Regio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model

Design, Synthesis, and Structural and Spectroscopic Studies of Push–Pull Two-Photon Absorbing Chromophores with Acceptor Groups of Varying Strength

(2013) Alma R. Morales et al.   JOURNAL OF ORGANIC CHEMISTRY

A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation

(2012) Marco Radi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Full Structure Assignments of Pyrrolizidine Alkaloid DNA Adducts and Mechanism of Tumor Initiation

(2012) Yuewei Zhao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

A progressive approach on zebrafish toward sensitive evaluation of nanoparticles' toxicity

(2012) Yang Liu et al.   Integrative Biology

A Bayesian Approach to in Silico Blood-Brain Barrier Penetration Modeling

(2012) Ines Filipa Martins et al.   Journal of Chemical Information and Modeling

Facile synthesis of spiro[indoline-3,3′-pyrrolo[1,2-a]quinolines] and spiro[indoline-3,1′-pyrrolo[2,1-a]isoquinolines] via 1,3-dipolar cycloaddition reactions of heteroaromatic ammonium salts with 3-phenacylideneoxindoles

(2012) Lei Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model

(2012) Carlos E. Puerto Galvis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

(2012) Jessy Aziz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Catalytic 1,3-Dipolar Cycloaddition Reaction of Nitrile Imines for the Synthesis of Chiral Spiro-Pyrazoline-Oxindoles

(2012) Gang Wang et al.   ORGANIC LETTERS

1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides with a Cellulose-Derived Chiral Enone. A Novel Route for Organocatalysts Development

(2012) Ariel M. Sarotti et al.   ORGANIC LETTERS

Catalytic Stereoselective Synthesis of Diverse Oxindoles and Spirooxindoles from Isatins

(2012) Jacob P. MacDonald et al.   ACS Combinatorial Science

A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity

(2012) Jian-Hui He et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The developing zebrafish (Danio rerio): A vertebrate model for high-throughput screening of chemical libraries

(2011) Charles A. Lessman   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC)

(2011) Usman SF Tambunan et al.   BMC BIOINFORMATICS

Plants containing pyrrolizidine alkaloids: toxicity and problems

(2011) H. Wiedenfeld   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Chlorination of isatins with trichloroisocyanuric acid

(2011) Bárbara V Silva et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

(2011) Mou-Nuo Cheng et al.   ORGANIC LETTERS

Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing

(2011) Shaukat Ali et al.   PLoS One

Zebrafish as a Potential Model Organism for Drug Test Against Hepatitis C Virus

(2011) Cun-Bao Ding et al.   PLoS One

Drug screening in a zebrafish model of Duchenne muscular dystrophy

(2011) G. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An expedient diastereoselective synthesis of pyrrolidinyl spirooxindoles fused to sugar lactone via [3+2] cycloaddition of azomethine ylides

(2011) J. Naga Siva Rao et al.   TETRAHEDRON LETTERS

Design and synthesis of spirotryprostatin-inspired diketopiperazine systems from prolyl spirooxoindolethiazolidine derivatives

(2010) Alessia Bertamino et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dechorionation as a tool to improve the fish embryo toxicity test (FET) with the zebrafish (Danio rerio)

(2010) Kirsten Henn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation

(2010) Pitchaimani Prasanna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regioselective Synthesis of Novel Spiropyrrolidines and Spirothiapyrrolizidines Through Multicomponent 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides

(2010) Hai Liu et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

The organocatalytic [3+2] cycloaddition of azomethine ylides and α,β-unsaturated aldehydes as a convenient tool for the enantioselective synthesis of pyrrolizidines and indolizidines

(2010) Ainara Iza et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library

(2010) Lauren R. Donaldson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Chiral Solvent Effect in Asymmetric Organocatalysis

(2010) Michael North et al.   ORGANIC LETTERS

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

An experimental and theoretical investigation of the regio- and stereoselectivity of the polar [3+2] cycloaddition of azomethine ylides to nitrostyrenes

(2010) Kamal Alimohammadi et al.   TETRAHEDRON

Ultrasound-promoted synthesis of novel spirooxindolo/spiroacenaphthen dicyano pyrrolidines and pyrrolizidines through regioselective azomethine ylide cycloaddition reaction

(2010) Seyed Jamal Tabatabaei Rezaei et al.   ULTRASONICS SONOCHEMISTRY

Synthesis of (E)-nitroalkenes Catalysed by Ethanolamine Supported on Silica

(2009) Manuel Mora et al.   CATALYSIS LETTERS

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

OSIRIS, an Entirely in-House Developed Drug Discovery Informatics System

(2009) Thomas Sander et al.   Journal of Chemical Information and Modeling

Enantioselectivity in Zebrafish Embryo Toxicity of the Insecticide Acetofenate

(2008) Chao Xu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY

The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing

(2008) Stefan Scholz et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

(2008) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

Theory of 1,3-Dipolar Cycloadditions: Distortion/Interaction and Frontier Molecular Orbital Models

(2008) Daniel H. Ess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

E/Z-Thesinine-O-4′-α-rhamnoside, pyrrolizidine conjugates produced by grasses (Poaceae)

(2008) Albert Koulman et al.   PHYTOCHEMISTRY

Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish

(2007) Demetrio Raldúa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY