Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Aki Juhani Karajamaki, Arto Korkiakoski, Janne Hukkanen, Y. Antero Kesaniemi, Olavi Ukkola
Summary: The presence of metabolic syndrome (MetS), but not obesity only, entails a greater risk of mortality and cardiovascular diseases. The risk of atrial fibrillation is increased only in subjects with both obesity and MetS. Obesity without MetS tends to progress eventually to obesity with MetS.
ANNALS OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
An-ran Ma, Fang Liu, Runnan Wang, Lanmei Lin, Yilun Wang, Qunyi Li, Xiaonian Lu, Juan Du
Summary: This study found a higher prevalence of MetS and its components in patients with EP, with factors such as MetS, abdominal obesity, hypertension, smoking, and alcohol use being positive independent predictors of EP. Early intervention for correcting these cardiovascular risk factors is encouraged for managing EP.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Antonello E. Rigamonti, Michele Dei Cas, Diana Caroli, Adele Bondesan, Silvano G. Cella, Rita Paroni, Alessandro Sartorio
Summary: Ceramide risk score (CERT1) has been reported as a potential marker for cardiovascular disease (CVD) risk prediction. This study aimed to evaluate CERT1 in obese subjects with and without metabolic syndrome (MetS) and compared them to a normal-weight group. Obesity was associated with higher CERT1 values, and the predictors of CERT1 included waist circumference, insulin resistance, and inflammation. However, the clinical diagnosis of MetS may not accurately assess CVD risk in the obese population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Hua Guan, Jin Zhang, Jing Luan, Hao Xu, Zhenghao Huang, Qi Yu, Xingchun Gou, Lixian Xu
Summary: SFRP family members are antagonistic inhibitors of the Wnt signaling pathway and play important roles in the pathogenesis of various metabolic diseases. They may potentially serve as disease biomarkers and therapeutic targets in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Li Chen, Rui Xu, Joshua D. McDonald, Richard S. Bruno, Fouad Choueiry, Jiangjiang Zhu
Summary: This study found that whey protein has an earlier and stronger impact in maintaining the stability of the lipidome compared to casein protein. Whey can protect against glucose-induced changes in glycerophospholipid and sphingolipid metabolism, while ether lipid metabolism and SP metabolism are the pathways most greatly impacted by casein.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Stine Smedegaard, Ulla Kampmann, Per G. Ovesen, Henrik Stovring, Nikolaj Rittig
Summary: Serving whey protein as a premeal can lower postprandial blood glucose concentrations by stimulating GLP-1, GIP, and insulin secretion, as well as slowing gastric emptying rate. This systematic review and meta-analysis of randomized clinical trials found that whey protein premeals significantly reduced peak glucose concentration, increased GLP-1 and peak insulin concentrations, and slowed gastric emptying rate compared to controls. The findings suggest that whey protein premeals have clinical potential for managing blood glucose levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Chen-Jie Ling, Xiao-Fang Chen, Jia-Ying Xu, Gui-Ping Wang, Yan Wang, Yue Sun, Yun-Liang Li, Zhong-Xiao Wan, Xing Tong, Khemayanto Hidayat, Wan-Zhan Zhu, Li-Qiang Qin, Jing Yang
Summary: Whey protein hydrolysates have good prospects in weight management for middle-aged individuals by reducing energy intake, slowing down weight gain, improving blood lipids and glucose, and enhancing muscle antioxidant capacity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Itay Aizenbud, Asaf Wilensky, Galit Almoznino
Summary: Periodontal disease is a chronic inflammatory condition that leads to bone and tooth loss. It has been linked to various systemic diseases, including diabetes and obesity. These diseases are part of the metabolic syndrome cluster, which significantly increases the risk of cardiovascular diseases, diabetes, and stroke. This review aims to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster, providing insights into the fundamental mechanisms that link each condition with the metabolic syndrome. Understanding this interplay can lead to more effective treatments considering the broader impact of managing periodontal disease on systemic disease treatment, and vice versa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Athanasia Tragomalou, George Paltoglou, Maria Manou, Ioannis V. Kostopoulos, Sofia Loukopoulou, Maria Binou, Ourania E. Tsitsilonis, Flora Bacopoulou, Penio Kassari, Marina Papadopoulou, George Mastorakos, Evangelia Charmandari
Summary: Obesity in adolescence is linked to cardiovascular disease. Non-traditional risk factors can be used as biomarkers to predict future CVD. Lifestyle intervention programs can improve these risk factors.
