Article
Chemistry, Organic
Javeed Ahmad Tali, Ravi Shankar
Summary: Here, we report an unprecedented protocol using ruthenium-catalyzed annulation for the synthesis of 6H-chromeno[4 ',3 ':4,5]imidazo[1,2-a]pyridin-6-one, and a new method for intramolecular chelation-assisted C-H activation to produce functionalized 2-(3-formylimidazo[1,2-a]pyridin-2-yl)phenyl acetate. Furthermore, a one-pot approach using ruthenium catalysis and formic acid has been developed for the gram-scale synthesis of bis(2-phenylimidazo[1,2-a]pyridin-3yl)methane (BIP) and the late-stage functionalization of zolimidine, a marketed drug, with good yield.
Article
Chemistry, Organic
Oleksandr Kolomiiets, Alexander Tsygankov, Maryna N. Kornet, Aleksander A. Brazhko, Vladimir I. Musatov, Valentyn A. Chebanov
Summary: Peptidomimetics with a substituted imidazo[1,2-a ]pyridine fragment were synthesized using a combination of Groebke-Black-burn-Bienayme and Ugi reactions. The resulting products contained substituted imidazo[1,2-a]pyridine and peptidomimetic moieties as pharmacophores, with four diversity points introduced from readily available starting materials. A focused compound library consisting of 20 Ugi products was prepared and screened for antibacterial activity.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Yueyue Zhu, Rupeng Dai, Chaoqun Huang, Wang Zhou, Xiaoyuan Zhang, Kundi Yang, Hongmei Wen, Wei Li, Jian Liu
Summary: In this study, a novel and efficient synthetic method was developed to construct isoquinolone scaffold and other valuable derivatives through catalytic reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Meng-Qi Ping, Ming-Zhong Guo, Rui-Tao Li, Zi-Chen Wang, Cheng Ma, Li-Rong Wen, Shao-Fei Ni, Weisi Guo, Ming Li, Lin-Bao Zhang
Summary: This study has successfully developed an efficient electrochemical method for the [3 + 2] annulation of imidazo[1,2-a]pyridines with alkynes, using traceless electrons as green reagents. It leads to the synthesis of a large class of polycyclic heteroaromatics with good yields and a broad substrate scope under mild and green conditions.
Article
Chemistry, Organic
Xianglong Chu, Yadi Niu, Xiaodong Wang, Yunliang Lin, Fuwei Li, Chen Ma
Summary: A rapid method for preparing a series of N-heteroarene fluorophores via palladium-catalyzed direct oxidative reactions has been developed, showing color-tunable emissions and high fluorescence quantum yields. The photophysical properties-structure relationship was systematically investigated, leading to the discovery of fluorophores with emissions ranging from 431-507 nm in CH2Cl2 and fluorescence quantum yields up to 91% in CH2Cl2.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Multidisciplinary
Rajavenkatesh Krishnamoorthy, Parthiban Anaikutti
Summary: An efficient iodine-catalyzed method for synthesizing imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyridines via one-pot three-component condensations has been reported. The photophysical properties of these new fluorescent derivatives are also presented. The synthesized compounds were evaluated for their anti-cancer activities and one compound showed promising results.
Article
Chemistry, Multidisciplinary
Kai Wang, Xiaoxue Du, Pengfei Zhang, Zhenjiang Wei, Xian-Ting Cao
Summary: A general and straightforward method utilizing N,N-dimethylaniline as the methylenation source has been reported for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions. The reaction proceeds through a radical pathway and affords C(sp(2))-C(sp(3)) functionalized products in good to excellent yields.
