Article
Chemistry, Multidisciplinary
Yingying Zhang, Xin Zhang, Hanjie Wang, Yu Tian, Huizhuo Pan, Lili Zhang, Feng Wang, Jin Chang
Summary: A magneto-luminescence microdevice (MLMD) was developed in this study to achieve optical emission through non-contact excitation using a rotating magnetic field, allowing for remote stimulation of biological tissues. This innovative approach has the potential to inspire new applications in biomedicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Multidisciplinary Sciences
Shan Jiang, Xiang Wu, Nicholas J. Rommelfanger, Zihao Ou, Guosong Hong
Summary: This review article provides an overview of recent advances in optical neuromodulation and its applications in addressing physical constraints of in vivo light delivery. The article presents the latest optical techniques for neuromodulation and explores new methods for minimal invasiveness and footprint.
NATIONAL SCIENCE REVIEW
(2022)
Article
Chemistry, Multidisciplinary
Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, Jian-Cheng Wang
Summary: RNA-based therapy is a promising strategy for disease treatment, and recent advances in non-viral delivery systems have shown potential in protecting RNA, facilitating cell internalization, and controlled release of therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Yu Tian, Yingying Zhang, Xinyu Zhang, Huizhuo Pan, Lili Zhang, Shuang Liu, Yulan Chen, Lin Su, Peiqi Zhao, Jin Chang, Hanjie Wang
Summary: The magnetism-optogenetic system developed in this study effectively combines wireless magnetic regulation with the high sensitivity of optogenetics, showing promise in neuromodulation research.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jing Chen, Wen Nie, Yuzhu Hu, Yangmei Shen, Yunzhu Lin, Bilan Wang, Zhiyong Qian, Xiang Gao
Summary: Drug resistance is a challenging problem in cancer chemotherapy. The combination of molecular targeted therapy and traditional chemotherapy shows potential clinical benefits. A folic acid-modified targeted drug/gene delivery system was developed to co-deliver Paclitaxel (PTX) and plasmid shBCL-2, which can enhance the sensitivity of cancer cells to chemotherapy drugs and improve therapeutic effect.
APPLIED MATERIALS TODAY
(2022)
Review
Oncology
Junsheng Li, Wen Wang, Jia Wang, Yong Cao, Shuo Wang, Jizong Zhao
Summary: Gene therapy using viral vectors to deliver therapeutic genes for specific antitumor effects is a promising approach for treating GBM, offering potential applications in the future.
FRONTIERS IN ONCOLOGY
(2021)
Review
Clinical Neurology
Robert Duba-Kiss, Yosuke Niibori, David R. Hampson
Summary: This Mini Review discusses the use of various gene regulatory elements for targeting GABAergic neurons, with a focus on adeno-associated viral vectors, the most widely used class of viral vectors for treating brain diseases.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Marco Ledri, My Andersson, Jenny Wickham, Merab Kokaia
Summary: The advent of optogenetic tools has revolutionized our understanding of the brain by offering precise manipulation of neurons with temporal precision. In epilepsy research, these tools have played a crucial role in understanding seizure generation and exploring therapeutic strategies. They have provided insights into the initiation of seizures, interactions between different brain regions, and potential for real-time control of seizure activity.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Kelsey R. Pflepsen, Cristina D. Peterson, Kelley F. Kitto, Maureen S. Riedl, R. Scott McIvor, George L. Wilcox, Lucy Vulchanova, Carolyn A. Fairbanks
Summary: The distribution and kinetics of AAV5 vector following lumbar intrathecal injection in mice were evaluated in this study. Results showed rapid distribution of AAV5 particles to all levels of the spinal cord and dorsal root ganglia, with preferential targeting of DRG tissue and possible clearance mechanisms via DRG macrophages.
