☆ 4.5 Article

Observation of Binuclear Palladium Clusters upon ESI-MS Monitoring of the Suzuki-Miyaura Cross-Coupling Catalyzed by a Dichloro-bis(aminophosphine) Complex of Palladium

ORGANOMETALLICS (2011)

期刊

ORGANOMETALLICS

卷 30, 期 13, 页码 3579-3587

出版社

AMER CHEMICAL SOC

DOI: 10.1021/om200274z

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Chemistry, Inorganic & Nuclear Chemistry, Organic

资金

Academy of Sciences of the Czech Republic [Z40550506]
European Research Council (AdG HORIZOMS)
Swiss National Science Foundation (SNSF)
University of Zurich

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摘要

Electrospray ionization mass spectrometry (ESI-MS) is used for monitoring the progress of the Suzuki-Miyaura cross-coupling reaction between bromobenzene and arylboronic acids using a palladium dichloro-bis(aminophosphine) complex as a precatalyst. The ESI-MS studies demonstrate that initiation of the catalytic reaction requires the presence of a base and that the selectivity for cross-coupling is favorable at elevated temperatures. Interestingly, after completion of the coupling reaction, the palladium is present as a dinuclear Pd-0/Pd-II cluster, which still acts as an active catalyst when a new aliquot of reactants is added to the reaction mixture.

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