Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Tajanna Stinn, Steve Kuntz, Dana Varon, Meei-Li Huang, Stacy Selke, Samuel Njikan, Emily S. Ford, Joan Dragavon, Robert W. Coombs, Christine Johnston, Marta E. Bull
Summary: This study suggests that subclinical HSV shedding in HIV/HSV-coinfected women during ART may sustain HIV tissue reservoirs through antigen exposure or HIV replication. Frequent subclinical HSV DNA shedding was associated with increased HIV DNA tissue concentrations and increased divergence from ancestral sequences, indicating a potential role of immune responses to common coinfections in sustaining HIV tissue reservoirs during suppressive ART.
JOURNAL OF VIROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Abhay Kulkarni, Shruti Wadne, Rajendra Birangane, Rohan Chaudhari, Nitin Kole, Supriya Sankpal
Summary: The study revealed a high prevalence of HSV in the oral cavity, especially HSV-2, even in asymptomatic individuals. There is a significant risk of infection and cross-infection for oral health workers. Therefore, identifying potential carriers and conducting follow-up is crucial.
JOURNAL OF INDIAN ACADEMY OF ORAL MEDICINE AND RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Review
Virology
Joshua D. Bernstock, Samantha E. Hoffman, Jason A. Chen, Saksham Gupta, Ari D. Kappel, Timothy R. Smith, E. Antonio Chiocca
Summary: Despite advances in surgical resection and chemoradiation, high-grade brain tumors remain associated with significant morbidity/mortality, necessitating novel therapeutic strategies. Immunotherapy and immunovirotherapy are among the forefront of these new approaches being investigated for incurable brain tumors. This mini review focuses on oncolytic herpes viruses (oHSV) currently in clinical trials.
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Matylda Barbara Mielcarska, Katarzyna Skowronska, Zbigniew Wyzewski, Felix Ngosa Toka
Summary: Current data strongly indicate that herpes simplex virus type 1 (HSV-1) infection is a contributing factor to Alzheimer's disease (AD). HSV-1 infection causes damage to neurons and glial cells, as well as modifications in their environment, leading to impaired signal transmission and homeostatic and immune functions. This review discusses the pathological alterations in central nervous system (CNS) cells following HSV-1 infection, including inflammatory responses, oxidative damage, and cellular dysfunctions associated with AD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Noemie Berry, Rodolphe Suspene, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stephane Rigaud, Herve Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Summary: HSV-1 impairs the mitochondrial network and releases mtDNA, leading to the upregulation of type I interferon and APOBEC3A expression. The RNA polymerase III/RIG-I pathway is crucial for interferon production. Released mtDNA causes mutations induced by APOBEC3A, resulting in DNA catabolism.
Article
Pharmacology & Pharmacy
Tiina Koivikko, Priscila Campioni Rodrigues, Mari Vehvilaeinen, Petra Hyvonen, Elias Sundquist, Riikka K. Arffman, Ahmed Al-Samadi, Hanna Valimaa, Tuula Salo, Maija Risteli
Summary: This study investigates the predominance of HSV-1 in oral HSV infections and its effect on oral tongue squamous cell carcinoma (OTSCC). The results show that HSV-1 is the predominant type in oral HSV infections and is also detected in OTSCC samples without clinical significance. Furthermore, low doses of HSV-1 do not affect cell survival or invasion in OTSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Meng-Shan Tsai, Shun-Hua Chen, Chih-Peng Chang, Yi-Ling Hsiao, Li-Chiu Wang
Summary: ILK reduces the accumulation of H3K9me3 on HSV-1 DNA by reducing SUV39H1 and TRIM28 binding, enhancing virus replication. ILK knockdown decreases TRIM28 phosphorylation, weakening its inhibition on lytic gene transcription. ILK inhibitor suppresses HSV-1 replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yeu-Yang Tseng, Anjali Gowripalan, Sarah N. Croft, Stewart A. Smith, Karla J. Helbig, Si Ming Man, David C. Tscharke
Summary: Studies have shown that the upregulation of viperin during HSV-1 infection is cell-type specific in mouse and human cells, with mouse viperin exhibiting inhibitory effects against HSV-1. The anti-HSV-1 activity of viperin is dependent on viral gene transcription and the N-terminal domain of the protein. Furthermore, the HSV-1 virion host shutoff protein is identified as a key viral factor that counters the effects of viperin in mouse cells.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Microbiology
Johanna Laakso, Tytti Vuorinen, Jaana Rautava, Katja Kero, Stina Syrjanen, Veijo Hukkanen
Summary: This study evaluated the HSV seroprevalence and seroconversion among pregnant women and their spouses in Finland over a six-year follow-up period. Results showed a higher overall HSV seroprevalence in women compared to their spouses, with similar seroconversion rates between spouses. Factors associated with HSV seropositivity varied between women and male spouses, with women's age and history of genital warts being significant factors, while male spouses' HSV seropositivity was linked to the practice of oral sex.