Article
Environmental Sciences
Dongying Yan, Liang Gao, Jing Lang, Xianhui Gao, Honglin Ma
Summary: Excessive exposure to manganese can lead to neurological diseases characterized by behavioral and motor impairments. Microglia-mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. SIRT1, PGC-1 alpha, NF-kappa B, and STAT3 are important factors in the regulation of neuroinflammatory responses and microglial polarization in mice exposed to manganese.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Tiantian Fang, Wei Chen, Yiyu Cheng, Yanyan Zhang, Qun Luo, Kui Wu, Fuyi Wang, Hao Lei, Yao Zhao
Summary: Manganese-enhanced MRI (MEMRI) is a powerful tool for studying neuronal activity and microarchitecture. However, the effect of exogenous manganese on the brain of Parkinson's disease model mice is not well understood. This study used laser ablation connected to inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging to assess the distribution of manganese and other endogenous metal ions in the brain regions of DJ-1 knockout PD model mice. The results showed that manganese mainly deposited in subcortical regions and the enhanced signal-to-noise ratio (S/N) determined by MEMRI was closely related to the signal in LA-ICP-MS imaging. Additionally, the treatment of MnCl2 disrupted the homeostasis of iron, zinc, copper, and calcium in the DJ-1 mouse.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo, Jin Wang
Summary: The study demonstrated that MnCl2 induces mitophagy and neurotoxicity in dopaminergic SH-SY5Y cells through BNIP3-mediated ROS generation. This suggests that BNIP3 plays a role in manganese-induced neurotoxicity by acting as a mitophagy receptor protein.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
David C. Dorman
Summary: This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. The review highlights contributions made by Professor Michael Aschner's laboratory in this field of study, which have significantly advanced our understanding of cellular responses to manganese exposure. His research has identified molecular targets of manganese toxicity and explored the role of astrocytes in neurotoxicity, as well as discovered new facets of manganese-induced neurotoxicity using C. elegans.
Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ji Yeon Hong, Yong Geun Lim, Yeong Jun Song, Kyeongsoon Park
Summary: In this study, histidine-modified hyaluronic acid (HA-His) was synthesized to quickly reduce permanganate to MnO2, resulting in the production of HA-His/MnO2 nanoparticles with good water-dispersibility and stability. These nanoparticles responded to the tumor microenvironment and were internalized into SCC7 cells with high CD44 expression. Systemically administered HA-His/MnO2 nanoparticles specifically accumulated in tumor tissues, enhancing T1 contrast in MRI.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen, Zhiping Zhang
Summary: The study successfully synthesized L-epigallocatechin gallate complexed Mn2+ nanoparticles with good biocompatibility, stability, pH sensitivity, and anti-tumor properties, potentially serving as an MRI contrast agent.
Article
Environmental Sciences
Jingjing Liu, Xin Zhang, Xiaojuan Ta, Miaomiao Luo, Xuhong Chang, Hui Wang
Summary: Manganese exposure can lead to neurotoxicity, resembling Parkinson's disease. Fecal microbiome transplantation (FMT) can alleviate the neurotoxic effects of manganese exposure through regulating the apelin signaling pathway. Autophagy plays a critical role in the neurotoxicity induced by manganese exposure and is attenuated by FMT.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biophysics
Emily Petrus, Galit Saar, Alexia Daoust, Steve Dodd, Alan P. Koretsky
Summary: Contrast agents like manganese ion (Mn2+) enhance MRI contrast due to their paramagnetic properties, and are widely used in imaging healthy and diseased states in animal models. Mn2+ accumulates in high activity brain regions and can compete with zinc (Zn2+) and iron (Fe2+) for uptake into cells. Studies in hippocampal slice cultures have established a hierarchy of agents influencing Mn2+ uptake, helping to understand its entry mechanisms.
NMR IN BIOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Lukasz Kalkowski, Dominika Golubczyk, Joanna Kwiatkowska, Piotr Holak, Kamila Milewska, Miroslaw Janowski, Joaquim Miguel Oliveira, Piotr Walczak, Izabela Malysz-Cymborska
Summary: Cell therapy holds promise for treating CNS disorders, but faces challenges in translation due to ineffective delivery methods. The intrathecal route of administration is attractive for global diseases like stroke or ALS, but precision and efficacy remain a challenge. Hydrogels and contrast agents have been introduced to improve delivery outcomes.
Article
Environmental Sciences
Muxue Lu, Ping Deng, Lingling Yang, Xue Wang, Xiang Mei, Chao Zhou, Mengyan Chen, Zhou Zhou, Huifeng Pi, Lichuan Wu, Zhengping Yu
Summary: This study investigates the pathogenesis of manganese-induced parkinsonism in C57BL/6 J mice. The results show that manganese overexposure alters the lipidome profiles, leading to lipid metabolism disorders, oxidative stress, and dopaminergic neuron injury, which may play important roles in the development of Parkinson-like symptoms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Kyle J. Horning, Xueqi Tang, Morgan G. Thomas, Michael Aschner, Aaron B. Bowman
Summary: Manganese is a biologically essential metal that is crucial for enzyme function, but neurotoxic in excess. Prolonged occupational exposure to manganese can lead to Parkinsonian conditions. Understanding the mechanisms of manganese transport and homeostasis, and identifying small molecules that can modulate intracellular manganese levels, have important pharmacological and scientific implications.
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Arsenic is a naturally occurring metalloid that can cause acute and chronic toxicity in humans. Neurotoxicity is a serious manifestation of arsenic toxicity. This study found that minocycline, an antimicrobial agent with antioxidant properties and the ability to cross the blood-brain barrier, can significantly attenuate arsenic-induced neurotoxicity by reducing oxidative stress and apoptosis. These findings suggest that minocycline could be a promising treatment for arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Md. Kamrul Islam, Ah-Rum Baek, Byeong-Woo Yang, Soyeon Kim, Dong Wook Hwang, Sung-Wook Nam, Gang-Ho Lee, Yongmin Chang
Summary: A non-gadolinium alternative, Mn-NOTA-NP, was designed and synthesized as a liver-specific MRI contrast agent, showing stronger imaging effect compared to Mn-DPDP and comparable to GBCAs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shohei Harada, Kazuki Takano, Motoaki Fukasawa, Seiji Shirakawa, Masayuki Yamada
Summary: Quantifying and confirming stress and detecting subclinical stressors are currently challenging. This study demonstrates that manganese-enhanced magnetic resonance imaging (MEMRI) can be used to evaluate stress in rat brains. Ultrasound stimuli have different effects on brain activity, which is crucial for the pathophysiological assessment of stress-related disorders.
MAGNETIC RESONANCE IMAGING
(2022)
Editorial Material
Cell Biology
Nils C. Gassen, Jakob Hartmann, Mathias V. Schmidt, Theo Rein
Article
Biochemistry & Molecular Biology
N. C. Gassen, J. Hartmann, A. S. Zannas, A. Kretzschmar, J. Zschocke, G. Maccarrone, K. Hafner, A. Zellner, L. K. Kollmannsberger, K. V. Wagner, D. Mehta, S. Kloiber, C. W. Turck, S. Lucae, G. P. Chrousos, F. Holsboer, E. B. Binder, M. Ising, M. V. Schmidt, T. Rein
MOLECULAR PSYCHIATRY
(2016)
Article
Neurosciences
M. Masana, M. M. Jukic, A. Kretzschmar, K. V. Wagner, S. Westerholz, M. V. Schmidt, T. Rein, C. Brodski, M. B. Mueller
Article
Endocrinology & Metabolism
Ulrike Schmidt, Dominik R. Buell, Irina A. Lonescu, Nils C. Gassen, Florian Holsboer, Marc B. Cox, Bozidar Novak, Christine Huber, Jakob Hartmann, Mathias V. Schmidt, Chadi Touma, Theo Rein, Leonie Herrmann
PSYCHONEUROENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
Christine Kohl, Xiao-Dong Wang, Jocelyn Grosse, Celine Fournier, Daniela Harbich, Soeren Westerholz, Ji-Tao Li, Alexandre Bacq, Claudia Sippel, Felix Hausch, Carmen Sandi, Mathias V. Schmidt
PSYCHONEUROENDOCRINOLOGY
(2015)
Article
Behavioral Sciences
Georgia Balsevich, Christian Namendorf, Tamara Gerlach, Manfred Uhr, Mathias V. Schmidt
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2015)
Article
Endocrinology & Metabolism
Christiana Labermaier, Christine Kohl, Jakob Hartmann, Christian Devigny, Andre Altmann, Peter Weber, Janine Arloth, Carina Quast, Klaus V. Wagner, Sebastian H. Scharf, Ludwig Czibere, Regina Widner-Andrae, Julia Brenndoerfer, Rainer Landgraf, Felix Hausch, Ken A. Jones, Marianne B. Mueller, Manfred Uhr, Florian Holsboer, Elisabeth B. Binder, Mathias V. Schmidt
Article
Neurosciences
S. V. Sotnikov, N. Y. Chekmareva, B. Schmid, D. Harbich, V. Malik, S. Bauer, C. Kuehne, P. O. Markt, J. M. Deussing, M. V. Schmidt, R. Landgraf
EUROPEAN JOURNAL OF NEUROSCIENCE
(2014)
Article
Clinical Neurology
Sara Santarelli, Sylvie L. Lesuis, Xiao-Dong Wang, Klaus V. Wagner, Jakob Hartmann, Christiana Labermaier, Sebastian H. Scharf, Marianne B. Mueller, Florian Holsboer, Mathias V. Schmidt
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Steffen Gaali, Alexander Kirschner, Serena Cuboni, Jakob Hartmann, Christian Kozany, Georgia Balsevich, Christian Namendorf, Paula Fernandez-Vizarra, Claudia Sippel, Anthony S. Zannas, Rika Draenert, Elisabeth B. Binder, Osborne F. X. Almeida, Gerd Ruehter, Manfred Uhr, Mathias V. Schmidt, Chadi Touma, Andreas Bracher, Felix Hausch
NATURE CHEMICAL BIOLOGY
(2015)
Article
Neurosciences
Klaus V. Wagner, Jakob Hartmann, Christiana Labermaier, Alexander S. Haeusl, Gengjing Zhao, Daniela Harbich, Bianca Schmid, Xiao-Dong Wang, Sara Santarelli, Christine Kohl, Nils C. Gassen, Natalie Matosin, Marcel Schieven, Christian Webhofer, Christoph W. Turck, Lothar Lindemann, Georg Jaschke, Joseph G. Wettstein, Theo Rein, Marianne B. Mueller, Mathias V. Schmidt
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Xiao-Dun Yang, Xue-Mei Liao, Andres Uribe-Marino, Rui Liu, Xiao-Meng Xie, Jiao Jia, Yun-Ai Su, Ji-Tao Li, Mathias V. Schmidt, Xiao-Dong Wang, Tian-Mei Si
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Endocrinology & Metabolism
Merce Masana, Yun-Ai Su, Claudia Liebl, Xiao-Dong Wang, Lara Jansen, Soeren Westerholz, Klaus V. Wagner, Christiana Labermaier, Sebastian H. Scharf, Sara Santarelli, Jakob Hartmann, Mathias V. Schmidt, Theo Rein, Marianne B. Mueller
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Endocrinology & Metabolism
Jan-Michael Heinzmann, Stefan Kloiber, Gabriele Ebling-Mattos, Maximilian Bielohuby, Mathias V. Schmidt, Rupert Palme, Florian Holsboer, Manfred Uhr, Marcus Ising, Chadi Touma
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Medicine, General & Internal
Nils C. Gassen, Jakob Hartmann, Juergen Zschocke, Jens Stepan, Kathrin Hafner, Andreas Zellner, Thomas Kirmeier, Lorenz Kollmannsberger, Klaus V. Wagner, Nina Dedic, Georgia Balsevich, Jan M. Deussing, Stefan Kloiber, Susanne Lucae, Florian Holsboer, Matthias Eder, Manfred Uhr, Marcus Ising, Mathias V. Schmidt, Theo Rein