Article
Biochemistry & Molecular Biology
Ting Gong, Ann C. Hashimoto, Alexandru R. Sasuclark, Vedbar S. Khadka, Alexandra Gurary, Matthew W. Pitts
Summary: SELENOM is a positive regulator of leptin signaling and thioredoxin antioxidant activity in the hypothalamus. Deficiency of SELENOM impairs downstream STAT3 phosphorylation and cytosolic calcium responses evoked by leptin treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Xuebin Yu, Qiufeng Teng, Kaimin Bao, Maryam Chudhary, Hui Qi, Wenying Zhou, Hongxin Che, Junli Liu, Xiang Ren, Li Kong
Summary: Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM), and Muller cell reactive gliosis is an early feature of DR. This study found that overexpression of Trx1 can protect Muller cells from diabetes-induced damage by inhibiting endoplasmic reticulum stress (ERS) via ASK1.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yoshiyuki Matsuo
Summary: The presence of a large number of thioredoxin superfamily members indicates a complex redox-based regulation mechanism in mammalian cells. Thioredoxin-like proteins are found in the endoplasmic reticulum, with a specific family of TMX proteins residing in the ER membrane and playing crucial roles in cellular processes. Further research is needed to understand the physiological roles of TMX family proteins and how they can be targeted for drug discovery in various human diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Xiansi Zeng, Wenshuo Geng, Yu Zhang, Jiayi Yin, Guangtao Xu, Meng Yu, Li Li, Jinjing Jia
Summary: This study reports for the first time that thioredoxin-1 (Trx-1) inhibits IRE1 activation in Parkinson's disease (PD) by regulating the expression of heat shock protein 90 (Hsp90) and phosphorylated cell division cycle 37 (p-Cdc37) as well as the interaction with IRE1.
AGEING RESEARCH REVIEWS
(2023)
Article
Agriculture, Multidisciplinary
Yicheng Tian, Xinyuan Feng, Zimo Zhou, Sen Qin, Senxiang Chen, Jihui Zhao, Jianglin Hou, Da Liu
Summary: The study found that ginsenoside compound K (CK) alleviated osteoarthritis (OA) by inhibiting the endoplasmic reticulum stress (ERS)-IRE1a-TXNIP-NLRP3 axis. The findings suggest that CK may be a potential treatment for OA and other chronic inflammatory diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Cheng Yang, Xiaoqing He, Jinqiu Zhao, Wenxiang Huang
Summary: This study demonstrated the hepatoprotective role of Ginsenoside Rg1 (G-Rg1) in alcoholic hepatitis, by blocking the induction of cytochrome P4502E1 (CYP2E1) and preventing the generation of reactive oxygen species, mitochondria damage, and hepatocellular apoptosis. This inhibition of NLRP3 inflammasome activation subsequently suppressed the production of active caspase-1 and inflammatory cytokines, suggesting potential therapeutic pathways for inflammatory liver diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yujie Zhao, Yao Liu, Jianjun Deng, Chenhui Zhu, Xiaoxuan Ma, Min Jiang, Daidi Fan
Summary: This study found that ginsenoside F4 can inhibit skeletal muscle insulin resistance and improve the state of T2DM, and its mechanism is related to the inhibition of PTP1B activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yicheng Tian, Xinyuan Feng, Zimo Zhou, Sen Qin, Senxiang Chen, Jihui Zhao, Jianglin Hou, Da Liu
Summary: The study found that ginsenoside compound K (CK) improved the progression of osteoarthritis (OA) by inhibiting the endoplasmic reticulum stress (ERS)-IRE1 alpha TXNIP-NLRP3 axis. CK has anti-inflammatory effects and could be used for the treatment of OA and other chronic inflammatory diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Physiology
Yu Guo, Chenghong Zhang, Chunyang Wang, Yufei Huang, Jingyun Liu, Haiying Chu, Xiang Ren, Li Kong, Haiying Ma
Summary: The study suggests that Trx-1 may alleviate diabetic encephalopathy (DE) and Alzheimer's disease (AD) by regulating endoplasmic reticulum stress (ERS) and oxidative stress response, thus preventing apoptosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huimin Zhu, Changyang Yan, Peng Yao, Ping Li, Yi Li, Hua Yang
Summary: Rg1 protects against septic cardiac injury by maintaining OPA1 stability and preserving mitochondrial cristae structure. It inhibits S-glutathionylation of OPA1 by interacting with GSTP1, thereby promoting OPA1-Mitofilin interaction and protecting mitochondrial structure.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Shao-jie Yang, Jing-ji Wang, Ping Cheng, Li-xia Chen, Jia-min Hu, Guo-qi Zhu
Summary: Ginseng, a traditional Chinese medicinal herb, has been used for thousands of years to nourish the organs, promote mental calmness, and enhance wisdom. One of its active components, ginsenoside Rg1, has been extensively studied for its anti-inflammatory, antioxidant, and neuroprotective properties, particularly in the treatment of brain disorders such as dementia and depression. This review summarizes the research progress on the mechanisms by which Rg1 improves depression-like behaviors, including its inhibition of the hypothalamic-pituitary-adrenal axis, regulation of synaptic plasticity, and modulation of gut flora. The findings suggest that Rg1 may have potential therapeutic effects on Alzheimer's disease, and its ability to regulate memory states caused by different stimuli. Future in-depth investigations are needed to fully understand the mechanisms of Rg1, and clinical trials in specific neuropsychiatric disorders will contribute to the development of effective drugs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Immunology
Ruifei Shao, Xiran Lou, Jinfang Xue, Yan Yang, Deyuan Ning, Guobing Chen, Lihong Jiang
Summary: This study reveals the role of Trx-1 in the ERS mediated IRE1 alpha/NLRP3 signaling pathway and its protective effect in sepsis.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Meili Lu, Fang Zhao, Chenyang Ran, Yu Xu, Jingliang Zhang, Hongxin Wang
Summary: The study found that ginsenoside Rg1 can protect against vascular endothelial dysfunction (VED) by suppressing the calpain-1/ROS/PKC-β axis and alleviating mitochondrial dysfunction and oxidative stress. Additionally, Rg1 reduces oxidative stress and the occurrence of endothelial dysfunction caused by diabetes. These findings provide new strategies for the treatment of cardiovascular complications in diabetes.
Article
Medicine, Research & Experimental
Ge Tian, Jing Li, Lina Zhou
Summary: In this study, it was found that treatment with G-Rg1 could enhance cell viability and suppress cell apoptosis in ethanol-stimulated H9c2 cells. Furthermore, G-Rg1 could attenuate cell autophagy and endoplasmic reticulum stress (ERS). These effects were achieved by inhibiting the AMPK/mTOR and PERK/ATF4/CHOP pathways.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Food Science & Technology
Yao Liu, Jingjing Zhang, Chao An, Chen Liu, Qiwen Zhang, Hao Ding, Saijian Ma, Wenjiao Xue, Daidi Fan
Summary: This study investigated the inhibition of α-glucosidase activity by ginsenoside Rg1. The results showed that Rg1 reversibly inhibited α-glucosidase activity and reduced postprandial blood glucose levels by decreasing glucose uptake and transport.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Neurosciences
Fucheng Luo, Jessie Zhang, Kathryn Burke, Robert H. Miller, Yan Yang
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Fucheng Luo, Karl Herrup, Xin Qi, Yan Yang
EXPERIMENTAL NEUROLOGY
(2017)
Article
Biochemistry & Molecular Biology
Yoshiyuki Matsuo, Kana Irie, Hiroshi Kiyonari, Hiroaki Okuyama, Hajime Nakamura, Aoi Son, Dorys Adriana Lopez-Ramos, Hai Tian, Shin-Ichi Oka, Katsuya Okawa, Shinae Kizaka-Kondoh, Hiroshi Masutani, Junji Yodoi
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Pharmacology & Pharmacy
Xian-Si Zeng, Xiao-Shuang Zhou, Fu-Cheng Luo, Jin-Jing Jia, Lei Qi, Zhao-Xiang Yang, Wei Zhang, Jie Bai
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2014)
Article
Developmental Biology
Yan Yang, Haibo Wang, Jie Zhang, Fucheng Luo, Karl Herrup, James A. Bibb, Richard Lu, Robert H. Miller
DEVELOPMENTAL BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Fu-Cheng Luo, Lei Qi, Tao Lv, Sheng-Dong Wang, Hua Liu, Hajime Nakamura, Junji Yodoi, Jie Bai
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Review
Nutrition & Dietetics
Hiroshi Masutani, Eiji Yoshihara, So Masaki, Zhe Chen, Junji Yodoi
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2012)
Article
Neurosciences
FuCheng Luo, Kathryn Burke, Christopher Kantor, Robert H. Miller, Yan Yang
JOURNAL OF NEUROSCIENCE
(2014)
Article
Gastroenterology & Hepatology
Shengdong Wang, Xiao Wang, Fucheng Luo, Xiaodan Tang, Kui Li, Xiaomei Hu, Jie Bai
LIVER INTERNATIONAL
(2014)
Article
Developmental Biology
Ping Hou, Lu Zhao, Ye Li, Fucheng Luo, Shengdong Wang, Junying Song, Jie Bai
MOLECULAR HUMAN REPRODUCTION
(2014)
Article
Oncology
Fu-Cheng Luo, Lu Zhao, Juan Deng, Min Liang, Xian-Si Zeng, Hua Liu, Jie Bai
MOLECULAR MEDICINE REPORTS
(2013)
Article
Clinical Neurology
Chen Wenli, Zeng Xiansi, Luo Fucheng, Lv Tao, Zhou Xiaoshuang, Bai Jie
NEUROMUSCULAR DISORDERS
(2014)
Review
Biochemistry & Molecular Biology
Hirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro, Junji Yodoi
Summary: Epithelial cells in the respiratory system are directly exposed to exogenous ROS, increasing the risk of oxidative stress; Dysfunction of redox regulation due to cellular aging accelerates COPD pathogenesis; Drugs targeting oxidative stress pathways can help precisely regulate the redox system.
Article
Biochemistry & Molecular Biology
Tiancheng Jin, Yitong You, Wenjie Fan, Junyang Wang, Yuhao Chen, Shujing Li, Siyuan Hong, Yaxuan Wang, Ruijie Cao, Junji Yodoi, Hai Tian
Summary: Geranylgeranylacetone (GGA) has been found to have protective effects against skin inflammation in mice by inducing endogenous TRX through the PI3K/Akt/Nrf2 signaling pathway.