Article
Cell Biology
Eun-Jun Kim, Jung Yun Kim, Sung-Ok Kim, Nayoung Hong, Sang-Hun Choi, Min Gi Park, Junseok Jang, Seok Won Ham, Sunyoung Seo, Seon Yong Lee, Kanghun Lee, Hyeon Ju Jeong, Sung Jin Kim, Sohee Jeong, Kyungim Min, Sung-Chan Kim, Xiong Jin, Se Hoon Kim, Sung-Hak Kim, Hyunggee Kim
Summary: JAG1 intracellular domain (JICD1) induces cancer stem cell properties and tumorigenicity by forming a transcriptional complex with DDX17, SMAD3, and TGIF2 to increase SOX2 expression.
Article
Multidisciplinary Sciences
Kimberly G. Laffey, Robert J. Stiles, Melissa J. Ludescher, Tessa R. Davis, Shariq S. Khwaja, Richard J. Bram, Peter J. Wettstein, Venkataraman Ramachandran, Christopher A. Parks, Edwin E. Reyes, Alejandro Ferrer, Jenna M. Canfield, Cory E. Johnson, Richard D. Hammer, Diana Gil, Adam G. Schrum
Summary: During normal T cell development, a low-frequency population of early all TCR+ DN cells is present, which requires CD3δ for their generation/detection. These cells can respond to MHC and display coreceptor-independent MHC reactivity. It has been observed that these cells are susceptible to T-ALL transformation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Luis Varela, Maria E. R. Garcia-Rendueles
Summary: Cancer and neurodegenerative diseases are leading causes of premature death in modern societies, with increasing incidence. They share dysregulation of molecular signaling pathways, but elicit opposite responses. Understanding these mechanisms is crucial for disease understanding and precise treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Archana Kamalakar, Jay M. McKinney, Daniel Salinas Duron, Angelica M. Amanso, Samir A. Ballestas, Hicham Drissi, Nick J. Willett, Pallavi Bhattaram, Andres J. Garcia, Levi B. Wood, Steven L. Goudy
Summary: This research indicates that exogenous delivery of JAG1 using synthetic hydrogels can promote robust bone regeneration in mice. JAG1 induces osteoblast proliferation through non-canonical genes, independent of the NOTCH canonical pathway. Pathway analysis reveals upregulation of multiple non-canonical pathways related to osteogenesis with JAG1 delivery, suggesting its translational potential as a bone-regenerative approach.
Article
Oncology
Yoon Soo Chang, Joell J. Gills, Shigeru Kawabata, Masahiro Onozawa, Giusy Della Gatta, Adolfo A. Ferrando, Peter D. Aplan, Phillip A. Dennis
Summary: The study found that nelfinavir inhibits the NOTCH1 pathway and the AKT/mTOR pathway, induces endoplasmic reticulum (ER) stress, and suppresses the viability of T-ALL cells. Additionally, nelfinavir upregulates the expression of CHAC1 and SESN2, which negatively regulate the NOTCH and mTOR pathways, respectively. Nelfinavir also exhibits therapeutic efficacy against T-ALL in an SCL-LMO1 transgenic mouse model.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengmeng Jin, Hui Zhang, Baijie Xu, Yanan Li, Huiwen Qin, Shuguang Yu, Jie He
Summary: This study reveals the interaction between neurons and glial cells mediated by Jag2b and Notch3/Notch1b in the developing zebrafish retina, which is crucial for the generation and differentiation of Muller glia (MG) and the irreversible differentiation of MG.
Review
Biochemistry & Molecular Biology
Parveen Shiraz, Waqas Jehangir, Vaibhav Agrawal
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive leukemia with CDKN2A/CDKN2B and NOTCH1 being the most common mutated genes. While outcomes for de-novo disease are improving, patients with relapsed and refractory T-ALL have poor prognosis. New targeted therapies show potential to further improve outcomes, and the role of allogeneic stem cell transplant is evolving with the increased use of pediatric-inspired regimens.
Review
Cell Biology
Laura Gragnani, Serena Lorini, Silvia Marri, Anna Linda Zignego
Summary: Notch receptors play critical roles in fundamental cellular processes and are implicated in hematopoiesis, angiogenesis, and various human malignancies. They could serve as potential therapeutic targets for hematological cancers.
Article
Orthopedics
Guangxi Wang, Jinglong Yan, Hao Zhang, Patrick Massey, J. Steven Alexander, Christopher G. Kevil, Shane Barton, Yufeng Dong
Summary: This study demonstrates that Notch activation in vivo can be induced by injecting Jagged1 peptide, leading to enhanced bone callus formation during allograft healing in a femur bone defect mouse model. The translational potential of this therapeutic strategy includes immediate application in chronic long bone defect repair and potential application in enhancing repair of other tissues and organs.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Medicine, Research & Experimental
Huizhong Xiong, Maicol Mancini, Michael Gobert, Shiqian Shen, Glaucia C. Furtado, Sergio A. Lira, Christopher N. Parkhurst, Veronique Garambois, Muriel Brengues, Carlos E. Tadokoro, Thomas Trimarchi, Gonzalo Gomez-Lopez, Amartya Singh, Hossein Khiabanian, Sonia Minuzzo, Stefano Indraccolo, Camille Lobry, Iannis Aifantis, Daniel Herranz, Juan J. Lafaille, Antonio Maraver
Summary: The study revealed that Notch pathway activity in T-ALL depends on DLL4 signaling, while the spleen plays a major role in DLL4-driven T-ALL.
Article
Biology
Wen-Cheng Chung, Lavanya Challagundla, Yunyun Zhou, Min Li, Azeddine Atfi, Keli Xu
Summary: Notch signaling in the pancreas has dual roles in cancer, acting both as an oncogene and a tumor suppressor. Deletion of Jag1 in combination with oncogenic Kras(G12D) leads to development of cystic neoplasms rather than ductal adenocarcinoma in mice, with Jag1 acting as a tumor suppressor by delaying precursor lesions. Loss of Jag1 promotes a phenotypic switch from malignant carcinoma to benign cystic lesions. JAG1 expression in pancreatic cancer patients is higher in cancerous tissue, associated with poor overall survival, and correlated with SOX9 expression which also has similar associations with survival outcomes.
LIFE SCIENCE ALLIANCE
(2021)
Article
Environmental Sciences
Yong Wang, Wen Li, Fangmei Huang, Xiaojian Wu, Wenbin Chen, Ming Dong, Jie Zhou
Summary: The study demonstrates that SCA inhibits the proliferation of myeloma cells by promoting pro-apoptotic proteins and targeting the expression of Notch3. This suggests that SCA may have potential for further development as a treatment for multiple myeloma.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Samyuktha Ramesh, Soohyung Park, Wonpil Im, Melissa J. Call, Matthew E. Call
Summary: The B cell receptor (BCR) and T cell receptor (TCR) share a common core transmembrane (TM) structure, which is vital for optimal receptor assembly and stability in the cell membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Martina Del Gaizo, Ilaria Sergio, Sara Lazzari, Samantha Cialfi, Maria Pelullo, Isabella Screpanti, Maria Pia Felli
Summary: This article reviews the literature on the regulatory role of miRNAs in the immune response of T-ALL, focusing on their roles in Natural Killer, T, T-regulatory, and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the field of leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marc Gutierrez, Patrick Bladek, Busra Goksu, Carlos Murga-Zamalloa, Dale Bixby, Ryan Wilcox
Summary: T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells. Correct identification of T-PLL is essential because treatment for this disease is distinct from that of other T-cell neoplasms. The T-PLL International Study Group (TPLL-ISG) established criteria for the diagnosis and treatment of T-PLL, focusing on the role of TCL1 family members and ATM in disease pathogenesis. Despite improved understanding of disease pathogenesis, alemtuzumab remains the frontline therapy for T-PLL, but there is a need for novel therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Giulia Diluvio, Francesca Del Gaudio, Maria Valeria Giuli, Giulia Franciosa, Eugenia Giuliani, Rocco Palermo, Zein Mersini Besharat, Maria Gemma Pignataro, Alessandra Vacca, Giulia d'Amati, Marella Maroder, Claudio Talora, Carlo Capalbo, Diana Bellavia, Saula Checquolo
