期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 12, 期 5, 页码 633-637出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc100035q
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-
资金
- Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province
A series of novel spiropyrrolidines and spirothiapyrrolizidines were synthesized via a three-component 1,3-dipolar cycloaddition reaction of isatin or acenaphthenequinone, sarcosine or thiaproline and 4-hydroxy-6-methyl-3-((E)-3-phenylacryloyl)-2H-pyran-2-ones in refluxing ethanol. Advantages of this method include the availability of starting materials, mild reaction conditions, high yields, and the complete regioselectivity observed.
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