Article
Engineering, Biomedical
Hyejung Choi, Jongil Lim, Sukho Lee
Summary: This study compared gait biomechanics between obese individuals and a weight-matched control group, with results showing that the normal group had greater muscle strength, flexibility, and maximum oxygen uptake. Foot-pressure measures revealed significantly higher peak pressure values in the normal group, with a positive correlation between muscle strength and BMI as well as a negative correlation between body fat percentage and gait variables.
CLINICAL BIOMECHANICS
(2021)
Article
Pediatrics
Pat R. Vehrs, Gilbert W. Fellingham, Angela McAferty, Laurel Kelsey
Summary: This study examines the trends in body fat percentage and body mass index percentile rank among 12- to 17-year-old children, as well as the relationship between the two. The study finds that girls have higher body fat percentage and fat mass, but lower fat-free mass compared to boys of the same age. For a given body mass index, girls tend to have higher body fat percentage and lower fat-free mass. The study highlights the importance of using other measures of body composition to assess children's adiposity.
Article
Pharmacology & Pharmacy
Yuqian Lv, Xiaoyan Lv, Jianshu Feng, Fanghui Cheng, Zhiyi Yu, Fengying Guan, Li Chen
Summary: This study used network pharmacology to predict and screen the active ingredients, action targets and signaling pathways of ginseng. It was found that (20R)-panaxadiol (PD) is a more desirable active ingredient due to its close relationship with the cAMP pathway and its ability to promote white adipocyte beigeing and increase thermogenesis, exerting anti-obesity effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Juan Sun, Chenyang Yue, Zhen Liu, Jie Li, Weiming Kang
Summary: This study revealed a significant positive relationship between total percent fat (TPF) and serum uric acid (SUA) among adults. This association remained statistically significant when stratified by sex and obesity status, but the shape of the smoothing curve differed between males and females.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Chaowei Li, Qi Chen, Yanrong Liu, Zhuwen Sun, Zhentong Shen, Shuhan Li, Dingrui Cha, Chao Sun
Summary: In this study, it was found that MetEnk effectively prevented obesity and improved glucose tolerance and insulin sensitivity. It also improved mitochondrial function, promoted lipolysis and thermogenesis through the activation of the cAMP/PKA pathway.
Article
Plant Sciences
Siyao Cheng, Xintao Ni, Yanjing Yao, Yunxia Sun, Xiaofeng Yu, Daozong Xia, Zhenggang Yang, Miaofen G. Hu, Xiaoli Hou
Summary: This study found that Hype, a major component of Hypericum perforatum L. and Crataegus pinnatifida Bunge, can help treat obesity and related metabolic diseases. Hype promotes the transition from white to beige fat, increases glucose and lipid metabolism, and resists obesity caused by a high-fat diet. The mechanism behind these effects involves the CDK6-TFEB pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu Li, Dongmei Wang, Xiaodan Ping, Yankang Zhang, Ting Zhang, Li Wang, Li Jin, Wenjun Zhao, Mingwei Guo, Fei Shen, Meiyao Meng, Xin Chen, Ying Zheng, Jiqiu Wang, Dali Li, Qiang Zhang, Cheng Hu, Lingyan Xu, Xinran Ma
Summary: This study discovered that local hyperthermia therapy promotes the activation of beige fat and offers a promising strategy against obesity via the HSF1-A2B1 transcriptional axis.
Review
Endocrinology & Metabolism
Tsui-Sui Annie Kao, Jiying Ling, Rachel Hawn, Christina Vu
Summary: This study found that motivational interviewing (MI) interventions are effective in improving children's anthropometric outcomes, including BMI, waist circumference, and body fat percentage. Potential moderators of MI effects on children's BMI changes include types of interveners, supplemental intervention activities, children's age, weight status, intervention setting, and targeted behaviors.
Review
Biochemistry & Molecular Biology
Peiwen Zhang, Yuxu He, Shuang Wu, Xinrong Li, Xutao Lin, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Xuewei Li, Li Zhu, Linyuan Shen
Summary: This article provides an overview of recent advances in understanding white fat browning and the role of brown adipose tissue (BAT) in lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Maneerat Puwanant, Ladda Mo-Suwan, Somchit Jaruratanasirikul, Wipa Jessadapakorn
Summary: This study aimed to generate sex-specific percentile curves for the percentage of body fat (PBF) in Thai children using bioelectrical impedance analysis (BIA). The study found that the body fat percentiles for boys had different patterns compared to girls, with a decrease and then increase in the lower percentiles. Body mass index (BMI) and waist-to-height ratios were strongly correlated with PBF and fat mass in both sexes, providing additional metrics for evaluating obesity in Thai children.
Review
Immunology
Yuexia Liu, Zunhai Liu, Juntong Liang, Chao Sun
Summary: This article reviews the types and functions of innate lymphoid cells (ILCs), with a focus on the relationship between group 2 innate lymphoid cells (ILC2s) and the conversion of white fat into beige fat. It also elaborates on the relationship between peripheral ILC2s and the browning of white fat and body energy homeostasis. This has important implications for the future treatment of obesity and related metabolic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diego Salagre, Meriem Chayah, Antonio Molina-Carballo, Maria-Jesus Oliveras-Lopez, Antonio Munoz-Hoyos, Miguel Navarro-Alarcon, Gumersindo Fernandez-Vazquez, Ahmad Agil
Summary: The role of melatonin in obesity control is widely accepted, but its mechanism of action is still unclear. This study demonstrated that melatonin increases brown fat in obese diabetic rats by both adipocyte transdifferentiation and de novo differentiation, and also promotes beige MSC adipogenesis in humans.
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Oncology
Peter T. Katzmarzyk, Justin C. Brown, Shengping Yang, Emily F. Mire, Xiao-Cheng Wu, Lucio Miele, Augusto C. Ochoa, Jovanny Zabaleta
Summary: This study found that both abdominal visceral adipose tissue (VAT) and total fat mass (FM) are associated with cancer incidence and mortality. The association between VAT and cancer incidence is largely independent of total FM. These results suggest that more direct measures of adiposity may be needed in assessing obesity-related cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
Hanh M. Pham, Nguyen D. Nguyen, Jacqueline R. Center, John A. Eisman, Tuan V. Nguyen
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Article
Endocrinology & Metabolism
Ha T. Mai, Thach S. Tran, Thao P. Ho-Le, Thuy T. Pham, Jacqueline R. Center, John A. Eisman, Tuan V. Nguyen
Editorial Material
Endocrinology & Metabolism
Tuan V. Nguyen, Fernando Rivadeneira, Roberto Civitelli
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Editorial Material
Endocrinology & Metabolism
Tuan V. Nguyen
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Letter
Immunology
Tuan V. Nguyen, Steve A. Frost
CLINICAL INFECTIOUS DISEASES
(2021)
Letter
Infectious Diseases
Tuan V. Nguyen
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Letter
Endocrinology & Metabolism
Thao P. Ho-Le, Tuan Nguyen
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Manju Chandran, Peter R. Ebeling, Paul J. Mitchell, Tuan Nguyen
Summary: In the Asia Pacific region, osteoporosis and fragility fractures are not widely recognized as a major public health problem. The Asia Pacific Consortium on Osteoporosis (APCO) aims to develop tangible solutions for the challenges of underdiagnosis and undertreatment. They have developed a harmonized set of standards of care, called The Framework, to address the large osteoporosis treatment gap in the region. APCO is working on embedding the Framework in clinical practice by partnering with regulatory bodies, conducting education programs, and benchmarking current services.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Thao P. Ho-Le, Thach S. Tran, Huy G. Nguyen, Jacqueline R. Center, John A. Eisman, Tuan Nguyen
Summary: This study aims to examine the association between a polygenic risk score (PRS) and lifetime fracture risk. The findings suggest that individuals with high PRS are at a greater risk of fractures, especially hip fractures. The study highlights the potential significance of incorporating the polygenic risk score into personalized fracture risk assessment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
Thach Tran, Thao Ho-Le, Dana Bliuc, Bo Abrahamsen, Louise Hansen, Peter Vestergaard, Jacqueline R. Center, Tuan Nguyen
Summary: The concept of "Skeletal Age" is introduced to convey the combined risk of fracture and fracture-associated mortality. Skeletal Age is defined as the sum of chronological age and the number of years of life lost associated with a fragility fracture. The study found that men tend to lose more years of life after a fragility fracture than women, and hip fractures result in the greatest loss of life years.
Article
Endocrinology & Metabolism
Thach S. Tran, Thao P. Ho-Le, Dana Bliuc, Jacqueline R. Center, Robert D. Blank, Tuan V. Nguyen
Summary: This study provides evidence that a population-wide strategy aimed at enhancing bone mineral density can lead to a substantial decrease in the incidence of hip fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Handoo Rhee, Anojan Navaratnam, Irina Oleinikova, Deborah Gilroy, Yolanda Scuderi, Peter Heathcote, Tuan Nguyen, Simon Wood, Ken K. Y. Ho
Summary: Liver-targeted testosterone treatment (LTTT) shows promise in preventing muscle and bone loss during androgen deprivation therapy (ADT), but may lead to reversible PSA rise in some patients. Further studies are needed to optimize the dose of LTTT in ADT for potential application in other catabolic states in men and women.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Huy G. Nguyen, Khanh B. Lieu, Thao P. Ho-Le, Lan T. Ho-Pham, Tuan Nguyen
Summary: In this population-based study, BUA modestly correlated with DXA BMD, suggesting that BUA is not a reliable method for screening of osteoporosis.
OSTEOPOROSIS AND SARCOPENIA
(2021)
Review
Endocrinology & Metabolism
Tuan Nguyen
OSTEOPOROSIS AND SARCOPENIA
(2020)
Article
Endocrinology & Metabolism
Tuan V. Nguyen, John A. Eisman