Article
Oncology
Quan Cheng, Anliu Tang, Zeyu Wang, Ning Fang, Zhuojing Zhang, Liyang Zhang, Chuntao Li, Yu Zeng
Summary: Caldesmon (CALD1) may play a crucial role in monitoring glioma patient prognosis and angiogenesis, with higher CALD1 expression associated with worse clinical outcomes and potential modulation of tumor angiogenesis. High CALD1 expression was also linked to abnormal microvessels in anaplastic astrocytoma and GBM, making CALD1 a possible key marker for monitoring glioma progress.
Article
Pharmacology & Pharmacy
Laura Lucia Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andres Golombek, Juan Jose Chiesa, Luciano Marpegan
Summary: The study revealed circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Article
Engineering, Biomedical
B. Sarala, G. Sumathy, A. V. Kalpana, J. Jasmine Hephzipah
Summary: In this study, Glioma brain tumor images are detected using Edge preserving image fusion and dual-deep learning Convolutional Neural Network. The first CNN module extracts internal features from the brain image, while the second module is used for feature classification. The training process involves fusing brain tumor and healthy brain images, augmenting the fused images, and classifying them with a proposed CNN classifier. In the testing process, the source brain images are fused, augmented, and classified into Glioma or healthy brain image, followed by tumor region segmentation using Histogram-Density Segmentation Algorithm.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Engineering, Environmental
Meng-Yi Xie, Guang-Long Huang, Zhi-Ying Lin, Xiang-Fei Sun, Chen-Chou Wu, Ya-Wei Liu, Liang-Ying Liu, Eddy Y. Zeng
Summary: Information on potential association between heavy metal concentrations and glioma incidences is limited, especially in human brain tissue. This study measured 13 heavy metals in glioma and non-glioma samples and found that all target heavy metals were present, indicating their ability to cross the blood-brain barrier. Concentrations of Mn, Cu, and Zn were higher in glioma samples, while Ni and Se were higher in non-glioma samples, suggesting their susceptibility to pathological changes. Furthermore, certain concentration ratios of heavy metals were statistically different between glioma and non-glioma samples, which may serve as chemical markers for differentiating tumor from healthy tissues. However, no direct link between heavy metal concentrations or concentration ratios and biomarkers of glioma was observed due to limited sample size, indicating that heavy metals may be a consequence rather than a cause of pathological changes in brain tumors.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Oncology
Colin Thorbinson, John-Paul Kilday
Summary: Brain tumors are the leading cause of childhood cancer deaths in developed countries, representing the most common solid tumor in this age group, accounting for approximately one-quarter of all pediatric cancers. Developments in neuro-imaging, neurosurgical techniques, adjuvant therapy, and supportive care have improved survival rates for certain tumors, allowing a focus on optimizing cure while minimizing long-term adverse effects. Recent advancements in the molecular characterization of common pediatric brain tumors have identified unique clinical and biological patient subgroups, but achieving a paradigm shift in translational therapy and subsequent survival for many tumors remains challenging, with recurrence presenting a significant clinical challenge. This review provides insight into key molecular developments and global cooperative trial results for the most common malignant pediatric brain tumors, highlighting potential future directions for management, including novel therapeutic options and unresolved critical challenges.
Review
Biochemistry & Molecular Biology
Safwan Alomari, Irma Zhang, Adrian Hernandez, Caitlin Y. Kraft, Divyaansh Raj, Jayanidhi Kedda, Betty Tyler
Summary: Glioblastoma is a common malignant brain tumor with poor prognosis, and there is a need for effective therapeutics. Drug repurposing is a potential strategy, with some drugs showing efficacy against GBM cell lines. However, the blood-brain barrier may limit their effectiveness.
Article
Medicine, Research & Experimental
Kittikun Viwatpinyo, Sujira Mukda, Sakan Warinhomhoun
Summary: This study demonstrates that MG induces cell death and cell cycle arrest, disrupts cell migration, and reduces the clonogenicity of brain tumor cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Seyed Mohammad Mousavi, Mehdi Shayanfar, Somaye Rigi, Minoo Mohammad-Shirazi, Giuve Shari, Ahmad Esmaillzadeh
Summary: The study showed that high adherence to the Mediterranean diet was significantly associated with a lower risk of glioma. This association persisted even after adjusting for other potential confounders.
CLINICAL NUTRITION
(2021)
Article
Engineering, Biomedical
Jun Wang, Wei Tang, Meng Yang, Ying Yin, Hui Li, Fangfang Hu, Lin Tang, Xiaoyue Ma, Yu Zhang, Yazhou Wang
Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.
Article
Medicine, General & Internal
Xiaokai Li, Lei Li, Ke Zhou, Huixiang Zhang, Ali Abdi Maalim, Xingyu Chen, Ximiao He, Xinmin Ding, Chuanrui Xu, Yonghong Wang
Summary: In this study, the infiltration of BBB constituent cells in the glioma tumor microenvironment was investigated using statistical analysis. The results showed a close relationship between the infiltration proportions of BBB constituent cell types and BBB alterations. A BBB score was developed and found to be associated with more malignant tumor features, higher WHO grade, shorter survival time, and unfavorable prognosis in glioma patients. Furthermore, TME-related pathways were found to regulate BBB alterations and coinhibitory immune checkpoints were enriched in samples with higher BBB scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Charlotte Berard, Charles Truillet, Benoit Larrat, Frederic Dhermain, Marie-Anne Esteve, Florian Correard, Anthony Novell
Summary: The therapeutic management of gliomas is a difficult task due to the challenges presented by brain tumors, including the presence of blood-brain barriers that prevent effective drug delivery. Focused ultrasound-mediated BBB disruption offers a promising non-invasive method to enhance drug delivery into brain tumors. Clinical trials and preclinical studies have demonstrated the potential of this approach in glioma therapy. However, there are still challenges to overcome for its clinical use.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Oncology
Zhenjie Yi, Lifu Long, Yu Zeng, Zhixiong Liu
Summary: Radiomics plays a crucial role in extracting quantitative features from complex clinical imaging arrays to study their relevance with tumor histological features. Recent studies have shown broad applications of radiomics in identifying primary tumors, conducting differential diagnosis, grading, evaluating mutation status and aggression, predicting treatment response and recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Giorgia Chinigo, Helene Castel, Oana Chever, Dimitra Gkika
Summary: Malignant glioma, especially glioblastoma (GBM), is a common primary brain tumor with high resistance to standard treatment. Recent studies have identified TRP channels as potential new molecular targets for glioma treatment, offering directions for innovative strategies to overcome high resistance and recurrence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mrunal Vitthal Wanjale, Vishnu Sunil Jaikumar, K. C. Sivakumar, Riya Ann Paul, Jackson James, G. S. Vinod Kumar
Summary: This study reports the synthesis of a polyester-based supramolecular hydrogel as a brain biocompatible implant for in situ delivery of hydrophobic drugs. The hydrogel showed good biocompatibility and was able to effectively restrict the aggressive regrowth of tumors. The combination of carmustine and curcumin as model hydrophobic drugs demonstrated a synergistic apoptotic effect on glioma cells. This study provides a promising strategy for site-specific drug delivery in brain tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Mahmoud S. Alghamri, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Ayman Taher, Rohit Thalla, Brandon L. McClellan, Maria L. Varela, Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anuska V. Andjelkovic, Jason V. Gregory, Padma Kadiyala, Alexandra Calinescu, Jennifer A. Jimenez, April A. Apfelbaum, Elizabeth R. Lawlor, Stephen Carney, Andrea Comba, Syed Mohd Faisal, Marcus Barissi, Marta B. Edwards, Henry Appelman, Yilun Sun, Jingyao Gan, Rose Ackermann, Anna Schwendeman, Marianela Candolfi, Michael R. Olin, Joerg Lahann, Pedro R. Lowenstein, Maria G. Castro
Summary: Glioblastoma (GBM) is an aggressive brain cancer with low survival rate. A study found that targeting the CXCL2/CXCR4 pathway with synthetic protein nanoparticles (SPNPs) can inhibit tumor growth and enhance immune response, improving therapeutic efficacy.