Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors

Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue

(2012) Alberto Oddo et al.   CARBOHYDRATE RESEARCH

Accelerating resistance, inadequate antibacterial drug pipelines and international responses

(2012) Ursula Theuretzbacher   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

(2011) Matthew F. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Antibiotics as probes of biological complexity

(2011) Shannon B Falconer et al.   Nature Chemical Biology

Activation ofEscherichia coliUDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine Deacetylase by Fe2+Yields a More Efficient Enzyme with Altered Ligand Affinity

(2010) Marcy Hernick et al.   BIOCHEMISTRY

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

(2010) Chul-Jin Lee et al.   CHEMISTRY & BIOLOGY

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthesis of sugar-based chelating surfactants for metal removal from wastewater

(2008) Nadège Ferlin et al.   CARBOHYDRATE RESEARCH