Article
Clinical Neurology
Massimo Cossu, Piergiorgio D'Orio, Carmen Barba, Sofia Asioli, Francesco Cardinale, Sara Casciato, Massimo Caulo, Gabriella Colicchio, Alessandro Consales, Alfredo D'Aniello, Alessandro De Benedictis, Luca De Palma, Giuseppe Didato, Giancarlo Di Gennaro, Roberta Di Giacomo, Vincenzo Esposito, Renzo Guerrini, Michele Nichelatti, Martina Revay, Michele Rizzi, Giampaolo Vatti, Flavio Villani, Nelia Zamponi, Laura Tassi, Carlo Efisio Marras
Summary: The study found that the coexistence of FCD IIIa did not significantly affect the clinical features and surgical outcomes of patients with HS-related epilepsy. Postoperative seizure outcome was similar in patients with FCD IIIa and iHS. These findings suggest limited clinical relevance of FCD IIIa in HS-related epilepsy and may help improve future FCD classifications. Further research is needed to clarify the correlation between class Ia outcome and the duration of follow-up.
Review
Clinical Neurology
Anna Willard, Ana Antonic-Baker, Zhibin Chen, Terence John O'Brien, Patrick Kwan, Piero Perucca
Summary: Based on a systematic review and meta-analysis of the literature, patients with MRI-detected focal cortical dysplasia (FCD) achieve a favorable seizure outcome rate of 70% after surgery, with complete resection of the FCD lesion and lesion location in the temporal lobe being predictors of favorable outcome.
Article
Clinical Neurology
Amanda Almacellas Barbanoj, Robert T. Graham, Benito Maffei, Jenna C. Carpenter, Marco Leite, Justin Hoke, Felisia Hardjo, James Scott-Solache, Christos Chimonides, Stephanie Schorge, Dimitri M. Kullmann, Vincent Magloire, Gabriele Lignani
Summary: Focal cortical dysplasias are a common type of cortical development abnormality that often leads to cognitive and behavioral abnormalities as well as drug-resistant epilepsy. A gene therapy approach targeting the overexpression of the Kv1.1 potassium channel has shown promising results in reducing seizures in a mouse model of frontal lobe focal cortical dysplasia.
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Pharmacology & Pharmacy
Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, Ramesh Sharanappa Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Poodipedi Sarat Chandra, Jyotirmoy Banerjee
Summary: The study identified that levels of kynurenic acid were reduced and quinolinic acid levels were raised in the hippocampus of patients with MTLE-HS, along with abnormal glutamatergic activities. Altered metabolism of tryptophan-kynurenine pathway metabolites in the hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Oliver C. Kiersnowski, Gavin P. Winston, Lorenzo Caciagli, Emma Biondetti, Maha Elbadri, Sarah Buck, John S. Duncan, John S. Thornton, Karin Shmueli, Sjoerd B. Vos
Summary: Using quantitative susceptibility mapping (QSM) and transverse relaxation rate (R2*), we investigated brain alterations in patients with temporal lobe epilepsy (TLE) compared to healthy controls (HC). We found significant changes in susceptibility and R2* in various brain regions, indicating selective loss of neurons and iron redistribution in the hippocampi, increased iron content in the thalamus and putamen, and correlations with disease severity and cognitive test scores.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin
Summary: This study revealed the molecular mechanisms of neuronal apoptosis in hippocampal sclerosis of intractable temporal lobe epilepsy patients through RNA sequencing and ceRNA network analysis, establishing a ceRNA network of lncRNA-mediated neuronal apoptosis in HS-TLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Chenmin He, Lingqi Ye, Cong Chen, Lingli Hu, Bo Jin, Yao Ding, Hong Li, Meiping Ding, Shan Wang, Shuang Wang
Summary: This study found that hippocampal malrotation (HIMAL) is common in patients with epilepsy caused by focal cortical dysplasia (FCD) as well as in healthy controls, but it may be less significant in FCD-related epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Hsin Tung, Szu-Yen Pan, Tsuo-Hung Lan, Yung-Yang Lin, Syu-Jyun Peng
Summary: High-resolution brain MRI was used to study the disruption of the prefrontal-thalamo-hippocampal network in patients with temporal lobe epilepsy (TLE). Thalamic subfield atrophy was found to be related to changes in gray matter density in the ipsilateral inferior frontal gyrus, and this association differed between left-TLE and right-TLE.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Ozge Kapar, Zahide Mail Gurkan, Muge Dolgun, Altay Sencer, Candan Gurses, Bilge Bilgic
Summary: In this study, the incidence of FCD in treatment-resistant epilepsy patients was determined, histomorphological and immunohistochemical features were explored, clinicopathological correlation was examined, mTOR pathway activation was demonstrated using a pS6 antibody, and a candidate for possible targeted therapies was introduced. The results showed significant pS6 expression in FCD type II, indicating the genomic nature of the disease noted in the literature. However, the known MTOR gene and mTOR pathway-related mutations remain insufficient to explain mTOR pathway activation in all FCD type II cases.