MOLECULAR PHARMACEUTICS
(2021)
Article
Neurosciences
Mary Gazea, Szabina Furdan, Peter Sere, Lukas Oesch, Benedek Molnar, Giuseppe Di Giovanni, Lief E. Fenno, Charu Ramakrishnan, Joanna Mattis, Karl Deisseroth, Susan M. Dymecki, Antoine R. Adamantidis, Magor L. Lorincz
Summary: The lateral hypothalamus selectively inhibits GABAergic neurons in the dorsal raphe nucleus, leading to increased firing of a substantial fraction of its neurons that ultimately promotes arousal. These wake active DRGABA neurons project to multiple brain areas involved in the control of arousal, including the LH, where their specific activation influences local network activity leading to arousal from sleep. Mutual inhibitory projections between the LH and the DR promote wakefulness and suggest a complex arousal control by intimate interactions between long-range connections and local circuit dynamics.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Tao Zhang, Peng Zou
Summary: The prediction of human transgene product expression is important in gene replacement therapies using viral vectors. This study evaluated different methods for predicting transgene expression and found that the normalized dose-response method had the highest accuracy. The allometric scaling method using body weight^-0.25 also showed superior accuracy compared to the logarithmic scaling method. This research extends the use of these methods from intravenous to locally delivered viral vectors.
Review
Biotechnology & Applied Microbiology
Zongmin Zhao, Aaron C. Anselmo, Samir Mitragotri
Summary: Gene therapies using viral vectors have shown promising outcomes in treating various diseases that were once considered incurable. The use of viral vectors allows for efficient delivery of gene therapeutics into target cells, leading to the approval of multiple products and ongoing clinical trials exploring their therapeutic potential.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Organic
Michela Lomazzi, Valentina Franceschi, Valentina Bagnacani, Carlo Alberto Vezzoni, Gaetano Donofrio, Alessandro Casnati, Francesco Sansone
Summary: The tetra-L-arginino-tetrahexyloxycalix[4]arene 1 has shown remarkable abilities to compact and deliver various types of nucleic acid cargos into cells. Small structural changes in the calixarene vectors may affect their ability to compact DNA and deliver cargo into cells.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Lu Zhang, Yuping Wang
Summary: Gene therapy could be a potential alternative for treating epilepsy, with tailored gene vectors and appropriate therapeutic target selection being crucial. Various treatment strategies have been tested in animal models, and emerging tools like optogenetics and genome editing hold promise for advancing gene therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Hui Zu, Danchen Gao
Summary: Although non-viral vectors in gene therapy have low cytotoxicity and immunogenicity, they still face challenges in gene transfer efficiency, specificity, gene expression duration, and safety. Overcoming these obstacles is necessary to enhance the effectiveness of non-viral vectors in gene therapy.
Editorial Material
Clinical Neurology
Jaimie M. Henderson
Article
Multidisciplinary Sciences
Francis R. Willett, Donald T. Avansino, Leigh R. Hochberg, Jaimie M. Henderson, Krishna V. Shenoy
Summary: BCIs can restore communication for individuals with paralysis by decoding attempted handwriting movements, achieving typing speeds of 90 characters per minute with high accuracy. This approach opens new possibilities for BCIs and demonstrates the feasibility of decoding rapid, dexterous movements even years after paralysis.
Article
Engineering, Biomedical
John D. Simeral, Thomas Hosman, Jad Saab, Sharlene N. Flesher, Marco Vilela, Brian Franco, Jessica N. Kelemen, David M. Brandman, John G. Ciancibello, Paymon G. Rezaii, Emad N. Eskandar, David M. Rosler, Krishna V. Shenoy, Jaimie M. Henderson, Arto V. Nurmikko, Leigh R. Hochberg
Summary: This study demonstrated the first human use of a wireless broadband iBCI system, achieving high-resolution recording and decoding of neural signals from individuals with paralysis. Results showed equivalent communication bitrates between wireless and cabled iBCIs, and participants were able to control a standard commercial tablet computer wirelessly for various tasks.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Josef Parvizi, Rodrigo M. Braga, Aaron Kucyi, Mike J. Veit, Pedro Pinheiro-Chagas, Claire Perry, Clara Sava-Segal, Michael Zeineh, Eric Klaas van Staalduinen, Jaimie M. Henderson, Matthew Markert
Summary: This study presents a rare case of seizures originating from the posteromedial cortex (PMC) causing self-dissociation in a patient. Electrical stimulation of the seizure zone and a homotopical region within the contralateral PMC induced a subjectively similar state, indicating the potential causal importance of the PMC in integrating self-referential information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Alfonso Fasano, Dawn Eliashiv, Susan T. Herman, Brian N. Lundstrom, Dara Polnerow, Jaimie M. Henderson, Robert S. Fisher
Summary: Deep brain stimulation of the anterior nuclei of thalamus (ANT-DBS) is effective for reducing seizures in patients with temporal or frontal epilepsy refractory to at least two medications. Motivations for therapy renewal upon battery depletion include reduced seizures, improved quality of life, and reduction of severe seizures. Stimulation parameters are mainly guided by magnetic resonance imaging and typically follow parameters similar to the SANTE study, with initial stimulation amplitudes in the 2-3 V or mA range.
Article
Computer Science, Cybernetics
Darrel R. Deo, Paymon Rezaii, Leigh R. Hochberg, Allison M. Okamura, Krishna Shenoy, Jaimie M. Henderson
Summary: Intracortical brain-computer interfaces (iBCIs) provide a means for paralysis patients to control devices with decoded brain signals, but further improvement is needed to approach able-bodied control levels. Providing proprioceptive feedback through mechanical haptic stimulation can enhance motor cortical neuron responses and iBCI control performance. Additionally, online iBCI cursor control with continuous skin-shear feedback led to slightly but significantly improved performance compared to visual feedback alone.
IEEE TRANSACTIONS ON HAPTICS
(2021)
Article
Neurosciences
Joshua K. Wong, Guenther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Anso, Ro'ee Gilron, Lawrence Poree, Giridhar P. Kalamangalam, Gregory A. Worrell, Kai J. Miller, Nicholas D. Schiff, Christopher R. Butson, Jaimie M. Henderson, Jack W. Judy, Adolfo Ramirez-Zamora, Kelly D. Foote, Peter A. Silburn, Luming Li, Genko Oyama, Hikaru Kamo, Satoko Sekimoto, Nobutaka Hattori, James J. Giordano, Diane DiEuliis, John R. Shook, Darin D. Doughtery, Alik S. Widge, Helen S. Mayberg, Jungho Cha, Kisueng Choi, Stephen Heisig, Mosadolu Obatusin, Enrico Opri, Scott B. Kaufman, Prasad Shirvalkar, Christopher J. Rozell, Sankaraleengam Alagapan, Robert S. Raike, Hemant Bokil, David Green, Michael S. Okun
Summary: The DBS Think Tank IX conference provided an open platform for clinicians, engineers, and researchers to discuss DBS technologies and related issues. The consensus among the speakers was that DBS is expanding its scope and being applied to various brain disorders. Over 230,000 DBS devices have been implanted globally.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Jamasb J. Sayadi, Adrian J. Rodrigues, Neal A. Patel, Amit Ayer, Jaimie M. Henderson
Summary: This retrospective study analyzed the medical records of adult patients who underwent initial deep brain stimulation (DBS) implantation surgery at Stanford Hospital from November 14, 2012, to November 9, 2020. The results showed that the use of antibacterial envelopes reduced the incidence of surgical site infections (SSI) in DBS surgery. However, this association did not remain statistically significant after controlling for confounding variables. Future prospective studies are needed to determine the efficacy of antibacterial envelopes in reducing post-DBS infections.
Article
Neurosciences
Christian Thaler, Qiyuan Tian, Max Wintermark, Pejman Ghanouni, Casey H. H. Halpern, Jaimie M. M. Henderson, Raag D. D. Airan, Michael Zeineh, Maged Goubran, Christoph Leuze, Jens Fiehler, Kim Butts Pauly, Jennifer A. McNab
Summary: This study detected microstructural changes within the CTCT after tcMRgFUS treatment and found a correlation between these changes and lesion-tract overlap, which helps to elucidate the treatment mechanism and improve targeting strategies.
