The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies

Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas

(2021) Gregory K. Friedman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses

(2020) Quazim A. Alayo et al.   Scientific Reports

Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

(2020) Joshua D. Bernstock et al.   HUMAN GENE THERAPY

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

(2020) E. Antonio Chiocca et al.   Molecular Therapy-Methods & Clinical Development

Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice

(2019) Joshua D. Bernstock et al.   CANCER GENE THERAPY

The Immunobiology of the Interleukin-12 Family: Room for Discovery

(2019) Elia D. Tait Wojno et al.   IMMUNITY

Oncolytic herpes simplex virus immunotherapy for brain tumors: current pitfalls and emerging strategies to overcome therapeutic resistance

(2019) Stacie K. Totsch et al.   ONCOGENE

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implications

(2019) Joshua D. Bernstock et al.   JOURNAL OF NEUROSURGERY

ATIM-14. RESULTS OF PHASE II CLINICAL TRIAL OF ONCOLYTIC HERPES VIRUS G47Δ IN PATIENTS WITH GLIOBLASTOMA

(2019) Tomoki Todo   NEURO-ONCOLOGY

Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression

(2018) Gregory K. Friedman et al.   Scientific Reports

Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis

(2017) Myra E. van Linde et al.   JOURNAL OF NEURO-ONCOLOGY

Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors

(2017) Alicia M. Waters et al.   Human Gene Therapy Clinical Development

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus–Host Interactions

(2016) Douglas R. Wilcox et al.   PLoS Pathogens

Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma

(2016) Daxa M. Patel et al.   Human Gene Therapy Clinical Development

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Cancer-treatment-induced neurotoxicity—focus on newer treatments

(2015) Jacqueline B. Stone et al.   Nature Reviews Clinical Oncology

A Phase 1 Trial of Oncolytic HSV-1, G207, Given in Combination With Radiation for Recurrent GBM Demonstrates Safety and Radiographic Responses

(2014) James M Markert et al.   MOLECULAR THERAPY

Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011

(2014) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Evaluation of the Safety and Biodistribution of M032, an Attenuated Herpes Simplex Virus Type 1 Expressing hIL-12, After Intracerebral Administration to Aotus Nonhuman Primates

(2014) Justin C. Roth et al.   Human Gene Therapy Clinical Development

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

(2012) Hideo Arai et al.   Brain Tumor Pathology

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells

(2011) Ryuichi Kanai et al.   JNCI-Journal of the National Cancer Institute

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors

(2009) H. Wakimoto et al.   CANCER RESEARCH

Pharmacologic and Chemical Adjuvants in Tumor Virotherapy

(2009) Christopher Alvarez-Breckenridge et al.   CHEMICAL REVIEWS

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY