a promising option due to their polypharmacological application. Further research is needed to explore their potential in addressing antimicrobial resistance.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hamid R. Shahsavari, Jiyun Hu, Samira Chamyani, Yoshie Sakamaki, Reza Babadi Aghakhanpour, Christopher Salmon, Masood Fereidoonnezhad, Ayyub Mojaddami, Parnian Peyvasteh, Hudson Beyzavi
Summary: Cationic cycloplatinated(II) complexes with bisphosphine ligands showed higher cytotoxicity compared to cisplatin across various cancer cell lines, especially complex 3 exhibiting excellent antiproliferative activity. The stability of these complexes in biological environments and their mode of interaction with DNA were also investigated.
Article
Biochemistry & Molecular Biology
Li-Qiang Wu, Xin Ma, Zhao-Peng Liu
Summary: A series of novel NQO1-targeted anticancer agents were synthesized, with compound 5k identified as a favorable NQO1 substrate that significantly suppressed tumor growth and decreased mitochondrial membrane potential in tumor cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Steven T. G. Street, Pablo Penalver, Michael P. O'Hagan, Gregory J. Hollingworth, Juan C. Morales, M. Carmen Galan
Summary: The study presents a facile imide coupling strategy for the one-step preparation of G-quadruplex ligands with varied core chemistries. The G-quadruplex stabilization of a library of nine compounds was examined, identifying several compounds with interesting selectivity profiles. Compound 3, based on a perylene scaffold, was found to be the best G4 ligand with 40-fold selectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Priyanka Thakur, Neeraj K. Saini, Vijay Kumar Thakur, Vijai Kumar Gupta, Reena V. Saini, Adesh K. Saini
Summary: Rhamnolipids are potent biosurfactants produced mainly by Pseudomonas aeruginosa, with a wide range of potential applications in therapy, immunomodulation, and antimicrobial activities. They also show promise in reducing post-harvest decay of food products.
MICROBIAL CELL FACTORIES
(2021)
Review
Chemistry, Medicinal
Ju Guo
Summary: This paper provides an up-to-date review of the structural modification and activity of bistetrahydroisoquinoline natural products, highlighting their importance as antitumor lead compounds. It offers valuable scientific references for pharmaceutical chemists engaged in developing novel antitumor agents based on such alkaloid modifications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sara Nasiri Sovari, Taryn M. Golding, Mziyanda Mbaba, Roxanne Mohunlal, Timothy J. Egan, Gregory S. Smith, Fabio Zobi
Summary: A small library of aminoquinoline and imidazolopiperidine (IMP)-based ligands showed potent inhibitory activities against chloroquine-sensitive (CQS) and multidrug-resistant (MDR) strains of P. falciparum. The compounds may act through hemozoin inhibition and the quinoline-based compounds exhibited higher binding affinities than the reference drug chloroquine.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Article
Biochemistry & Molecular Biology
Taryn M. Golding, Reinner O. Omondi, Supratim Biswas, Suparna Chakraborty, Sharon Prince, Gregory S. Smith
Summary: The success of small metal-containing molecules as pharmaceutical agents has led to investigations into the pharmacological activity of supramolecular coordination complexes (SCCs), which have shown promising anticancer activity. The present study evaluated the anticancer activity of quinoline-containing binuclear complexes and metallarectangles in breast cancer cell lines. The results demonstrated that some of these complexes exhibited superior or comparable activity to the clinical chemotherapeutic drugs cisplatin in different breast cancer cell lines. Additionally, the compounds showed increased selectivity towards breast cancer cells over non-tumorigenic cells and displayed favorable binding to DNA and albumin.
Article
Chemistry, Inorganic & Nuclear
Tara K. Davids, Wade F. Petersen, Gregory S. Smith
Summary: A trinuclear bis-cyclometalated iridium(III) polypyridyl complex was synthesized and evaluated as a photoredox catalyst for visible light-mediated thiol-ene coupling reactions. The complex exhibited a blue-shifted emission spectrum and showed promising catalytic activity in photoredox reactions. Compared to a trinuclear ruthenium congener, the trinuclear iridium polypyridyl complex exhibited the highest NMR yields in hydrothiolation coupling reactions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Stephen de Doncker, Eva Fischer-Fodor, Catalin Ioan Vlad, Patriciu Achimas-Cadariu, Gregory S. Smith, Siyabonga Ngubane
Summary: Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated for their anticancer activity against ovarian cancer cell lines. The dirhodium(II,II) complexes exhibited moderate cytotoxicity, with acetate and methyl-substituted formamidinate compounds showing increased cytotoxicity compared to cisplatin in the cisplatin resistant cell line. Methyl- and fluoro-substituted formamidinate complexes also demonstrated comparable or increased cytotoxic activity in another cell line. The low-valent metallodendrimers exhibited some activity, but generally showed decreased cytotoxicity compared to the precursor complexes, except for one case where an acetate-derived metallodendrimer showed higher cytotoxicity than dirhodium(II,II) tetraacetate.
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Chemistry, Multidisciplinary
Haodan Guo, Yanyan Fang, Yan Lei, Jinpeng Wu, Minghua Li, Xiangrong Li, Hong Bo Cheng, Yuan Lin, Paul J. Dyson
Summary: This study demonstrates the use of a self-assembled ionic insulating layer to improve the performance of wide-bandgap perovskite solar cells. The layer effectively suppresses halide phase separation, reducing open-circuit voltage loss and improving device stability.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Chemistry, Multidisciplinary
Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh
Summary: Catalytic hydrodeoxygenation is a crucial technology for converting biomass-based feedstocks into essential chemicals and fuels. This study reports the preparation and application of Ni nanoparticles supported on ZSM-5 as an efficient hydrodeoxygenation catalyst. The Ni-based nanoparticles exhibit selective hydrodeoxygenation of various functional substrates, showcasing their versatility.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Patrick Doerflinger, Yong Ding, Valentin Schmid, Melina Armer, Roland C. Turnell-Ritson, Bin Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Vladimir Dyakonov
Summary: This study investigates the effect of a stabilizing additive on the charge carrier mobility and lifetime in triple cation perovskite thin films under thermal stress. The results reveal different conductivity behaviors in two temperature regions and identify two dominant scattering mechanisms. The stabilizing additive limits temperature-activated mobile ions and retards degradation of the perovskite film, leading to improved performance and stability.
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)