Review
Biochemistry & Molecular Biology
Sepiso K. Masenga, Lombe S. Kabwe, Martin Chakulya, Annet Kirabo
Summary: Metabolic syndrome is a collection of conditions that increase the risk of type 2 diabetes mellitus and cardiovascular diseases. Obesity is closely linked to metabolic syndrome, as it promotes inflammation and oxidative stress, which are precursors of complications relating to metabolic syndrome components such as insulin resistance, hypertension, and hyperlipidemia. While oxidative stress and chronic inflammation are known to play a significant role in the development of metabolic syndrome, there has been limited research on the mechanisms underlying the contribution of oxidative stress. This review highlights the mechanisms by which reactive oxygen species contribute to mitochondrial dysfunction, protein damage, lipid peroxidation, and impaired antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be utilized for disease diagnosis and severity evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Amit Frishberg, Inge van den Munckhof, Rob Ter Horst, Kiki Schraa, Leo A. B. Joosten, Joost H. W. Rutten, Adrian C. Iancu, Ioana M. Dregoesc, Bogdan A. Tigu, Mihai G. Netea, Niels P. Riksen, Irit Gat-Viks
Summary: By mapping similarities among clinical parameters in normal physiological settings, a quantitative two-dimensional model representing the whole-body state has been identified, including both traditional metabolic syndrome and a novel non-classical metabolic syndrome. These findings offer new avenues for improved personalized diagnosis and treatment of diseases.
Review
Endocrinology & Metabolism
Mimi S. Kim, Nicole R. Fraga, Nare Minaeian, Mitchell E. Geffner
Summary: Classical CAH patients have a higher prevalence of cardiovascular metabolic risk factors, although the complete metabolic syndrome is relatively rare in children and adolescents. Understanding the traditional and non-traditional risk factors in CAH patients can guide treatment options and prevent the onset of metabolic syndrome in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dermatology
Meron Teklu, Wunan Zhou, Promita Kapoor, Nidhi Patel, Amit K. Dey, Alexander V. Sorokin, Grigory A. Manyak, Heather L. Teague, Julie A. Erb-Alvarez, Aparna Sajja, Khaled M. Abdelrahman, Aarthi S. Reddy, Domingo E. Uceda, Sundus S. Lateef, Sujata M. Shanbhag, Colin Scott, Nina Prakash, Maryia Svirydava, Philip Parel, Justin A. Rodante, Andrew Keel, Evan L. Siegel, Marcus Y. Chen, David A. Bluemke, Martin P. Playford, Joel M. Gelfand, Nehal N. Mehta
Summary: The study revealed a significant association between metabolic syndrome and its factors with noncalcified coronary burden in patients with psoriasis. Individuals with metabolic syndrome had higher cardiovascular disease risk factors and systemic inflammation, highlighting the importance of increasing awareness and addressing metabolic syndrome in psoriasis patients to reduce cardiovascular risk.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Nutrition & Dietetics
Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antonio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss, Maria Cristina Foss-Freitas
Summary: This study aimed to investigate the benefits of dietary restriction in patients with metabolic syndrome and determine whether it is the calorie or protein restriction that mediates the effects. The findings showed that isocaloric dietary protein restriction can achieve similar clinical outcomes as calorie restriction, making it a more attractive and less drastic dietary strategy for patients with metabolic syndrome and has potential as an adjuvant therapy.
Letter
Endocrinology & Metabolism
Joshua R. Lewis, Simone Radavelli-Bagatini, Lars Rejnmark, Jian Sheng Chen, Judy M. Simpson, Joan M. Lappe, Leif Mosekilde, Ross L. Prentice, Richard L. Prince
JOURNAL OF BONE AND MINERAL RESEARCH
(2015)
Article
Nutrition & Dietetics
S. Pal, S. Radavelli-Bagatini, M. Hagger, V. Ellis
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2014)
Article
Endocrinology & Metabolism
Joshua R. Lewis, Simone Radavelli-Bagatini, Lars Rejnmark, Jian Sheng Chen, Judy M. Simpson, Joan M. Lappe, Leif Mosekilde, Ross L. Prentice, Richard L. Prince
JOURNAL OF BONE AND MINERAL RESEARCH
(2015)
Article
Endocrinology & Metabolism
Simone Radavelli-Bagatini, Kun Zhu, Joshua R. Lewis, Richard L. Prince
JOURNAL OF BONE AND MINERAL RESEARCH
(2014)
Article
Peripheral Vascular Disease
Sebely Pal, Simone Radavelli-Bagatini
JOURNAL OF CLINICAL HYPERTENSION
(2013)
Letter
Peripheral Vascular Disease
Sebely Pal, Simone Radavelli-Bagatini
JOURNAL OF CLINICAL HYPERTENSION
(2013)
Review
Peripheral Vascular Disease
Sebely Pal, Simone Radavelli-Bagatini, Suleen Ho
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
(2013)
Article
Nutrition & Dietetics
Emma L. Connolly, Catherine P. Bondonno, Marc Sim, Simone Radavelli-Bagatini, Kevin D. Croft, Mary C. Boyce, Anthony P. James, Karin Clark, Reindolf Anokye, Nicola P. Bondonno, Richard J. Woodman, Amanda Devine, Seng Khee Gan, Carl J. Schultz, Richard F. Mithen, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Article
Nutrition & Dietetics
Lauren C. Blekkenhorst, Marc Sim, Simone Radavelli-Bagatini, Nicola P. Bondonno, Catherine P. Bondonno, Amanda Devine, John T. Schousboe, Wai H. Lim, Douglas P. Kiel, Richard J. Woodman, Jonathan M. Hodgson, Richard L. Prince, Joshua R. Lewis
Summary: The study suggests that higher intake of cruciferous vegetables may protect against vascular calcification, while total vegetable intake and other vegetable types were not related to extensive calcification in the abdominal aorta.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Caroline R. Hill, Lauren C. Blekkenhorst, Simone Radavelli-Bagatini, Marc Sim, Richard J. Woodman, Amanda Devine, Jonathan E. Shaw, Jonathan M. Hodgson, Robin M. Daly, Joshua R. Lewis
Article
Medicine, General & Internal
Reindolf Anokye, Simone Radavelli-Bagatini, Catherine P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Emma Connolly, Nicola P. Bondonno, John T. Schousboe, Richard Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Amanda Devine, Peter L. Thompson, Jenny Gianoudis, Belinda De Ross, Robin M. Daly, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley
Article
Medicine, General & Internal
Simone Radavelli-Bagatini, Catherine P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Reindolf Anokye, Emma Connolly, Nicola P. Bondonno, John T. Schousboe, Richard J. Woodman, Kun Zhu, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Mandy Stanley, Amanda Devine, Peter L. Thompson, Jenny Gianoudis, Belinda De Ross, Robin M. Daly, Joshua R. Lewis, Jonathan M. Hodgson
Meeting Abstract
Endocrinology & Metabolism
J. R. Lewis, K. L. Ivey, S. Radavelli-Bagatini, L. Rejnmark, J. S. Chen, J. M. Simpson, J. M. Lappe, L. Mosekilde, R. L. Prentice, R. L. Prince
OSTEOPOROSIS INTERNATIONAL
(2014)
Article
Endocrinology & Metabolism
Simone Radavelli-Bagatini, Francisco L. R. Lhullier, Elaine S. Mallmann, Poli Mara Spritzer
NEUROENDOCRINOLOGY LETTERS
(2013)
Article
Endocrinology & Metabolism
S. Radavelli-Bagatini, I. O. de Oliveira, R. B. Ramos, B. R. Santos, M. S. Wagner, S. B. Lecke, D. P. Gigante, B. L. Horta, P. M. Spritzer
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2013)