Article
Surgery
Isidoro Musmarra, Paola Aguilar, Samuel Struk, Claire Couteau, Christophe Tresallet, Julien Quilichini
Summary: This study aimed to describe the authors' vertical body lift (VBL) surgical technique and its clinical applications, and compared the outcomes with the classic inferior body lift (IBL) technique. The results showed that VBL and IBL had similar operative details and postoperative outcomes, indicating that VBL is a reliable technique that can improve aesthetic and functional outcomes in patients with massive weight loss.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Rawan ElAbd, Malak AlMojel, Salman AlSabah, Abdulaziz AlRashid, Meshari AlNesf, Becher Alhallabi, Hisham Burezq
Summary: This study found no significant differences in the rates of short- and long-term complications or the need for operative revisions after abdominoplasty between patients who underwent surgical weight loss and those who achieved weight loss through diet and exercise alone.
Article
Food Science & Technology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea Toft Hansen, Joanne A. Harrold, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: This study examines the relationship between changes in circulating metabolites during diet-induced weight loss and changes in adiposity, finding significant associations between lipid species and citric acid with body weight and adiposity reduction. The results also show that changes in lysophosphatidylcholines and citric acid concentrations during weight loss are linked to adiposity regain and loss during the maintenance period, highlighting the importance of adipose lipid metabolism in weight and adiposity maintenance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Surgery
Lisa R. Miller-Matero, Kaitlin Ross, Eve DePascale, Camila Arellano, Logan Zelenak, Jordan M. Braciszewski, Leah M. Hecht, Erin N. Haley, Amy M. Loree, Arthur M. Carlin
Summary: This study examined the impact of cannabis use on weight loss outcomes in patients undergoing bariatric surgery. The results showed that pre-surgical cannabis use was not associated with weight loss, but post-surgical cannabis use was linked to poorer weight loss outcomes and increased risk of weight recurrence. Frequent cannabis use (i.e., weekly) was particularly problematic. Healthcare providers should screen patients for cannabis use and educate them about the potential effects of postoperative cannabis use on weight loss.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Clinical Neurology
Cody L. Goessl, Jeffrey J. VanWormer, Ram D. Pathak, Edward F. Ellerbeck, Daniel L. Kurz, Christie A. Befort
Summary: This analysis examined how the mental component score (MCS-12) from the Short Form health survey changed over 24 months in weight loss trial participants with vs. without treatment seeking for affective symptoms (TxASx) and by weight change quintiles. The results showed that participants with TxASx who lost the most weight had the largest increase in MCS-12 scores (+5.3 points [12%]), while participants without TxASx who gained the most weight had the largest decrease in MCS-12 scores (-1.8 points [-3%]).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Jean-Eric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu, Francis Nguyen, Richard Perez, Valerie H. Taylor, Feng Xie, Vanessa Boudreau, Eleanor Pullenayegum, David R. Urbach, Mehran Anvari
Summary: This study compared 4-year health care expenditures after RYGB and sleeve gastrectomy, finding no significant differences in all-cause mortality and number of hospital admissions between the two procedures, but more frequent nonelective hospitalizations with RYGB. Patients who underwent RYGB had a lower rate of subsequent bariatric procedures.
Article
Nutrition & Dietetics
Maggie A. Stanislawski, Daniel N. Frank, Sarah J. Borengasser, Danielle M. Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, Liza Wayland, Janet C. Siebert, Daniel H. Bessesen, Paul S. MacLean, Edward L. Melanson, Victoria A. Catenacci
Summary: The ongoing weight loss trial comparing daily caloric restriction to intermittent fasting in overweight or obese adults found significant improvements in clinical health measures and altered composition and diversity of fecal microbiota in the first three months. Significant associations were observed between gut microbiota features and clinical measures such as weight and waist circumference. Differences in the relative abundance of Akkermansia were also seen between the intervention groups.
Article
Public, Environmental & Occupational Health
Alisa Weiland, Lena Kasemann Nannette, Stephan Zipfel, Stefan Ehehalt, Katrin Ziser, Florian Junne, Isabelle Mack
Summary: This study systematically reviewed the predictors of body weight loss and weight loss maintenance in children and adolescents after behavioral weight loss intervention. The results showed that genetics and blood parameters were significant predictors in physiology, while behavior and environment factors were less investigated.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Microbiology
Silvia Raineri, Julia A. Sherriff, Kevin S. J. Thompson, Huw Jones, Paul T. Pfluger, Nicholas E. Ilott, Jane Mellor
Summary: This study investigated the impact of pharmacologically induced weight loss on the faecal microbiome in obese rats. The results showed that sibutramine treatment induced consistent weight loss, improved metabolic health, and changes to the faecal microbiome consistent with a reduction in obesity-induced bacterially-driven inflammation.
Article
Gastroenterology & Hepatology
Dimitrios A. Koutoukidis, Susan A. Jebb, Jeremy W. Tomlinson, Jeremy F. Cobbold, Paul Aveyard
Summary: This study found that weight change is associated with changes in biochemical and histological features of NASH in patients. Weight loss can improve NASH and fibrosis, while weight gain may worsen disease activity. Therefore, NASH management should include recommendations for avoiding weight gain and supporting weight loss.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Multidisciplinary Sciences
Katja Kurnik Mesaric, Jernej Pajek, Bernarda Logar Zakrajsek, Spela Bogataj, Jana Kodric
Summary: This systematic review and meta-analysis investigated the impact of cognitive behavioral therapy (CBT) on implementing lifestyle changes, considering health-related and behavioral outcomes. Multiple databases were searched for relevant studies, and nine randomized controlled trials met the inclusion criteria. The results showed a medium, significant effect of CBT interventions on weight loss and maintenance, but a low, non-significant effect on reducing HbA1c levels. The overall effect size was medium and significant. The review concluded that CBT interventions are effective in implementing lifestyle changes, particularly for weight loss and maintenance.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Wendy Winslow, Ian McDonough, Savannah Tallino, Annika Decker, Austin S. Vural, Ramon Velazquez
Summary: Transgenic rodent models of Alzheimer's disease were used in the study to investigate pathogenic mechanisms related to cognitive decline. The study found that 3xTg-AD mice had impairments in attention and working memory compared to non-transgenic mice, and completion of tasks in the IntelliCage was associated with lower levels of insoluble amyloid-beta(40).
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kyle R. Noll, Henry S. Chen, Jeffrey S. Wefel, Vinodh A. Kumar, Ping Hou, Sherise D. Ferguson, Ganesh Rao, Jason M. Johnson, Donald F. Schomer, Dima Suki, Sujit S. Prabhu, Ho-Ling Liu
Summary: The study found that decline in neurocognitive functioning was common shortly following resection of glioma involving eloquent brain regions, most frequently in verbal learning/memory and executive functioning. Better postoperative outcomes accompanied reductions in centrality and resilience connectomic measures.
Article
Multidisciplinary Sciences
Yi-Ya Fang, Jia-In Lee, Nai-Yuan Wu, Chiao- Chang, Meng-Chuan Huang, Chun-Ying Lee, Jui-Yen Huang, Gwo Giun Chris Lee, Cheng-Sheng Chen
Summary: Obesity is a major public health issue that is associated with various physical problems, as well as comorbidities with depression and anxiety. Recent studies have focused on technology-based interventions for weight reduction, but there has been less discussion on the mood component and eating behavior related to obesity. This pilot study aimed to investigate the effect of a telehealth assisted intervention using a smartphone app with 3D food picture recognition and cognitive behavioral training programs on weight reduction, mood status, and eating behavior change.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Vivi F. H. Jensen, Anne-Marie M. Molck, Majken Dalgaard, Fiona E. McGuigan, Kristina E. Akesson
Summary: This review discusses the effects of obesity and weight loss on bone health in humans and rodents, highlighting the differences between the two species. It also emphasizes the importance of considering factors such as sex, age, and nutritional status when using animal models to study these effects, in order to enhance the translatability of research findings.
Article
Rehabilitation
Beatrice Lee, Timothy N. Tansey, Fong Chan, Malachy Bishop, William T. Hoyt, Laura M. Hancock
Summary: Functional impairments can lead to stress in individuals with multiple sclerosis, and factors such as positive cognitive stress appraisal, core self-evaluations, resilience, hope, social support, and environmental supports play a role as partial mediators. Additionally, the CSE variable was identified as a protective factor in reducing the association between functional impairments and stress.
REHABILITATION COUNSELING BULLETIN
(2022)
Article
Urology & Nephrology
Michael Grasing, Palash Sharma, Rebecca J. Lepping, Robyn Honea, Jeffrey M. Burns, William M. Brooks, Aditi Gupta
Summary: This study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to investigate the association between estimated glomerular filtration rate (eGFR) and brain volumes. The results indicate that mild to moderate kidney dysfunction is not associated with brain atrophy.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Neurosciences
Rebecca J. Lepping, Walker S. McKinney, Grant C. Magnon, Sarah K. Keedy, Zheng Wang, Stephen A. Coombes, David E. Vaillancourt, John A. Sweeney, Matthew W. Mosconi
Summary: Research indicates that individuals with autism spectrum disorder exhibit increased force variability and reduced entropy during visuomotor behavior, along with greater brain activation and decreased functional connectivity. Additionally, delayed maturation is observed in the functional connectivity between cerebellar-cortical sensorimotor and nonsensorimotor networks.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Laura M. Hancock, Bruce Hermann, Menno M. Schoonheim, Scott J. Hetzel, Bruno Brochet, John DeLuca
Summary: This study compared two diagnostic methods to determine how to identify cognitive impairment among people with multiple sclerosis (MS). The results showed that compared to research criteria, the DSM-5 criteria classified far more MS patients as having cognitive impairment. However, more work is needed to establish a standardized and validated method for characterizing these impairments.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Andrew T. Marshall, Daniel A. Hackman, Fiona C. Baker, Florence J. Breslin, Sandra A. Brown, Anthony Steven Dick, Marybel R. Gonzalez, Mathieu Guillaume, Orsolya Kiss, Krista M. Lisdahl, Connor J. McCabe, William E. Pelham, Chandni Sheth, Susan F. Tapert, Amandine Van Rinsveld, Natasha E. Wade, Elizabeth R. Sowell
Summary: Socioeconomic disadvantage is associated with larger COVID-19 disease burdens and economic impacts. A study found that both family- and neighborhood-level disadvantage were related to greater family COVID-19 disease burden, lower perceived exposure risk, increased caregiver-youth conversations about COVID-19 risk/prevention, and more youth preventative behaviors.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Clinical
William E. I. I. I. I. I. I. Pelham, Susan F. Tapert, Marybel R. Gonzalez, Mathieu Guillaume, Anthony Steven Dick, Chandni S. Sheth, Fiona C. Baker, Arielle Baskin-Sommers, Andrew T. Marshall, Krista M. Lisdahl, Florence J. Breslin, Amandine Van Rinsveld, Sandra A. Brown
Summary: There is a negative association between parental knowledge/monitoring and adolescents' depressive symptoms, but this association may be driven by confounding variables rather than a causal process.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2022)
Article
Psychology, Developmental
Orsolya Kiss, Elisabet Alzueta, Dilara Yuksel, Kilian M. Pohl, Massimiliano de Zambotti, Eva M. Muller-Oehring, Devin Prouty, Ingrid Durley, William E. Pelham, Connor J. McCabe, Marybel R. Gonzalez, Sandra A. Brown, Natasha E. Wade, Andrew T. Marshall, Elizabeth R. Sowell, Florence J. Breslin, Krista M. Lisdahl, Anthony S. Dick, Chandni S. Sheth, Bruce D. McCandliss, Mathieu Guillaume, Amandine M. Van Rinsveld, Gayathri J. Dowling, Susan F. Tapert, Fiona C. Baker
Summary: This longitudinal study identifies young adolescents who are most vulnerable to the psychological toll of the COVID-19 pandemic and provides insights to inform strategies to help adolescents cope better in times of crisis. The findings highlight the importance of social connectedness and healthy behaviors as buffering factors against the deleterious effects of the pandemic on adolescents' mental health.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Medicine, Research & Experimental
Amanda Szabo-Reed, Jonathan Clutton, Sydney White, Angela Van Sciver, Dreu White, Jill Morris, Laura Martin, Rebecca Lepping, Ashley Shaw, Jaime Perales Puchalt, Robert Montgomery, Jonathan Mahnken, Richard Washburn, Jeffrey Burns, Eric D. Vidoni
Summary: This article introduces the design and objectives of the COMET trial, which aims to investigate the independent and combined effects of aerobic exercise and resistance training on brain health. By enrolling 280 older adults aged 65-80 years and conducting a 52-week community-based exercise program, the trial will assess cognitive performance, brain volume, physical function, and blood-based factors. The study will provide rigorous randomized controlled trial data to understand the effects of common exercise modalities, including their combination, on brain health.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Multidisciplinary Sciences
Eric D. Vidoni, Jill K. Morris, Jacqueline A. Palmer, Yanming Li, Dreu White, Paul J. Kueck, Casey S. John, Robyn A. Honea, Rebecca J. Lepping, Phil Lee, Jonathan D. Mahnken, Laura E. Martin, Sandra A. Billinger
Summary: This clinical trial investigates the impact of acute aerobic exercise on brain blood flow and neurotrophic factors in older adults. The study finds that both APOE4 carriers and non-carriers exhibit similar effects of exercise-induced increases in cerebral blood flow and neurotrophic response.
Article
Psychology, Clinical
William E. Pelham, Susan F. Tapert, Marybel R. Gonzalez, Natasha E. Wade, Krista M. Lisdahl, Mathieu Guillaume, Andrew T. Marshall, Amandine Van Rinsveld, Anthony Steven Dick, Fiona C. Baker, Florence J. Breslin, Arielle Baskin-Sommers, Chandni S. Sheth, Sandra A. Brown
Summary: This study provides strong evidence for a causal relationship between parental knowledge/monitoring and adolescent substance use. The findings suggest that fluctuations in parental knowledge/monitoring are associated with changes in youth engagement in substance use.
Article
Geriatrics & Gerontology
Adam J. Paulsen, Carla R. Schubert, Alex A. Pinto, Richard J. Chappell, Yanjun Chen, Karen J. Cruick, Corinne D. Engelman, Luigi Ferrucci, Laura M. Hancock, Sterling C. Johnson, Natascha Merten
Summary: Sensory and motor changes in aging adults, especially hearing impairment and worse motor function, may be early markers of neurodegeneration and are associated with faster increases in serum NfL level.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Robyn A. Honea, Casey S. John, Zachary D. Green, Paul J. Kueck, Matthew K. Taylor, Rebecca J. Lepping, Ryan Townley, Eric D. Vidoni, Jeffery M. Burns, Jill K. Morris
Summary: This study found a longitudinal relationship between change in blood glucose metabolism and regional brain changes in older adults. Individuals with improving fasting glucose exhibited less brain atrophy and regional amyloid accumulation compared to those with worsening fasting glucose. These findings suggest that dysregulation of glucose in late life may be an early indicator of preclinical brain changes.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Meeting Abstract
Surgery
I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Geriatrics & Gerontology
Yanjun Chen, Scott Hetzel, Alex A. Pinto, Adam J. Paulsen, Carla R. Schubert, Laura M. Hancock, Barbara E. Klein, Natascha Merten, Karen J. Cruickshanks
Summary: This study evaluated the association between pupil light reflex (PLR) and cognition in community-dwelling middle-aged and older individuals. The results showed a significant correlation between pupil reactivity and cognition, suggesting the potential of PLR as a biomarker of brain aging.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
