Article
Immunology
Carolina Lyon De Ana, Anukul T. Shenoy, Kimberly A. Barker, Emad I. Arafa, Neelou S. Etesami, Filiz T. Korkmaz, Alicia M. Soucy, Michael P. Breen, Ian M. C. Martin, Brian R. Tilton, Priyadharshini Devarajan, Nicholas A. Crossland, Riley M. F. Pihl, Wesley N. Goltry, Anna C. Belkina, Matthew R. Jones, Lee J. Quinton, Joseph P. Mizgerd
Summary: Streptococcus pneumoniae is a common bacterial pathogen that causes pneumonia, leading to significant mortality in children and the elderly worldwide. This study identifies a unique subset of CD4+ TRM cells in the lungs that play a crucial role in lung immunity during pneumococcal infections. These cells exhibit distinct functional characteristics compared to other subsets, suggesting their importance in protecting against reinfection.
MUCOSAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Garry Dolton, Cristina Rius, Md Samiul Hasan, Aaron Wall, Barbara Szomolay, Enas Behiry, Thomas Whalley, Joel Southgate, Anna Fuller, Theo Morin, Katie Topley, Li Rong Tan, Philip J. R. Goulder, Owen B. Spiller, Pierre J. Rizkallah, Lucy C. Jones, Thomas R. Connor, Andrew K. Sewell
Summary: This study examined the CD8 T cell response against a specific epitope of the Spike glycoprotein of SARS-CoV-2 and found that a specific mutation was not recognized by the majority of HLA A*02(+) convalescent patients and vaccinated individuals. This highlights the potential problem of viral escape at prevalent T cell epitopes restricted by high frequency HLAs and suggests the inclusion of multiple viral proteins in next generation vaccines. Monitoring T cell escape in new SARS-CoV-2 variants is crucial.
Article
Oncology
Carmen M. Anadon, Xiaoqing Yu, Kay Hanggi, Subir Biswas, Ricardo A. Chaurio, Alexandra Martin, Kyle K. Payne, Gunjan Mandal, Patrick Innamarato, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Carla Cortina, John J. Powers, Tara Lee Costich, Bradford A. Perez, Chandler D. Gatenbee, Sandhya Prabhakaran, Douglas Marchion, Mirjam H. M. Heemskerk, Tyler J. Curiel, Alexander R. Anderson, Robert M. Wenham, Paulo C. Rodriguez, Jose R. Conejo-Garcia
Summary: This study reveals that tissue-resident memory (TRM) cells are the main type of T cells infiltrating ovarian cancer. These TRM cells, specifically the progenitor TRMstem cells, play a crucial role in predicting the outcome of ovarian cancer. The findings suggest that ovarian cancer is immunogenic, but only a small portion of tumor-infiltrating T cells have tumor antigen reactivity.
Article
Oncology
Jiang-Ping Li, Chang-You Wu, Ming-Yuan Chen, Shang-Xin Liu, Shu-Mei Yan, Yin-Feng Kang, Cong Sun, Jennifer R. Grandis, Mu-Sheng Zeng, Qian Zhong
Summary: The study revealed the presence of a PD-1(+)CXCR5(-)CD4(+) Th-CXCL13 cell subset in NPC, which serves as a major source of CXCL13 and is comparable in numbers to Th1 and Tfh cells in the TLSs. Monocytes activated by toll-like receptor 4 agonists efficiently trigger the expansion of Th-CXCL13 cells, with TGF-beta 1 stimulation and activation of Sox4 being crucial for their induction and polarization. Additionally, the recruitment of TABs by Th-CXCL13 cells in TLSs induces plasma cell differentiation and immunoglobulin production, potentially leading to improved survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Mallory Paynich Murray, Isaac Engel, Gregory Seumois, Sara Herrera-De la Mata, Sandy Lucette Rosales, Ashu Sethi, Ashmitaa Logandha Ramamoorthy Premlal, Goo-Young Seo, Jason Greenbaum, Pandurangan Vijayanand, James P. Scott-Browne, Mitchell Kronenberg
Summary: The study found that iNKT cell subsets are similar regardless of tissue location, with lung iNKT cells possessing the most distinct location-specific features possibly due to increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes, giving rise to additional subsets.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Naiara G. Bediaga, Alexandra L. Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L. Stone, Joanna Cobb, Jessica E. Harbison, John M. Wentworth, Annette-G. Ziegler, Jennifer J. Couper, Gordon K. Smyth, Leonard C. Harrison
Summary: This study found that cytotoxic CD4(+) T cells play a role in promoting the progression of type 1 diabetes, based on analysis of gene expression and chromatin accessibility in children with the disease.
