Antibiotics as probes of biological complexity

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

(2010) Catherine Paradis-Bleau et al.   CELL

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

(2010) Athanasios Typas et al.   CELL

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Probing Translation with Small-Molecule Inhibitors

(2010) Scott C. Blanchard et al.   CHEMISTRY & BIOLOGY

Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity

(2010) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

Bacterial actin MreB assembles in complex with cell shape protein RodZ

(2010) Fusinita van den Ent et al.   EMBO JOURNAL

Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis

(2010) Tsuyoshi Uehara et al.   EMBO JOURNAL

Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system

(2010) Yuhei Chadani et al.   MOLECULAR MICROBIOLOGY

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor

(2010) Kalinka Koteva et al.   Nature Chemical Biology

Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase

(2010) Jérémie Piton et al.   PLoS One

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

NAViGaTOR: Network Analysis, Visualization and Graphing Toronto

(2009) Kevin R. Brown et al.   BIOINFORMATICS

A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds

(2009) Robert G.K. Donald et al.   CHEMISTRY & BIOLOGY

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis

(2009) Michael A. D'Elia et al.   CHEMISTRY & BIOLOGY

Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis

(2009) Kathrin Schirner et al.   EMBO JOURNAL

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

(2009) Ranjana Pathania et al.   Nature Chemical Biology

Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling

(2009) Samuel H Sternberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid  -lactam-induced lysis requires successful assembly of the cell division machinery

(2009) H. S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY

(2009) J. van Stelten et al.   SCIENCE

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

(2008) Michael Y Pavlov et al.   EMBO JOURNAL

Determination of Antibiotic Hypersensitivity among 4,000 Single-Gene-Knockout Mutants of Escherichia coli

(2008) C. Tamae et al.   JOURNAL OF BACTERIOLOGY

Recycling of Aborted Ribosomal 50S Subunit-Nascent Chain-tRNA Complexes by the Heat Shock Protein Hsp15

(2008) Linhua Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

Precise Alignment of Peptidyl tRNA by the Decoding Center Is Essential for EF-G-Dependent Translocation

(2008) Lucia Garcia-Ortega et al.   MOLECULAR CELL

eSGA: E. coli synthetic genetic array analysis

(2008) Gareth Butland et al.   NATURE METHODS

High-throughput, quantitative analyses of genetic interactions in E. coli

(2008) Athanasios Typas et al.   NATURE METHODS

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE