Article
Thermodynamics
Sangeeta Mukhopadhyay, Pinaki Sarkar, Reginald E. Masto, Ashok K. Singh, Pradeep K. Singh
Summary: The study found that different parts of Cassia siamea have varying combustion characteristics, with cellulose and lignin influencing the combustion process differently. This has implications for the potential use of each plant part as fuel or as a component of blended fuel.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Biochemistry & Molecular Biology
Sachin Honnenahalli Rajegowda, Sneha Rani Athahalli Honnagirigowda
Summary: This study reports the purification and characterization of a novel serine protease inhibitor from the seeds of Cassia siamea, a nonedible legume, and evaluates its anti-inflammatory activity. The purified inhibitor shows promising potential as an anti-inflammatory agent by targeting serine proteases.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Integrative & Complementary Medicine
Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati, Tutik Sri Wahyuni
Summary: Extract from Cassia spectabilis DC leaf has potent antiplasmodial activity, offering potential for effective and affordable antimalarial phytomedicine.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Geosciences, Multidisciplinary
Sangeeta Mukhopadhyay, Reginald E. Masto
Summary: The nature of tree species used for revegetation of post-mining land can affect soil carbon and nutrient stocks. This study compared Cassia siamea and Albizia lebbeck for their potential to increase carbon and nutrient stocks in mined land. Results showed that Cassia siamea performed better in increasing soil carbon and nutrient stocks than Albizia lebbeck, with significant differences observed in biomass carbon stock, soil dehydrogenase activity, and microbial biomass. Overall, reclamation time played a major role in increasing soil carbon and nutrient stocks, and Cassia siamea showed superior performance compared to Albizia lebbeck.
Article
Chemistry, Multidisciplinary
Sajjad Hussain Parrey, Mohsin Maseet, Rabia Ahmad, Abbul Bashar Khan
Summary: Silver nanoparticles (Ag NPs) were synthesized for the first time using Cassia siamea flower petal extract (CSFE) as a reducing agent. The effects of anionic surface-active agent sodium dodecyl sulfate (SDS) on the development and texture of Ag NPs were studied, showing different shapes and sizes of Ag NPs under various synthesis conditions. The synthesized Ag NPs exhibited promising antifungal activity against different Candida strains, especially Candida tropicalis.
Article
Biochemistry & Molecular Biology
Duc Hoang Lande, Abed Nasereddin, Arne Alder, Tim W. Gilberger, Ron Dzikowski, Johann Gruenefeld, Conrad Kunick
Summary: Malaria is a dangerous infectious disease for which novel antiplasmodial agents are needed due to parasite resistance. N-unsubstituted bisindolylcyclobutenediones were designed as potential drugs and showed promising antiplasmodial activity through molecular docking and synthesis.
Article
Microbiology
Nanang R. Ariefta, Baldorj Pagmadulam, Masaki Hatano, Noriko Ikeda, Kunio Isshiki, Kazuaki Matoba, Masayuki Igarashi, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: The increasing burden and spread of resistant malaria parasites have driven the demand for a new therapeutic agent. Phebestin showed nanomolar efficacy against Plasmodium falciparum 3D7 and inhibited parasite multiplication in vitro. It exhibited no cytotoxicity against human cells and inhibited parasite stages at high concentrations. In vivo evaluation in mice infected with different malaria strains also showed promising results.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Nanoscience & Nanotechnology
Tanushree Ghosh, Suchita Kandpal, Chanchal Rani, Devesh K. Pathak, Manushree Tanwar, Anjali Chaudhary, Hem C. Jha, Rajesh Kumar
Summary: The optical and electrochemical properties of Cassia and Giloy leaves' raw extract have been studied, revealing differences in their emission properties under UV excitation. Despite their similar appearance, both can act as antioxidants and exhibit similar redox properties. The variation in relative emission intensities is explained by the presence of different ratios of color centers in the two leaves.
ACS APPLIED BIO MATERIALS
(2021)
Article
Plant Sciences
Maram B. Alhawarri, Roza Dianita, Mira Syahfriena Amir Rawa, Toshihiko Nogawa, Habibah A. Wahab
Summary: The phytoconstituents of C. timoriensis and C. grandis were identified, and their inhibitory activity against AChE and BChE was evaluated. Two compounds were isolated from C. timoriensis and five compounds were identified from C. grandis. Compound 2 showed significant inhibition towards AChE and BChE. Molecular docking revealed that compound 2 has good binding affinity towards TcAChE and HsBChE.
