Review
Biology
Inseok Choi, Hyewon Son, Jea-Hyun Baek
Summary: The TCA cycle is a series of chemical reactions that occur in the mitochondria of aerobic organisms to generate energy from acetyl-CoA. The intermediates of the TCA cycle may leak from dysfunctional mitochondria and regulate immune responses under cell stress conditions. Increasing evidence suggests that the metabolites of the TCA cycle play important roles in the regulation of immune activation and suppression.
Article
Neurosciences
Carlos Rodriguez-Lopez, Alfredo Santalla, Pedro. L. Valenzuela, Alberto Real-Martinez, Monica Villarreal-Salazar, Irene Rodriguez-Gomez, Tomas Pinos, Ignacio Ara, Alejandro Lucia
Summary: This study compared the fat oxidation rate between patients with McArdle disease and healthy controls. The results showed that despite having a lower peak oxygen uptake, McArdle patients had a higher fat oxidation rate. This may be a compensatory adaptation due to the complete blockade of muscle glycogen metabolism in these patients.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pal O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Summary: This study found that chronic nighttime physical activity can significantly alter the daily rhythms of murine muscle gene expression and support the fluctuations in daily exercise performance.
MOLECULAR METABOLISM
(2022)
Review
Nutrition & Dietetics
Isabel A. Ely, Bethan E. Phillips, Kenneth Smith, Daniel J. Wilkinson, Mathew Piasecki, Leigh Breen, Mads S. Larsen, Philip J. Atherton
Summary: This review highlights the anabolic effects of leucine (LEU) supplementation in the context of aging, exercise, and unloading states. LEU has been shown to increase muscle protein synthesis (MPS) and maximize muscle anabolism, especially when combined with resistance exercise. Low doses of LEU-enriched protein/essential amino acids (EAA) can achieve maximal MPS stimulation without the need for larger protein doses, making LEU supplementation a promising strategy for promoting muscle growth and net protein accretion.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sang-Hyeon Ju, Eu Jin Lee, Byeong Chang Sim, Ha Thi Nga, Ho Yeop Lee, Jingwen Tian, Kyu Jeong Cho, Hyoungsu Park, Dae Eun Choi, Young Rok Ham, Hyon-Seung Yi
Summary: This study investigated the preventive effects of leucine-enriched amino acid supplementation and resistance exercise in non-sarcopenic hemodialysis patients, and characterized the profiles of those who benefited from the intervention. The results showed that 95.4% of the patients showed improvement in muscle mass, grip strength, or physical performance. Therefore, the intervention can help prevent sarcopenia in selected patients on maintenance hemodialysis.
FRONTIERS IN NUTRITION
(2023)
Article
Physiology
Yan Zhao, Jason Cholewa, Huayu Shang, Yueqin Yang, Xiaomin Ding, Shaosheng Liu, Zhi Xia, Nelo Eidy Zanchi, Qianjin Wang
Summary: Studies have shown that resistance exercise can increase muscle protein synthesis and deposition, leading to muscle hypertrophy through the LeuRS/mTOR signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaofan Jiang, Yuwei Zhang, Weichao Hu, Yuxiu Liang, Liang Zheng, Juan Zheng, Baozhen Wang, Xin Guo
Summary: This study aimed to investigate the role of leucine and exercise in adiposity, systemic insulin resistance, and inflammation to provide theoretical and guiding basis for early prevention and treatment of obesity. The results showed that exercise increased insulin sensitivity and decreased adiposity in LFD mice, while the combined intervention of exercise and leucine reduced inflammation and increased adiponectin expression in HFD mice. Different mechanisms were found in the effects of exercise and leucine on insulin resistance and inflammation in LFD-fed mice or HFD-fed mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marc Yehya, Doria Boulghobra, Pierre-Edouard Grillet, Pablo R. Fleitas-Paniagua, Patrice Bideaux, Sandrine Gayrard, Pierre Sicard, Jerome Thireau, Cyril Reboul, Olivier Cazorla
Summary: The aim of this study was to investigate the effects of four different natural extracts with recognized antioxidant properties on the contractile function of skeletal and cardiac muscles after prolonged exhausting exercise. The results showed that all natural extracts provided protection for both cardiac and skeletal muscles, with different degrees depending on muscle type and duration of recovery. These findings suggest that acute antioxidant supplementation can help protect against the toxic effects of prolonged exhausting exercise.
