Article
Oncology
Nathan W. Watson, Seth A. Wander, Joseph J. Shatzel, Hanny Al-Samkari
Summary: The CDK4/6 inhibitor abemaciclib, a mainstay of treatment for hormone receptor-positive breast cancer, is associated with a higher rate of venous thromboembolism (VTE) in real-world populations compared to clinical trials. Patients who develop thrombosis while on abemaciclib have a significantly higher risk of death.
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Koenigsbruegge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: Patients with cancer have a significantly higher risk of both arterial thromboembolism (ATE) and venous thromboembolism (VTE) compared to those without cancer. Different types of cancer show variations in the incidence of ATE and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Konigsbrugge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: This study in Austria found a significantly higher risk of arterial and venous thrombosis in cancer patients using International Classification of Disease 10th Revision (ICD-10) diagnosis codes, indicating a strong association between cancer, ATE, and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Hematology
Noori A. M. Guman, Frits I. Mulder, Bart Ferwerda, Aeilko H. Zwinderman, Pieter W. Kamphuisen, Harry R. Buller, Nick van Es
Summary: This study evaluated the use of polygenic risk scores to predict venous thromboembolism (VTE) in patients with cancer. The results showed that these scores can identify patients at higher risk of VTE independent of cancer type.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Oded Icht, Avi Leader, Erez Batat, Lilach Yosef, Tzippy Shochat, Daniel A. Goldstein, Elizabeth Dudnik, Galia Spectre, Pia Raanani, Ariel Hammerman, Alona Zer
Summary: This study found that patients with ALK-positive NSCLC have a higher risk of VTE, but no significant difference in ATE risk. Prospective studies are needed to evaluate thromboprophylaxis in ALK-positive NSCLC.
Article
Oncology
Oded Icht, Avi Leader, Erez Batat, Lilach Yosef, Tzippy Shochat, Daniel A. Goldstein, Elizabeth Dudnik, Galia Spectre, Pia Raanani, Ariel Hammerman, Alona Zer
Summary: This study found that patients with ALK-positive NSCLC had a higher risk of VTE compared to those without ALK rearrangement, but there was no association between ALK positivity and ATE incidence.
Review
Hematology
Rayna J. S. Anijs, Yen Nhi Nguyen, Suzanne C. Cannegieter, Henri H. Versteeg, Jeroen T. Buijs
Summary: MicroRNAs (miRNAs) are small noncoding RNAs with gene regulatory functions that can serve as promising biomarkers for the diagnosis and prediction of cancer and cardiovascular diseases. They play important roles in regulating the pathophysiology of venous thromboembolism (VTE) and cancer-associated thrombosis (CAT). Validation studies using comparable patient populations are needed to determine the potential use of miRNAs as standalone or incorporated biomarkers in risk prediction models for VTE and CAT.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Review
Cardiac & Cardiovascular Systems
Yilu Zhou, Weimin Tao, Fuyi Shen, Weijia Du, Zhendong Xu, Zhiqiang Liu
Summary: Neutrophil extracellular traps (NETs) play a crucial role in the formation of arterial, venous, and cancer-related thrombosis by promoting coagulation and disrupting vascular microenvironmental homeostasis. These findings provide new targets for the prevention and treatment of thrombosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Letter
Oncology
Yukari Tsubata, Takamasa Hotta, Kosuke Hamai, Naoki Furuya, Toshihide Yokoyama, Ryota Saito, Atsushi Nakamura, Takeshi Masuda, Megumi Hamaguchi, Shoichi Kuyama, Ryoichi Honda, Tadashi Senoo, Masamoto Nakanishi, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe
Summary: The study aimed to create a new scoring system that can predict the likelihood of concurrent or incident VTE in patients with advanced lung cancer, which could assist in identifying cases requiring VTE monitoring.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Hematology
Ang Li, Nicole M. Kuderer, Chih-Yuan Hsu, Yu Shyr, Jeremy L. Warner, Dimpy P. Shah, Vaibhav Kumar, Surbhi Shah, Amit A. Kulkarni, Julie Fu, Shuchi Gulati, Rebecca L. Zon, Monica Li, Aakash Desai, Pamela C. Egan, Ziad Bakouny, K. C. Devendra, Clara Hwang, Imo J. Akpan, Rana R. McKay, Jennifer Girard, Andrew L. Schmidt, Balazs Halmos, Michael A. Thompson, Jaymin M. Patel, Nathan A. Pennell, Solange Peters, Amro Elshoury, Gilbero de Lima Lopes, Daniel G. Stover, Petros Grivas, Brian Rini, Corrie A. Painter, Sanjay Mishra, Jean M. Connors, Gary H. Lyman, Rachel P. Rosovsky
Summary: Hospitalized patients with cancer and COVID-19 are at increased risk of VTE and ATE. A simplified RAM model named CoVID-TE was developed to predict VTE in this vulnerable population, showing good performance in stratifying patients into low-risk and high-risk cohorts based on clinical risk factors. The CoVID-TE RAM may aid in real-time data-driven decisions for thrombosis prevention in this population.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Oncology
Lorenzo Gervaso, Heloni Dave, Alok A. Khorana
Summary: VTE, including DVT and PE, is a major cause of morbidity and mortality in cancer patients, with higher risk seen in specific cancers; DOACs are emerging as the preferred treatment option, but managing VTE beyond 6 months and challenging clinical situations remain knowledge gaps.
JACC: CARDIOONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Kuo Zhao, Junzhe Zhang, Junyong Li, Hongyu Meng, Zhiyong Hou, Yingze Zhang
Summary: This study aimed to investigate the incidence of and risk factors for postoperative new-onset deep venous thrombosis (PNO-DVT) following intertrochanteric fracture surgery. Results showed a high incidence of PNO-DVT in inpatients after surgery, with a significant number of cases diagnosed within 8 days post-surgery. Routine DVT examinations for patients after surgery are recommended based on the findings.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Rukhmi Bhat, Soyang Kwon, Isabella Zaniletti, Karna Murthy, Robert Liem
Summary: This study aimed to identify risk factors associated with venous and arterial thrombosis in neonates admitted to the neonatal intensive care unit (NICU) and examine differences in risk factors for venous versus arterial thrombosis. The results showed that factors such as bloodstream infection, maternal diabetes, and abdominal or gastrointestinal surgery were associated with venous thrombosis, while factors such as maternal hypertension, prolonged mechanical ventilation, and small gestational age were associated with arterial thrombosis. Characteristics of central access devices were also found to be related to neonatal thrombosis.
LANCET HAEMATOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Tiphaine Raia-Barjat, Osasere Edebiri, Celine Chauleur
Summary: Venous thromboembolism (VTE) is a significant health issue for pregnant women worldwide. Pregnancy increases the risk of blood clot formation, with known risk factors for VTE during pregnancy. Practice varies between countries and institutions, and personalized risk assessment and treatment using risk score systems are recommended.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Emergency Medicine
Alexandra Lucas, Rachel Rosovsky, Maureen Clark, Eric Grabowski, Phoebe Yager
Summary: In this study of pediatric pulmonary embolism patients, risk factors, clinical presentation, and laboratory values did not correlate with disease severity or clot burden, and CTPA was necessary for diagnosis in almost all cases.
PEDIATRIC EMERGENCY CARE
(2022)
Article
Medicine, General & Internal
Brett J. Carroll, Sebastian E. Beyer, Colby Shanafelt, Christopher Kabrhel, Parth Rali, Belinda Rivera-Lebron, Rachel Rosovsky, Charles B. Ross, Duane S. Pinto, Eric A. Secemsky
Summary: This study evaluated patients with acute pulmonary embolism and compared the characteristics, treatment, and outcomes of transferred and non-transferred patients. Transferred patients had higher-risk features, more frequently received advanced therapy, and had higher definite pulmonary embolism-related mortality.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Behnood Bikdeli, Candrika D. D. Khairani, Briana M. M. Barns, Rachel P. P. Rosovsky, David Jimenez, Manuel Monreal, Katelyn W. W. Sylvester, Saskia Middeldorp, Shannon M. M. Bates, Harlan M. M. Krumholz, Samuel Z. Z. Goldhaber, Beverley J. J. Hunt, Gregory Piazza
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Medicine, General & Internal
Jessica E. Hawley, Tianyi Sun, David D. Chism, Narjust Duma, Julie C. Fu, Na Tosha N. Gatson, Sanjay Mishra, Ryan H. Nguyen, Sonya A. Reid, Oscar K. Serrano, Sunny R. K. Singh, Neeta K. Venepalli, Ziad Bakouny, Babar Bashir, Mehmet A. Bilen, Paolo F. Caimi, Toni K. Choueiri, Scott J. Dawsey, Leslie A. Fecher, Daniel B. Flora, Christopher R. Friese, Michael J. Glover, Cyndi J. Gonzalez, Sharad Goyal, Thorvardur R. Halfdanarson, Dawn L. Hershman, Hina Khan, Chris Labaki, Mark A. Lewis, Rana R. McKay, Ian Messing, Nathan A. Pennell, Matthew Puc, Deepak Ravindranathan, Terence D. Rhodes, Andrea Rivera, John Roller, Gary K. Schwartz, Sumit A. Shah, Justin A. Shaya, Mitrianna Streckfuss, Michael A. Thompson, Elizabeth M. Wulff-Burchfield, Zhuoer Xie, Peter Paul Yu, Jeremy L. Warner, Dimpy P. Shah, Benjamin French, Clara Hwang
Summary: The study aimed to quantify spatiotemporal variation in COVID-19 outcomes among cancer patients in the US. Results showed no significant differences in outcomes across US census divisions, but substantial heterogeneity was found across cancer care delivery centers.
Article
Urology & Nephrology
Caroline M. Hsu, Shruti Gupta, Hocine Tighiouart, Nitender Goyal, Anthony J. Faugno, Asma Tariq, Ritesh Raichoudhury, Jill H. Sharma, Leah Meyer, Ravi K. Kshirsagar, Aju Jose, David E. Leaf, Daniel E. Weiner
Summary: This study examined the clinical factors that determine kidney recovery in critically ill patients with COVID-19. The results showed that lower baseline eGFR and reduced urine output at the time of kidney replacement therapy initiation are strongly associated with kidney nonrecovery.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Oncology
Elizabeth A. Griffiths, Vivek Roy, Laura Alwan, Kimo Bachiashvili, John Baird, Rita Cool, Shira Dinner, Mark Geyer, John Glaspy, Ivana Gojo, Ashley Hicks, Avyakta Kallam, Wajih Zaheer Kidwai, Dwight D. Kloth, Eric H. Kraut, Daniel Landsburg, Gary H. Lyman, Anjlee Mahajan, Ryan Miller, Victoria Nachar, Seema Patel, Shiven Patel, Lia E. Perez, Adam Poust, Fauzia Riaz, Rachel Rosovsky, Hope S. Rugo, Shayna Simon, Sumithira Vasu, Martha Wadleigh, Kelly Westbrook, Peter Westervelt, Ryan A. Berardi, Lenora Pluchino
Summary: The NCCN Guidelines provide recommendations for the appropriate use of growth factors in the management of certain conditions in adult patients with nonmyeloid malignancies. The guidelines aim to evaluate, prevent, and treat febrile neutropenia, chemotherapy-induced thrombocytopenia, and chemotherapy-induced anemia, allowing patients and clinicians to assess management options based on individual patient's condition. The recent updates emphasize the incorporation of a newly developed section on chemotherapy-induced thrombocytopenia.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Hematology
Behnood Bikdeli, Gregory Piazza, David Jimenez, Alfonso Muriel, Yun Wang, Candrika D. Khairani, Rachel P. Rosovsky, Ghazaleh Mehdipoor, Michelle L. O'Donoghue, Primavera Spagnolo, Rachel P. Dreyer, Laurent Bertoletti, Luciana Lopez-Jimenez, Manuel Jesus Nunez, Angeles Blanco-Molina, Shannon M. Bates, Marie Gerhard-Herman, Samuel Z. Goldhaber, Manuel Monreal, Harlan M. Krumholz
Summary: The SERIOUS-PE study aims to uncover sex differences in the presentation, care, and outcomes of patients with pulmonary embolism (PE). By utilizing international and US databases, the study seeks to understand the sex differences in risk factors, treatment patterns, and prognosis of older adults with PE.
THROMBOSIS RESEARCH
(2022)
Article
Medicine, General & Internal
Vincent D. Pellegrini, John William Eikelboom, C. McCollister Evarts, Patricia D. Franklin, Kevin L. Garvin, Samuel Z. Goldhaber, Richard Iorio, Carol Ann Lambourne, Jay Magaziner, Laurence Magder
Summary: This study aims to compare the effectiveness and safety of three commonly used chemoprophylaxis agents in preventing pulmonary embolism and venous thromboembolism in patients undergoing total hip and knee replacements. The study utilizes a randomized pragmatic comparative effectiveness trial design and will analyze patient-reported outcomes as well as safety and efficacy measures.
