New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

(2013) Kimberly M. Lincoln et al.   CHEMICAL COMMUNICATIONS

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

(2013) Masha G. Savelieff et al.   CHEMICAL COMMUNICATIONS

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

Design of β-Amyloid Aggregation Inhibitors from a Predicted Structural Motif

(2012) Paul A. Novick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship of N-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors

(2012) Roberto Di Santo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liberation of Copper from Amyloid Plaques: Making a Risk Factor Useful for Alzheimer’s Disease Treatment

(2012) Jie Geng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity

(2011) Alberto Granzotto et al.   PLoS One

Inhibition of Aβ42 Peptide Aggregation by a Binuclear Ruthenium(II)−Platinum(II) Complex: Potential for Multimetal Organometallics as Anti-amyloid Agents

(2010) Amit Kumar et al.   ACS Chemical Neuroscience

Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats

(2010) Izet M. Kapetanovic et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: a population-based study involving twenty-three developed countries

(2010) Kristopher Beking et al.   PUBLIC HEALTH NUTRITION

Cholinesterase Inhibitors and Beyond

(2009) Giancarlo Pepeu et al.   Current Alzheimer Research

Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as β-amyloid aggregation inhibitors

(2009) Marco Catto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

All-transretinoic acid as a novel therapeutic strategy for Alzheimer’s disease

(2009) Hyun-Pil Lee et al.   Expert Review of Neurotherapeutics

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

(2007) Tamar Amit et al.   FASEB JOURNAL