☆ 4.8 Article

First total synthesis of cassiarin A, a naturally occurring potent antiplasmodial alkaloid

ORGANIC LETTERS (2008)

期刊

ORGANIC LETTERS

卷 10, 期 10, 页码 1921-1922

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AMER CHEMICAL SOC

DOI: 10.1021/ol8004112

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Chemistry, Organic

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The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6-endo-dig-cyclization of phenolic oxygens to the resulting alkynes.

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