Article
Oncology
Laura Antonucci, Laura Di Magno, Davide D'Amico, Simona Manni, Silvia Maria Serrao, Fiorella Di Pastena, Rosa Bordone, Zuleyha Nihan Yurtsever, Miriam Caimano, Marialaura Petroni, Alessandra Giorgi, Maria Eugenia Schinina, John R. Yates, Lucia Di Marcotullio, Enrico De Smaele, Saula Checquolo, Carlo Capalbo, Enzo Agostinelli, Marella Maroder, Sonia Coni, Gianluca Canettieri
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Review
Cell & Tissue Engineering
Simona Ceccarelli, Francesca Megiorni, Diana Bellavia, Cinzia Marchese, Isabella Screpanti, Saula Checquolo
STEM CELLS INTERNATIONAL
(2019)
Article
Oncology
Luca Tottone, Nadezda Zhdanovskaya, Alvaro Carmona Pestana, Michele Zampieri, Fabrizio Simeoni, Sara Lazzari, Valeria Ruocco, Maria Pelullo, Paola Caiafa, Maria Pia Felli, Saula Checquolo, Diana Bellavia, Claudio Talora, Isabella Screpanti, Rocco Palermo
FRONTIERS IN ONCOLOGY
(2019)
Review
Immunology
Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Review
Oncology
M. V. Giuli, E. Giuliani, I. Screpanti, D. Bellavia, S. Checquolo
JOURNAL OF ONCOLOGY
(2019)
Article
Oncology
Maria Pelullo, Francesca Nardozza, Sabrina Zema, Roberta Quaranta, Carmine Nicoletti, Zein MersiniBesharat, Maria Pia Felli, Bruna Cerbelli, Giulia d'Amati, Rocco Palermo, Carlo Capalbo, Claudio Talora, Lucia Di Marcotullio, Giuseppe Giannini, Saula Checquolo, Isabella Screpanti, Diana Bellavia
Review
Genetics & Heredity
Maria Pelullo, Sabrina Zema, Francesca Nardozza, Saula Checquolo, Isabella Screpanti, Diana Bellavia
FRONTIERS IN GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Carlo De Blasio, Azzurra Zonfrilli, Matteo Franchitto, Germano Mariano, Samantha Cialfi, Nagendra Verma, Saula Checquolo, Diana Bellavia, Rocco Palermo, Dario Benelli, Isabella Screpanti, Claudio Talora
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
Maria Valeria Giuli, Patrizia Nadia Hanieh, Eugenia Giuliani, Federica Rinaldi, Carlotta Marianecci, Isabella Screpanti, Saula Checquolo, Maria Carafa
Article
Oncology
Maria Valeria Giuli, Giulia Diluvio, Eugenia Giuliani, Giulia Franciosa, Laura Di Magno, Maria Gemma Pignataro, Luca Tottone, Carmine Nicoletti, Zein Mersini Besharat, Giovanna Peruzzi, Maria Pelullo, Rocco Palermo, Gianluca Canettieri, Claudio Talora, Giulia D'Amati, Diana Bellavia, Isabella Screpanti, Saula Checquolo
Review
Biochemistry & Molecular Biology
Martina Del Gaizo, Ilaria Sergio, Sara Lazzari, Samantha Cialfi, Maria Pelullo, Isabella Screpanti, Maria Pia Felli
Summary: This article reviews the literature on the regulatory role of miRNAs in the immune response of T-ALL, focusing on their roles in Natural Killer, T, T-regulatory, and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the field of leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Nadezda Zhdanovskaya, Mariarosaria Firrincieli, Sara Lazzari, Eleonora Pace, Pietro Scribani Rossi, Maria Pia Felli, Claudio Talora, Isabella Screpanti, Rocco Palermo
Summary: The Notch signaling pathway plays a context-dependent role in regulating cell fate decisions and has been implicated in both promoting and suppressing tumorigenesis. Targeting Notch signaling shows potential against tumor growth and recurrence, but current strategies face limitations in clinical success due to toxicity and efficacy issues, highlighting the need for novel agents and optimized combinations.
Article
Oncology
Nadezda Zhdanovskaya, Sara Lazzari, Diego Caprioglio, Mariarosaria Firrincieli, Chiara Maioli, Eleonora Pace, Daniela Imperio, Claudio Talora, Diana Bellavia, Saula Checquolo, Mattia Mori, Isabella Screpanti, Alberto Minassi, Rocco Palermo
Summary: The study shows that curcumin and its derivatives have anti-cancer effects and inhibit Notch signaling in T-ALL cells. These findings suggest the potential of curcumin-based bioactive agents for treating Notch-dependent T-ALL.