Review
Hematology
Mateo Porres-Aguilar, Rachel P. Rosovsky, Belinda N. Rivera-Lebron, Scott Kaatz, Debabrata Mukherjee, Javier E. Anaya-Ayala, David Jimenez, Carlos Jerjes-Sanchez
Summary: Pulmonary embolism response teams (PERTs) are multidisciplinary teams that have changed the approach to complex acute pulmonary embolism (PE) cases. PERTs are positively impacting the treatment paradigm for acute PE through global adoption by the healthcare community.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Medicine, General & Internal
Rachel P. Rosovsky, Eva Kline-Rogers, Leslie Lake, Tracy Minichiello, Gregory Piazza, Bishoy Ragheb, Beth Waldron, Daniel M. Witt, Stephan Moll
Summary: In clinical practice, direct oral anticoagulants (DOACs) are used for venous thromboembolism treatment and prevention. The use of DOACs in obese patients is still controversial, with limited supporting data previously. There are also evidence gaps regarding the treatment of severe obesity and the appropriate use of DOACs in different situations.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Hematology
Thita Chiasakul, Barbara D. Lam, Megan Mcnichol, William Robertson, Rachel P. Rosovsky, Leslie Lake, Ioannis S. Vlachos, Alys Adamski, Nimia Reyes, Karon Abe, Jeffrey I. Zwicker, Rushad Patell
Summary: This systematic review assessed the performance of artificial intelligence (AI) in diagnosing and predicting venous thromboembolism (VTE) and compared it to clinical risk assessment models or logistic regression models. AI showed promising results in VTE prediction, but there was a high risk of bias observed across studies. Future research should focus on transparent reporting, external validation, and clinical application of AI models.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Letter
Hematology
Mateo Porres-Aguilar, Rachel P. Rosovsky, David Jimenez, Debabrata Mukherjee, Belinda N. Rivera-Lebron, Scott Kaatz, Javier E. Anaya-Ayala, Carlos Jerjes-Sanchez
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Orly Leiva, Umberto Campia, Julia Snyder, Briana M. Barns, Samantha Rizzo, Candrika D. Khairani, Andrew Brunner, Hanny Al-Samkari, Rebecca Karp Leaf, Rachel Rosovsky, Katayoon Goodarzi, Larissa Bornikova, Amir Fathi, Samuel Z. Goldhaber, Gabriela Hobbs, Gregory Piazza
Summary: Among COVID-19 patients, individuals with MPNs have a higher risk of arterial thrombosis compared to those without MPNs, but similar risks of VTE, bleeding, and death. Larger studies are required to confirm these findings due to the limited sample size.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Hematology
Dana E. Angelini, Scott Kaatz, Rachel P. Rosovsky, Rebecca L. Zon, Shreejith Pillai, William E. Robertson, Pavania Elavalakanar, Rushad Patell, Alok Khorana
Summary: This article reviews the mechanisms of coagulopathy associated with COVID-19 and the epidemiology and pathophysiology of venous thromboembolism in patients. It also provides updated strategies for the prevention and treatment of VTE associated with SARS-CoV-2 infection.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Geriatrics & Gerontology
Arielle Elkrief, Cassandra Hennessy, Nicole M. Kuderer, Samuel M. Rubinstein, Elizabeth Wulff-Burchfield, Rachel P. Rosovsky, Karen Vega-Luna, Michael A. Thompson, Orestis A. Panagiotou, Aakash Desai, Donna R. Rivera, Ali Raza Khaki, Lisa Tachiki, Ryan C. Lynch, Catherine Stratton, Rawad Elias, Gerald Batist, Anup Kasi, Dimpy P. Shah, Ziad Bakouny, Angelo Cabal, Jessica Clement, Jennifer Crowell, Becky Dixon, Christopher R. Friese, Stacy L. Fry, Punita Grover, Shuchi Gulati, Shilpa Gupta, Clara Hwang, Hina Khan, Soo Jung Kim, Elizabeth J. Klein, Chris Labaki, Rana R. McKay, Amanda Nizam, Nathan A. Pennell, Matthew Puc, Andrew L. Schmidt, Armin Shahrokni, Justin A. Shaya, Christopher T. Su, Sarah Wall, Nicole Williams, Trisha M. Wise-Draper, Sanjay Mishra, Petros Grivas, Benjamin French, Jeremy L. Warner, Tanya M. Wildes
Summary: This study aims to quantify the association of a novel geriatric risk index with COVID-19 severity and 30-day mortality among older adults with cancer. The results show a strong association between the geriatric risk index and COVID-19 severity and mortality, providing clinicians with a risk stratification method to identify high-risk older adults.
LANCET HEALTHY LONGEVITY
(2022)