Article
Microbiology
Setsu Kato, Kenta Suzuki, Taiki Kenjo, Junya Kato, Yoshiteru Aoi, Yutaka Nakashimada
Summary: Saccharomyces cerevisiae is widely used as a model organism for aging and longevity studies. In a clonal population, cell death in the stationary phase is asynchronous, highlighting heterogeneity in survival at a single-cell level. Cell size heterogeneity and its correlation with death rate are observed, with cells shrinking upon death and a constant proportion between cell size and shrinkage noted in different strains. Further investigation is needed to understand the mechanisms behind this shrinkage event and its implications for cell death and survival heterogeneity.
Article
Biochemical Research Methods
Andreas P. Cuny, Aaron Ponti, Tomas Kundig, Fabian Rudolf, Jorg Stelling
Summary: TracX improves the accuracy of single-cell tracking using a fingerprinting approach to measure cell similarity across consecutive images. It is applicable across different cell types and image modalities, aiding in accurate cell observation and biological discovery in single-cell biology.
Article
Telecommunications
Yun Lin, Ya Tu, Zheng Dou, Lei Chen, Shiwen Mao
Summary: This article discusses the challenges posed by the rapid development of communication systems and the potential of using deep learning to address these challenges. It presents a framework to transform complex-valued signal waveforms into contour stellar images (CSI) to bridge the gap between signal waveforms and DL amenable data formats, showcasing effective solutions for signal recognition challenges. The investigation validates that CSI is a promising method to bridge the gap between signal recognition and DL.
IEEE TRANSACTIONS ON COGNITIVE COMMUNICATIONS AND NETWORKING
(2021)
Article
Microbiology
Ariane Brault, Berthy Mbuya, Simon Labbe
Summary: Saccharomyces cerevisiae can assimilate iron from the siderophore ferrichrome produced by other microbes via the Arn1 transporter. Schizosaccharomyces pombe synthesizes and secretes ferrichrome (Fc) using the sib1(+) and sib2(+) genes. Deletion of these genes in S. pombe impairs the ability to support the growth of S. cerevisiae when Fc is the sole source of iron. Further analysis identified the sib3(+) gene, encoding an N-5-transacetylase required for Fc production in S. pombe.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuta Yamazaki, Keiko Kono
Summary: This study reveals that clathrin-mediated trafficking of phospholipid flippases is critical for the recruitment of the exocyst complex to the damage site during plasma membrane/cell wall repair in budding yeast.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Thermodynamics
Ezddin Hutli, Petar B. Petrovic, Milos Nedeljkovic, David Legrady
Summary: The study examines the dynamic behavior and properties of cavitation clouds in a cavitating water jet, using computer vision and image processing tools to define the surface features of the clouds. Measurements and analysis of the clouds show that the quality of results heavily depends on input threshold values.
FLOW TURBULENCE AND COMBUSTION
(2022)
Article
Biotechnology & Applied Microbiology
Nicholas J. McGlincy, Zuriah A. Meacham, Kendra K. Reynaud, Ryan Muller, Rachel Baum, Nicholas T. Ingolia
Summary: This study introduces a comprehensive yeast CRISPRi library based on empirical design rules, which has been validated to provide comprehensive genome coverage through competitive growth experiments. The fitness defects of essential genes caused by different guides targeting them were used to refine yeast CRISPRi design rules, and guide abundance measurements in pooled screens were improved by linking guides with random nucleotide barcodes and carrying out linear amplification.
Article
Computer Science, Hardware & Architecture
Shengli Yang, Haoliang Wang, Qiang Chen
Summary: Road detection is crucial for ADAS, and our proposed improved algorithm utilizing deep learning network effectively improves the speed and accuracy of road recognition.
JOURNAL OF SUPERCOMPUTING
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Foltman, Alberto Sanchez-Diaz
Summary: This article focuses on the significance of the highly conserved TOR signaling pathway, particularly the connection between TORC1 complex in budding yeast and the cell cycle, and the importance of this connection for cell size and chromosome stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Daniel Williamson, William Tasker-Brown, James A. H. Murray, Angharad R. Jones, Leah R. Band
Summary: This article investigates the mechanisms of cell-size control in plant cells and establishes a mathematical model to simulate the key interactions in the cell cycle. The study finds that both size-independent synthesis and equal inheritance of cell-cycle proteins contribute to cell-size control, but combining these mechanisms at the two key transitions in the cell cycle is essential in maintaining cell-size homeostasis.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin Wang, Lei Li, Zhenhua Ming, Lijie Wu, Liming Yan
Summary: The tubules of endoplasmic reticulum (ER) spread into yeast buds through an actin-based mechanism and become attached to the proteinaceous micro-compartment called polarisome. The minimal tether between polarisome and cortical ER is formed by a protein complex consisting of Epo1, Scs2, and Cdc42 guanosine triphosphatase-activating protein Bem3. This study presents the crystal structure of the complex between Epo1 and Bem3, providing a structural insight into the link between cortical ER and polarisome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Diana Cook, Sarah Long, John Stanton, Patrick Cusick, Colleen Lawrimore, Elaine Yeh, Sarah Grant, Kerry Bloom
Summary: The study revealed that the pericentromere region of chromosomes is a site of confined biochemical activities, and the repair of chromosome breaks varies depending on the distance and position between centromeres. Different repair pathways are utilized for breaks in the pericentromeric chromatin versus breaks in the arms of chromosomes, indicating spatial control over DNA repair pathways in different nuclear regions.
