Article
Oncology
Zhuang Kang, Shan Li, Xun Kang, Jing Deng, Huarong Yang, Feng Chen, Jiandong Jiang, Jie Zhang, Wenbin Li
Summary: This study aimed to evaluate the efficacy and safety of injectable chlorogenic acid (CGA) in patients with recurrent high-grade glioma. The results showed that CGA was well tolerated, with a maximum tolerated dose of 5.5 mg/kg. The most common adverse events occurred at the injection sites. Clinical pharmacokinetic study demonstrated rapid elimination of CGA from plasma, and after the first treatment cycle, 52.2% of patients achieved stable disease.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jonas Feldheim, Almuth F. Kessler, Julia J. Feldheim, Ellina Schulz, David Wend, Lazaros Lazaridis, Christoph Kleinschnitz, Martin Glas, Ralf-Ingo Ernestus, Sebastian Brandner, Camelia M. Monoranu, Mario Loehr, Carsten Hagemann
Summary: Glioblastoma is a fatal tumor and chemotherapy with temozolomide (TMZ) is a crucial treatment. However, TMZ treatment may lead to changes in MGMT promoter methylation and affect the migration and proliferation behavior of tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mohammad Hazaymeh, Ronja Loeber-Handwerker, Katja Doering, Tammam Abboud, Dorothee Mielke, Veit Rohde, Vesna Malinova
Summary: Approximately 25% of glioblastomas show corpus callosum infiltration at diagnosis, which is associated with poor prognosis. The extent of corpus callosum involvement ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Harrison Snyder, Andy Yu -Der Wang, Leonel Ampie, Danyas Sarathy, Ajay Chatrath, Ashok R. Asthagiri, Christopher I. Shaffrey, Justin S. Smith, Mark E. Shaffrey, Chun -Po Yen, Avery L. Buchholz, Hasan R. Syed, James Kryzanski, Julian K. Wu, Carl B. Heilman
Summary: This study provides a retrospective analysis of primary spinal cord astrocytoma patients from 1997 to 2020. The results indicate that higher grades are associated with poorer outcomes and more difficult postoperative periods. Clinicians should be vigilant for thromboembolic complications.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jacob P. Fisher, David C. Adamson
Summary: The standard of care for high-grade gliomas includes surgical resection, radiation therapy, and temozolomide, which have improved patient survival rates. Besides temozolomide, there are several other FDA-approved treatments for HGG, with tumor treatment fields being the only one shown to significantly improve survival rates.
Article
Cell Biology
I de Souza, L. K. S. Monteiro, C. B. Guedes, M. M. Silva, M. Andrade-Tomaz, B. Contieri, M. T. Latancia, D. Mendes, B. F. M. M. Porchia, M. Lazarini, L. R. Gomes, C. R. R. Rocha
Summary: The study reveals the role of NRF2 in modulating ferroptosis in glioblastoma cells, as well as its correlation with ABCC1 expression. Moreover, high levels of NRF2 result in collateral sensitivity and contribute to GSH depletion when the system xc(-) is blocked. These findings suggest that ferroptosis induction could be a potential therapeutic strategy to reverse drug resistance in gliomas.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Olga Renner, Markus Burkard, Holger Michels, Claudia Vollbracht, Tobias Sinnberg, Sascha Venturelli
Summary: Standard therapy for glioblastoma typically results in limited survival and quality of life improvements, but pharmacological ascorbate shows potential efficacy. The biological complexity and resistance of glioblastoma calls for further research to confirm ascorbate's potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Yao Yu, Javier Villanueva-Meyer, Matthew R. Grimmer, Stephanie Hilz, David A. Solomon, Serah Choi, Michael Wahl, Tali Mazor, Chibo Hong, Anny Shai, Joanna J. Phillips, Bruce H. Wainer, Michael McDermott, Daphne Haas-Kogan, Jennie W. Taylor, Nicholas Butowski, Jennifer L. Clarke, Mitchel S. Berger, Annette M. Molinaro, Susan M. Chang, Joseph F. Costello, Nancy Ann Oberheim Bush
Summary: The study found that hypermutation induced by temozolomide greatly increased the risk of high-grade disease recurrence in low-grade IDH-mutant glioma patients previously treated with TMZ, and was associated with shorter survival after transformation. Tumors with hypermutation were more likely to develop discontiguous foci of disease in the brain and spine.
Review
Oncology
Maximilian J. Mair, Marjolein Geurts, Martin J. van den Bent, Anna S. Berghoff
Summary: WHO grade II-III gliomas are rare primary brain tumors with longer median survival compared to grade IV glioblastoma. Treatment involves maximal safe resection and adjuvant therapies, with challenges in conducting clinical trials due to rarity and long follow-up times. The 2016 WHO Classification introduced a molecular diagnostic framework for more homogenous subgroups. Available evidence for adjuvant treatment was generated pre-molecular era, emphasizing the need for further research in this field.
CANCER TREATMENT REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Parveen Kumar, Vivek Verma, Dheeraj Mohania, Surbhi Gupta, Avneet K. Babbar, Bhawna Rathi, Rakesh S. Dhanda, Manisha Yadav
Summary: The study revealed that RUNX1T1 is mutated in different cancers and associated with poor overall survival in glioma patients, possibly affecting glioma growth and development through HIF1α regulation. Experimental results showed that downregulation of RUNX1T1 may lead to degradation of HIF1α, reducing proliferation and invasiveness of glioblastoma cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Giuseppe Minniti, Sergio Paolini, Manila Antonelli, Francesca Gianno, Paolo Tini, Gaetano Lanzetta, Antonella Arcella, Raffaella De Pietro, Martina Giraffa, Luca Capone, Andrea Romano, Alessandro Bozzao, Vincenzo Esposito
Summary: This study reports the long-term outcomes in adult patients with grade 2 IDH-mutant astrocytoma treated with temozolomide-based chemoradiation, and found that chemoradiation can improve the survival of patients. Delayed chemoradiation can be considered for younger patients after extensive resection, while early treatment should be recommended for high-risk patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Giuseppe Minniti, Sergio Paolini, Manila Antonelli, Francesca Gianno, Paolo Tini, Gaetano Lanzetta, Antonella Arcella, Raffaella De Pietro, Martina Giraffa, Luca Capone, Andrea Romano, Alessandro Bozzao, Vincenzo Esposito
Summary: TMZ-based chemoradiation is associated with survival benefit in adult patients with grade 2 IDH-mutant astrocytoma. For this group of patients, chemoradiation can be deferred until time of progression in younger patients receiving extensive resection, while early treatment should be recommended in high-risk patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Weir-Chiang You, Hsu-Dung Lee, Hung-Chuan Pan, Hung-Chieh Chen
Summary: This study aimed to evaluate the effectiveness of combining re-irradiation and bevacizumab in treating patients with recurrent glioblastoma multiforme (GBM) resistant to bevacizumab monotherapy. The results showed that the group receiving re-irradiation had higher survival rates and longer median survival time than the group receiving no re-irradiation. The target volume of re-irradiation was identified as a significant factor for overall survival time after re-irradiation.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
David Lofgren, Antonios Valachis, Magnus Olivecrona
Summary: This retrospective study investigated the risk of postoperative complications in older patients with high grade gliomas after neurosurgery, and explored changes over time. The study found an increase in surgical interventions over time, with relatively low postoperative morbidity and mortality rates. This suggests that surgery can be a feasible option for older patients with high grade gliomas.
Article
Dermatology
Anna Elisa Verzi, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Micali, Francesco Lacarrubba
Summary: Lentigo maligna is a subtype of melanoma that typically affects elderly patients and may progress into invasive melanoma. Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive technique for real-time skin imaging, showing high-resolution features of LM which correlate strongly with histopathological findings. This study demonstrates the potential of LC-OCT to enhance the non-invasive diagnosis of LM.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Sebastiano Giallongo, Laura Orlando, Giuseppe Broggi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Cesarina Giallongo, Ignazio Barbagallo, Michelino Di Rosa, Rosario Giuffrida, Rosalba Parenti, Giovanni Li Volti, Nunzio Vicario, Daniele Tibullo
Summary: This study aimed to investigate the role of lactate in uveal melanoma (UM) cells. The results showed that lactate could inhibit cell proliferation and migration, and switch cell metabolism towards oxidative phosphorylation. It was also found that an increase in lactate transporters MCT4 and HCAR1 was associated with a spindle-shape histological type in UM. These findings suggest that lactate metabolism may serve as a prognostic marker of UM progression and a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Giuseppe Broggi, Roberto Altieri, Valeria Barresi, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Magda Zanelli, Andrea Palicelli, Gaetano Magro, Rosario Caltabiano
Summary: The extent of resection beyond the enhancing core in GBM, IDHwt is a controversial topic in neuro-oncology. This study provides a comprehensive description of the histological features of FLAIR hyperintensity regions, which are often visible beyond the conventional EC. The histological analysis reveals that FLAIR areas consist of infiltrated white matter, reactive astrogliosis with grey matter, and tumor tissue.
Article
Chemistry, Multidisciplinary
Giuseppe Broggi, Jessica Farina, Andrea Palicelli, Magda Zanelli, Gaetano Zizza, Francesca Sorci, Riccardo Morici, Rosario Caltabiano
Summary: Although malignant melanoma (MM) typically spreads to the lymph nodes, liver, lung, and brain, there have been cases of unusual metastasis reported in the literature. This paper presents two rare cases of isolated MM metastasis to the gallbladder and uterus, which were not known to have previous malignancies at the time of examination. The study highlights the importance of considering MM metastasis in the differential diagnosis when encountering patients with a known history of MM and the development of a new mass/lesion in uncommon sites.
APPLIED SCIENCES-BASEL
(2023)
Review
Oncology
Magda Zanelli, Martina Quintini, Salvatore Magnasco, Lara Aprile, Andrea Palicelli, Maurizio Zizzo, Francesca Sanguedolce, Stefano Ricci, Saverio Pancetti, Valeria Zuccala, Veronica Martino, Giuseppe Broggi, Rosario Caltabiano, Alberto Cavazza, Paola Parente, Cristina Mecucci, Giovanni Martino, Stefano Ascani
Summary: This study reviews the current knowledge on MCL with the aim of increasing awareness among clinicians and pathologists of this rare, still incompletely understood disease with a grim prognosis.
Article
Neuroimaging
Marco Catalano, Luca Crimi, Giuseppe Belfiore, Daniele Grippaldi, Emanuele David, Corrado Spatola, Concetto Cristaudo, Pietro Valerio Foti, Stefano Palmucci, Antonio Basile
Summary: This article introduces the anatomy of the basilar artery, which is formed by the union of the vertebral arteries and supplies essential structures in the body. It discusses the congenital and acquired anomalies of the basilar artery, as well as the imaging findings and clinical cases associated with these anomalies. The article emphasizes the importance of understanding these anomalies for radiologists, neuroradiologists, and neurosurgeons.
NEURORADIOLOGY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Corrado Ini, Giulio Distefano, Filippo Sanfilippo, Davide Giuseppe Castiglione, Daniele Falsaperla, Francesco Giurazza, Cristina Mosconi, Francesco Tiralongo, Pietro Valerio Foti, Stefano Palmucci, Massimo Venturini, Antonio Basile
Summary: This systematic review examines the clinical practice and outcomes of blind and preventive embolization for upper and lower gastrointestinal bleedings. The study finds that blind transcatheter arterial embolization has a high technical and clinical success rate for upper gastrointestinal bleeding, but caution should be exercised for lower gastrointestinal bleeding due to the risk of poor vascular anastomoses and intestinal ischemia.
Review
Oncology
Magda Zanelli, Francesca Sanguedolce, Maurizio Zizzo, Valentina Fragliasso, Giuseppe Broggi, Andrea Palicelli, Giuseppe Gaetano Loscocco, Camilla Cresta, Cecilia Caprera, Matteo Corsi, Giovanni Martino, Alessandra Bisagni, Marialisa Marchetti, Nektarios Koufopoulos, Paola Parente, Rosario Caltabiano, Stefano Ascani
Summary: This paper focuses on the clinical and pathological features of lymphoblastic lymphoma of B- or T-cell origin and mantle cell lymphoma, particularly its blastoid variant, involving the skin. It emphasizes the importance of precise diagnosis for different diseases with similar blastic characteristics that have different outcomes and require distinct therapeutic strategies in patient management. The assessment of skin biopsies of hematological neoplasms with blastic features poses diagnostic challenges and requires consideration of a wide range of differential diagnoses.
Article
Respiratory System
Gianluca Sambataro, Alessandro Libra, Lucia Spicuzza, Stefano Palmucci, Paola Conti, Eugenio Spagnolo, Michele Colaci, Lorenzo Malatino, Martina Orlandi, Domenico Sambataro, Carlo Vancheri
Summary: Compared to patients diagnosed in a rheumatologic unit (RU), patients with rheumatoid arthritis (RA) and connective tissue disease-associated interstitial lung disease (CTD-ILD) diagnosed in a pulmonary unit (PU) show a more complex clinical presentation. In the PU, CTD-ILD patients are predominantly male, older, and more likely to progress from undifferentiated CTD to a specific condition. RA-PU patients have a higher proportion of polymyalgia rheumatica-like manifestations, SSc-PU patients commonly exhibit a usual interstitial pneumonia pattern, and pSS-PU patients are often those with preexisting ILD who develop sicca syndrome during follow-up.
