Article
Oncology
Nao Sukeda, Hidetsugu Fujigaki, Tatsuya Ando, Honomi Ando, Yasuko Yamamoto, Kuniaki Saito
Summary: Cisplatin is a chemotherapeutic drug used for treating malignant tumors, but nephrotoxicity is a dose-limiting factor. The study identified 2',4',6'-trihydroxyacetophenone (THA) as an inhibitor of cisplatin-induced nephrotoxicity. THA pretreatment can effectively alleviate cisplatin-induced kidney damage.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Food Science & Technology
Shucen Feng, Haitao Wang, Xinping Lin, Huipeng Liang, Sufang Zhang, Yingxi Chen, Chaofan Ji
Summary: The increasing demand for healthy food has sparked interest in developing new food products containing probiotics. This study assessed the potential of probiotics and prebiotics to create novel gummies. The results confirmed the safety of 25 strains of Lactobacillus plantarum derived from fermented foods, showing their tolerance to simulated gastrointestinal fluids. Moreover, mushroom polysaccharides were found to have a proliferative effect on potential probiotics and protected their survival in the gastrointestinal fluids. These findings demonstrate the promising application of probiotics and prebiotics in the form of gummies as a probiotic food.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Eshita Sharma, Milan Kumar Lal, Arvind Gulati, Ashu Gulati
Summary: An extracellular gamma-glutamyl transpeptidase (GGT) from Bacillus altitudinis IHB B1644 was purified using ion-exchange chromatography, and it was composed of two subunits of 40 and 22 kDa determined by SDS-PAGE. The enzyme showed optimal activity at pH 9 and 37 degrees C, and it was stable in a pH range of 5-10 and below 50 degrees C. The enzyme exhibited highest affinity for L-methionine and serine or threonine and tryptophan residues were found to be essential for its activity. The production of L-theanine was optimized by a one-variable-at-a-time approach with a conversion rate of 60-65%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Dongwei Wang, Yao Wang, Haibo Lan, Kai Wang, Lei Zhao, Zhuoyan Hu
Summary: The study used a LAB strain isolated from traditional Chinese kimchi as a starter culture to enhance GABA production in fermented litchi juice. A strain of Lactobacillus plantarum named HU-C2W exhibited the highest GABA-producing ability, along with resistance to artificial gastric conditions. Fermented litchi juice by this strain showed a significant increase in GABA content and a reduction in total carbohydrates, indicating its potential as a probiotic starter culture for functional fermented litchi juice.
Article
Multidisciplinary Sciences
Hironobu Nishijima, Matthew J. Zunitch, Masafumi Yoshida, Kenji Kondo, Tatsuya Yamasoba, James E. Schwob, Eric H. Holbrook
Summary: This study identified two fluorescence probes that can rapidly detect and evaluate the entire extent of mice OE. These probes can be used to monitor OE degeneration and the regenerative response to therapeutic interventions.
Article
Chemistry, Multidisciplinary
Yohei Kondo, Yutaro Saito, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Tatsuya Nishihara, Marino Itoda, Hiroshi Nonaka, Masayuki Matsuo, Shinsuke Sando
Summary: Dynamic nuclear polarization (DNP) is an emerging method for acquiring metabolic and physiological information in vivo. The development of a deuterated probe, gamma-Glu-[1-C-13]Gly-d(2), has been shown to extend the lifetime of hyperpolarized signals. By evaluating enzymatic conversion and magnetic properties, this study confirms the effectiveness of gamma-Glu-[1-C-13]Gly as a DNP NMR molecular probe for detecting GGT activity in serum.
Review
Plant Sciences
Takehiro Ito, Naoko Ohkama-Ohtsu
Summary: GSH is an essential thiol for plants, but its degradation has not been fully elucidated, limiting our understanding of plant life. Recent studies have shown that GSH is degraded by cytosolic enzymes or after conjugation with other molecules. This highlights the need to reassess previous assumptions and provide a novel overview of the plant GSH degradation pathway. This review aims to summarize current understanding of GSH/glutathione conjugate degradation and lay a foundation for future studies.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Pharmacology & Pharmacy
Jingxin Fu, Likang Lu, Manzhen Li, Yaoyao Guo, Meihua Han, Yifei Guo, Xiangtao Wang
Summary: A novel nanoparticle drug delivery system was developed for the targeted treatment of GGT-positive cervical cancer, which achieved good tumor accumulation and improved anti-tumor efficacy through GGT-triggered charge reversal.
Article
Microbiology
Ezgi Ozcan, Michelle R. Rozycki, David A. Sela
Summary: The study reveals that the probiotic Lactobacillus plantarum demonstrates varied physiological responses to different dietary oligosaccharides and cranberry polyphenols, with PAC1 fraction increasing growth and PAC2 positively impacting growth during xyloglucan metabolism. This differential response is also reflected in the metabolite ratios of acetic acid to lactic acid, indicating the potential synergistic effects of oligosaccharides and polyphenols on the physiology of L. plantarum.
Article
Food Science & Technology
Yuhan Xu, Qiaoling Xie, Wei Zhang, Meizhen Zhu, Xiaoxuan Chen, Dongbei Guo, Lili Pan, Junru Li, Hui Lan, Hongwei Li
Summary: The effects of probiotics Lp662 and Lp299v on severe inflammatory bowel disease induced by dextran sodium sulfate were evaluated. The results showed that these probiotics can reduce weight loss caused by colitis, decrease tissue injury, and lower inflammatory factor levels. Additionally, probiotics can also increase bone density. Therefore, probiotics have the potential to be a treatment option for inflammatory bowel disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Li-Long Pan, Ming Zhang, Zhengying Li, Binbin Li, Xiaohua Pan, Xiaopei Chen, Bo Yang, Hao Zhang, Wei Chen, Le Zhang, Jia Sun
Summary: In this study, engineered probiotics encoding CRAMP were shown to increase colonic CRAMP production, reduce colon shortening and weight loss, and suppress inflammatory responses in experimental colitis. These findings suggest that CRAMP-encoding L. plantarum may have therapeutic potential for colitis through modulation of colonic CRAMP production.
Article
Chemistry, Multidisciplinary
Hui Wang, Xiaoting Zhang, Ping Li, Fang Huang, Tiancong Xiu, Hongtong Wang, Wei Zhang, Wen Zhang, Bo Tang
Summary: Atherosclerosis, a disease driven by lipoproteins, lacks effective therapy for reversal. Therefore, there is an urgent need for a noninvasive and reliable early detection approach to prevent plaque formation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Mengwei Wang, Yang Li, Jie Yang, Rui Shi, Liu Xiong, Qingjie Sun
Summary: This study investigated the adsorption amounts and antibacterial effects of inorganic nanoparticles on probiotic bacteria. Results showed that food-grade NPs have bactericidal effects on L. plantarum and L. fermentum.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Faranak Gholipour, Mohammad Amini, Behzad Baradaran, Ahad Mokhtarzadeh, Morteza Eskandani
Summary: Probiotic bacteria treated with curcumin showed unaffected anticancer properties, ability to combat pathogenic bacteria, and survival in acidic conditions. They exhibited stronger inhibitory effects on colon cancer cells compared to untreated bacteria, inducing cell apoptosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qi Guo, Jiaxin Tang, Shidong Li, Liyue Qiang, Shuaidan Chang, Gengan Du, Tianli Yue, Yahong Yuan
Summary: This study investigates the encapsulation of Lactobacillus plantarum into whey protein isolate and dextran conjugates, and finds that this method can enhance the viability of the probiotics under processing stress conditions, gastrointestinal conditions, and storage. Microencapsulation of probiotics offers better protection and can be a useful technique in the development of functional food products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.