Review
Chemistry, Multidisciplinary
Anna-Carin C. Carlsson, Staffan Karlsson, Rachel H. Munday, Matthew R. . Tatton
Summary: Atropisomerism is a stereochemical phenomenon exhibited by molecules with a rotationally restricted sigma bond. Atropisomers exist as a dynamic mixture and can be interconverted without breaking and reforming bonds. They are frequent targets in medicinal chemistry projects due to their axial chirality and unique 3D structures. However, selecting a single atropisomer presents problems such as interconversion and separation challenges. Chromatography, enzymatic or chiral catalysts can be used for separation, but each method has limitations. This Account discusses the successes, failures, and challenges of developing methods for resolution and synthesis of atropisomeric drug candidates.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lara E. Zetzsche, Jessica A. Yazarians, Suman Chakrabarty, Meagan E. Hinze, Lauren A. M. Murray, April L. Lukowski, Leo A. Joyce, Alison R. H. Narayan
Summary: This study demonstrates the use of cytochrome P450 enzymes for biocatalytic cross-coupling reactions, enabling the formation of sterically hindered biaryl bonds through oxidative C-C bond formation. By engineering the substrate and atroposelectivity of the P450 enzyme, a highly efficient and selective process has been developed.
Article
Chemistry, Physical
Talat Baran, Sema Akay, Berkant Kayan
Summary: The study demonstrated the potential of using Pd NPs@VT/Fe3O4 derived from volcanic tuff as a heterogeneous catalyst for the efficient synthesis of biaryl compounds via Suzuki-Miyaura coupling reactions, with a high yield of 99%. Furthermore, the catalyst showed stable and efficient catalytic performance even after eight consecutive cycles, with a yield of up to 92%.
Article
Chemistry, Physical
Julia E. Borowski, Samuel H. Newman-Stonebraker, Abigail G. Doyle
Summary: A comparison study of mono- and bisphosphine ligands in Ni-catalyzed Suzuki-Miyaura cross-coupling reactions revealed that monophosphines exhibit higher reactivity, particularly with electronically deactivated and sterically hindered substrates. Mechanistic experiments showed that monoligated (P1Ni) species accelerate the organometallic steps of the catalytic cycle, while bisligated (P2Ni) species prevent off-cycle reactions and catalyst poisoning by heterocyclic motifs. These findings provide guidelines for ligand selection against challenging substrates and future ligand design tailored to the mechanistic demands of Ni-catalyzed cross-coupling reactions.
Article
Chemistry, Organic
Yi Le, Yan Zhang, Qin Wang, Nian Rao, Dan Li, Li Liu, Guiping Ouyang, Longjia Yan
Summary: An efficient method was developed to prepare biphenylpyrimidine scaffolds via a Suzuki-Miyaura coupling reaction under microwave irradiation in water, and biguanidine analogues were employed as ligands.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Jie Xu, Samantha Grosslight, Kyle A. Mack, Sierra C. Nguyen, Kyle Clagg, Ngiap-Kie Lim, Jacob C. Timmerman, Jeff Shen, Nicholas A. White, Lauren E. Sirois, Chong Han, Haiming Zhang, Matthew S. Sigman, Francis Gosselin
Summary: An efficient asymmetric synthesis of a potent KRAS G12C covalent inhibitor, GDC-6036, was reported. The synthesis involved a highly selective Negishi coupling and a series of reaction sequences, leading to the desired compound with a 40% overall yield from the starting materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Changyue Ren, Hang Zhang, Zhengjun Chen, Jie Gao, Mingyan Yang, Zeli Yuan, Xinmin Li
Summary: This study presents a Pd/C catalyzed Suzuki-Miyaura reaction in water extract of suaeda salsa, which does not require external phosphine ligand, base, and organic solvent. The reaction shows a broad substrate scope and high purity of the products can be obtained.
Article
Chemistry, Physical
Paul O. Peterson, Matthew Joannou, Eric M. Simmons, Steven R. Wisniewski, Junho Kim, Paul J. Chirik
Summary: The synthesis and characterization of phenoxy(imine) iron(II) alkyl precatalysts for C(sp2)-C(sp3) Suzuki-Miyaura cross-coupling reaction is reported. This method utilizes mild alkoxide bases and nonpolar solvents to achieve high efficiency C(sp2)-C(sp3) bond formation with various aryl boronic esters and alkyl bromides. The study also highlights the compatibility of the precatalysts with base-sensitive functionality and the role of boronate intermediates in transmetalation.
Article
Chemistry, Physical
Craig S. S. Day, Angel Renteria-Gomez, Stephanie J. J. Ton, Achyut Ranjan Gogoi, Osvaldo Gutierrez, Ruben Martin
Summary: Polypyridine-ligated nickel complexes are widely used as privileged catalysts in cross-coupling reactions due to their ability to shuttle between different oxidation states. However, the mechanistic understanding of these reactions is limited. In this study, the reactivity of pseudohalide- and halide-ligated Ni(II) complexes with polypyridine ligands in electron-transfer reactions is investigated. Electrochemical techniques and quantum mechanical calculations support the observations regarding the different behaviors of Ni(II) halide and pseudohalide complexes. Reactivation of catalytically inactive Ni(II) pseudohalide complexes in the presence of exogenous salts is also demonstrated. Overall, this study provides insights into the overlooked steps in Ni-catalyzed cross-coupling reactions and offers guidance for future reaction design.
Article
Chemistry, Multidisciplinary
Yan-Long Zheng, Pei-Pei Xie, Omid Daneshfar, Kendall N. Houk, Xin Hong, Stephen G. Newman
Summary: A new method has been developed to convert alkyl esters into alkyl ketones, resulting in the synthesis of 65 different alkyl ketones with various functional groups and heterocyclic structures. The study found that catalyst-controlled chemoselectivity could activate the C(acyl)-O bond in the substrate, while density functional theory calculations supported the mechanism of the nickel catalytic cycle.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Junyi Han, Yuta Uetake, Yumi Yakiyama, Hidehiro Sakurai
Summary: A series of sumanenetrione derivatives were synthesized via Lewis acid-mediated Suzuki-Miyaura cross-coupling. The optical properties of these derivatives showed the strong electron-accepting ability of sumanenetrione. The ring-opening response adjacent to the substituent in the 2-hydroxyphenyl derivative occurred even at room temperature without the need for any activation, which typically requires harsh conditions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sheng-Qi Qiu, Yu Chen, Xiang-Jun Peng, Shi-Jiang He, Jun Kee Cheng, Yong-Bin Wang, Shao-Hua Xiang, Jun Song, Peiyuan Yu, Junmin Zhang, Bin Tan
Summary: In this study, we achieved the arene-alkene Suzuki-Miyaura coupling reaction between hindered aryl halides and vinyl boronates by designing appropriate ligands and reaction parameters. The axially chiral acyclic aryl-alkenes obtained exhibited remarkable efficiency, enantioselectivity, and E/Z selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Matias Vidal, Jose Rodriguez-Aguilar, Ignacio Aburto, Carolina Aliaga, Moises Dominguez
Summary: The reactivity of four 4-pyrimidyl sulfonic esters in Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions was studied with various boronic acids, showing that electron-rich aryl boronic acids exhibit higher yields when triflate is used as the pseudohalide, while electron-poor aryl boronic acids react faster when nonaflate is employed. The reactivity guide for Pd-catalyzed coupling of these accessible pseudohalides with boron-based coupling partners was applied to synthesize a bipyrimidine in excellent yield, with the resulting 2-methylpyrimidines suitable for the synthesis of luminescent sensors.
Article
Chemistry, Organic
Wen-Xin Li, Bo-Wen Yang, Xuan Ying, Zhuo-Wen Zhang, Xue-Qiang Chu, Xiaocong Zhou, Mengtao Ma, Zhi-Liang Shen
Summary: The direct cross-coupling of diaryl sulfoxides with aryl bromides via C-S bond cleavage was achieved using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF. This reaction showed a wide range of substrates and could be used for gram-scale synthesis. The one-pot reaction is operationally simple and economically efficient.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
L. Reginald Mills, David Gygi, Jacob R. Ludwig, Eric M. Simmons, Steven R. Wisniewski, Junho Kim, Paul J. Chirik
Summary: In this study, efficient precatalysts for the C(sp(2))-C(sp(3)) Suzuki-Miyaura cross-coupling reaction between alkyl bromides and neopentylglycol (hetero)arylboronic esters were generated in situ using Cobalt(II) halides in combination with phenoxyimine (FI) ligands. The protocol allowed for efficient C-C bond formation with various nucleophiles and electrophiles. The results also suggested that alkyl radicals play an important role in the catalytic reaction.
Article
Engineering, Chemical
Ana Isabel Martin-Perales, Daily Rodriguez-Padron, Angel Garcia Coleto, Christophe Len, Gustavo de Miguel, Mario J. Munoz-Batista, Rafael Luque
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Review
Chemistry, Multidisciplinary
Ting Su, Deyang Zhao, Yantao Wang, Hongying Lu, Rajender S. Varma, Christophe Len
Summary: This Minireview discusses recent advancements in the catalytic oxidation of HMF to 2,5-furandicarboxylic acid (FDCA) and other intermediates using noble, non-noble, and metal-free systems deploying emerging protocols.
