Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Review
Cardiac & Cardiovascular Systems
Tiphaine Raia-Barjat, Osasere Edebiri, Celine Chauleur
Summary: Venous thromboembolism (VTE) is a significant health issue for pregnant women worldwide. Pregnancy increases the risk of blood clot formation, with known risk factors for VTE during pregnancy. Practice varies between countries and institutions, and personalized risk assessment and treatment using risk score systems are recommended.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Alok A. Khorana, Maria T. DeSancho, Howard Liebman, Rachel Rosovsky, Jean M. Connors, Jeffrey Zwicker
Summary: Venous and arterial thromboembolism are common and burdensome in cancer patients, with varying risks across different cancer subpopulations. Predicting and targeting high-risk cancer patients for thromboprophylaxis is critical, with recent trials showing benefit in outpatient settings. Implementation of risk-adapted prophylaxis is important for improving compliance in cancer patients.
Article
Hematology
Noori A. M. Guman, Frits I. Mulder, Bart Ferwerda, Aeilko H. Zwinderman, Pieter W. Kamphuisen, Harry R. Buller, Nick van Es
Summary: This study evaluated the use of polygenic risk scores to predict venous thromboembolism (VTE) in patients with cancer. The results showed that these scores can identify patients at higher risk of VTE independent of cancer type.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Cameron Brown, Willem Brandt, Tzu-Fei Wang, Aurelien Delluc, Marc Carrier
Summary: This study assessed the incidence of recurrent venous thromboembolism (VTE) and bleeding complications in patients with cancer and isolated distal deep vein thrombosis (IDDVT). The results showed that these patients are at high risk of developing recurrent VTE and bleeding events, emphasizing the need for further research to determine optimal treatment strategies.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study investigated the association between plasma leptin levels and the risk of incident VTE. Results suggest that the apparent association between leptin levels and VTE risk is confounded by BMI, and leptin is not a relevant mediator for VTE risk in obesity.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Surgery
Osama Moussa, Maddalena Ardissino, Alice Tang, Laura Lazzari, Ophelia Millar, Paul Ziprin, Ara Darzi, Omar Khan, Peter Collins, Sanjay Purkayastha
Summary: The study demonstrates that bariatric surgery significantly reduces the long-term risk of VTEs in obese patients, mainly by lowering the occurrence of deep vein thrombosis.
Article
Pediatrics
Shannon C. Walker, C. Buddy Creech, Henry J. Domenico, Benjamin French, Daniel W. Byrne, Allison P. Wheeler
Summary: A predictive model for pediatric HA-VTE was developed and validated, including 11 variables strongly associated with HA-VTE. The model showed excellent discriminatory ability in two separate cohorts. Early identification of high-risk patients is expected to increase prophylactic interventions and decrease the incidence of pediatric HA-VTE.
Article
Hematology
Helle Jorgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid K. Braekkan, John-Bjarne Hansen, Henrik Toft Sorensen
Summary: This study examines the association between acute venous thromboembolism (VTE) and the risk of subsequent depression. Based on Danish nationwide registries, a population-based cohort of 64,596 individuals with incident VTE and a comparison cohort of 322,999 randomly selected individuals were established. The results show that VTE is associated with a 2.35-fold increased risk of depression compared to the comparison cohort, even after adjusting for socioeconomic status and comorbidities.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Hirotsugu Kenmotsu, Akifumi Notsu, Keita Mori, Shota Omori, Takahiro Tsushima, Yasuomi Satake, Yoshihiro Miki, Masakazu Abe, Masahito Ogiku, Toshio Nakamura, Masakazu Takagi, Hideto Ochiai, Hirofumi Yasui, Toshiaki Takahashi
Summary: This study revealed a high incidence of VTE in patients with advanced cancer, particularly in those with lung cancer. Although most VTE cases were asymptomatic, intensive screening may be necessary, especially for female patients with elevated D-dimer levels and decreased platelet counts.
Article
Hematology
Alexander T. Cohen, Christopher Wallenhorst, Satarupa Choudhuri, Ayman Nassar, Kevin G. Pollock, Carlos Martinez
Summary: This study used UK Clinical Practice Research Datalink data and developed a scoring scheme to predict bleeding risk in patients receiving anticoagulant treatment for Ca-VTE. The results showed that factors such as cancer type and surgical history were associated with the risk of major bleeding.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Hematology
Lingyun Tian, Wan Li, Yanan Su, Huimin Gao, Qiuhong Yang, Pan Lin, Liqian Wang, Jiaqi Zeng, Yinglan Li
Summary: Patient history of thrombosis, gastrointestinal/liver disease, hematologic disease, and cancer are correlated with an increased risk of CVAD-related thrombosis. Treatment-related factors such as parenteral nutrition, hemodialysis, extracorporeal membrane oxygenation, and cardiac catheterization are associated with an increased CRT risk, while antibiotics are associated with a reduced risk. CVAD-related factors show that peripherally inserted central catheter increases CRT risk significantly compared to tunneled lines or totally implantable venous access port, and subclavian vein catheterization contributes to a lower CRT risk compared to femoral vein catheterization. Multiple catheter lines, multiple catheter lumens, central line-associated bloodstream infection, and catheter malfunction are associated with an increased CRT risk. Identifying these risk factors can help in developing risk assessment tools for stratifying risks.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Oncology
Salah Eddine Ousama Kacimi, Aysan Moeinafshar, Shirin Shahsavar Haghighi, Amene Saghazadeh, Nima Rezaei
Summary: VTE is a clinical disease that frequently occurs in cancer patients, and immunotherapy, although effective for cancer treatment, can also increase the risk of VTE.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Chiara A. Cella, Maren Knoedler, Marcia Hall, Michele Arcopinto, Vincenzo Bagnardi, Lorenzo Gervaso, Stefania Pellicori, Francesca Spada, Maria G. Zampino, Paola S. Ravenda, Samuele Frassoni, Antonio Passaro, Monica Milano, Alice Laffi, Nicola Fazio, Florian Lordick
Summary: The study validates the ONKOTEV score as a reliable risk assessment model for cancer-associated thrombosis, and suggests its adoption into clinical practice as a decision-making tool for primary prophylaxis.
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Koenigsbruegge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: Patients with cancer have a significantly higher risk of both arterial thromboembolism (ATE) and venous thromboembolism (VTE) compared to those without cancer. Different types of cancer show variations in the incidence of ATE and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