BRAIN CONNECTIVITY
(2023)
Article
Neurosciences
Joshua K. K. Wong, Helen S. S. Mayberg, Doris D. D. Wang, R. Mark Richardson, Casey H. H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro'ee Gilron, James F. F. Cavanagh, Jack W. W. Judy, Svjetlana Miocinovic, Annaelle D. D. Devergnas, Roy V. V. Sillitoe, Stephanie Cernera, Carina R. R. Oehrn, Aysegul Gunduz, Wayne K. K. Goodman, Erika A. A. Petersen, Helen Bronte-Stewart, Robert S. S. Raike, Mahsa Malekmohammadi, David Greene, Petra Heiden, Huiling Tan, Jens Volkmann, Valerie Voon, Luming Li, Pankaj Sah, Terry Coyne, Peter A. A. Silburn, Cynthia S. S. Kubu, Anna Wexler, Jennifer Chandler, Nicole R. R. Provenza, Sarah R. R. Heilbronner, Marta San Luciano, Christopher J. J. Rozell, Michael D. D. Fox, Coralie de Hemptinne, Jaimie M. M. Henderson, Sameer A. A. Sheth, Michael S. S. Okun
Summary: The Deep Brain Stimulation (DBS) Think Tank X was held in Orlando FL on August 17-19, 2022, with the theme of women in neuromodulation. Dr. Helen Mayberg, the keynote speaker, discussed the development of DBS for depression. The consensus among the speakers was that DBS has expanded in scope but certain indications have faced challenges.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Daniel B. Rubin, A. Bolu Ajiboye, Laurie Barefoot, Marguerite Bowker, Sydney S. Cash, David Chen, John P. Donoghue, Emad N. Eskandar, Gerhard Friehs, Carol Grant, Jaimie M. Henderson, Robert F. Kirsch, Rose Marujo, Maryam Masood, Stephen T. Mernoff, Jonathan P. Miller, Jon A. Mukand, Richard D. Penn, Jeremy Shefner, Krishna V. Shenoy, John D. Simeral, Jennifer A. Sweet, Benjamin L. Walter, Ziv M. Williams, Leigh R. Hochberg
Summary: This study reports the safety results of a large and long-running clinical trial of an implanted brain-computer interface. The findings show a low rate of serious adverse events in appropriately selected individuals, supporting further research and development.
Proceedings Paper
Computer Science, Artificial Intelligence
Nishal P. Shah, Matthew S. Willsey, Nick Hahn, Foram Kamdar, Donald T. Avansino, Leigh R. Hochberg, Krishna V. Shenoy, Jaimie M. Henderson
Summary: This paper introduces a new iBCI communication prosthesis that allows individuals with paralysis to type using a 3D keyboard interface. The study found that decoding neural activity using 3 degrees of freedom (DOF) was more accurate (95%) than using 5 DOF (76%). A virtual keyboard was developed based on natural language statistics, resulting in improved typing accuracy and speed for the participant.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Article
Biochemistry & Molecular Biology
Nicholas D. Schiff, Joseph T. Giacino, Christopher R. Butson, Eun Young Choi, Jonathan L. Baker, Kyle P. O'Sullivan, Andrew P. Janson, Michael Bergin, Helen M. Bronte-Stewart, Jason Chua, Laurel Degeorge, Sureyya Dikmen, Adam Fogarty, Linda M. Gerber, Mark Krel, Jose Maldonado, Matthew Radovan, Sudhin A. Shah, Jason Su, Nancy Temkin, Thomas Tourdias, Jonathan D. Victor, Abigail Waters, Stephanie A. Kolakowsky-Hayner, Joseph J. Fins, Andre G. Machado, Brian K. Rutt, Jaimie M. Henderson
Summary: This feasibility study demonstrates that deep brain stimulation within the central lateral thalamus can be safely applied and is associated with improved executive control in patients with moderate-to-severe traumatic brain injury.
Article
Health Care Sciences & Services
Joseph J. J. Fins, Megan S. S. Wright, Jaimie M. M. Henderson, Nicholas D. D. Schiff
Summary: This article explores subject and family perspectives on the use of Medtronic PC + S invasive neurological device trial for cognitive restoration in moderate to severe traumatic brain injury. Interviews conducted prior to surgery revealed that informed consent and enrollment decisions were complex and often resulted in divided opinions between subjects and their families. Despite the risks involved, both subjects and families expressed hopes for cognitive improvement and better quality of life through study participation.
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Francis R. Willett, Donald T. Avansino, Leigh R. Hochberg, Jaimie M. Henderson, Krishna V. Shenoy
Summary: Brain-computer interfaces (BCIs) are capable of restoring communication abilities for individuals who have lost the ability to move or speak. This study presents the development of an intracortical BCI that can decode attempted handwriting movements from neural activity and translate them to text in real time, achieving high typing speeds and accuracy.
10TH INTERNATIONAL WINTER CONFERENCE ON BRAIN-COMPUTER INTERFACE (BCI2022)
(2022)
