Associations of sensory and motor function with blood-based biomarkers of neurodegeneration and Alzheimer's disease in midlife

Pathological biomarkers of dementia and Alzheimer's disease (AD) change decades before clinical symp-toms. Common sensory and motor changes in aging adults may be early markers of neurodegeneration. We investigated if midlife sensory and motor functions in Beaver Dam Offspring Study (BOSS) participants (N = 1529) were associated with longitudinal changes in blood-based biomarkers of neurodegeneration (neurofilament light chain (NfL); total tau (TTau)) and AD (amyloid beta (A beta)). Mixed-effects models with baseline sensory and motor function as determinants and 10-year biomarker change as outcome were used. Participants with hearing impairment and worse motor function (among women) showed faster increases in NfL level over time (0.8% per year; 0.3% per year, respectively). There were no significant associations with TTau or A beta. We found consistent relationships between worse baseline hearing and motor function with a faster increase in neurodegeneration, specifically serum NfL level. Future studies with longer follow-up should determine if sensory and motor changes are more reflective of general neu-rodegeneration than AD-specific pathology and whether sensory and motor tests may be useful screening tools for neurodegeneration risk.(c) 2022 Elsevier Inc. All rights reserved.

Automated summary

Sensory and motor changes in aging adults, especially hearing impairment and worse motor function, may be early markers of neurodegeneration and are associated with faster increases in serum NfL level.