A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling

β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer

(2014) D Jia et al.   CELL DEATH AND DIFFERENTIATION

The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells

(2014) A. Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved Oct4/POUV-Dependent Network Links Adhesion and Migration to Progenitor Maintenance

(2013) Alessandra Livigni et al.   CURRENT BIOLOGY

A membrane-associated  -catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells

(2013) F. Faunes et al.   DEVELOPMENT

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

(2013) Hoon Kim et al.   Nature Communications

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation

(2012) Amar M. Singh et al.   Cell Stem Cell

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

(2012) H. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/ -catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

(2012) K. C. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

(2012) Timothy A. Blauwkamp et al.   Nature Communications

β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism

(2011) Kevin F. Kelly et al.   Cell Stem Cell

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming

(2011) Torben Redmer et al.   EMBO REPORTS

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

(2011) Natalia Lyashenko et al.   NATURE CELL BIOLOGY

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

(2011) Derk ten Berge et al.   NATURE CELL BIOLOGY

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

An enhanced chemically defined SILAC culture system for quantitative proteomics study of human embryonic stem cells

(2011) Shuai Wang et al.   PROTEOMICS

A WNTer Revisit: New Faces of  -Catenin and TCFs in Pluripotency

(2011) K. Watanabe et al.   Science Signaling

Wnt/β-catenin Signaling in Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming

(2011) Toshio Miki et al.   Stem Cell Reviews and Reports

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

(2011) Hideaki Tsutsui et al.   Nature Communications

Individual Cell Movement, Asymmetric Colony Expansion, Rho-Associated Kinase, and E-Cadherin Impact the Clonogenicity of Human Embryonic Stem Cells

(2010) Li Li et al.   BIOPHYSICAL JOURNAL

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells

(2010) Romaine I. Fernando et al.   JOURNAL OF CLINICAL INVESTIGATION

Extrinsic regulation of pluripotent stem cells

(2010) Martin F. Pera et al.   NATURE

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

(2010) Christophe Fuerer et al.   PLoS One

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-Cadherin-Mediated Cell-Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation

(2010) Taotao Chen et al.   STEM CELLS

Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression

(2010) Ryan T. Wagner et al.   STEM CELLS

Requirement of the Akt/β-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug

(2009) Makoto Saegusa et al.   AMERICAN JOURNAL OF PATHOLOGY

Metastable Pluripotent States in NOD-Mouse-Derived ESCs

(2009) Jacob Hanna et al.   Cell Stem Cell

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Developing safe therapies from human pluripotent stem cells

(2009) Melissa K Carpenter et al.   NATURE BIOTECHNOLOGY

The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells

(2008) Yu-Fen Chou et al.   CELL

Wnt signaling and stem cell control

(2008) Roel Nusse   CELL RESEARCH

Periodic Activation of Wnt/β-Catenin Signaling Enhances Somatic Cell Reprogramming Mediated by Cell Fusion

(2008) Frederic Lluis et al.   Cell Stem Cell

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells

(2008) M. F. Cole et al.   GENES & DEVELOPMENT

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE