Review
Chemistry, Inorganic & Nuclear
Yidan Wang, Bo Zhang, Shuai Guo
Summary: The combination of NHC and pincer framework in transition metal complexes has been widely studied and applied in various fields, including catalysis and optical material chemistry. This minireview focuses on the synthesis, reactivity study and applications of metal pincer NHCs.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Enrica Bortolamiol, Giacomo Isetta, Isabella Caligiuri, Nicola Demitri, Stefano Paganelli, Flavio Rizzolio, Thomas Scattolin, Fabiano Visentin
Summary: A general method for synthesizing novel cationic Pd(II) indenyl complexes with one alkyl/aryl phosphine and one N-heterocyclic carbene is reported. The complexes showed high stability in both solid and solution states. These organopalladium compounds have shown promising potential as antiproliferative agents against ovarian cancer cells and as catalysts in Suzuki-Miyaura coupling reactions in aqueous media.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joel Poupon, Jerome Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-Francois Betzer, Angela Marinetti, Sophie Bombard
Summary: This article introduces a new series of bimetallic platinum-(II) complexes with NHC-type bridging ligands, which exhibit cytotoxicity, cell accumulation, and DNA binding properties in cancerous cells. These complexes demonstrate significant radiosensitizing effects by inhibiting DNA repair mechanisms, leading to persistent accumulation of irradiation-induced DNA damages. This study provides the first in vitro evidence for the radiosensitizing properties of NHC-platinum complexes, suggesting their potential use in combined chemo-radiotherapy protocols.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Thomas Scattolin, Andrea Piccin, Matteo Mauceri, Flavio Rizzolio, Nicola Demitri, Vincenzo Canzonieri, Fabiano Visentin
Summary: Newly synthesized palladium allyl complexes exhibit lower antiproliferative activity, with similar anticancer activity in two ovarian cancer cell lines, suggesting a different mechanism of action compared to platinum-based anticancer drugs. Some compounds show lower cytotoxicity on normal cells and higher selectivity towards cancer cells. Comparing the IC50 values of NHC/PTA complexes and their trifluoromethyl congeners indicates similar antiproliferative activity against cancer cells, but the absence of the CF3 group decreases selectivity towards them.
Article
Chemistry, Multidisciplinary
Chiara Masaro, Giammarco Meloni, Marco Baron, Claudia Graiff, Cristina Tubaro, Beatriz Royo
Summary: A series of Mn(I) complexes with different ligand structures have been studied for their catalytic performance in the reductive N-formylation and N-methylation of amines, showing high selectivity and good catalytic activity.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Lachlan J. Watson, Anthony F. Hill
Summary: The pro-ligands react with [RhCl(CE)(PPh3)2] to form bimetallic complexes, which undergo double C-H activation to form N-heterocyclic carbene (NHC) pincer complexes. Reduction and treatment with tritylium, ferrocenium or triphenylcyclopropenium tetrafluoroborates result in the formation of mononuclear NHC pincer complex salts. Treatment with lithium (trimethylsilyl)acetylide provides another bimetallic species, which can be obtained from [RhCl(RPm)] and LiCuCSiMe3.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Diana V. Aleksanyan, Svetlana G. Churusova, Valentina V. Brunova, Alexander S. Peregudov, Aleksander M. Shakhov, Ekaterina Yu. Rybalkina, Zinaida S. Klemenkova, Elena G. Kononova, Gleb L. Denisov, Vladimir A. Kozlov
Summary: The study examined the cyclopalladation characteristics of a series of non-classical pincer-type ligands based on monothiooxalyl amides under conventional solution-based synthesis conditions and in solvent-free solid-phase methodology involving mechanochemical activation. The results showed that grinding functionalized monothiooxamides with PdCl2(NCPh)(2) in a mortar can serve as an efficient and environmentally friendly alternative to the synthesis of complex metal-organic systems. The confirmation of the coordination of S,N,N- or S,N,S-monoanionic tridentate in the resulting pincer complexes was achieved through various spectroscopic methods and SEM/EDS analysis, while preliminary evaluation demonstrated high cytotoxic activity against cancer cells for some cyclopalladated derivatives.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Amy L. Speelman, Kazimer L. Skubi, Brandon Q. Mercado, Patrick L. Holland