Review
Medicine, General & Internal
Maria Chiara Lo Greco, Giulia Marletta, Giorgia Marano, Alessandro Fazio, Emanuele Buffettino, Arianna Iudica, Rocco Luca Emanuele Liardo, Roberto Milazzotto, Pietro Valerio Foti, Stefano Palmucci, Antonio Basile, Francesco Marletta, Francesco Cuccia, Giuseppe Ferrera, Silvana Parisi, Antonio Pontoriero, Stefano Pergolizzi, Corrado Spatola
Summary: At the time of diagnosis, most prostate carcinoma patients have a localized form of the disease, with low- or intermediate-risk prostate cancer being the most common. Treatment options for localized prostate cancer include surgery, external beam radiotherapy, and brachytherapy. Moderate hypofractionated radiotherapy has been shown to be a valid alternative strategy. High-dose-rate brachytherapy can be administered in different schedules. Proton beam radiotherapy shows promise, but further research is needed to improve affordability and accessibility. New technologies like MRI-guided radiotherapy have great potential.
MEDICINA-LITHUANIA
(2023)
Article
Respiratory System
Marco Catalano, Luca Crimi, Federica Galioto, Maria Coronella, Pietro Valerio Foti, Stefano Palmucci, Antonio Basile
Summary: A clinical case of pulmonary artery intimal sarcoma (PAIS) is presented, highlighting its imaging features that resemble pulmonary embolism (PE). CT findings of PAIS, including endoluminal filling defect and characteristic morphology, are described along with specific elements like wall eclipse sign and metastasis. The overlap of clinical-radiological findings and the differences in epidemiology between PAIS and PE may cause a diagnostic delay, emphasizing the importance of early detection for optimal management.
RESPIRATORY MEDICINE CASE REPORTS
(2023)
Article
Oncology
Magda Zanelli, Alberto Lugli, Andrea Palicelli, Francesca Sanguedolce, Maurizio Zizzo, Camilla Cresta, Samuele Biancafarina, Giovanni Martino, Barbara Crescenzi, Saverio Pancetti, Giuseppe Broggi, Rosario Caltabiano, Luca Cimino, Cristina Mecucci, Stefano Ascani
Summary: Mantle cell lymphoma (MCL) is rarely reported in the ocular adnexa, which is more commonly affected by extranodal marginal zone B-cell lymphoma. The diagnosis of MCL in this location can be challenging as it may be overlooked and misinterpreted as marginal zone B-cell lymphoma due to its rarity and CD5 negativity. Here, we present a case of primary bilateral CD5-negative MCL in the ocular adnexa and discuss potential diagnostic pitfalls.
Article
Oncology
Pietro Valerio Foti, Corrado Ini, Giuseppe Broggi, Renato Farina, Stefano Palmucci, Corrado Spatola, Maria Chiara Lo Greco, Emanuele David, Rosario Caltabiano, Lidia Puzzo, Andrea Russo, Antonio Longo, Teresio Avitabile, Antonio Basile
Summary: Histologic type is an important prognostic factor in uveal melanoma (UM). Biopsy, while able to provide the histologic type, is not routinely performed. Noninvasive biomarkers have gained interest as alternative prognostic methods. This study aimed to assess the correlation between diffusion-weighted magnetic resonance imaging (DWI) and the histologic type of UM.
Article
Medicine, General & Internal
Stefano Di Pietro, Alfredo Gaetano Torcitto, Carmelita Marcantoni, Gabriele Giordano, Christian Campisi, Giovanni Failla, Licia Saporito, Rosa Giunta, Massimiliano Veroux, Pietro Valerio Foti, Stefano Palmucci, Antonio Basile
Summary: This study assessed the performance of two methods, the ellipsoid method and the semi-automatic segmentation method, for measuring total kidney volume (TKV) and single kidney volume (SKV) in patients with autosomal dominant polycystic renal disease (ADPKD). The results showed that the semi-automatic segmentation method had better inter-observer reproducibility, while the ellipsoid method was more affected by inter-observer variability, especially when performed by operators with limited experience.