Article
Multidisciplinary Sciences
Masahito Tanaka, Toshiko Kitanishi-Yumura, Shigehiko Yumura
Summary: This study accurately measured the total cell surface area of Dictyostelium cells throughout the cell cycle, showing an exponential increase in surface area during interphase, with cell size regulation primarily governed by the adder or near-adder model. This dynamic adder model suggests that cell membrane turnover plays a key role in maintaining cell size homeostasis during interphase.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Gulperi Yalcin, Juri Kim, Dongseong Seo, Cheol-Koo Lee
Summary: FK506-sensitive proline rotamase 1 protein (Fpr1p), a homologue of mammalian FKBP12, plays important roles in protein folding and preventing protein aggregation. This study shows that deletion of FPR1 reduces yeast lifespan, and rapamycin treatment does not extend lifespan in the absence of FPR1, indicating that FPR1 is essential for the lifespan extension mechanism of rapamycin in yeast. Additionally, caloric restriction has a different effect on lifespan compared to rapamycin, suggesting that rapamycin affects lifespan through a distinct pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Cell Biology
Marieke M. Glazenburg, Liedewij Laan
Summary: Cell polarization is an important phenomenon in the evolution of cellular life, driven by self-organization and leading to the establishment of preferential axis. The evolution of polarization can be studied using Saccharomyces cerevisiae and its fungal relatives as model species, providing insights on the relationship between self-organization and evolutionary change at the microscopic scale.
JOURNAL OF CELL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Judith Langer, Dorleta Jimenez de Aberasturi, Javier Aizpurua, Ramon A. Alvarez-Puebla, Baptiste Auguie, Jeremy J. Baumberg, Guillermo C. Bazan, Steven E. J. Bell, Anja Boisen, Alexandre G. Brolo, Jaebum Choo, Dana Cialla-May, Volker Deckert, Laura Fabris, Karen Faulds, F. Javier Garcia de Abajo, Royston Goodacre, Duncan Graham, Amanda J. Haes, Christy L. Haynes, Christian Huck, Tamitake Itoh, Mikael Ka, Janina Kneipp, Nicholas A. Kotov, Hua Kuang, Eric C. Le Ru, Hiang Kwee Lee, Jian-Feng Li, Xing Yi Ling, Stefan A. Maier, Thomas Mayerhofer, Martin Moskovits, Kei Murakoshi, Jwa-Min Nam, Shuming Nie, Yukihiro Ozaki, Isabel Pastoriza-Santos, Jorge Perez-Juste, Juergen Popp, Annemarie Pucci, Stephanie Reich, Bin Ren, George C. Schatz, Timur Shegai, Sebastian Schlucker, Li-Lin Tay, K. George Thomas, Zhong-Qun Tian, Richard P. Van Duyne, Tuan Vo-Dinh, Yue Wang, Katherine A. Willets, Clauanlai Xu, Hongxin Xu, Yikai Xu, Yuko S. Yamamoto, Bing Zhao, Luis M. Liz-Marzan
Review
Chemistry, Multidisciplinary
Hana Sipova-Jungova, Daniel Andren, Steven Jones, Mikael Kall
Article
Chemistry, Multidisciplinary
Steven Jones, Daniel Andren, Tomasz J. Antosiewicz, Alexander Stilgoe, Halina Rubinsztein-Dunlop, Mikael Kall
Article
Biology
Mikael Molin, Katarina Logg, Kristofer Bodvard, Ken Peeters, Annabelle Forsmark, Friederike Roger, Anna Jorhov, Neha Mishra, Jean-Marc Billod, Sabiha Amir, Mikael Andersson, Leif A. Eriksson, Jonas Warringer, Mikael Kall, Anders Blomberg
Article
Nanoscience & Nanotechnology
Samira Khadir, Daniel Andren, Ruggero Verre, Qinghua Song, Serge Monneret, Patrice Genevet, Mikael Kall, Guillaume Baffou
Summary: An optical metasurface is composed of scattering nanostructures and can be used to design ultrathin lenses, beam deflectors, and holograms. Improving metasurface design involves developing postcharacterization techniques, with quadriwave lateral shearing interferometry being a versatile method for achieving full optical characterization of metasurfaces.