Article
Biochemistry & Molecular Biology
Anna Jaromin, Anna Czopek, Silvia Parapini, Nicoletta Basilico, Ernest Misiak, Jerzy Gubernator, Agnieszka Zagorska
Summary: This study synthesized novel derivatives and conducted preliminary physicochemical characterization, showing strong inhibitory effects against Plasmodium falciparum, particularly the chloroquine-resistant strain. These molecules exhibited no hemolytic action on human erythrocytes and low toxicity on mammalian cell line.
Article
Biochemistry & Molecular Biology
Nattapong Wongchum, Ananya Dechakhamphu
Summary: The ethanolic stem extract of Cassia siamea prolonged the lifespan of Drosophila melanogaster and reduced oxidative stress, as shown by increased activity of SOD and CAT enzymes.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Chemistry, Applied
Ngozichukwuka P. Igoli, Naser F. Al-Tannak, Ifeoma C. Ezenyi, Alexander I. Gray, John O. Igoli
Summary: The phytochemical constituents of Siphonochilus aethiopicus from Nigeria and South Africa were examined, revealing novel compounds in the South African variety and known compounds in the Nigerian variety. An isolated diarylheptanoid from the South African variety showed significant antiplasmodial activity against Plasmodium falciparum in vitro, suggesting a potential direct mechanism of action in parasite growth inhibition.
NATURAL PRODUCT RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Francisco Flavio Vieira de Assis, Jose Sousa de Almeida Junior, Tania Mara Pires Moraes, Fernando de Pilla Varotti, Camila Castilho Moraes, Adilson Sartoratto, Waldiney Pires Moraes, Antonio Humberto Hamad Minervino
Summary: This study evaluated the in vitro antimalarial activity and cytotoxicity of the hydroalcoholic extract of Juca (Libidibia ferrea). The results showed that the Juca extract exhibited significant antimalarial activity and no significant cytotoxicity.
Article
Robotics
Zhiwei Li, Nosang Vincent Myung, Yadong Yin
Summary: This study presents a steam-driven photothermal oscillator that can perform continuous or pulsed mechanical oscillations under constant light irradiation. By utilizing a hydrogel containing Fe3O4/Cu hybrid nanorods as the key component, this oscillator can convert light into heat and generate steam bubbles, enabling controllable perturbation to achieve either continuous or pulsed oscillation modes, showcasing high adaptability.
Article
Pharmacology & Pharmacy
Nanang Rudianto Ariefta, Baldorj Pagmadulam, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: This study evaluated the growth-inhibitory effects of the antimalarial agent sparsomycin against drug-resistant malaria parasites. The results showed that sparsomycin had inhibitory effects on both sensitive and resistant strains of the parasites. This study suggests that sparsomycin has potential as an alternative treatment for malaria.
Article
Integrative & Complementary Medicine
Wiwied Ekasari, Dwi Widya Pratiwi, Zelmira Amanda, Suciati, Aty Widyawaruyanti, Heny Arwati
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Integrative & Complementary Medicine
Hilkatul Ilmi, Irfan Rayi Pamungkas, Lidya Tumewu, Achmad Fuad Hafid, Aty Widyawaruyanti
Summary: The tablet derived from Andrographis paniculata ethyl acetate fraction (AS201-01) exhibited significant analgesic and antipyretic activities in animal models, showing a reduction in writhing response and a maximum antipyretic effect at specific doses of andrographolide per kg body weight.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Veterinary Sciences
Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati
Summary: This study aimed to investigate the toxicity and protective effects of Cassia spectabilis extract on the liver and kidneys of mice infected with P. berghei ANKA. The results showed that the extract was not toxic in mice and improved the liver and kidney functions of infected mice.
VETERINARY MEDICINE INTERNATIONAL
(2022)
Review
Chemistry, Analytical
Gunawan Indrayanto
Summary: Many scientific publications on herbal drugs fail to accurately report their chemical, biological, and pharmacological aspects, making it difficult to prove their safety, efficacy, and consistency. The development of modern drugs from herbal drugs requires comprehensive chemical and pharmacological characterizations of their bioactive metabolites, as well as the development, assessment, and standardization of methods based on current technology.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Pharmacology & Pharmacy
Eka Noviana, Gunawan Indrayanto, Abdul Rohman
Summary: This article evaluates various fingerprinting techniques applicable to the standardization and quality control of herbal medicines, and discusses the application of multivariate data analysis or chemometrics in analyzing complex datasets for herbal medicine determination. Fingerprint analysis, as a useful technique, provides a method for assessing the quality of herbal materials and formulations, particularly considering the complexity of herbal drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Wiwied Ekasari, Dwi Fatmawati, Siti M. Khoiriah, Wenda A. Baqiuddin, Hawi Q. Nisa, Adinda A. S. Maharupini, Tutik S. Wahyuni, Rice D. Oktarina, Eko Suhartono, Ram K. Sahu
Summary: The study found that the leaves of Sauropus androgynus have antimalarial activity, with the most active fraction being FV. The ethanolic extract showed good parasitic suppressive activity and was more effective than prophylactic activity.