Article
Multidisciplinary Sciences
Takehito Yokoi, Mari Murakami, Takako Kihara, Shigeto Seno, Mitsuru Arase, James Badger Wing, Jonas Norskov Sondergaard, Ryuichi Kuwahara, Tomohiro Minagawa, Eri Oguro-Igashira, Daisuke Motooka, Daisuke Okuzaki, Ryota Mori, Atsuyo Ikeda, Yuki Sekido, Takahiro Amano, Hideki Iijima, Keiichi Ozono, Tsunekazu Mizushima, Seiichi Hirota, Hiroki Ikeuchi, Kiyoshi Takeda
Summary: This study provides insights into the pathogenesis of inflammatory bowel disease (IBD) by profiling the T cells in the intestinal mucosa. A CD4+ tissue-resident memory T cell (Trm) subset was identified, which is increased in Crohn's disease (CD) and exhibits unique inflammatory properties. Specifically, a CD-specific CD4+ Trm subset was found to be the predominant producer of type 1 inflammatory cytokines. These findings contribute to the understanding of the molecular mechanisms underlying IBD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Nathalie Meijerink, Daphne A. van Haarlem, Francisca C. Velkers, Arjan J. Stegeman, Victor P. M. G. Rutten, Christine A. Jansen
Summary: This study characterized various NK subsets in the intestines of broiler chickens, with differences observed between organs rather than over time. Targeting these intestinal NK subsets may be a strategy to improve immune-mediated resistance in broiler chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Respiratory System
Amy M. de Waal, Pieter S. Hiemstra, Tom H. M. Ottenhoff, Simone A. Joosten, Anne M. van der Does
Summary: The lung epithelium plays a crucial role in tuberculosis disease, acting as a barrier to Mycobacterium tuberculosis and responding to infection by producing immune mediators. The interactions between epithelial cells, immune cells, and Mtb are important for understanding the early events of Mtb infection.
Article
Multidisciplinary Sciences
Bingqian Zhou, Kuikui Fan, Jingjing Guo, Jiesi Feng, Changxi Yang, Yulong Li, Songhai Shi, Lingjie Kong
Summary: In vivo detection of neurochemicals is crucial for understanding brain mechanisms and diagnosing brain diseases. However, current sensors lack high specificity for real-time monitoring. In this study, fiber-optic probes based on engineered cells (FOPECs) were developed for plug-and-play, real-time detection of neurochemicals in freely moving animals. FOPECs demonstrated unprecedented chemical specificity and could be widely used in vertebrates without viral infection. They also showed potential for monitoring drug metabolisms in vivo.
Article
Plant Sciences
Yijun Tu, Xinyao Luo, Dan Liu, Huijun Li, Heyuan Xia, Chaozhi Ma, Dandan Zhang, Yuying Yang, Xiang Pan, Tianhe Wang, Yu Xia, Hanxiong Dan, Pengtao You, Xiaochuan Ye
Summary: This study investigated the therapeutic effects of Poria cocos and its three extracts on functional dyspepsia (FD) in rats. The study explored the mechanisms of action based on brain-gut peptides, immunity, and repair of the gastrointestinal mucosa.
Article
Oncology
Shi Yong Neo, Xu Jing, Le Tong, Dongmei Tong, Juan Gao, Ziqing Chen, Mireia Cruz De Los Santos, Nutsa Burduli, Sabrina De Souza Ferreira, Arnika Kathleen Wagner, Evren Alici, Charlotte Rolny, Yihai Cao, Andreas Lundqvist
Summary: Downregulation of MHCI molecules on tumor cells is recognized as a resistance mechanism of cancer immunotherapy. This study found that the expression of MHCI by tumor cells influences systemic immune responses and NK cells play an important role in regulating tumor progression. Mice bearing MHCI-deficient tumor cells showed reduced tumor-associated extramedullary myelopoiesis in the spleen, which was reversed by NK cell depletion. Furthermore, an upregulation of TNF-alpha by NK cells was observed in mice with MHCI-expressing tumors, and inhibition of TNF-alpha enhanced host myelopoiesis in mice receiving adoptive transfer of tumor-experienced NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Elise J. Huisman, A. Rick Brooimans, Samone Mayer, Marieke Joosten, Louis de Bont, Marielle Dekker, Elisabeth L. M. Rammeloo, Frans J. Smiers, P. Martin van Hagen, C. Michel Zwaan, Masja de Haas, Marjon H. Cnossen, Virgil A. S. H. Dalm
Summary: Patients with disorders of the long arm of chromosome 11 (11q) often experience immunodeficiency and are susceptible to various infections. This study found that these patients had a high prevalence of respiratory tract infections, varicella infections, chronic eczema, warts, and fungal infections. Immunological screening and treatment are of great importance for this patient group.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Chantal L. Duurland, Saskia J. Santegoets, Ziena Abdulrahman, Nikki M. Loof, Gregor Sturm, Tom H. Wesselink, Ramon Arens, Sanne Boekestijn, Ilina Ehsan, Mariette I. E. van Poelgeest, Francesca Finotello, Hubert Hackl, Zlatko Trajanoski, Peter Ten Dijke, Veronique M. Braud, Marij J. P. Welters, Sjoerd H. van der Burg
Summary: The expression of CD4+CD161+ effector memory T cells is associated with improved survival in HPV16+ oropharyngeal squamous cell carcinoma. Therapeutic vaccination activates and expands CD4+CD161+ effector T cells. CD161 functions dynamically and is regulated by cell intrinsic and extrinsic factors. CD161 expressing CD4+ T cells respond more vigorously to suboptimal antigen stimulation and may amplify TCR signals.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Jing B. Li, Jing J. Li, Mingyan Li, Changxing Gao, Lingzhi Zhang, Meihan Li, Qing Zhu
Summary: The study aims to determine the specific involvement of homing receptors in retaining effector T cells in the small intestine after oral immunization. The results demonstrate that CXCR6 chemokine receptor, integrins beta 7, and CD29 play differential roles in the epithelial retention phenotype of CD8(+) T cells in the small intestine of mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.