Article
Nutrition & Dietetics
Nicola Theis, Meghan A. Brown, Paula Wood, Mark Waldron
Summary: This study found that after long-term leucine supplementation, muscle strength and volume increased in individuals with cerebral palsy, while inflammation levels decreased and overall wellbeing improved.
JOURNAL OF NUTRITION
(2021)
Review
Physiology
Abram Katz
Summary: Glycogen is the storage form of glucose in cells, traditionally believed to play a key role in high-energy demand situations, but its mechanism and regulation are still controversial.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Sarah A. Tabozzi, Giovanni Stancari, Enrica Zucca, Michela Tajoli, Luca Stucchi, Claudio L. Lafortuna, Francesco Ferrucci
Summary: This study evaluated the feasibility of ultrasound assessment of muscle glycogen in horses. The results showed significant differences in greyscale intensity between different muscle tissues, and a significant increase in intensity in one muscle after exercise, indicating changes possibly associated with glycogen utilization.
BMC VETERINARY RESEARCH
(2021)
Article
Food Science & Technology
Hao Zhang, Huanhuan Liu, Lin Shu, Huimin Xu, Ying Cheng, Zhitao Mao, Bin Liu, Xiaoping Liao, Di Huang
Summary: Monascus azaphilones pigments (MonAzPs) produced by microbial fermentation are widely used as food chemicals for coloring and providing beneficial biological attributes. This study used a fermentation perturbation strategy to investigate the metabolic changes induced by the addition of different amino acids. The results identified fumarate and malate as the hub metabolites involved in the tricarboxylic acid cycle, which played a crucial role in the synthesis of MonAzPs. Exogenous addition of fumarate or malate significantly increased red pigment production while reducing orange/yellow pigment production. The study also highlighted the importance of the tricarboxylic acid cycle in MonAzPs synthesis through measurements of intracellular ATP, NAD(P)H levels, and expression of oxidoreductase-coding genes. Overall, metabolomics is a powerful approach for identifying key metabolic regulatory factors and advancing engineering strategies for the fermented food chemistry industries.
Article
Medicine, Research & Experimental
Everton Lopes Vogt, Maiza Cristina Von Dentz, Debora Santos Rocha, Jorge Felipe Argenta Model, Lucas Stahlhofer Kowalewski, Diane Silveira, Marjoriane de Amaral, Paulo Ivo Homem de Bittencourt Junior, Luiz Carlos Kucharski, Mauricio Krause, Anapaula Sommer Vinagre
Summary: This study investigated the immediate effects of a single moderate-intensity exercise bout performed in fast or fed states on the metabolism of gastrocnemius and soleus of lean and obese rats. The results showed that exercise and fasting had different effects on the metabolism of the muscles in obese rats, which can promote health benefits in these animals.
Article
Biotechnology & Applied Microbiology
Sota Ikeda, Keisuke Tomita, Gen Nakagawa, Atsushi Kouzuma, Kazuya Watanabe
Summary: It is unclear why S. oneidensis MR-1 cannot undergo fermentative growth despite having the necessary genes. Understanding the molecular mechanisms behind this defect will aid in developing innovative fermentation technologies for the production of valuable chemicals from biomass feedstocks. Furthermore, this study contributes to our understanding of how bacteria thrive in redox-stratified environments.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jennifer Maurer, Miriam Hoene, Cora Weigert
Summary: Regular physical activity is an effective strategy to prevent and ameliorate aging-associated diseases, with metabolites released from skeletal muscles during exercise potentially playing a crucial role in the adaptation process.
Review
Nutrition & Dietetics
Geovana S. F. Leite, Ayane S. Resende, Nicholas P. West, Antonio H. Lancha
Article
Genetics & Heredity
Joao Paulo L. F. Guilherme, Marcelo Bigliassi, Antonio H. Lancha Junior
Meeting Abstract
Sport Sciences
Juliana M. Lino Aparecido, Hellyelson Lopes de Omena Couto, Alison Fabiano Cunha Cruz, Thais Miria, Marcelo Santin Cascapera, Cristiane Kochi, Vera Lucia Santos Alves, Antonio H. Lancha, Marcelo Luis Marquezi
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Meeting Abstract
Sport Sciences
Geovana S. F. Leite, Valdir de Aquino Lemos, Helena A. P. Batatinha, Edgar Tavares, Ayane S. Resende, Ricardo A. Fock, Jose C. R. Neto, Ronaldo V. T. dos Santos, Antonio H. Lancha Junior
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Meeting Abstract
Sport Sciences
Marcelo L. Marquezi, Juliana M. Lino, Antonio H. Lancha
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Genetics & Heredity
Joao Paulo Limongi Franca Guilherme, Antonio Herbert Lancha
ANNALS OF HUMAN GENETICS
(2020)
Review
Physiology
Patricia S. Rogeri, Sandro O. Gasparini, Gabriel L. Martins, L. K. F. Costa, Caue C. Araujo, Rebeca Lugaresi, Mariana Kopfler, Antonio H. Lancha Jr
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Nutrition & Dietetics
Ayane S. Resende, Geovana S. F. Leite, Antonio H. Lancha Junior
Summary: The study showed that moderate aerobic exercise improved cardiorespiratory fitness and affected the gut bacteria composition of non-obese men with a balanced nutrient consumption profile. The correlation between body composition, cardiorespiratory fitness, and specific genera of gut bacteria was also observed.
Article
Nutrition & Dietetics
Luis H. B. Ferreira, Scott C. Forbes, Marcelo P. Barros, Andre C. Smolarek, Alysson Enes, Antonio H. Lancha-Junior, Gabriel L. Martins, Tacito P. Souza-Junior
Summary: This study investigated the effects of caffeine on muscle strength and plasma calcium, and found that an 8 mg/kg dose of caffeine can effectively improve upper and lower body muscular strength and calcium release.
Meeting Abstract
Sport Sciences
Joao Paulo Limongi F. Guilherme, Antonio Herbert Lancha Junior
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Marcelo L. Marquezi, Caroline Santana Frientes, Juliana M. Lino, Marcelo S. Cascapera, Antonio H. Lancha
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Helena A. Batatinha, Edgar Silva, Geovana Leite, Ayane Resende, Jose Antonio Albuquerque, Ronaldo Dos Santos, Antonio Lancha, Fabio Lira, Jose Rosa Neto
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Henry Chan, Roberta C. Muzy, Paula H. D. Kanas, Luciana O. P. Lancha, Ivan S. Rabelo, Katia Rubio, Paulo C. Muzy, Antonio H. Lancha
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Multidisciplinary Sciences
Helena Batatinha, Edgar Tavares-Silva, Geovana S. F. Leite, Ayane S. Resende, Jose A. T. Albuquerque, Christina Arslanian, Ricardo A. Fock, Antonio H. Lancha, Fabio S. Lira, Karsten Krueger, Ronaldo Thomatieli-Santos, Jose C. Rosa-Neto
SCIENTIFIC REPORTS
(2020)
Article
Nanoscience & Nanotechnology
R. C. Andrades, R. F. Neves, F. R. Diaz, A. H. M. Junior
JOURNAL OF NANO RESEARCH
(2020)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.