Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movement

(2014) Pyae P Hein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues

(2014) Liang Xu et al.   NUCLEIC ACIDS RESEARCH

Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator

(2014) K. Hollands et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase

(2014) Anssi M. Malinen et al.   Nature Communications

Structural Basis of Transcriptional Pausing in Bacteria

(2013) Albert Weixlbaumer et al.   CELL

Antisense Oligonucleotide-stimulated Transcriptional Pausing Reveals RNA Exit Channel Specificity of RNA Polymerase and Mechanistic Contributions of NusA and RfaH

(2013) Kellie E. Kolb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cys-Pair Reporters Detect a Constrained Trigger Loop in a Paused RNA Polymerase

(2013) Dhananjaya Nayak et al.   MOLECULAR CELL

Interplay between the trigger loop and the F loop during RNA polymerase catalysis

(2013) Nataliya Miropolskaya et al.   NUCLEIC ACIDS RESEARCH

The RNA polymerase trigger loop functions in all three phases of the transcription cycle

(2013) T. Fouqueau et al.   NUCLEIC ACIDS RESEARCH

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

(2013) Manchuta Dangkulwanich et al.   eLife

The RNA polymerase bridge helix YFI motif in catalysis, fidelity and translocation

(2012) Yuri A. Nedialkov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

An Insertion in the Catalytic Trigger Loop Gates the Secondary Channel of RNA Polymerase

(2012) Ran Furman et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2

(2012) Ellen James et al.   MOLECULAR CELL

Active site opening and closure control translocation of multisubunit RNA polymerase

(2012) Anssi M. Malinen et al.   NUCLEIC ACIDS RESEARCH

Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II

(2012) M. H. Larson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics and mutational analysis of the catalytic and translocation cycle of RNA polymerase

(2012) Maria L Kireeva et al.   BMC Biophysics

Dissection of Pol II Trigger Loop Function and Pol II Activity–Dependent Control of Start Site Selection In Vivo

(2012) Craig D. Kaplan et al.   PLoS Genetics

RNA Transcript 3′-Proximal Sequence Affects Translocation Bias of RNA Polymerase

(2011) Pyae P. Hein et al.   BIOCHEMISTRY

Structural basis of initial RNA polymerase II transcription

(2011) Alan C M Cheung et al.   EMBO JOURNAL

Activity Map of theEscherichia coliRNA Polymerase Bridge Helix

(2011) Milija Jovanovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of Pyrophosphate Ion Release and Its Coupled Trigger Loop Motion from Closed to Open State in RNA Polymerase II

(2011) Lin-Tai Da et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

(2010) Steve A. Seibold et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Translocation by multi-subunit RNA polymerases

(2010) Maria Kireeva et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain

(2010) Robert OJ Weinzierl   BMC BIOLOGY

Stepwise mechanism for transcription fidelity

(2010) Yulia Yuzenkova et al.   BMC BIOLOGY

Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein

(2010) Shunsuke Tagami et al.   NATURE

RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media

(2010) T. M. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Structural Model of Escherichia coli RNA Polymerase from a Hybrid Approach

(2010) Natacha Opalka et al.   PLOS BIOLOGY

Molecular Evolution of Multisubunit RNA Polymerases: Sequence Analysis

(2009) William J. Lane et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of the RNA polymerase trigger loop in catalysis and pausing

(2009) Jinwei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric control of catalysis by the F loop of RNA polymerase

(2009) Nataliya Miropolskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution

(2009) D. Wang et al.   SCIENCE

Applied Force Reveals Mechanistic and Energetic Details of Transcription Termination

(2008) Matthew H. Larson et al.   CELL

Transient Reversal of RNA Polymerase II Active Site Closing Controls Fidelity of Transcription Elongation

(2008) Maria L. Kireeva et al.   MOLECULAR CELL

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

(2008) Craig D. Kaplan et al.   MOLECULAR CELL