Article
Neurosciences
Alice F. Tarantal, Dennis J. Hartigan-O'Connor, Elisa Penna, Anna Kreutz, Michele L. Martinez, Stephen C. Noctor
Summary: Inoculating Zika virus in early gestation has lasting effects on fetal cortical structure, leading to abnormal development of the fetal brain including changes in microglial cells, blood vessels, and the cortical plate.
Article
Multidisciplinary Sciences
Munehisa Shimamura, Koichi Kaikita, Hironori Nakagami, Tomohiro Kawano, Nan Ju, Hiroki Hayashi, Ryo Nakamaru, Shota Yoshida, Tsutomu Sasaki, Hideki Mochizuki, Kenichi Tsujita, Ryuichi Morishita
Summary: Researchers redesigned an S100A9 vaccine that successfully produced antibodies and showed anti-thrombotic effects in cynomolgus monkeys. The vaccine was able to neutralize the anti-thrombotic effects of the produced antibodies and did not prolong bleeding time in vaccinated monkeys. Further studies are needed to enhance the vaccine's effectiveness and safety, but it may offer a promising approach to improving adherence to antiplatelet drugs in clinical settings.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Bangrong Cao, Liping Zhang, Huifen Liu, Shiqi Ma, Kun Mi
Summary: The study found that ACE2 and TMPRSS2 receptors are highly expressed in neonates, indicating higher susceptibility to infection. There is a high correlation between the expression of receptors and proteases during lung development, with TMPRSS9 being highly expressed in neonates. Additionally, immune cell infiltration analysis revealed immaturity in neonates, suggesting an association with mild or moderate cases of COVID-19.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Bo Rao, Dan Xu, Chaoyang Zhao, Shouchao Wang, Xuan Li, Wenbo Sun, Yadong Gang, Jian Fang, Haibo Xu
Summary: This study identified 8 RSNs in monkeys, showing similar development patterns as humans but with fine-tuning adjustments. The results suggest that monkeys can be a good animal model for studying human brain function.
Article
Multidisciplinary Sciences
Joey A. Charbonneau, Lara Maister, Manos Tsakiris, Eliza Bliss-Moreau
Summary: The ability to perceive internal bodily signals plays a critical role in biological and psychological functions. Rhesus monkeys have a human-like capacity to integrate interoceptive signals from the heart with exteroceptive audiovisual information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Min Zhu, Guangneng Liao, Xiaohong Liu, Xu Luo, Gen Chen, Lingyun Wang, Chengshi Wang, Wen Liu, Xin Zeng, Yanrong Lu, Guang Yang, Jingqiu Cheng, Younan Chen
Summary: The loss of beta cell mass and function in aged population is closely related to the prevalence of Type 2 diabetes. This study focuses on the causal relations between aging and age-related pancreatic islets degeneration using rhesus monkeys as an animal model. The findings indicate that the decreased islet size, compromised insulin secretion, and loss of beta cell identity markers are key molecular changes in islet senescence.
Article
Cell & Tissue Engineering
Suhas Sureshchandra, Chi N. Chan, Jacob J. Robino, Lindsay K. Parmelee, Michael J. Nash, Stephanie R. Wesolowski, Eric M. Pietras, Jacob E. Friedman, Diana Takahashi, Weining Shen, Xiwen Jiang, Jon D. Hennebold, Devorah Goldman, William Packwood, Jonathan R. Lindner, Charles T. Roberts, Benjamin J. Burwitz, Ilhem Messaoudi, Oleg Varlamov
Summary: Maternal obesity affects fetal hematopoiesis, leading to inflammatory responses in fetal bone marrow cells and decreased B cell development. Maternal high-fat diet also impairs the engraftment of fetal hematopoietic stem and progenitor cells in immunodeficient mice.
Article
Engineering, Multidisciplinary
Tsuyoshi Takamura, Kenji Matsui, Naoto Matsumoto, Yatsumu Saito, Toshinari Fujimoto, Susumu Tajiri, Shuichiro Yamanaka, Kei Matsumoto, Akimitsu Kobayashi, Izumi Yamamoto, Hiroshi Sasaki, Haruyuki Hirayama, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Akihiko Kiyoshi, Takao Kuroda, Makoto Inoue, Takeshi Miyawaki, Takashi Yokoo, Eiji Kobayashi
Summary: This study compared the transplant rejection between neonatal and fetal pig kidneys in renal heterotransplantation. The results showed that fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal kidneys.
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Yennifer Cortes-Araya, F. Xavier Donadeu, Cheryl J. Ashworth
Summary: This study aimed to investigate the temporal changes in testicular gene expression during testes development in fetuses of different size. The results showed that testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at gestational days 60 and 90. Fetal size was not associated with seminiferous tubule area and number, as well as the number of germ or Sertoli cells per tubule. The expression of DMRT1 and SPP1 mRNA was lower in testes associated with the lightest fetuses compared to the closest to mean litter weight fetuses at gestational day 90. These findings provide insights into the expression profiles of genes associated with testicular development and function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Veterinary Sciences
Christophe Casteleyn, Nina Robin, Jaco Bakker
Summary: This manuscript provides detailed anatomical data on the pelvic limb of the rhesus monkey, including the muscular, circulatory, and peripheral nerve systems. The study aims to improve the understanding of the anatomy of this widely used model in biomedical research, as well as enhance the welfare of captive individuals.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Christophe Casteleyn, Charlotte Gram, Jaco Bakker
Summary: This manuscript provides detailed anatomical data on the rhesus monkey thoracic limb, fulfilling the needs of researchers and veterinarians. The anatomical structures are described and illustrated using colored images. The study identifies both similarities and differences between the anatomy of rhesus monkeys and humans, emphasizing the importance of understanding the anatomy of this primate species.
VETERINARY SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Lauren M. Robinson, Natalie K. Waran, Ian Handel, Matthew C. Leach
Summary: The study found a correlation between animal welfare and subjective well-being, which is closely related to individual personality traits. Observer ratings serve as a psychometrically valid way to assess primate welfare based on observed behavioral states.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Article
Virology
Fengmei Yang, Yanyan Li, Yongjie Li, Weihua Jin, Suqin Duan, Hongjie Xu, Yuan Zhao, Zhanlong He, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Naokazu Takeda, Wenjing Zhang, Masamichi Muramatsu, Tian-Cheng Li
Summary: Through experimental studies, it was found that cynomolgus and rhesus monkeys are susceptible to rat hepatitis E virus (rat HEV) and may cause zoonotic infections. These findings provide an animal model for the development of vaccines.
Article
Clinical Neurology
Danielle Beckman, Paramita Chakrabarty, Sean Ott, Amanda Dao, Eric Zhou, William G. Janssen, Kristine Donis-Cox, Scott Muller, Jeffrey H. Kordower, John H. Morrison
Summary: This study successfully simulated tau protein misfolding and propagation similar to humans in rhesus monkeys, along with observing biomarkers of neuroinflammation and neuronal loss. These findings provide hope for the development of new therapies for AD.
ALZHEIMERS & DEMENTIA
(2021)
Article
Microbiology
Yaping Yan, Junfeng Wang, Shuai Qiu, Yanchao Duan, Wei Si
Summary: This study analyzed the intestinal microbiota composition of healthy rhesus monkeys in 6 GIT regions, providing important reference data for better understanding the regional organization and functions of gut microbial communities in humans.
MICROBIOLOGY SPECTRUM
(2022)