Iron Promotes Cardiac Doxorubicin Retention and Toxicity Through Downregulation of the Mitochondrial Exporter ABCB8

Disruption of endothelial cell intraflagellar transport protein 88 exacerbates doxorubicin-induced cardiotoxicity

(2020) Vincent Z. Luu et al.   LIFE SCIENCES

Cardioprotective role of phyllanthin against myocardial ischemia-reperfusion injury by alleviating oxidative stress and inflammation with increased adenosine triphosphate levels in the mice model

(2020) Cong Zhao et al.   ENVIRONMENTAL TOXICOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells

(2019) Khuloud Bajbouj et al.   Cancer Management and Research

Oxidative stress injury in doxorubicin-induced cardiotoxicity

(2019) Mei Songbo et al.   TOXICOLOGY LETTERS

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

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Mitochondrial accumulation of doxorubicin in cardiac and diaphragm muscle following exercise preconditioning

(2018) Aaron B. Morton et al.   MITOCHONDRION

Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

(2018) Kaytee L. Pokrzywinski et al.   Biology of Sex Differences

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

(2018) Leif Carlsson et al.   Molecular Therapy-Methods & Clinical Development

Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

(2018) Shao-hsuan Wen et al.   Cancer Cell International

Brain iron loading impairs DNA methylation and alters GABAergic function in mice

(2018) Qi Ye et al.   FASEB JOURNAL

Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis

(2017) Abitha Sukumaran et al.   Scientific Reports

Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps

(2017) Reetobrata Basu et al.   Hormones & Cancer

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

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Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model

(2016) Zhi-yong Zhou et al.   TOXICOLOGY LETTERS

The Role of Frataxin in Doxorubicin Mediated Cardiac Hypertrophy

(2015) Shravanthi Mouli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice

(2015) Charles Guenancia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia

(2013) Steven E. Lipshultz et al.   CANCER

Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin

(2013) VASYL F. CHEKHUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells

(2013) Emiliano Cocco et al.   MOLECULAR BIOLOGY REPORTS

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

(2012) Y. Ichikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Expression of P-Glycoprotein Is Associated with Doxorubicin Chemoresistance in the Metastatic 4T1 Breast Cancer Model

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Mitochondrial ABC proteins in health and disease

(2009) Ariane Zutz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ABCB8 Mediates Doxorubicin Resistance in Melanoma Cells by Protecting the Mitochondrial Genome

(2009) Aaron M. Elliott et al.   MOLECULAR CANCER RESEARCH

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(2008) Hani Jouihan et al.   MOLECULAR MEDICINE