Article
Chemistry, Physical
Remi Nguyen, Nicolas Galy, Fatmah Ali Alasmary, Christophe Len
Summary: In this study, glycerol oligomerization for the formation of polyglycerol was successfully carried out under microwave activation using a potassium carbonate catalyst. The effects of temperature, flow rate, and residence time on the reaction were studied, and the main diglycerol and triglycerol regioisomers were quantified. By utilizing successive cyclic mode processes and short distance distillation, the mixture was enriched with glycerol ethers to obtain a mixture consisting of diglycerol, triglycerol, tetraglycerol, and pentaglycerol.
Review
Chemistry, Multidisciplinary
Mohamad Reza Khodadadi, Julien Thiel, Rajender S. Varma, Christophe Len
Summary: Solketal is identified as a promising chemical for oleochemicals, particularly for ketalisation of glycerol. Recent advancements in catalytic ketalisation of glycerol in laboratories involve homogeneous, commercial heterogeneous, and specifically designed heterogeneous catalysts.
JOURNAL OF FLOW CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ajit Kumar, Preeti Kaushik, Sandra Incerpi, Jens Z. Pedersen, Sanjay Goel, Ashok K. Prasad, Vishwajeet Rohil, Virinder S. Parmar, Luciano Saso, Christophe Len
Summary: The study revealed that ellagic acid and its acetylated product have significant ability to scavenge free radicals and exhibit antioxidative properties, as well as potential for inhibiting ROS production.
Article
Chemistry, Physical
Fatemeh Rajabi, Mika Sillanpaa, Christophe Len, Rafael Luque
Summary: The study demonstrates the efficient catalytic performance of an ionic solid nanomaterial PMO-Py-IL for the one-pot Biginelli condensation reaction under solvent-free conditions. The catalyst exhibits remarkable stability and reusability, making it a promising candidate for green synthesis.
Article
Chemistry, Physical
Robbie Radjagobalou, Virgile Rouffeteau, Alexia Deleu, Pierre Nabokoff, Janine Cossy, Christophe Len
Summary: A mild and efficient continuous-flow catalytic reductive alkylation method for methanol has been developed, which can produce high yields of O-methyl ethers and tolyl derivatives using a Pd/C catalyst under certain temperature and pressure conditions, providing an effective synthetic route for organic compounds.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Anitha Muralidhara, Ed De Jong, Hendrikus (Roy) A. Visser, Gert-Jan M. Gruter, Christophe Len, Jean-Pierre Bertrand, Guy Marlair
Summary: This paper focuses on the safety aspects of the YXY process for the production of furandicarboxylic acid (FDCA) and polyethylene furanoate (PEF). The results indicate that FDCA has a better safety margin than other furanic compounds, while PEF exhibits slightly better energy release and combustion completeness compared to bulk polyester PET.
Article
Chemistry, Multidisciplinary
Aurore Richel, Pedro Maireles-Torres, Christophe Len
Summary: This report outlines recent advances in reducing furfural to high-value chemicals, with a focus on biobased chemicals such as furfuryl alcohol, tetrahydrofurfuryl alcohol, 2-methylfuran, and 2-methyltetrahydrofuran.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method for the preparation of alcohols and ketones containing a CF2-OR scaffold using visible-light promotion is reported. The PDI catalysis method is characterized by its easy operation, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The addition or absence of a base plays a key role in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Pouya Ghamari Kargar, Mohammad Mehdi Sadughi, Ashkan Bahadoran, Rahman S. Zabibah, Christophe Len
Summary: Recently, the green synthesis of metal nanoparticles using plant constituents and extracts has gained attention. In this study, Ag NP colloids were synthesized using Stevia plant leaf extracts and their performance as a catalyst was evaluated. The catalytic oxidation reaction carried out in deep eutectic mixtures showed high efficiency and selectivity in synthesizing the target molecule.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Physical
Wissal Adhami, Aurore Richel, Christophe Len
Summary: The production of biobased furfural has been well-studied for a long time. Recently, the concepts of bioeconomy and circular economy have driven research towards improving production methods and exploring diverse applications. This review focuses on the recent advancements in furfural production from organic feedstocks rich in free sugars and/or polysaccharides.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Sabikeh Azimi, Muna S. Merza, Fatemeh Ghasemi, Hasan Ali Dhahi, Farid Baradarbarjastehbaf, Mehdi Moosavi, Pouya Ghamari Kargar, Christophe Len
Summary: In this study, small non-peptide molecules were synthesized to inhibit the major proteinase (Mpro) of SARS-CoV-2. The antiviral potential of imidazoline derivatives as inhibitors of (SARS-CoV-2) Mpro was evaluated using in-silico techniques. The results confirmed that these compounds interacted satisfactorily with the active site of the coronavirus and showed strong interactions with specific residues.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Organic
Xinxin Han, Xin Liu, Christophe Len, Le Liu, Dongdong Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
Summary: A switchable synthesis method is developed for the production of alcohols and ketones with a CF2-OR scaffold using visible-light promotion. The PDI catalysis method is characterized by its simplicity, broad substrate scopes, and the ability to switch between desired products without the need for transition metal catalysts. The presence or absence of a base is crucial in controlling the synthesis of the major desired products.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Deyang Zhao, Ting Su, Christophe Len, Rafael Luque, Zhenglong Yang
Summary: This article provides a comprehensive review on the oxidative esterification of 5-Hydroxymethylfurfural (HMF) to furan-2,5-dimethylcarboxylate (FDMC), which is considered as a potential replacement for 2,5-furan dicarboxylic acid (FDCA) in bioplastics synthesis. The recent progress in various catalytic approaches, including the use of noble or non-noble metal catalysts in different reaction environments, is discussed. The continuous flow regime for FDMC preparation is also summarized. Furthermore, the perspective towards industrialization of HMF oxidative esterification to FDMC in a more sustainable, efficient, and economical way is proposed.
Article
Chemistry, Multidisciplinary
Zihan Ma, Lishuang Wang, Tingting Chen, Guangning Wang
Summary: In this study, two kinds of 3D self-doped (N/O) lilac-based and coriander-based porous carbons with high performance have been prepared.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qin Wang, Yun-Fan Yan, Jiao-Lin Weng, Ying Huang, Fu Yang, Hao-Hui Xie, Fei Tan, Fa-Kun Zheng, Jian-Gang Xu
Summary: Balancing energy and mechanical sensitivities is a challenging issue in the field of energetic materials. This study constructed a 3D energetic metal-organic framework with nitrogen-rich ligand and NO3- anions. The framework demonstrated high stability, energy density, and excellent mechanical sensitivities, making it a potential insensitive energetic material.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Marrium Saeed, Urooj Kamran, Amina Khan, Md Irfanul Haque Siddiqui, Hasan Jamal, Haq Nawaz Bhatti
Summary: In this study, magnesium-aluminum layered double hydroxides (Mg-Al-LDH) were synthesized using an environmentally friendly hydrothermal technique for adsorbing the dye reactive green 5 (RG5). To improve the adsorption capability, composites were prepared by combining Mg-Al-LDH with low-cost Mangifera indica stone biomass (MISB). The results showed that the composites had high adsorption capacities for RG5 dye and could be regenerated.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Xuanlin Zhan, Xiaojie Li, Yunyan Zeng, Siyan Jiang, Chao Pan, Shiyu Pan, Jiaquan Huang, Heqian Zhang, Zhiwei Qin
Summary: This study reports on the potential prospects of natural products derived from the rhizosphere for the development of antibiotics and herbicides, as well as the advancements in cultivating a mutant strain that produces a substantial quantity of lydicamycins, a potent family for herbicide development.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jie Zhu, Jiangtao Yu, Linhua Zhu, Xiaoxiao Yu, Jixing Liu, Yanhong Chao, Jingzhou Yin, Peiwen Wu, Jian Liu, Wenshuai Zhu
Summary: This study successfully demonstrates the 3D printing of attapulgite monoliths and investigates the influence of thermal treatment on their properties. The thermal treated monoliths show superior catalytic performance at low temperatures.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yanzhu Ye, Yixiang Ye, Jiannan Cai, Zhongshui Li, Shen Lin
Summary: In this paper, a novel Pt/CoP/C photo-electro synergistic catalyst was successfully synthesized and its performance was investigated. The catalyst exhibited excellent photo-electro catalytic performance, with significantly higher hydrogen production compared to a commercial catalyst. The introduction of cobalt phosphide and the existence of Co3O4 were identified as key factors for enhancing the catalytic activity.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nurul Hidayah Abu Bakar, Wan Norfazilah Wan Ismail, Hartina Mohd Yusop, Noreen Farzuhana Mohd Zulkifli
Summary: Hydrophobic coatings inspired by the lotus effect have gained popularity for their ability to solve various problems. The sol-gel method, utilizing silica, alumina, and titania, is explored as an environmentally friendly approach to produce water-based hydrophobic coatings. This study focuses on producing water-based hydrophobic coatings for cotton and polyester fabrics using a one-step sol-gel method. The coated fabrics exhibited improved hydrophobic properties, altered surface morphologies, and lower air permeability compared to uncoated fabrics. TEOS-PDMS coating provides a promising approach for enhancing the hydrophobic and surface properties of cotton and polyester fabrics.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nikita Belko, Hanna Maltanava, Anatol Lugovski, Polina Shabunya, Sviatlana Fatykhava, Evgeny Bondarenko, Pavel Chulkin, Sergey Poznyak, Michael Samtsov
Summary: This study investigates the difference in electrochemical behavior between rhodamine B hydrazide and rhodamine B acylhydrazone, and finds that rhodamine B acylhydrazone exhibits higher reversibility in electrooxidation. These results can be applied for developing new sensors with desired electrochemical properties.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Showket Ahmad Bhat, Mohd Ikram
Summary: In this study, 0-3 particulate multiferroic composites were synthesized and characterized. The composites exhibited excellent ferroelectric and ferromagnetic properties, as well as high piezoelectric strain and magnetoelectric coupling effects.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Carla Gomes, Mariana Costa, Susana M. M. Lopes, Bernardo Albuquerque Nogueira, Rui Fausto, Jose A. Paixao, Teresa M. V. D. e Melo, Luisa M. D. R. S. Martins, Marta Pineiro
Summary: The development of sustainable processes requires the integration of green chemistry principles. In this study, a solvent-free synthesis method was developed to prepare new copper catalysts, which efficiently catalyze cycloaddition reactions under solvent-free mechanochemical conditions. Through this process, the principles of atom economy, reduction of solvents and auxiliaries, design for energy efficiency, and reduction of derivatives and catalysis are combined.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Zhihua Liu, Jinzhe Li, Jianguo Zhou
Summary: This study demonstrates the enhancement of photoelectrochemical activity of BiFeO3 photoelectrodes through ion modification, which increases visible light absorption and active area, leading to improved PEC water splitting performance.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yisheng Zhang, Wensong Li, Jing Li, Fang Li, Wei Xue, Xinqiang Zhao, Yanji Wang
Summary: Pt/C and SO42-/ZrO2 were used as catalysts for the synthesis of p-aminophenol through the catalytic transfer hydrogenation of nitrobenzene in water with formic acid as the hydrogen source. The optimal Pt loading for PAP selectivity was found to be 1 wt%. The presence of different valence states of Pt affected both the nitrobenzene hydrogenation and formic acid decomposition. Among different solid acid catalysts tested, SO42-/ZrO2 exhibited the highest catalytic activity for p-aminophenol formation. Under the optimized reaction conditions, the conversion of nitrobenzene reached 80.0%, with a selectivity of 47.6% for p-aminophenol.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Pradyota Kumar Behera, Papita Behera, Amlan Swain, Santosh Kumar Sahu, Ajeena Sahoo, Laxmidhar Rout
Summary: We have developed a simple and direct method for the synthesis of diaryl ether using an oxygen bridged bimetallic CuMoO4 nanocatalyst under mild reaction conditions. The catalyst exhibited tolerance towards a wide range of substrates with various functional groups. It is efficient and recyclable. This methodology allows easy access to nitrofen derivatives (herbicides) from unactivated 2,4-dichlorophenol, which are important for agriculture and pharmaceuticals.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yihua Fu, Yan Zhang, Changwei Hu, Zhishan Su
Summary: The mechanism of the reaction between CO2 and styrene oxide for cyclic carbonate was revealed using density functional theory calculations. The noncatalytic reaction occurred via a concerted mechanism, while in the presence of guanidine and tetrabutylammonium iodide (TBAI) co-catalysts, the epoxide ring-opening by nucleophilic attack of an iodide anion was predicted to be the rate-determining step. Guanidine acted as the H-bond donor to activate styrene oxide, facilitating the reaction with a lower activation barrier.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Saikat Khamarui, Sirshendu Ghosh
Summary: Copper nanorods (Cu-NRs) exhibit significant plasmonic behavior and can act as efficient catalysts in redox processes and coupling. A benign decarboxylative approach, utilizing localized surface plasmon resonance (LSPR) assisted catalysis with Cu-NRs, has been developed for the production of alkane analogues from alkyl carboxylic acids under visible light. The catalyst shows a broad substrate scope and high functional group tolerance, without the need for an external oxidant or proton source. A plausible mechanism for this recyclable nano-catalyst has also been proposed based on control experiments.
NEW JOURNAL OF CHEMISTRY
(2024)
