期刊
NUTRITION
卷 28, 期 10, 页码 978-983出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2011.12.001
关键词
Rate of eating; Interleukin-1 beta; Interleukin-6; Japanese men; Subjects not being treated for metabolic diseases
资金
- Global COE Program for the Center of Excellence for Innovation in Human Health Sciences from the Ministry of Education, Science, Sports and Culture of Japan
- Dannon Institute for Nutrition and Health
- Grants-in-Aid for Scientific Research [23300276] Funding Source: KAKEN
Objective: In this study, we examined the relations between the rate of eating and circulating interleukin (IL)-1 beta and IL-6 levels in Japanese men not being treated for metabolic diseases. Methods: We conducted a cross-sectional study of 170 men 40 to 59 y old (mean +/- standard deviation, 51.4 +/- 5.7 y old) who participated in health checkups in Japan and were not being treated for metabolic diseases. We measured clinical serum parameters and plasma IL-1 beta and IL-6 concentrations and assessed by questionnaire lifestyle factors such as the dietary intake of food/nutrition and the rate of eating. Using multivariate linear regression analysis, we analyzed the relations between the rate of eating and IL-beta and IL-6 concentrations, clinical parameters, and lifestyle factors. Results: Significant Spearman correlation coefficients with the rate of eating were observed for IL-1 beta and IL-6 (0.250 and 0.195, respectively). The rate of eating was positively associated with IL-1 beta independently of IL-6, body mass index, homeostasis model assessment for insulin resistance, alcohol intake, energy intake, smoking status, and physical activity. Conclusions: These results indicate that a higher rate of eating is positively and independently associated with circulating IL-1 beta concentrations in Japanese men not being treated for metabolic diseases. (C) 2012 Elsevier Inc. All rights reserved.
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