Article
Chemistry, Multidisciplinary
Barbora Spackova, Hana Sipova-Jungova, Mikael Kall, Joachim Fritzsche, Christoph Langhammer
Summary: Research shows that applying nanofluidics to plasmonic nanoparticles can achieve efficient single-molecule detection in ultra-small sample volumes, which conventional microfluidic devices cannot accomplish. By downsizing fluidic structures, both detection times and the number of detected binding events can be significantly improved.
Article
Multidisciplinary Sciences
Falko Schmidt, Hana Sipova-Jungova, Mikael Kaell, Alois Wuerger, Giovanni Volpe
Summary: Active nanoparticles in a critical solution show behavior far from equilibrium, with fast orbital rotations observed around the beam axis even with an increase in effective temperature.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Daniel Andren, Denis G. Baranov, Steven Jones, Giovanni Volpe, Ruggero Verre, Mikael Kall
Summary: Utilizing optomechanical effects, optical metavehicles can be constructed for microscopic particles to travel long distances under low-intensity plane-wave illumination and be steered by the polarization of the incident light. Demonstrating movement in complex patterns, self-correcting motion, and application as transport vehicles for microscopic cargoes, including unicellular organisms. The abundance of possible optical metasurfaces suggests the potential for developing a wide variety of metavehicles with specialized functional behaviors.
NATURE NANOTECHNOLOGY
(2021)
Article
Optics
Rajath Sawant, Daniel Andren, Renato Juliano Martins, Samira Khadir, Ruggero Verre, Mikael Kall, Patrice Genevet
Summary: The study focuses on correcting various aberrations in optical systems using hybrid metalenses. Results show that at centimeter-scale hybrid metalenses, chromatic aberration and spherical aberration can be corrected by at least 80% and 70% respectively. The flexibility of adjusting various optical parameters with hybrid metasurfaces opens up new design opportunities for compact and broadband imaging, augmented reality/virtual reality, and holographic projection.
Article
Physics, Multidisciplinary
Falko Schmidt, Agnese Callegari, Abdallah Daddi-Moussa-Ider, Battulga Munkhbat, Ruggero Verre, Timur Shegai, Mikael Kaell, Hartmut Loewen, Andrea Gambassi, Giovanni Volpe
Summary: Researchers have demonstrated the tunable repulsive critical Casimir forces, which are important for the development of micro- and nanodevices. The stiction between parts in micro- and nanodevices, caused by attractive Casimir-Lifshitz forces, has been successfully counteracted by the repulsive critical Casimir forces. This breakthrough provides active control and precise tunability in the forces acting between the constituent parts.
Article
Optics
Mohammad Mahdi Shanei, Einstom Engay, Mikael Kaell
Summary: Researchers have proposed an ultra-thin silicon-based metasurface technology that enables simultaneous confinement and propulsion of microparticles, allowing for the trapping and transport of microscopic particles in a thin liquid cell. This technology is expected to play a significant role in areas such as miniaturized optical sensing, driving, and sorting.
Article
Optics
Mindaugas Juodenas, Erik Strandberg, Alexander Grabowski, Johan Gustavsson, Hana Sipova-Jungova, Anders Larsson, Mikael Kall
Summary: Flat metaoptics components have the potential to replace classical optics elements, leading to compact biophotonics devices when integrated with on-chip light sources and detectors. However, shaping light into wide angular range wavefronts with high efficiency using metasurfaces, as required in high-contrast microscopy applications, remains a challenge.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Review
Nanoscience & Nanotechnology
Daniel Midtvedt, Vasilii Mylnikov, Alexander Stilgoe, Mikael Kall, Halina Rubinsztein-Dunlop, Giovanni Volpe
Summary: The deep-learning revolution is providing new opportunities for manipulating and harnessing light. It has already shown success in improving the design of nanophotonic devices and analyzing experimental data. However, challenges arise in understanding and interpreting the results and reliability of deep learning.
Proceedings Paper
Engineering, Electrical & Electronic
Rajath Sawant, Daniel Andren, Mikael Kall, Ruggero Verre, Patrice Genevet
2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2020)
Article
Nanoscience & Nanotechnology
Denis G. Baranov, Battulga Munkhbat, Nils Odebo Lank, Ruggero Verre, Mikael Kall, Timur Shegai
