DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy

Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP-F and XFE

(2012) Li Jing Tan et al.   GENES TO CELLS

Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair

(2012) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Biological Evaluation, and Structure–Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

(2012) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition

(2012) Maureen Bowles et al.   NUCLEIC ACIDS RESEARCH

XPF-ERCC1: On the Bubble

(2012) Steven M. Shell et al.   STRUCTURE

The Structure of the XPF-ssDNA Complex Underscores the Distinct Roles of the XPF and ERCC1 Helix- Hairpin-Helix Domains in ss/ds DNA Recognition

(2012) Devashish Das et al.   STRUCTURE

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1

(2011) Brittney A. Manvilla et al.   BIOCHEMISTRY

The knock-down of ERCC1 but not of XPF causes multinucleation

(2011) Julie Rageul et al.   DNA REPAIR

The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality

(2011) Hanspeter Naegeli et al.   DNA REPAIR

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Role of Interaction of XPF with RPA in Nucleotide Excision Repair

(2011) Laura A. Fisher et al.   JOURNAL OF MOLECULAR BIOLOGY

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

(2011) Chantal Stoepker et al.   NATURE GENETICS

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

(2011) Gerry P Crossan et al.   NATURE GENETICS

Mutations of the SLX4 gene in Fanconi anemia

(2011) Yonghwan Kim et al.   NATURE GENETICS

Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance

(2011) W Li et al.   ONCOGENE

Identification of DNA repair gene Ercc1 as a novel target in melanoma

(2011) Liang Song et al.   Pigment Cell & Melanoma Research

The Fanconi Anemia Protein, FANCG, Binds to the ERCC1-XPF Endonuclease via Its Tetratricopeptide Repeats and the Central Domain of ERCC1

(2010) Chuan Wang et al.   BIOCHEMISTRY

Downregulation of XPF–ERCC1 enhances cisplatin efficacy in cancer cells☆

(2010) Sanjeevani Arora et al.   DNA REPAIR

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression

(2010) Svetlana Usanova et al.   Molecular Cancer

Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair

(2010) Yuliya S. Krasikova et al.   NUCLEIC ACIDS RESEARCH

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

(2010) Dorjbal Dorjsuren et al.   NUCLEIC ACIDS RESEARCH

Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients

(2010) Anwaar Ahmad et al.   PLoS Genetics

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

(2009) Barbara Orelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of an inhibitory dynamic pharmacophore for the ERCC1–XPA interaction using a combined molecular dynamics and virtual screening approach

(2009) Khaled H. Barakat et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

(2009) N. Bhagwat et al.   MOLECULAR AND CELLULAR BIOLOGY

Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination

(2009) Sabrina L. Andersen et al.   MOLECULAR CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel

(2008) Lifeng Wang et al.   BMC CANCER

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation

(2008) H J Jun et al.   BRITISH JOURNAL OF CANCER

Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer

(2008) J Matsubara et al.   BRITISH JOURNAL OF CANCER

Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms

(2008) Yili Wu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics

ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer

(2007) Min Kyoung Kim et al.   EUROPEAN JOURNAL OF CANCER