Article
Medicine, General & Internal
Salam Alkindi, Vinodh Panjwani, Sarah Al-Rahbi, Khalid Al-Saidi, Anil Pathare
Summary: The study evaluated iron overload in SCD patients on chronic blood transfusions and found a correlation between SF and MRI imaging techniques. Most patients were female, and iron overload had a negative impact on disease progression and mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincenzo Positano, Antonella Meloni, Maria Filomena Santarelli, Laura Pistoia, Anna Spasiano, Liana Cuccia, Tommaso Casini, Maria Rita Gamberini, Massimo Allo, Pier Paolo Bitti, Alessia Pepe, Filippo Cademartiri
Summary: This study developed a deep-learning method for unsupervised classification of liver iron content (LIC) from TEE multiecho MR images. The results showed that the HippoNet-Ensemble network achieved higher accuracy, sensitivity, and specificity in LIC staging compared to other networks.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan M. Brendel, Alina Kratzenstein, Josephine Berger, Florian Hagen, Konstantin Nikolaou, Meinrad Gawaz, Simon Greulich, Patrick Krumm
Summary: The purpose of this study was to assess the diagnostic capabilities of cardiac magnetic resonance (CMR) T2* mapping in detecting incidental hepatic and cardiac iron overload. The study found that approximately 3.9% of patients had incidental hepatic iron overload and 1.1% of patients had incidental cardiac iron overload. The results suggest that T2* imaging can be used as a method for detecting iron overload and has implications for further patient management.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Review
Medicine, General & Internal
Abdulqadir J. Nashwan, Mohamed A. Yassin, Mohamed Izham Mohamed Ibrahim, Hanan F. Abdul Rahim, Mujahed Shraim
Summary: Currently, there is no agreement on the most reliable marker of iron status in chronic kidney disease (CKD) patients. Serum ferritin, commonly used for this purpose, may provide misleading information about iron overload. The success of T2* MRI in monitoring iron overload in patients with hemoglobinopathies can be beneficial in monitoring CKD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Computer Science, Information Systems
Nicola Martini, Antonella Meloni, Vincenzo Positano, Daniele Della Latta, Petra Keilberg, Laura Pistoia, Anna Spasiano, Tommaso Casini, Angelica Barone, Antonella Massa, Andrea Ripoli, Filippo Cademartiri
Summary: This study presents a fully-automated method using a deep convolutional neural network for the analysis of myocardial T2* distribution. The proposed method demonstrated excellent performance in testing and evaluating patients with iron overload diseases.
Article
Biochemistry & Molecular Biology
Ruilong Peng, Xilei Liu, Cong Wang, Fanjian Li, Tuo Li, Lei Li, Hejun Zhang, Yalong Gao, Xuefang Yu, Shu Zhang, Jianning Zhang
Summary: This study investigated the mechanism of myocardial damage induced by traumatic brain injury (TBI) through ferroptosis, and found that inhibiting iron overload can alleviate myocardial injury and reduce inflammation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aaryani Tipirneni-Sajja, Ralf B. Loeffler, Jane S. Hankins, Cara Morin, Claudia M. Hillenbrand
Summary: This study demonstrated the feasibility of using ARMA-QSM to simultaneously estimate susceptibility-based wet HIC, R2*-based dry HIC, and FFs. The results showed strong correlations between ARMA R2* and susceptibility values with iron concentrations in phantoms, and high correlation with clinical HIC values in patients. ARMA-QSM has the potential to provide a confounder-free assessment of hepatic iron overload.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Acoustics
Deniz Delibas, Sehnaz Evrimler, Karabekir Ercan, Mehmet Gumus, Abdullah Sariyildirim, Halil Arslan
Summary: Elevated ferritin levels can serve as an indicator of iron overload in hemodialysis patients, as shown by the correlation between serum iron parameters and liver T2* value.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Neurosciences
Chantal M. W. Tax, Elena Kleban, Maxime Chamberland, Muhamed Barakovic, Umesh Rudrapatna, Derek K. Jones
Summary: This study investigates the orientation-dependence of brain white matter microstructure using a novel experimental setup, revealing that the extra-axonal water signal has a greater impact on anisotropy effects compared to the intra-axonal water signal. The results indicate that the orientation-dependence of extra-axonal T-2 is mainly driven by magnetic susceptibility effects, while the orientation-dependence of intra-axonal T-2 may be influenced by a combination of microstructural effects.
Article
Radiology, Nuclear Medicine & Medical Imaging
Narumol Chaosuwannakit, Pattarapong Makarawate, Chinnadol Wanitpongpun
Summary: Cardiac T2* MRI is a valuable tool for monitoring cardiac iron overload in thalassemia major patients, allowing for early diagnosis and treatment of patients at risk of cardiac siderosis, thus reducing cardiac mortality associated with myocardial siderosis.
Article
Oncology
Yao Zhang, Chao Xiao, Jing Li, Lu-xi Song, You-shan Zhao, Shuang Han, Zhao-wei Li, Cha Guo, Jun-gong Zhao, Chun-kang Chang
Summary: DECT and MRI were complementary in liver iron detection, with DECT being more reliable than MRI in MDS patients with high iron content. MRI was more reliable than DECT in patients with low iron content. The appropriate detection method can be selected according to ASF for more accurate evaluation of iron content.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Muhammad Naeem, Sabine Schipf, Robin Buelow, Nicole Werner, Marcus Doerr, Markus M. Lerch, Jens-Peter Kuehn, Wolfgang Rathmann, Matthias Nauck, Marcello Ricardo Paulista Markus, Giovanni Targher, Till Ittermann, Henry Volzke
Summary: Hepatic iron overload, as assessed by MRI, is positively associated with 2-hour plasma glucose and the combined impaired fasting glucose and glucose tolerance category. There are no significant associations between hepatic iron overload and other glucose intolerance states or biomarkers of glucose metabolism.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Pharmacology & Pharmacy
Archita Venugopal Menon, Jonghan Kim
Summary: This study investigates the impact of iron on doxorubicin-induced cardiotoxicity and finds that ABCB8 mediates the efflux of doxorubicin. High iron increases the retention and toxicity of doxorubicin, while iron deficiency improves this effect. The results are further validated in a mouse model of hereditary hemochromatosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrienne E. Campbell-Washburn, Christine Mancini, Anna Conrey, Lanelle Edwards, Sujata Shanbhag, John Wood, Hui Xue, Peter Kellman, W. Patricia Bandettini, Swee Lay Thein
Summary: The study aimed to evaluate the performance of a 0.55 T MRI system for assessing patients with liver iron overload. Results showed significantly lower R2* values at 0.55 T, but the predictive model accurately predicted R2* values at 1.5 T based on measurements at 0.55 T for evaluating the degree of iron overload.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Ying Liu, Carine Fillebeen, Anik Forest, Amy Botta, Thibault V. Varin, Andre Marette, Yan Burelle, Christine Des Rosiers, Kostas Pantopoulos, Gary Sweeney
Summary: This study using the Th3/+ mouse model found that altered lipid metabolism and gut microbiota may be related to the development of cardiomyopathy in thalassemia. These findings are important for understanding the early biomarkers and therapeutic targets for the development of cardiomyopathy in thalassemia.
Article
Hematology
Antonella Meloni, Laura Pistoia, Alessandra Quota, Giuseppe Messina, Paolo Ricchi, Sergio Bagnato, Calogera Gerardi, Roberto Lisi, Liana Cuccia, Stefania Renne, Antonino Vallone, Riccardo Righi, Vincenzo Positano, Alessia Pepe, Filippo Cademartiri
Summary: The aim of this multicenter study was to assess the predictive value of multiparametric cardiac magnetic resonance (CMR) for cardiovascular complications in sickle cell disease (SCD) patients. Reduced left ventricular ejection fraction and increased right ventricular mass index showed a significant prognostic value in patients with SCD.