Article
Chemistry, Medicinal
Pratibha Shukla, Deepa Deswal, Mansi Pandit, Narayanan Latha, Divyank Mahajan, Tapasya Srivastava, Anudeep Kumar Narula
Summary: New imidazo[1,2-a]pyridine candidates were designed by synthesizing derivatives using 2-amino pyridine, TOSMIC, and various aldehydes, showing antioxidant and antifungal potential. The highest antifungal inhibition was observed in compound 12 against Aspergillus fumigatus and Candida albicans, with confocal images and UPLC analysis revealing the antifungal mechanism. In silico studies confirmed the interaction of the synthesized compounds with the active site of the target enzyme, while ADME analysis indicated drug-likeliness of the compounds.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Organic
Jingyun Zhu, Ziyue Chen, Meng He, Daoxin Wang, Liangsen Li, Junchao Qi, Renyi Shi, Aiwen Lei
Summary: The study developed an efficient and metal-free synthesis method for the production of biologically and synthetically useful compounds. The reaction exhibited high yields, and the scaled-up experiment resulted in an ideal yield of the desired product.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Medicinal
Ivana Mejdrova, Jan Dusek, Krystof Skach, Alzbeta Stefela, Josef Skoda, Karel Chalupsky, Klara Dohnalova, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutna, Vojtech Duchoslav, Tomas Smutny, Petr Pavek, Radim Nencka
Summary: The nuclear constitutive androstane receptor (CAR, NR1I3) plays significant roles in hepatic functions and has been proposed as a target for metabolic or liver disease therapy. However, current CAR agonists have limited selectivity. We discovered derivatives that directly activate human CAR and are selective, non-toxic, and show in vivo activity, highlighting CAR as a therapeutic target.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rashmi Semwal, Gaurav Badhani, Subbarayappa Adimurthy
Summary: The annulation of imidazo[1,2-a]pyridines with different substrates under various conditions leads to the formation of different fused products, with the phenyl ring at the C-2 position of the imidazo[1,2-a]pyridines playing a more crucial role in the reaction than alkyl groups. Both transformations follow the ionic mechanism by Pd-catalyzed double C-H bond activation, resulting in highly fluorescent characteristics in the annulated products.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Shen Zhao, Shimin Yang, Guopeng Du, Daopeng Zhang, Hui Liu, Feng-Gang Sun
Summary: Here, a three-component Catellani-type reaction catalyzed by the Pd/NBE/CuI cooperative system is reported. This reaction provides a convenient method for synthesizing aromatic ketones and can be performed in the presence of water. The reaction exhibits a broad substrate scope, allowing for the use of various acyl electrophiles and termination reagents.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Applied
Fengxiang Zhu, Yifan Yang, Shanshan Shi
Summary: A cobalt-catalyzed intermolecular 1,2-difunctionalization of alkenes with anilines/indoles and acetonitrile has been developed for the synthesis of functionalized cyano-containing molecules. The reaction shows good tolerance towards a variety of nucleophiles and electronically diverse arenes. Additionally, the kinetic isotope effect has been studied in this research.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Mahanandaiah Kurva, Miguel Angel Claudio-Catalan, Angel Renteria-Gomez, J. Oscar C. Jimenez-Halla, Gerardo Gonzalez-Garcia, Jayaramakrishnan Velusamy, Gabriel Ramos-Ortiz, Karen Castano-Gonzalez, Valeria Piazza, Rocio Gamez-Montano
Summary: In this study, a series of novel fluorescent Imidazo [1,2-a] pyridines (IMPs) (4a-4p) were synthesized via an eco-friendly microwave-assisted Groebke-Blackburn-Bienayme reaction (GBBR) with good to excellent yields (80-92%) and a green catalyst. These target molecules exhibited absorption in the UV-vis region and emitted blue-to-greenish fluorescence with large Stokes shifts (6780-9011 cm-1) due to an intramolecular charge transfer (ICT) process. Time-dependent density functional theory (DFT) calculations were performed to analyze the structure-property relationships and confirm the ICT characteristics and energy band gaps. Furthermore, imaging studies on HEK293 and HeLa cell lines demonstrated that IMP 4e, which had the highest fluorescence quantum yield (phi fl) of 66%, served as a specific blue fluorescent probe for staining the DNA of the nucleus.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Organic
Vikrant V. Kumbhar, Bhushan B. Khairnar, Manohar G. Chaskar, Ramdas A. Pawar, Gulab S. Gugale
Summary: Imidazo[1,2-a]pyridines are important nitrogen-containing heterocyclic scaffolds with wide applications in medicinal chemistry, organometallics, and material science. This review discusses the rigorous efforts made in the past decade towards the regioselective and straightforward synthesis of 3-aroyl and 2-aroyl imidazo[1,2-a]pyridines, as well as highlights the challenges in achieving regioselective aroylation at the C-2 position.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Engineering, Industrial
Anil Kumar, Sangita Choudhary, Jose Arturo Garza-Reyes, Vikas Kumar, Syed Abdul Rehman Khan, Nishikant Mishra
Summary: Many threats such as scarcity of sources and climate change are driving businesses to reexamine their commitment to the environment and society. As a result, companies are integrating long-term sustainable practices into their operations, such as circular supply chain (CSC) and Industry 4.0. This study aims to analyze the critical success factors (CSFs) for the integration of CSC and Industry 4.0 to achieve sustainable supply chain operations. The research findings highlight the importance of "knowledge of CSC and Industry 4.0" and "top management commitment".
PRODUCTION PLANNING & CONTROL
(2023)
Article
Green & Sustainable Science & Technology
Upendra Rajak, Abhishek Dasore, Prem Kumar Chaurasiya, Tikendra Nath Verma, Prerana Nashine, Anil Kumar
Summary: In this study, the fuel blend combination of spirulina microalgae biodiesel (SMAB), diesel, ethanol, and methanol was prepared and assessed. It was found that increasing the percentage of SMAB in the blend improves spray characteristics and engine performance, while reducing smoke and NOX emissions.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Management
Guilherme F. Frederico, Vikas Kumar, Jose Arturo Garza-Reyes, Anil Kumar, Rohit Agrawal
Summary: This study investigates the impact of I4.0 technologies and their interoperability on supply chain performance and explores how the integration of such technologies and their interoperability can create pathways for supply chain resilience post-COVID-19. The findings indicate that the integration of I4.0 technologies and their interoperability have a positive impact on supply chain performance and profitability, but do not improve efficiency.
INTERNATIONAL JOURNAL OF LOGISTICS MANAGEMENT
(2023)
Article
Computer Science, Artificial Intelligence
Sathishkumar Karupusamy, J. Refonaa, Sakthidasan Sankaran, Priyanka Dahiya, Mohd Anul Haq, Anil Kumar
Summary: The development of IoT systems has created higher demands for processing and storage environment, as well as raised issues such as energy consumption and data compression. This article proposes an approach that utilizes data mining to optimize energy usage and compress data, validated through the analysis of driving behavior.
Article
Computer Science, Artificial Intelligence
Selvin Shabu Lilly Pushpam Jany Shabu, Kusum Yadav, Elham Kariri, Kamal Kumar Gola, Mohd AnulHaq, Anil Kumar
Summary: This paper investigates trajectory data query processing and similarity measurement methods in a cloud environment. By extending traditional data processing techniques and leveraging the highly parallel processing capabilities of large clusters in the cloud, a two-phase trajectory similarity measure is proposed. Additionally, new methods for trajectory clustering and query processing are developed, which involve trajectory analysis and evaluation to reduce computational difficulty and workload compared to existing methods.
Article
Automation & Control Systems
J. Refonaa, Dinh Tran Ngoc Huy, Nguyen Dinh Trung, Hoang Van Thuc, Roop Raj, Mohd Anul Haq, Anil Kumar
Summary: Structural engineering is a specialized field that deals with the stability of structures and buildings. Optimization of cost and time is crucial in construction processes. Artificial neural network (ANN) has been developed to handle issues related to cost estimation and optimization, enhancing construction procedures and methodologies using deep learning techniques.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
P. Saini, L. K. Balyan, A. Kumar, G. K. Singh
Summary: This paper presents a comparison scenario of adaptive spectral filtering for resolution of the Gibbs phenomenon. Several spectral filter functions are compared using Chebyshev collocation and Legendre collocation spectral methods, in terms of pointwise and L-2 normed-wise convergence analysis of computed filtered approximations.
SIGNAL IMAGE AND VIDEO PROCESSING
(2023)
Article
Pharmacology & Pharmacy
Radhika T. Krishnakumar, Amrita Asok, Zubair U. Mohamed, Uma D. Padma, Dipu T. Sathyapalan, Merlin Moni, Sabarish Balachandran, Anil Kumar, Rajesh Nair, Surendran Sudhindran, Sanjeev K. Singh
JOURNAL OF PHARMACY PRACTICE
(2023)
Correction
Computer Science, Hardware & Architecture
Priyanka Paliwal, Julian L. Webber, Abolfazl Mehbodniya, Mohd Anul Haq, Anil Kumar, Prem Kumar Chaurasiya
JOURNAL OF SUPERCOMPUTING
(2023)
Article
Computer Science, Information Systems
Himanshu Singh, Anil Kumar, Lokendra K. Balyan
Summary: This paper introduces an image enhancement method based on fractional differintegral based adaptive filtering, which utilizes the advantages of fractional-order differentiation and fractional-order integration for adaptive textural boosting and contrast enhancement. It also proposes a differintegration based fractional-order multi-scale Retinex framework for effective reflectance channel computation. The paper discusses the compatibility of the proposed method with other image pre-processing methods and presents different variants for overall quality improvement.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Green & Sustainable Science & Technology
B. Sarkar, B. Das, P. K. Sundaram, S. S. Mali, A. P. Anurag, A. Upadhyaya, N. Chandra, B. P. Bhatt, A. Kumar
Summary: This study analyzed the energy input-output and GHG emission in vegetable production in the Chotanagpur plateau region and found that both tomato and okra cultivation were profitable. The study also emphasized the importance of efficient input use in reducing GHG emissions.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Business
Naveen Virmani, Urmi Ravindra Salve, Anil Kumar, Sunil Luthra
Summary: This article identifies the roadblocks of implementing Industry 4.0 through a literature review and expert opinions. The roadblocks are categorized into five sections and validated through a case study in the automobile industry. The implications for industrialists, practitioners, and academicians are provided.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Article
Chemistry, Organic
Vikki N. Sonam, Vikki N. Shinde, Krishnan Rangan, Anil Kumar
Summary: A selectfluor-promoted oxidative coupling reaction was developed for the formation of C-O, C-N, C-S, and C-Se bonds by reacting quinoxalin-2(1H)-ones with alcohols, amines, thiols, and selenols. The protocol showed high yields (53-95%) and allowed for the decoration of a wide range of quinoxalin-2(1H)-ones at the C3-position with various functional groups. The reaction proceeds via a radical pathway and features mild reaction conditions, broad substrate scope, and metal-and photocatalyst-free conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Srijita Paul Chowdhuri, Shiv Dhiman, Subhendu K. Das, Neha Meena, Sonali Das, Anil Kumar, Benu Brata Das
Summary: This study reports a novel antileishmanial agent C17, which can poison topoisomerase 1-DNA covalent complexes (LdTop1cc) inside parasites and inhibit its religation activity. C17 is effective against both drug sensitive and antimony-resistant L. donovani isolates without affecting human Top1. It overcomes the chemical instability of camptothecin (CPT) and shows promising results in clearing Leishmania parasites in infected mice.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Neha Meena, Vikki N. Shinde, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: This study presents a catalyst-dependent regioselective oxidative annulation of 2-arylimidazo[1,2-a]pyridines with cinnamaldehyde derivatives to construct fused N-heterocyclic frameworks. The annulation reaction using [RhCp*Cl-2](2) as catalyst afforded 5-arylnaphtho[1',2':4,5]imidazo[1,2-a]pyridine-6-carbaldehydes, while Pd(OAc)(2) catalyst led to the formation of 1,7-diarylimidazo[5,1,2-cd]indolizine-6-carbaldehydes. The reaction exhibited high yields, broad substrate scope, and excellent functional group tolerance, providing valuable compounds with different functionalities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