Editorial Material
Pharmacology & Pharmacy
Abdul Rohman, Gunawan Indrayanto, Kornkanok Ingkaninan
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Elly Sufriadi, Rinaldi Idroes, Hesti Meilina, Agus Arip Munawar, Lelifajri, Gunawan Indrayanto
Summary: This study aims to detect adulteration of patchouli oil (PO) with gurjun balsam oil (GBO) using chemometrically partial least squares-discriminant analysis (PLS-DA) classification models and Fourier transform infrared spectroscopy. Unsupervised analysis and model testing were performed on the original spectrum and pre-processed spectrum. The PLS-DA model successfully detected the presence of counterfeiting material even at the lowest counterfeiting ratio (0.5%). The model showed high accuracy and low prediction errors, with a validation accuracy above 99%.
Article
Pharmacology & Pharmacy
Tutik Sri Wahyuni, Hilkatul Ilmi, Ade Syamsi Kristiaji, Martiana Candra Dewi, Hanifah Khairun Nisa, Achmad Fuad Hafid, Aty Widyawaruyanti
Summary: This study evaluated the acute and sub-chronic toxicity of the ethanol extract of Ruta angustifolia leaves in rats. The results showed that the extract had no significant toxicity at low doses, but may have toxic effects on the liver at higher doses.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Suciati, Erlinda R. Laili, Wiwied Ekasari, Kuatman, Nitra Nuengchamnong, Nungruthai Suphrom
Summary: The ethanolic and water extracts of Cassia spectabilis flower were studied for their potential as cholinesterase inhibitors for Alzheimer's disease treatment. Chemical analysis and molecular networking revealed the presence of piperidine alkaloids, which could be responsible for the inhibitory activity. The ethanolic extract exhibited higher potency, possibly due to its higher concentration of alkaloids.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aty Widyawaruyanti, Hilkatul Ilmi, Lidya Tumewu, Dwi Ayu Fitrianingtyas, Yesinta Kurniawati, Alfin Laila Najiha, Hanifah Khairun Nisa, Che Puteh Osman, Nor Hadiani Ismail, Achmad Fuad Hafid
Summary: Andrographis paniculata has been found to have antimalarial activity and is safe when administered orally at an equivalent therapeutic dose in an animal model.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2023)
Review
Multidisciplinary Sciences
Gunawan Indrayanto
Summary: New methods for evaluating accuracy and precision are mentioned in the latest edition of the USP, while other validation parameters remain relatively unchanged. It is essential to validate or verify the analytical procedure according to the latest edition of the pharmacopoeia in order to obtain reliable data from chemical/pharmaceutical analyses. The author has published some review articles on general validation methods. This review focuses on the implementation and discussion of accuracy and precision evaluation based on the current USP and Indonesian pharmacopoeia, including examples of calculation for several accuracy and precision determinations.
MAKARA JOURNAL OF SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Imam Taufik, Ati Widyawaruyanti, Mochammad Yuwono
Summary: The study revealed significant differences in metabolite fingerprints, toxicity, and antimalarial activity of A. champeden stembark, with the potential influence of nutrients such as copper, zinc, and manganese on metabolite content. Specific compounds with certain Rf values could serve as markers for antimalarial activity and toxicity. Indonesian A. champeden from Maluku showed the highest antimalarial activity and safety, recommending it as a material source for herbal medicine development.
INDONESIAN JOURNAL OF PHARMACY
(2021)
Article
Integrative & Complementary Medicine
Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati, Tutik Sri Wahyuni
Summary: Extract from Cassia spectabilis DC leaf has potent antiplasmodial activity, offering potential for effective and affordable antimalarial phytomedicine.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Multidisciplinary Sciences
Silvy Juliana, Suciati, Gunawan Indrayanto
MAKARA JOURNAL OF SCIENCE
(2019)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