ANNALS OF HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonella Meloni, Luna Gargani, Cosimo Bruni, Camilla Cavallaro, Marco Gobbo, Andreina D'Agostino, Gennaro D'Angelo, Nicola Martini, Francesco Grigioni, Gianfranco Sinagra, Raffaele De Caterina, Emilio Quaia, Sophie Mavrogeni, Filippo Cademartiri, Marco Matucci-Cerinic, Alessia Pepe
Summary: This study evaluated the prevalence of myocardial involvement in SSc patients using native T1 and T2 mapping, as well as the diagnostic performance of mapping in addition to conventional LLC. The results showed that myocardial T1 and T2 values were significantly higher in SSc patients. Native T1 and/or T2 increases were present in 62.1% of patients with normal conventional CMR techniques.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Antonella Meloni, Christian Cadeddu, Lucia Cugusi, Maria Pia Donataccio, Martino Deidda, Susanna Sciomer, Sabina Gallina, Cristina Vassalle, Federica Moscucci, Giuseppe Mercuro, Silvia Maffei
Summary: Metabolic syndrome is a clinical condition characterized by the aggregation of major risk factors for cardiovascular disease and type 2 diabetes, including dyslipidemia, high blood pressure, abnormal blood sugar, and abdominal obesity. These risk factors have an independent effect but become synergistic when combined, leading to a doubled risk of cardiovascular diseases and a 1.5-fold increase in all-cause mortality. This article explores gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of metabolic syndrome components, as well as gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Federica Moscucci, Sabina Gallina, Valentina Bucciarelli, Alberto Aimo, Giovanna Pela, Christian Cadeddu-Dessalvi, Savina Nodari, Silvia Maffei, Antonella Meloni, Martino Deidda, Giuseppe Mercuro, Roberto Pedrinelli, Maria Penco, Susanna Sciomer, Anna Vittoria Mattioli
Summary: COVID-19 is a highly variable disease with different symptoms and signs. Men are more susceptible to the infection, with a higher rate of hospitalization and mortality compared to women. The impact of cardiovascular diseases on COVID-19 outcomes differs between men and women, potentially due to sex-related biological factors and behavioral traits. The renin-angiotensin system and the angiotensin-converting enzyme 2 play key roles in disease pathogenesis, showing hormone-dependent actions. Men also have a higher incidence of myocardial injury associated with inflammation and coagulation disorders. The relationship between cardiovascular diseases and COVID-19 during pregnancy is also discussed.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa Anita De Santi, Elena Pasini, Maria Filomena Santarelli, Dario Genovesi, Vincenzo Positano
Summary: This study developed a CNN for the diagnosis of Alzheimer's Disease and experimented with two explainable artificial intelligence techniques. The results showed that LRP was more effective in mapping importance metrics, but no clear relationship was found between the heatmap and the PET signal.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Oncology
Gianluca Carloni, Cristina Garibaldi, Giulia Marvaso, Stefania Volpe, Mattia Zaffaroni, Matteo Pepa, Lars Johannes Isaksson, Francesca Colombo, Stefano Durante, Giuliana Lo Presti, Sara Raimondi, Lorenzo Spaggiari, Filippo de Marinis, Gaia Piperno, Sabrina Vigorito, Sara Gandini, Marta Cremonesi, Vincenzo Positano, Barbara Alicja Jereczek-Fossa
Summary: This study investigated the ability of radiomic features extracted by two different radiomic platforms to predict clinical outcomes in patients treated with radiosurgery for brain metastases from non-small cell lung cancer. The results showed differences in the quality and number of features extracted using the two platforms, leading to mismatches in terms of performance, statistical significance, and clinical variables found in combined models. This study sheds new light on the discrepancies that can arise from extracting radiomic features using different platforms.
