Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis

(2013) Shireena A. Yasin et al.   ACTA NEUROPATHOLOGICA

Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia

(2013) Adele Finardi et al.   ACTA NEUROPATHOLOGICA

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

BRAFV600E mutation is a negative prognosticator in pediatric ganglioglioma

(2013) Sonika Dahiya et al.   ACTA NEUROPATHOLOGICA

Evolving neurobiology of tuberous sclerosis complex

(2013) Peter B. Crino   ACTA NEUROPATHOLOGICA

Dysembryoplastic Neuroepithelial Tumors Share with Pleomorphic Xanthoastrocytomas and Gangliogliomas BRAFV600EMutation and Expression

(2013) Céline Chappé et al.   BRAIN PATHOLOGY

BRAF V600E Mutation Is Associated with mTOR Signaling Activation in Glioneuronal Tumors

(2013) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

Cell injury and Premature Neurodegeneration in Focal Malformations of Cortical Development

(2013) Anand Iyer et al.   BRAIN PATHOLOGY

Is there evidence for clinical differences related to the new classification of temporal lobe cortical dysplasia?

(2013) Susanne Fauser et al.   EPILEPSIA

A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II

(2013) Caterina Shepherd et al.   EPILEPSIA

Original article Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis

(2013) Harvey Sarnat et al.   FOLIA NEUROPATHOLOGICA

Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions

(2013) Avanita S Prabowo et al.   Journal of Neuroinflammation

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Glial adenosine kinase – A neuropathological marker of the epileptic brain

(2013) Eleonora Aronica et al.   NEUROCHEMISTRY INTERNATIONAL

Focal malformations of cortical development: New vistas for molecular pathogenesis

(2013) K.-C. Lim et al.   NEUROSCIENCE

Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex

(2012) Leah Marcotte et al.   ACTA NEUROPATHOLOGICA

Detection of human papillomavirus in human focal cortical dysplasia type IIB

(2012) Julie Chen et al.   ANNALS OF NEUROLOGY

A developmental and genetic classification for malformations of cortical development: update 2012

(2012) A. James Barkovich et al.   BRAIN

Long-Term Epilepsy-Associated Tumors

(2012) Maria Thom et al.   BRAIN PATHOLOGY

Malformations of Cortical Development

(2012) Eleonora Aronica et al.   BRAIN PATHOLOGY

Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation

(2012) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Dysembryoplastic neuroepithelial tumors: Epileptogenicity related to histologic subtypes

(2012) Francine Chassoux et al.   CLINICAL NEUROPHYSIOLOGY

Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias

(2012) Roland Coras et al.   EPILEPSIA

Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Matrix metalloproteinase-9 (MMP-9) in human intractable epilepsy caused by focal cortical dysplasia

(2012) Anna Konopka et al.   EPILEPSY RESEARCH

The extracellular matrix and diffusion barriers in focal cortical dysplasias

(2012) Josef Zamecnik et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

Tuberous sclerosis and epilepsy: Role of astrocytes

(2012) Michael Wong et al.   GLIA

Astrocyte immune responses in epilepsy

(2012) Eleonora Aronica et al.   GLIA

mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma

(2012) Alexandra Faustino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β

(2012) Emanuele Zurolo et al.   Journal of Neuroinflammation

Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex

(2012) Tracy S. Ma et al.   Journal of Neurosurgery-Pediatrics

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Before Epilepsy Unfolds: Finding the epileptogenesis switch

(2012) Annamaria Vezzani   NATURE MEDICINE

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines

(2012) Brenden Chen et al.   PLoS One

Albumin storage in neoplastic astroglial elements of gangliogliomas

(2012) Ann Kristin Schmitz et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI

(2011) Angelika Mühlebner et al.   ACTA NEUROPATHOLOGICA

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

(2011) Genevieve Schindler et al.   ACTA NEUROPATHOLOGICA

Enhanced Epidermal Growth Factor, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor Expression in Tuberous Sclerosis Complex

(2011) Whitney E. Parker et al.   AMERICAN JOURNAL OF PATHOLOGY

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment

(2011) M. de Groot et al.   BRAIN

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Neuropathological work-up of focal cortical dysplasias using the new ILAE consensus classification system – practical guideline article invited by the Euro-CNS Research Committee

(2011) I. Blümcke et al.   CLINICAL NEUROPATHOLOGY

Factors associated with seizure freedom in the surgical resection of glioneuronal tumors

(2011) Dario J. Englot et al.   EPILEPSIA

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Anomalous levels of Cl− transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex

(2011) Luca Conti et al.   EPILEPSIA

Intrinsic epileptogenicity of gangliogliomas may be independent from co-occurring focal cortical dysplasia

(2011) Carmen Barba et al.   EPILEPSY RESEARCH

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

One Hundred and One Dysembryoplastic Neuroepithelial Tumors: An Adult Epilepsy Series With Immunohistochemical, Molecular Genetic, and Clinical Correlations and a Review of the Literature

(2011) Maria Thom et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study

(2011) Jane de Tisi et al.   LANCET

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

The new order—classifying focal cortical dysplasias

(2011) Sanjay Sisodiya   Nature Reviews Neurology

Expression of connexin 43 in the human epileptic and drug-resistant cerebral cortex

(2011) R. Garbelli et al.   NEUROLOGY

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

(2011) Sharon S. McDaniel et al.   NEUROSCIENCE LETTERS

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy

(2010) George Hadjivassiliou et al.   ACTA NEUROPATHOLOGICA

Hemimegalencephaly: a fetal case with neuropathological confirmation and review of the literature

(2010) Branavan Manoranjan et al.   ACTA NEUROPATHOLOGICA

Focal Cortical Dysplasias: clinical implication of neuropathological classification systems

(2010) Roberto Spreafico et al.   ACTA NEUROPATHOLOGICA

Analysis of TSC Cortical Tubers by Deep Sequencing of TSC1, TSC2 and KRAS Demonstrates that Small Second-Hit Mutations in these Genes are Rare Events

(2010) Wei Qin et al.   BRAIN PATHOLOGY

Aquaporin 4 expression in control and epileptic human cerebral cortex

(2010) Valentina Medici et al.   BRAIN RESEARCH

Tuberous sclerosis: A primary pathology of astrocytes?

(2010) Alexander A. Sosunov et al.   EPILEPSIA

Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias

(2010) Anand Iyer et al.   EPILEPSIA

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

(2010) Anja E. Eisenhardt et al.   INTERNATIONAL JOURNAL OF CANCER

Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

(2010) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

MRI findings reveal three different types of tubers in patients with tuberous sclerosis complex

(2010) Anne Gallagher et al.   JOURNAL OF NEUROLOGY

Early Progenitor Cell Marker Expression Distinguishes Type II From Type I Focal Cortical Dysplasias

(2010) Ksenia A. Orlova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients

(2010) Edward F. Chang et al.   Journal of Neurosurgery-Pediatrics

The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis

(2010) J. M. Spangle et al.   JOURNAL OF VIROLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas

(2010) Margaret J. Dougherty et al.   NEURO-ONCOLOGY

Biallelic TSC gene inactivation in tuberous sclerosis complex

(2010) P. B. Crino et al.   NEUROLOGY

Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies

(2010) A.M. Iyer et al.   NEUROSCIENCE

Selective degradation of p62 by autophagy

(2010) Yoshinobu Ichimura et al.   Seminars in Immunopathology

The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study

(2009) Mustafa Onur Ulu et al.   ACTA NEUROCHIRURGICA

Deletion of 15q11.2–15q13.1 in isolated human hemimegalencephaly

(2009) Marianna Baybis et al.   ACTA NEUROPATHOLOGICA

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

Multi-focal occurrence of cortical dysplasia in epilepsy patients

(2009) S. Fauser et al.   BRAIN

Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors

(2009) Karin Boer et al.   BRAIN PATHOLOGY

Pi3K-mTOR Signaling and AMOG Expression in Epilepsy-associated Glioneuronal Tumors

(2009) Karin Boer et al.   BRAIN PATHOLOGY

Astrocyte dysfunction in epilepsy

(2009) Gerald Seifert et al.   BRAIN RESEARCH REVIEWS

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer

(2009) X B Trinh et al.   BRITISH JOURNAL OF CANCER

Interobserver and intraobserver reproducibility in focal cortical dysplasia (malformations of cortical development)

(2009) Wendy A. Chamberlain et al.   EPILEPSIA

Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings

(2009) Catherine J. Chu-Shore et al.   EPILEPSIA

Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers

(2009) Karin Boer et al.   EPILEPSIA

Doublecortin expression in focal cortical dysplasia in epilepsy

(2009) Nisaharan Srikandarajah et al.   EPILEPSIA

Focal brain malformations: Seizures, signaling, sequencing

(2009) Peter B. Crino   EPILEPSIA

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

DLG3/SAP102 protein expression in malformations of cortical development: A study of human epileptic cortex by tissue microarray

(2009) Mingqi Qu et al.   EPILEPSY RESEARCH

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

(2009) Jieun Choi et al.   Journal of Neuroinflammation

Hamartin Variants That Are Frequent in Focal Dysplasias and Cortical Tubers Have Reduced Tuberin Binding and Aberrant Subcellular Distribution In Vitro

(2009) Céline Lugnier et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Temporal Lobe Sclerosis Associated With Hippocampal Sclerosis in Temporal Lobe Epilepsy: Neuropathological Features

(2009) Maria Thom et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Focal cortical dysplasia type II: biological features and clinical perspectives

(2009) Sanjay M Sisodiya et al.   LANCET NEUROLOGY

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

(2009) Bin Zheng et al.   MOLECULAR CELL

Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions

(2009) E. Aronica et al.   NEUROBIOLOGY OF DISEASE

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

(2009) Lin Xu et al.   NEUROBIOLOGY OF DISEASE

Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex

(2009) C. J. Chu-Shore et al.   NEUROLOGY

Clinical and imaging characteristics of localized megalencephaly: a retrospective comparison of diffuse hemimegalencephaly and multilobar cortical dysplasia

(2009) Masumi Nakahashi et al.   NEURORADIOLOGY

Tumor-associated epilepsy

(2009) Kiran F. Rajneesh et al.   Neurosurgical Focus

Brain tumors and epilepsy: pathophysiology of peritumoral changes

(2009) Mohammed F. Shamji et al.   NEUROSURGICAL REVIEW

MR imaging of the fetal brain

(2009) Orit A. Glenn   PEDIATRIC RADIOLOGY

Uncoupling of the LKB1-AMPKα Energy Sensor Pathway by Growth Factors and Oncogenic BRAFV600E

(2009) Rosaura Esteve-Puig et al.   PLoS One

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers

(2008) Delia M. Talos et al.   ANNALS OF NEUROLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors

(2008) Jana Fassunke et al.   BRAIN

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Dysembryoplastic neuroepithelial tumors in pediatric patients

(2008) Jeehun Lee et al.   BRAIN & DEVELOPMENT

Comprehensive Characterization of Genomic Aberrations in Gangliogliomas by CGH, Array-based CGH and Interphase FISH

(2008) Alexander Hoischen et al.   BRAIN PATHOLOGY

Are cortical tubers epileptogenic? Evidence from electrocorticography

(2008) Philippe Major et al.   EPILEPSIA

Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II

(2008) Pavel Krsek et al.   EPILEPSIA

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2008) K. Boer et al.   NEUROSCIENCE

MOLECULAR GENETIC ANALYSIS IN A CASE OF GANGLIOGLIOMA

(2008) Antonio De Tommasi et al.   NEUROSURGERY

Epilepsy surgery and tuberous sclerosis complex: special considerations

(2008) Robert J. Bollo et al.   Neurosurgical Focus

Mechanisms of Epileptogenesis in Tuberous Sclerosis Complex and Related Malformations of Cortical Development with Abnormal Glioneuronal Proliferation

(2007) Michael Wong   EPILEPSIA

Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2007) K. Boer et al.   EPILEPSY RESEARCH

Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature

(2007) S.B. Wortmann et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Gene expression profile analysis of epilepsy-associated gangliogliomas

(2007) E. Aronica et al.   NEUROSCIENCE