Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Environmental Sciences
Zhe Wang, Zhenzhu Ma, Xiaodie Cheng, Xiaoya Li, Ning Wang, Fengquan Zhang, Bing Wei, Qingqing Li, Zhen An, Weidong Wu, Sijin Liu
Summary: This study investigated the deleterious effects of silver nanoparticles on lactating mice and their offspring. The results showed that the nanoparticles could accumulate in the mammary glands of the mothers and disrupt the epithelial barrier. Additionally, the nanoparticles could be transferred to the brains of the breastfed offspring and cause developmental impairments. This study provides important insights into the environmental health and safety impacts of silver nanoparticle consumption during lactation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Lucie Marousez, Sandy Hanssens, Laura Butruille, Celine Petit, Charlene Pourpe, Capucine Besengez, Thameur Rakza, Laurent Storme, Philippe Deruelle, Jean Lesage, Delphine Eberle
Summary: Recent studies have shown that breast milk apelin levels increase with maternal obesity, while plasma apelin levels decrease. In lactating rats, maternal high-fat feeding leads to increased breast milk apelin levels without changing body weight. Additionally, breast milk leptin levels increase with maternal obesity in humans.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Nutrition & Dietetics
Elena Sinkiewicz-Darol, Urszula Bernatowicz-Lojko, Katarzyna Lubiech, Iwona Adamczyk, Magdalena Twaruzek, Barbara Baranowska, Krzysztof Skowron, Diane L. Spatz
Summary: This study found that milk from tandem breastfeeding mothers had higher fat content, energy value, and total protein concentration compared to milk after weaning, while the carbohydrate content remained stable. The composition of breastmilk changes after weaning to meet the nutritional requirements of the younger child.
Article
Agriculture, Dairy & Animal Science
L. Bernard, Y. Chilliard, K. Hove, H. Volden, R. A. Inglingstad, M. Eknaes
Summary: In this study, adding lipid to the diet of dairy goats was found to affect milk fat and fatty acid composition. The expression of mammary genes in goats was more regulated by lactation stage than by the dietary treatments applied.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Wenting Dai, Robin White, Jianxin Liu, Hongyun Liu
Summary: The mammary gland undergoes remarkable changes during development and has the ability to remodel and regenerate during lactation. Multiple processes, including cell proliferation, differentiation, and metabolic changes, under the control of cellular and hormonal signaling pathways, are required for the flexibility of the mammary gland. Understanding the subcellular events within mammary epithelial cells and how they relate to milk production and secretion provides insights into maintaining mammary/breast health.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Genetics & Heredity
Yaqi Fei, Yedan Gai, Qingchao Liao, Linxi Zhang, Zheng Li, Bojiang Li, Man Bai, Na Li, Liang Deng
Summary: In this study, mRNA-seq and miRNA-seq were performed to investigate the regulatory profile of miRNAs and mRNAs in lactation in donkeys. The results revealed differentially expressed miRNAs and mRNAs in lactating and nonlactating groups, and identified key miRNAs that target genes involved in immunity and milk component metabolism. These findings contribute to our understanding of the molecular mechanisms regulating bioactive milk component metabolism in donkeys and have potential implications for improving milk production.
Article
Agriculture, Dairy & Animal Science
Uffe Krogh, Helene Quesnel, Nathalie Le Floch, Aude Simongiovanni, Jaap van Milgen
Summary: The study integrated physiological and empirical knowledge to establish a dynamic model for quantifying parameters controlling mammary gland output in sows. By modifying and extending a cattle mammary gland model, the production process of milk in sow mammary glands during lactation was successfully simulated.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Agata Witczak, Anna Pohorylo, Hassan Abdel-Gawad
Summary: The study assessed the safety of infants related to endocrine-disrupting organochlorine pesticides (OCP) in breast milk. It was found that certain dietary habits of pregnant mothers could affect the levels of OCP compounds in breast milk. The consumption of specific food products, such as pork, beef, poultry, eggs, and dairy, was linked to increased pesticide residues in breast milk.
Article
Nutrition & Dietetics
Yifan Zhang, Xiaoxu Zhang, Lijuan Mi, Chuangang Li, Yiran Zhang, Ran Bi, Jinzhu Pang, Yixuan Li
Summary: Breast milk is essential for infants as it provides the necessary nutrients and acquired immunity in the first month. The composition of breast milk protein varies with lactation stage, with colostrum containing the most characteristic proteins. The protein expression in breast milk undergoes significant changes between day 3 and day 14 and stabilizes after 14 days.
Article
Multidisciplinary Sciences
Alecia-Jane Twigger, Lisa K. Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H. Scheel, Walid T. Khaled
Summary: This study characterizes cells in human milk and identifies epithelial cells similar to luminal progenitors and immune cells. The findings contribute to understanding the remodelling of human mammary tissue during pregnancy and lactation, and provide insights into the interplay between pregnancy, lactation, and breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Nutrition & Dietetics
Thomas Sevrin, Charlene Sirvins, Agnes David, Audrey Aguesse, Alexis Gandon, Blandine Castellano, Dominique Darmaun, Clair-Yves Boquien, Marie-Cecile Alexandre-Gouabau
Summary: The study found that supplementation of arginine during gestation and lactation can enhance milk flow and mammary lipogenesis in rat dams nursing large litters.
JOURNAL OF NUTRITION
(2021)
Article
Immunology
Peng Liu, Penghao Zhang, Chen Yuan, Jianda Li, Qian Yang
Summary: Lymphocytes in colostrum play crucial roles in protecting newborn piglets from infections, with transport mechanism largely unknown. This study identified maternal lymphocytes in sow colostrum and observed their transmigration in breast acinar lumen. Furthermore, a co-culture system revealed the role of CCL2 and CCL28 in lymphocyte transmigration across mammary epithelial cells.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Food Science & Technology
Wenqing Li, Wanli Li, Xiaoyang Wang, Honglu Zhang, Linfeng Wang, Tengyun Gao
Summary: The study found a high consistency of miRNA types between milk extracellular vesicles (EVs) and bovine mammary glands, as well as a significant correlation in miRNA expression levels.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Nutrition & Dietetics
Wan Jun Tie, Hazel Gardner, Ching Tat Lai, Anna Rachel Hepworth, Yasir Al-Tamimi, Michael James Paech, Peter Edwin Hartmann, Donna Tracy Geddes
MATERNAL AND CHILD NUTRITION
(2017)
Article
Pediatrics
Zoya Gridneva, Anna R. Hepworth, Leigh C. Ward, Ching T. Lai, Peter E. Hartmann, Donna T. Geddes
PEDIATRIC RESEARCH
(2017)
Article
Pediatrics
Sharon L. Perrella, Anna R. Hepworth, Zoya Gridneva, Karen N. Simmer, Peter E. Hartmann, Donna T. Geddes
PEDIATRIC RESEARCH
(2018)
Article
Medicine, General & Internal
Doris Fok, Izzuddin Mohd Aris, Jiahui Ho, Yiong-Huak Chan, Mary Rauff, James K. C. Lui, Mark D. Cregan, Peter Hartmann, Yap Seng Chong, Citra N. Z. Matter
SINGAPORE MEDICAL JOURNAL
(2019)
Article
Nutrition & Dietetics
Zoya Gridneva, Alethea Rea, Anna R. Hepworth, Leigh C. Ward, Ching T. Lai, Peter E. Hartmann, Donna T. Geddes
Article
Nutrition & Dietetics
Zoya Gridneva, Sambavi Kugananthan, Alethea Rea, Ching Tat Lai, Leigh C. Ward, Kevin Murray, Peter E. Hartmann, Donna T. Geddes
Article
Nutrition & Dietetics
Jacqueline C. Kent, Hazel Gardner, Ching-Tat Lai, Peter E. Hartmann, Kevin Murray, Alethea Rea, Donna T. Geddes
Article
Nutrition & Dietetics
Zoya Gridneva, Wan J. Tie, Alethea Rea, Ching Tat Lai, Leigh C. Ward, Kevin Murray, Peter E. Hartmann, Donna T. Geddes
Article
Pediatrics
Ching Tat Lai, Alethea Rea, Leon R. Mitoulas, Jacqueline C. Kent, Karen Simmer, Peter Edwin Hartmann, Donna Geddes
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2020)
Article
Nutrition & Dietetics
Zoya Gridneva, Alethea Rea, Wan Jun Tie, Ching Tat Lai, Sambavi Kugananthan, Leigh C. Ward, Kevin Murray, Peter E. Hartmann, Donna T. Geddes
Article
Nutrition & Dietetics
Melinda Boss, Peter Hartmann, Jennifer Turner, Douglas Pritchard, Rafael Perez-Escannilla, Rhonda Clifford
MATERNAL AND CHILD NUTRITION
(2020)
Article
Pediatrics
Zoya Gridneva, Ching T. Lai, Alethea Rea, Wan J. Tie, Leigh C. Ward, Kevin Murray, Peter E. Hartmann, Donna T. Geddes
Summary: The study found associations between human milk immunomodulatory proteins (IMPs) and infant body composition, with lactoferrin and lysozyme influencing infant fat mass and fat-free mass. This highlights the importance of breastfeeding for infant growth and development, emphasizing careful consideration of the dose effects of supplemented formula.
PEDIATRIC RESEARCH
(2021)
Article
Obstetrics & Gynecology
Melinda Boss, Jennifer Turner, Patrick Boss, Peter Hartmann, Douglas Pritchard, Rhonda Clifford
Summary: The study demonstrated that a theory-based approach to guideline development methodology can be easily integrated with a common-sense approach. Factors identified by the AGREE II theory-based framework provided practical guidance for changes in methodology that were integrated before the publication of the LactaMap website.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Nutrition & Dietetics
Donna Tracy Geddes, Zoya Gridneva, Sharon Lisa Perrella, Leon Robert Mitoulas, Jacqueline Coral Kent, Lisa Faye Stinson, Ching Tat Lai, Vanessa Sakalidis, Alecia-Jane Twigger, Peter Edwin Hartmann
Summary: Researchers are calling for human lactation research to be viewed as a biological framework, studying factors impacting human milk and relationships to infant growth and health. This approach allows for evidence-based interventions to support breastfeeding globally and improve study design for future investigations.
Article
Nutrition & Dietetics
Zoya Gridneva, Alethea Rea, Ching Tat Lai, Wan Jun Tie, Sambavi Kugananthan, Kevin Murray, Peter E. Hartmann, Donna T. Geddes
Summary: Maternal adiposity is related to infant subcutaneous abdominal fat area. 24-h milk intake is positively associated with infant subcutaneous-abdominal depth and visceral depth. The differential effects of HM components and maternal adiposity on infant abdominal adiposity development are significant.