RADIOTHERAPY AND ONCOLOGY
(2023)
Letter
Hematology
Antonella Meloni, Laura Pistoia, Paolo Ricchi, Massimo Allo, Rosamaria Rosso, Liana Cuccia, Tommaso Casini, Valerio Cecinati, Marilena Serra, Vincenza Rossi, Riccardo Righi, Stefania Renne, Antonino Vallone, Vincenzo Positano, Filippo Cademartiri
Article
Endocrinology & Metabolism
Antonella Meloni, Laura Pistoia, Silvia Maffei, Paolo Ricchi, Tommaso Casini, Elisabetta Corigliano, Maria Caterina Putti, Liana Cuccia, Crocetta Argento, Vincenzo Positano, Alessia Pepe, Filippo Cademartiri, Cristina Vassalle
Summary: The purpose of this study was to investigate the relationship between hepatitis C virus (HCV) infection and bone mineral density (BMD), vitamin D, and bone turnover biomarkers in multi-transfused patients with thalassemia major (TM). The results showed that HCV infection was positively associated with the prevalence of low bone mass, suggesting that HCV infection is an additive risk factor for low bone mass in TM patients. Osteocalcin may play a role in this association.
Article
Chemistry, Analytical
Lisa Anita De Santi, Antonella Meloni, Maria Filomena Santarelli, Laura Pistoia, Anna Spasiano, Tommaso Casini, Maria Caterina Putti, Liana Cuccia, Filippo Cademartiri, Vincenzo Positano
Summary: This paper focuses on using the Visual Transformer (ViT) neural network architecture to automatically detect the left ventricle (LV) from cardiac magnetic resonance (CMR) relaxometry sequences. Performance evaluation showed variations in performance based on slice location, but overall performance was comparable to other state-of-the-art methods. The study confirms the feasibility of using ViT architectures for LV detection and establishes a benchmark for relaxometry imaging.
Article
Cardiac & Cardiovascular Systems
Antonella Meloni, Laura Pistoia, Vincenzo Positano, Nicola Martini, Rita Laura Borrello, Sara Sbragi, Anna Spasiano, Tommaso Casini, Pier Paolo Bitti, Maria Caterina Putti, Liana Cuccia, Massimo Allo, Francesco Massei, Paola Maria Grazia Sanna, Raffaele De Caterina, Emilio Quaia, Filippo Cademartiri, Alessia Pepe
Summary: In this study, myocardial T-2 values were measured by a segmental approach in patients with thalassaemia major (TM), comparing them with T-2* values for the detection of myocardial iron overload (MIO), evaluating their potential in detecting subclinical inflammation, and correlating with clinical status. The study found that T-2 values were significantly higher in TM patients than in a cohort of healthy subjects, and there was a significant correlation between T-2 and T-2* values. Patients with decreased T-2* values also had reduced T-2 values, and these patients had higher hepatic and pancreatic iron deposition.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Filippo Cademartiri, Antonella Meloni, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: Photon-counting detector (PCD) is a novel computed tomography detector technology that has many advantages in the neurovascular field, such as increased spatial resolution, reduced radiation exposure, and optimization of contrast agents and material decomposition. This overview of literature on PCCT describes the principles, advantages, and disadvantages of conventional detectors and PCDs, and focuses specifically on its implementation in the neurovascular field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Antonella Meloni, Filippo Cademartiri, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: Photon-counting computed tomography (PCCT) is an emerging technology that is expected to revolutionize clinical CT imaging. PCCT offers various advantages over conventional CT, which can be utilized to enhance and broaden the diagnostic capabilities of CT angiography. This article discusses the potential opportunities and promising future applications of PCCT in vascular imaging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Antonella Meloni, Filippo Cademartiri, Vicenzo Positano, Simona Celi, Sergio Berti, Alberto Clemente, Ludovico La Grutta, Luca Saba, Eduardo Bossone, Carlo Cavaliere, Bruna Punzo, Erica Maffei
Summary: Photon-counting computed tomography (PCCT) is an emerging technology that offers several advantages over conventional CT, including improved spatial resolution and signal behavior, reduced noise and artifacts, decreased radiation dose, and enhanced material discrimination. This review highlights the potential diagnostic capabilities of PCCT in cardiovascular applications, such as detection of coronary artery calcifications and evaluation of coronary plaque extent and composition.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
