Article
Nutrition & Dietetics
Xiaoxiao Lin, Shuai Wang, Jinyu Huang
Summary: Alternate-day fasting (ADF) is a promising diet intervention for human health. A comprehensive bibliometric analysis was conducted to investigate publication trends and hotspots in the field of ADF. The study found that the main research hotspots are ADF for obesity and cardiometabolic risk, and ADF for different population groups including healthy adults and patients with diabetes, NAFLD, and cancer.
Article
Physiology
Arthur Ingersen, Hildegunn Romma Helset, Monika Calov, Elizaveta Chabanova, Eva Gjerlevsen Harreskov, Christina Jensen, Christina Neigaard Hansen, Clara Prats, Jorn Wulff Helge, Steen Larsen, Flemming Dela
Summary: Alternate-day fasting can improve metabolic health in patients with obesity and T2DM by reducing visceral and liver fat deposits. However, it does not directly improve insulin secretion or sensitivity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Aarti Asnani, Mikhail Kosiborod, Jie Zheng, Robert J. Hayashi, Pamela K. Woodard, Attila Kovacs, Kenneth B. Margulies, Joel Schilling, Babak Razani, Abhinav Diwan, Ali Javaheri
Summary: Fasting strategies are being investigated in patients on chemotherapy. Alternate-day fasting was found to aggravate doxorubicin cardiotoxicity and increase mortality and impaired cardiac function in mice. The study also showed that TFEB and GDF15 pathways contribute to doxorubicin-induced heart failure.
Article
Nutrition & Dietetics
Bruna L. Endl Bilibio, Welerson R. dos Reis, Leticia Compagnon, Diovana G. de Batista, Lucas M. Sulzbacher, Juliana F. Pinheiro, Mirna S. Ludwig, Matias N. Frizzo, Vinicius Cruzat, Thiago G. Heck
Summary: This study investigated the effects of alternate-day fasting and time-restricted feeding on middle-aged obese female rats. While both intermittent fasting protocols were able to reduce body weight, they did not promote health benefits and led to increased inflammatory biomarkers, potentially increasing the risk of obesity-associated comorbidities.
Article
Cardiac & Cardiovascular Systems
Shuhao Lin, Manoela Lima Oliveira, Kelsey Gabel, Faiza Kalam, Sofia Cienfuegos, Mark Ezpeleta, Surabhi Bhutani, Krista A. Varady
Summary: This study found no significant difference in weight loss and metabolic benefits of alternate day fasting (ADF) according to sex or menopausal status in adults with obesity. Energy intake on fast days exceeded prescribed values, with no differences between groups.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cell Biology
Mark Ezpeleta, Kelsey Gabel, Sofia Cienfuegos, Faiza Kalam, Shuhao Lin, Vasiliki Pavlou, Zhenyuan Song, Jacob M. Haus, Sean Koppe, Shaina J. Alexandria, Lisa Tussing-Humphreys, Krista A. Varady
Summary: This study compared the effects of alternate day fasting (ADF) combined with exercise to fasting alone, or exercise alone, on intrahepatic triglyceride (IHTG) content in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that combining intermittent fasting with exercise is effective for reducing hepatic steatosis in patients with NAFLD but may offer no additional benefit versus fasting alone.
Article
Nutrition & Dietetics
Shaoyong Xu, Yuxin Jiang, Yuhai Zhang, Wenlei Xu, Hao Zhang, Qiongjie Yan, Ling Gao, Lei Shang
Summary: The study shows that alternate-day fasting is an effective short-term weight loss strategy that is well tolerated by most Chinese participants. It also suggests that the dietary pattern on fasting days is less important, with the focus being on calorie restriction during those days.
Editorial Material
Endocrinology & Metabolism
Huachun Pan, Shumin Yang, Wenke Cheng, Qiang Cai, Quazi T. H. Shubhra
Summary: Doxorubicin (Dox) is an effective chemotherapy drug, but its clinical use is limited due to cardiotoxicity and the risk of heart failure. Recent research by Ozcan et al. suggests that alternate-day fasting (ADF) can significantly worsen the cardiotoxicity of Dox.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Faiza Kalam, Kelsey Gabel, Sofia Cienfuegos, Mark Ezpeleta, Eric Wiseman, Krista A. Varady
Summary: The study found that the ADF-LC diet does not impact sleep quality, duration, insomnia severity or the risk of obstructive sleep apnea in adults with obesity.
Article
Immunology
Mehdi Barati, Amirali Ghahremani, Hasan Namdar Ahmadabad
Summary: Intermittent fasting has potential benefits for autoimmune diseases by reducing inflammation, modulating the immune system, improving gut microbiota, and enhancing cellular repair mechanisms. However, evidence on its effects for certain autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, thyroid diseases, and psoriasis is limited and inconclusive. Further research is needed to determine optimal intermittent fasting guidelines and long-term effects on autoimmune diseases.
AUTOIMMUNITY REVIEWS
(2023)
Article
Nutrition & Dietetics
Ian Zajac, Danielle Herreen, Hugh Hunkin, Genevieve James-Martin, Mathilde Doyen, Naomi Kakoschke, Emily Brindal
Summary: Studies suggest that true fasting and modified fasting have different effects on subjective experience, with modified fasting showing improvements in blood glucose levels, cravings, hunger, and fatigue compared to true fasting. However, cognitive function does not appear to be impaired by either fasting method.
Article
Endocrinology & Metabolism
Paloma Elortegui Pascual, Maryann R. Rolands, Alison L. Eldridge, Amira Kassis, Fabio Mainardi, Kim-Anne Le, Leonidas G. Karagounis, Philipp Gut, Krista A. Varady
Summary: This meta-analysis compared the effectiveness of different intermittent fasting regimens with traditional caloric energy restriction for weight loss. The results showed that intermittent fasting was comparable to caloric energy restriction and is a promising alternative for weight loss. Among the three regimens examined, alternate day fasting showed the highest effectiveness, followed by caloric energy restriction and time-restricted eating. Further well-powered randomized controlled trials with longer durations are needed to draw solid conclusions.
Article
Nutrition & Dietetics
Mark Ezpeleta, Kelsey Gabel, Sofia Cienfuegos, Faiza Kalam, Shuhao Lin, Vasiliki Pavlou, Krista A. Varady
Summary: This study investigated the effects of alternate-day fasting (ADF) combined with aerobic exercise on body weight and sleep in adults with non-alcoholic fatty liver disease (NAFLD). The results showed that the combination of ADF and exercise can reduce body weight and intrahepatic triglyceride content, but it does not improve sleep quality.
Article
Biochemistry & Molecular Biology
Dongfang Li, Shoko Onodera, Shu Deng, Bashaer Alnujaydi, Qing Yu, Jing Zhou
Summary: This study found that alternate-day fasting (ADF) can improve salivary gland inflammation in a mouse model of Sjogren's syndrome (SS), reducing inflammatory cells and pro-inflammatory factors, increasing salivary flow rate, and restoring normal salivary secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xiangwei Hu, Kai Xia, Minhui Dai, Xiaofeng Han, Peng Yuan, Jia Liu, Shiwei Liu, Fuhuai Jia, Jiayu Chen, Fangfang Jiang, Jieyao Yu, Huanming Yang, Jian Wang, Xun Xu, Xin Jin, Karsten Kristiansen, Liang Xiao, Wei Chen, Mo Han, Shenglin Duan
Summary: Intermittent fasting is a promising weight loss method that modulates the gut microbiota. A three-week IF program resulted in an average weight loss of 3.67 kg and improved clinical parameters, regardless of initial BMI and gut microbiota status.
NPJ BIOFILMS AND MICROBIOMES
(2023)