NEUROSURGICAL FOCUS
(2022)
Article
Behavioral Sciences
Bulent Guven, Asli Ece Cilliler
Summary: Approximately half of patients with HS-MTLE had headaches, with about one third reporting migraine type headaches. This highlights the potential pathogenetic role of HS in the development of headaches, especially migraines, in patients with epilepsy. Further studies are necessary to determine if accompanying headaches, particularly migraine attacks, could be determining factors for HS-MTLE, and if they have a lateralizing value for HS.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
Yuming Li, Peiwen Liu, Qiuxing Lin, Dong Zhou, Dongmei An
Summary: This study conducted a systematic review and meta-analysis to evaluate the seizure and memory outcomes of temporal lobe epilepsy with different hippocampal sclerosis subtypes. The results showed no significant difference in seizure freedom and improved outcome between different subtypes, and the long-term seizure outcome and memory impairment remained controversial.
Article
Clinical Neurology
Wenbiao Xiao, Zhiquan Yang, Xiaoxin Yan, Li Feng, Lili Long, Tian Tu, Na Deng, Wenjuan Chen, Bo Xiao, Hongyu Long, Yi Zeng
Summary: This study investigated proteomic alterations in the DG region of TLE-HS patients and found that differentially expressed proteins were enriched in areas such as synaptic vesicle, mitochondrion, and cell-cell adhesion. A key protein module related to oxidative phosphorylation was also identified.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Zhonghua Xiong, Xiongfei Wang, Yujiao Yang, Yifan Zhang, Chongyang Tang, Jing Zhang, Yuguang Guan, Fan Chen, Kun Yao, Pengfei Teng, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Summary: Mesial temporal lobe epilepsy without hippocampal sclerosis (no-HS MTLE) patients have resistance to antiepileptic drugs, difficulties in precise seizure location, and poor surgical outcomes. This study found maladaptive changes in adenosine metabolism and neuronal pathology in no-HS MTLE patients, suggesting potential new therapeutic targets.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Theo Demerath, Christoph P. Kaller, Marcel Heers, Anke Staack, Ralf Schwarzwald, Tobias Kober, Marco Reisert, Andreas Schulze-Bonhage, Hans-Juergen Huppertz, Horst Urbach
Summary: The study showed that utilizing MP2RAGE sequences for FCD detection had higher sensitivity compared to using MPRAGE sequences. Additionally, incorporating cluster volume information helped differentiate between true and false positive results in MP2RAGE imaging.
Article
Neurosciences
Olga Glanz (Iljina), Marina Hader, Andreas Schulze-Bonhage, Peter Auer, Tonio Ball
Summary: The linguistic complexity of words in uninstructed, spontaneous conversations has been explored on the neural level using synchronized audio, video, and electrocorticographic recordings. Proportional relation between the number of consonants and vowels was found to be the most informative parameter for the neural representation of word complexity, with effects observed in two specific brain areas.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Nursing
Andrea Egger-Rainer, Sophie Martina Hettegger, Raphael Feldner, Stephan Arnold, Christian Bosselmann, Hajo Hamer, Anna Hengsberger, Johannes Lang, Stefan Lorenzl, Holger Lerche, Soheyl Noachtar, Ekaterina Pataraia, Andreas Schulze-Bonhage, Anke Maren Staack, Eugen Trinka, Iris Unterberger, Georg Zimmermann
Summary: This study aimed to identify variables associated with patient comfort in an epilepsy monitoring unit. Factors such as gender, occupation, and specific center were found to potentially influence comfort levels. While certain sociodemographic variables had some impact on comfort scores, there are likely additional factors that play a role in individual comfort experiences which warrant further exploration.
JOURNAL OF ADVANCED NURSING
(2022)
Review
Clinical Neurology
Raphael Rauh, Andreas Schulze-Bonhage, Birgitta Metternich
Summary: Approximately 20% of people with epilepsy also suffer from anxiety. Various screening tools are used in clinical care and research to assess the complexity of epilepsy-specific anxieties.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Farrokh Manzouri, Marc Zoellin, Simon Schillinger, Matthias Duempelmann, Ralf Mikut, Peter Woias, Laura Maria Comella, Andreas Schulze-Bonhage
Summary: This study proposes three patient-specific, energy-efficient seizure detectors and validates their applicability and energy consumption. The results show that seizure detection can be achieved using a few channels with limited spatial distribution, which has implications for designing new models for responsive neurostimulation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jonas Christian Bruder, Kathrin Wagner, Daniel Lachner-Piza, Kerstin Alexandra Klotz, Andreas Schulze-Bonhage, Julia Jacobs
Summary: This study aimed to investigate the relationship between mesial-temporal spindle-ripples and memory performance. The study found that all ripple rates were significantly higher in seizure onset zone channels. Patients with pre-surgical verbal memory impairment had significantly higher overall ripple rates in the left mesial-temporal channels. There was a highly significant negative correlation between pre-surgical verbal memory performance and left mesial-temporal spike-associated ripples and overall ripples.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andreea Nissenkorn, Gerhard Kluger, Susanne Schubert-Bast, Allan Bayat, Marya Bobylova, Paolo Bonanni, Berten Ceulemans, Antonietta Coppola, Carlo Di Bonaventura, Martha Feucht, Anne Fuchs, Gudrun Groeppel, Gali Heimer, Brigitte Herdt, Sviatlana Kulikova, Konstantin Mukhin, Stefania Nicassio, Alessandro Orsini, Maria Panagiotou, Milka Pringsheim, Burkhard Puest, Olga Pylaeva, Georgia Ramantani, Maria Tsekoura, Paolo Ricciardelli, Tally Lerman Sagie, Brigit Stark, Pasquale Striano, Andreas van Baalen, Matthias De Wachter, Emanuele Cerulli Irelli, Claudia Cuccurullo, Celina von Stuelpnagel, Angelo Russo
Summary: A study involving 137 patients with different genetic epilepsies showed that perampanel had high efficacy in treating rare genetic epilepsies, especially in genes such as SCN1A, GNAO1, PIGA, PCDH19, SYNGAP1, CDKL5, NEU1, and POLG. This suggests a targeted effect of perampanel related to glutamate transmission in these patients, demonstrating good safety and efficacy.
Article
Behavioral Sciences
Rupprecht Thorbecke, Margarete Pfafflin, Christian G. Bien, Hajo M. Hamer, Martin Holtkamp, Dietz Rating, Andreas Schulze-Bonhage, Hans-Beatus Straub, Adam Strzelczyk, Theodor W. May
Summary: Objective: This study aimed to investigate changes in attitudes toward epilepsy (AE) over a 50-year period in Germany, including the 2018 survey. Emotional reactions towards people with epilepsy (PWE) were measured for the first time using the Scales of Attitudes toward People with Epilepsy (SAPE). Predictors of AE were also identified. Findings showed significant improvement in AE over the past 50 years. Excluding the "don't know" response option in the 2018 survey increased negative responses regarding contact and marriage with PWE. Many respondents felt insecure or uncomfortable when encountering PWE and expressed concerns about their safety during seizures. Knowledge about seizure management and treatment, personal contact with PWE, younger age, and higher education were strong predictors of positive AE.
EPILEPSY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Marie L. A. Bronnec, Dirk-Matthias Altenmueller, Thomas Fuchs, Claas Lahmann, Andreas Schulze-Bonhage, Prisca R. Bauer
Summary: Mental health comorbidities are common in epilepsy, highlighting the importance of psychotherapy. Understanding the subjective experiences of seizures is crucial for addressing the psychological needs of people with epilepsy. The study identified three categories of seizure descriptions: phenomena related to the body and emotions, moments that are difficult to describe, and the use of figurative language and metaphors. The metaphor of battle was most frequently used and closely related to perception and nature metaphors, representing a key aspect of the personal experience of seizures.
EPILEPSY & BEHAVIOR
(2023)
Review
Genetics & Heredity
Adam Strzelczyk, Sameer M. M. Zuberi, Pasquale Striano, Felix Rosenow, Susanne Schubert-Bast
Summary: This study conducted a systematic literature review on the burden of illness in Lennox-Gastaut syndrome (LGS), finding that LGS patients suffer from drug-resistant epilepsy and cognitive dysfunction. The research on the epidemiology, treatment costs, and patient quality of life in LGS is limited, indicating a need for further investigation.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Multidisciplinary Sciences
Adriano Cattani, Franziska Schwarzer, Mario Schwarzer, Andrea Spyrantis, Gerhard Marquardt, Susanne Schubert-Bast, Volker Seifert, Thomas M. Freiman
Summary: This study analyzed the influence of adjustable differential pressure valve ventriculoperitoneal shunt on head circumference and ventricular size in infants with hydrocephalus. The results showed that after long-term follow-up and multiple valve adjustments, normalization of head circumference and ventricular size is possible. However, infants with hydrocephalus due to intraventricular hemorrhage require a higher valve value compared to those with other etiologies.
Article
Medicine, General & Internal
Hannah Dunkel, Adam Strzelczyk, Susanne Schubert-Bast, Matthias Kieslich
Summary: Previous studies have found facial emotion recognition (FER) impairments in individuals with epilepsy, but there are few studies on individuals with generalized epilepsies, especially juvenile myoclonic epilepsy (JME). This cross-sectional study aimed to examine FER and social adjustment in individuals with JME. The results showed that individuals with JME performed worse in global FER and fear and surprise recognition than healthy controls. Further studies with larger sample size are needed to confirm the potential FER impairment in JME patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Margarita Maltseva, Felix Rosenow, Susanne Schubert-Bast, Silke Flege, Markus Wolff, Sarah von Spiczak, Regina Trollmann, Steffen Syrbe, Susanne Ruf, Tilman Polster, Bernd A. Neubauer, Thomas Mayer, Julia Jacobs, Gerhard Kurlemann, Gerhard Kluger, Kerstin A. Klotz, Matthias Kieslich, Lara Kay, Frauke Hornemann, Ulrich Bettendorf, Astrid Bertsche, Thomas Bast, Adam Strzelczyk
Summary: This study aimed to investigate the monitoring, interventions, and occurrence of critical incidents in patients with Dravet syndrome and caregivers' knowledge about SUDEP. Results showed that monitoring devices were frequently used and associated with age and history of status epilepticus. Caregivers were well informed about SUDEP and performed interventions at night when necessary.
Review
Clinical Neurology
Susanne Schubert-Bast, Moninder Kaur, Lars Joeres, Nadia Foskett, Robert Roebling, Adam Strzelczyk
Summary: The present study provides an overview of the epidemiology of focal onset seizures in children aged >1 month to 4 years through a literature review. The estimated incidence and prevalence of focal onset seizures in this age group are reported, along with the commonly associated neurodevelopmental outcomes and psychiatric disorders.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Review
Clinical Neurology
Adam Strzelczyk, Lieven Lagae, Jo M. Wilmshurst, Andreas Brunklaus, Pasquale Striano, Felix Rosenow, Susanne Schubert-Bast
Summary: Dravet syndrome (DS) is a disease characterized by drug-resistant epilepsy with neurocognitive and neurobehavioral impairment, and it results in a significant burden on patients, caregivers, the healthcare system, and society. This literature review and narrative synthesis identified the evidence associated with the burden of DS, including epidemiology, quality of life, costs, and resource utilization. The study found variations in the incidence and prevalence of DS, lower quality of life in patients, significant impacts on caregivers, high direct costs, and a strong association between seizure burden and disease burden.