Review
Biochemistry & Molecular Biology
Antoni Parcerisas, Alba Ortega-Gasco, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2, the second member of the NCAM family, plays a crucial role in nervous system development and adulthood, especially in neuronal morphogenesis and synaptic plasticity. Its functions are related to its ability to adapt to external inputs of the cell and modify the cytoskeleton accordingly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jan A. Knobloch, Gilles Laurent, Marcel A. Lauterbach
Summary: This study used superresolution STED microscopy to explore the shape and distribution characteristics of dendritic spines in the turtle cortex. The results showed that dendritic spines can be classified into several distinguishable shape categories, and spines of a given category are not randomly distributed, but rather appear more frequently on certain dendrites. Additionally, significant inter-dendrite differences in parameters such as spine density and length were observed.
PROGRESS IN NEUROBIOLOGY
(2023)
Review
Neurosciences
Massimo M. Onesto, Caitlin A. Short, Sarah K. Rempel, Timothy S. Catlett, Timothy M. Gomez
Summary: Growth cones navigate through developing organisms by probing extracellular cues, with the ability of various growth factors to guide axons now underappreciated. In vitro experiments have shown the effects of these growth factors on axon morphogenesis and signaling mechanisms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yang Lu, Chen-Zi Zhao, Jiang-Kui Hu, Shuo Sun, Hong Yuan, Zhong-Heng Fu, Xiang Chen, Jia-Qi Huang, Minggao Ouyang, Qiang Zhang
Summary: This study uncovers the principles of interfacial void evolution in solid-state batteries and establishes a model for void nucleation and growth. Through electrochemical calculations and in situ observations, the microscopic features of void defects under different stripping conditions are studied, and the quantification of void-induced contact loss processes is conducted. The electrochemical-morphological relationship helps to understand and design solid-solid interfaces for advanced solid-state batteries.
Article
Neurosciences
Oualid Sbai, Rabia Soussi, Angelique Bole, Michel Khrestchatisky, Monique Esclapez, Lotfi Ferhat
Summary: The study showed that the expression of alpha-actn-2 decreased during granule cell spinogenesis and morphogenesis in a rat model of chronic limbic seizures, persisting into the chronic stage when new synapses are formed. The balance between alpha-actn-2 and DA expression levels may modulate NR1 anchoring in dendritic spines.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daiane B. Fraga, Anderson Camargo, Gislaine Olescowicz, Dayane Azevedo Padilha, Francielle Mina, Josiane Budni, Patricia S. Brocardo, Ana Lucia S. Rodrigues
Summary: Both ascorbic acid and ketamine can rapidly alleviate CORT-induced depressive-like behaviors and improve hippocampal synaptic markers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Neurosciences
Juliana E. Shaw, Michaela B. C. Kilander, Yu-Chih Lin, Anthony J. Koleske
Summary: Dendritic spines are enriched in a network of actin filaments, with stable actin filaments maintained by interactions between Abl2 and cortactin being crucial for spine stability. Disruption of these interactions leads to reduced spine density and impaired spine stability, while increased synaptic activity can rescue spine loss by promoting cortactin enrichment in vulnerable spines.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Christopher J. Alexander, Melanie Barzik, Ikuko Fujiwara, Kirsten Remmert, Ya-Xian Wang, Ronald S. Petralia, Thomas B. Friedman, John A. Hammer
Summary: Myosin 18A alpha is a myosin 2-like protein that co-assembles with myosin 2 in the spines of cerebellar Purkinje neurons, playing a role in dendritic spine maturation. It interacts with beta-Pix, promoting assembly of actin and myosin filaments in spines. Knockdown of Myosin 18A results in spine maturation defects, which can be rescued by an RNAi-immune version of Myosin 18A.
Article
Multidisciplinary Sciences
Minhyeok Chang, O-Chul Lee, Gayun Bu, Jaeho Oh, Na-Oh Yunn, Sung Ho Ryu, Hyung-Bae Kwon, Anatoly B. Kolomeisky, Sang-Hee Shim, Junsang Doh, Jae-Hyung Jeon, Jong-Bong Lee
Summary: The study discovered that membrane nanotubes are formed from double filopodial bridges through physical contact and helical deformation. The transition of a double filopodial bridge to a closed-end membrane nanotube is likely triggered by the disruption of adhesion between two filopodia due to accumulated mechanical energy in the twisted double filopodial bridge.
Article
Multidisciplinary Sciences
Barbara Calabrese, Steven Jones, Yoko Yamaguchi-Shiraishi, Michael Lingelbach, Uri Manor, Tatyana M. Svitkina, Henry N. Higgs, Andy Y. Shih, Shelley Halpain
Summary: Ischemia and excess NMDA receptor activation cause actin to reorganize, protecting neurons from death induced by cell edema.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Brikha R. Shrestha, Anita Burgos, Wesley B. Grueber
Summary: The study reveals the important role of the cell surface molecule Basigin in complex dendrite morphogenesis, with loss of the gene leading to defects in dendrite formation. Knock down of Basigin also affects dendrite elaboration of class IV neurons, suggesting a non-autonomous role in dendrite development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Akihito Yasuoka, Toshitada Nagai, Seonmi Lee, Hitonari Miyaguchi, Yoshikazu Saito, Keiko Abe, Tomiko Asakura
Summary: This study found that mastication stimuli during the weaning period can increase dendrite branches of hippocampal CA1 neurons and regulate genes related to dendrite growth, enhancing the learning ability of rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Ashutosh G. Bhagurkar, Rongshan Qin
Summary: The microstructure of slag film solidified on the inner wall of mold in continuous casting of low carbon steel has been experimentally examined and theoretically analyzed. This work has solved a puzzle for the crystallization sequence and is useful for guiding the modification of slag microstructure in efficient casting of advanced steels. Three crystalline bands, each containing an initial block-shaped crystal sub-band and late-developed dendrite sub-band, were observed in the experiments. The grain size and morphology change monotonically across the crystalline layers to form a gradient structure, due to solute segregation causing an increase in viscosity and constitutional undercooling in the liquid phase. This phenomenon is rarely seen in alloy casting and has not been pointed out previously in the casting of oxide mixtures.
Article
Chemistry, Physical
Nobuhiko J. Suematsu, Junpei Iwamoto, Yuya Ishii, Akira Yamamoto
Summary: A variety of crystal structures are found in nature, including equilibrium structures reflecting molecular structures, and non-equilibrium structures which depend on the physicochemical conditions during crystal growth. The dendrite structure of sodium chloride formed by evaporating an aqueous NaCl solution was studied in this paper, with observations suggesting that higher initial concentrations lead to easier dendrite structure formation. The growth rate was found to oscillate over time and synchronize with the wetting of the crystal, with the detailed mechanism for dendrite pattern formation still being investigated.
Article
Biochemistry & Molecular Biology
Amanda Schneeweis, Daniel T. S. Pak
Summary: Tau protein has been found to localize in various subcellular domains of neurons and has multiple physiological functions. However, the lack of comprehensive phosphosite analysis obscures our understanding of these functions. Therefore, establishing a comprehensive map of tau phosphorylation signatures can clarify its diverse physiological functions in different locations and guide the development of novel therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)