CuBr-Catalyzed Reaction of N,N-Dimethylanilines and Silyl Enol Ethers: An Alternative Route to β-Arylamino Ketones

A wide range of silyl enol ethers undergo the reactions with N,N-dimethylanilines in the presence of transition metal catalysts under mild conditions to give beta-arylamino ketones. In the cases of silyl enol ethers derived from unsymmetrical ketones, regiospecific addition of carbonyl compounds was obtained at the olefinic position of silyl enol ether.