Summary: Recent experimental evidence indicates that during N-2 reduction, the FeMoco of nitrogenase undergoes structural rearrangement, leading to the generation of coordinatively unsaturated iron sites. New designed ligands have shown the potential flexibility in structural arrangement of metal complexes, mimicking the resting state of nitrogenase.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Arpan Das, Soumi Chakraborty, Swadhin K. Mandal
Summary: Abnormal N-heterocyclic carbene (aNHC) based Ni(II) pi-allyl complexes (3 and 4) were synthesized from a Ni(0) precursor and characterized. The mechanism for the formation of Ni(II) eta(3)-allyl complexes from a Ni(0) precursor using a free abnormal N-heterocyclic carbene was elucidated. Exposure of complex 3 to O-2 gas under ambient pressure resulted in the activation of molecular oxygen to form a mu-hydroxo bridged Ni(II) dimer.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Ceren Akpunar, Namik Ozdemir, Mert Olgun Karatas, Bulent Alici, Ismail Ozdemir
Summary: In this study, we synthesized five new coumarin-functionalised PEPPSI type Pd-NHC complexes to examine their catalyst properties. The complexes showed slightly distorted square-planar geometry and exhibited catalytic activity in the Suzuki-Miyaura reaction of phenylboronic acid and aryl bromide derivatives.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Yingxin Ye, Zhongxian Liu, Yazhou Wang, Yin Zhang, Fan Yin, Qi He, Jiahao Peng, Kai Tan, Yuehai Shen
Summary: PEPPSI-type Pd complexes with NHC ligands containing N-(4-indolyl) side chains were synthesized and evaluated for their catalytic activity in three reactions. The results showed that complex 8g, with an unsymmetric N-(3-isopropyl-1,5,7-trimethyl-2-phenylindol-4-yl) NHC, exhibited the highest activity and outperformed Pd-PEPPSI-IPr. This study demonstrates the promising platform of N-(4-indolyl) side chains for the development of synthetically useful NHC ligands.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yaru Jing, Jingxing Jiang, Yan Liu, Zhuofeng Ke
Summary: This study presents a theoretical evaluation of the electronic and steric properties of various N-Heterocyclic boryl (NHB) ligands using NHB-Ir(CO)(3) as the model complex. The results reveal the influence of substitution, backbone saturation, ring size, and heteroatoms on the NHB properties. The findings suggest that these scales are crucial for the design, application, and mechanistic understanding of NHB-based complexes or molecules.
Article
Chemistry, Multidisciplinary
Ming Li, Sandeep K. Gupta, Sebastian Dechert, Serhiy Demeshko, Franc Meyer
Summary: Synthetic routes have been developed for a dicobalt(I) complex using a unique pyrazolate-bridged dinucleating ligand, showing efficient catalytic activity in the reductive silylation of nitrogen. Protonation leads to the formation of a tetracobalt(I) complex, demonstrating potential in the field of molecular nitrogen fixation catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Physical
Csilla Eniko Czegeni, Ferenc Joo, Agnes Katho, Gabor Papp
Summary: This review summarizes the recent advances in the synthesis and catalytic applications of heterobimetallic carbene complexes. New synthetic methods and catalytic activity studies are presented. It is found that certain heterobimetallic complexes exhibit significantly higher catalytic activity compared to their homobimetallic analogs or mixtures, highlighting the importance of metal cooperation in catalysis.
Article
Chemistry, Inorganic & Nuclear
Lingyu Kong, Yajie Chou, Muriel Albalat, Marion Jean, Nicolas Vanthuyne, Stephane Humbel, Paola Nava, Herve Clavier
Summary: The concept of atropisomeric N-heterocyclic carbene (NHC)-metal complexes with C-2-symmetry was extended to palladium-based complexes. Through a comprehensive study of NHC precursors and screening of various NHC ligands, the formation of meso complexes was successfully circumvented. Eight atropisomeric NHC-palladium complexes were prepared and obtained with high enantiopurities through efficient chiral HPLC resolution. These complexes demonstrated good activity in the intramolecular alpha-arylation of amides, leading to the isolation of cyclic products with excellent enantioselectivities (up to 98% ee).
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Analytical
Bo Lin, Li Fan, Zhou Ying, Jinyin Ge, Xueli Wang, Tongxin Zhang, Chuan Dong, Shaomin Shuang, Man Shing Wong
Article
Neurosciences
Chen Chen, Di Xu, Zhong-Hao Zhang, Shi-Zheng Jia, Xian-Chun Cao, Yu-Bin Chen, Guo-Li Song, Man Shing Wong, Hung Wing Li
EXPERIMENTAL NEUROLOGY
(2020)
Article
Chemistry, Multidisciplinary
Yuanyuan Ma, Zhongju Ye, Chen Zhang, Xueli Wang, Hung-Wing Li, Man Shing Wong, Hai-Bin Luo, Lehui Xiao
Article
Chemistry, Analytical
Xueli Wang, Chengke Wang, Hei-Nga Chan, Iyaswamy Ashok, Senthil Kumar Krishnamoorthi, Min Li, Hung-Wing Li, Man Shing Wong
Summary: Novel near infrared emissive fluorophores exhibit strong selectivity towards Aβ oligomers and monomers, good biocompatibility and stability, and significant inhibitory effects on Aβ aggregation.
Article
Nanoscience & Nanotechnology
Xueli Wang, Hei Nga Chan, Nicolas Desbois, Claude P. Gros, Frederic Bolze, Yinhui Li, Hung Wing Li, Man Shing Wong
Summary: The developed Gd(DOTA)-cyanine dyad is the first imaging probe targeting Aβ that can be applied for one- and two-photon excited fluorescence and magnetic resonance imaging in AD mouse models. It possesses various desirable properties such as good biocompatibility, high Aβ selectivity, strong fluorescence enhancement, and inhibition of Aβ aggregation and toxicity. This theranostic probe shows promise for diagnosis and therapy of AD and has potential for MRI imaging of Aβ in humans.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Correction
Nanoscience & Nanotechnology
Xueli Wang, Hei Nga Chan, Nicolas Desbois, Claude P. Gros, Frederic Bolze, Yinhui Li, Hung Wing Li, Man Shing Wong
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Huanxin Xue, Jiaye Lu, Hongwei Yan, Ju Huang, Hai-Bin Luo, Man Shing Wong, Yuqi Gao, Xiaolei Zhang, Lei Guo
Summary: In this study, a novel organic fluorescent probe was developed for rapid detection of lung cancer cells and specific targeting of the nucleolus in the cell. By interfering with rRNA synthesis in the nucleolus, the probe induced cell apoptosis, showing promising anti-cancer effects.
Article
Biochemistry & Molecular Biology
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Summary: The accumulation of phosphorylated Tau aggregates and A beta oligomers are crucial factors in the development of Alzheimer's disease. A study found that the fluorescent probe F-SLOH effectively inhibited A beta aggregation and reduced various neuropathological changes in AD mouse models by promoting autophagy lysosomal degradation pathway.
Article
Nanoscience & Nanotechnology
Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung-Wing Li, Man Shing Wong
Summary: This study reports the development of the first A beta-targeted ratiometric H2O2-responsive fluorescent probe for real-time detection and monitoring of A beta-induced H2O2 levels. This probe can be used as a powerful tool for diagnosing high-risk subjects and diseased brains of AD, as well as studying the role of ROS in AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Surgery
Hongyu Lyu, Yongqin Ye, Vincent Chi Hang Lui, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Hung-Wing Li, Man Shing Wong, Paul Kwong Hang Tam, Bin Wang
Summary: Elevated plasma levels of A beta 42/A beta 40 were found in patients with biliary atresia (BA), showing correlations with liver function parameters and good predictive power for cholestasis. Combining A beta 42/A beta 40 with other hepatic function parameters significantly improved the diagnostic ability for BA, making it a potentially useful screening tool for jaundiced neonates.
FRONTIERS IN SURGERY
(2022)
Article
Materials Science, Biomaterials
Bo Lin, Li Fan, Ying Zhou, Jinyin Ge, Xueli Wang, Chuan Dong, Shaomin Shuang, Man Shing Wong
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Analytical
Li Fan, Qi Zan, Bo Lin, Xiaodong Wang, Xiaojuan Gong, Zhonghua Zhao, Shaomin Shuang, Chuan Dong, Man Shing Wong
Article
Chemistry, Analytical
Jinyin Ge, Kai Zhang, Li Fan, Xiaodong Wang, Caihong Zhang, Chuan Dong, Man Shing Wong, Shaomin Shuang
Article
Medicine, Research & Experimental
Hei-Nga Chan, Di Xu, See-Lok Ho, Dinggeng He, Man Shing Wong, Hung-Wing Li
Article
Materials Science, Multidisciplinary
Lei Guo, Xiao Liu, Tongxin Zhang, Hai-Bin Luo, Hai Hua Fan, Man Shing Wong
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
