Article
Immunology
Marius Piepke, Bettina H. Clausen, Peter Ludewig, Jonas H. Vienhues, Tanja Bedke, Ehsan Javidi, Bjoern Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S. Schaedlich, Immo Prinz, Richard A. Flavell, Yasushi Kobayashi, Thomas Renne, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom
Summary: This study investigated the role of IL-10 in ischemic stroke and found that IL-10 plays a key function in controlling IL-17A signaling. IL-10 acts differently on alpha beta and gamma delta T cells, and it was also discovered that IL-17A could be a therapeutic opportunity for stroke treatment.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Ran Chen, Xu Zhang, Lijuan Gu, Hua Zhu, Yi Zhong, Yingze Ye, Xiaoxing Xiong, Zhihong Jian
Summary: Ischemic stroke leads to nerve cell death and immune cell activation, with immune cell infiltration having both negative and positive effects in the central nervous system, highlighting the need for further exploration of their role in cerebral ischemia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
R. D. Szepanowski, S. Haupeltshofer, S. E. Vonhof, B. Frank, C. Kleinschnitz, A. Casas
Summary: Despite efforts in translational research, ischemic stroke remains a major unmet medical need, causing significant burden to global healthcare systems. This study reviews the role of different immune cell types, such as neutrophils, macrophages, T and B cells, as mediators of the neuroinflammatory response after stroke. Additionally, the interaction between platelets and immune cells is highlighted for its relevance in microvascular dysfunction, neovascularization, and cellular adhesion. The study also provides an up-to-date overview of therapeutic approaches targeting thromboinflammation in various clinical trials.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Immunology
Ayan Mohamud Yusuf, Nina Hagemann, Peter Ludewig, Matthias Gunzer, Dirk M. Hermann
Summary: Polymorphonuclear neutrophils (PMNs) exacerbate stroke injury by releasing reactive oxygen species, proteases, and proinflammatory cytokines after ischemic stroke. PMNs may also contribute to reperfusion deficits by obstructing brain capillaries. However, clinical studies targeting PMN brain infiltration did not improve stroke outcome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Yanting Gu, Yinfeng Dong, Jieru Wan, Honglei Ren, Raymond C. Koehler, Jian Wang
Summary: This study demonstrates that deficiency of anti-inflammatory cytokine interleukin-10 (IL-10) affects recovery from traumatic brain injury (TBI) in a sex-dependent manner, resulting in worse outcomes in male mice with increased lesion volume, impaired sensorimotor function, cognitive deficits, and anxiety and depression-related behavior. Increased gliosis and neuronal loss were selectively observed in IL-10-deficient male mice, suggesting the recruitment of IL-10 limits damage in a sex-dependent manner.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cell Biology
Brooke J. Wanrooy, Shu Wen Wen, Raymond Shim, Jenny L. Wilson, Kathryn Prame Kumar, Connie Hy Wong
Summary: Previous studies have conflicting results regarding the recruitment of innate immune cells after cerebral ischemia. This study used different cell markers to evaluate the contributions of these cells and their inflammatory states. The results showed that brain-associated innate immune cells display various stroke-induced inflammatory states that depend on the experimental stroke setting.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Immunology
Yanying Liu, Kalpana Subedi, Aravind Baride, Svetlana Romanova, Eduardo Callegari, Christa C. Huber, Xuejun Wang, Hongmin Wang
Summary: The study showed that mice with cardiomyocyte-restricted overexpression of a missense mutant small heat shock protein exhibited increased infarct volume, delayed brain functional recovery, enhanced neuroinflammation, and protein aggregation following ischemia/reperfusion-induced brain injury. Exosomes isolated from the mutant mice exacerbated cerebral injury in wild-type mice, suggesting a potential mechanism of heart-brain crosstalk through the transfer of misfolded proteins via exosomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Geriatrics & Gerontology
Qian Suo, Lidong Deng, Tingting Chen, Shengju Wu, Lin Qi, Ze Liu, Tingting He, Heng-Li Tian, Wanlu Li, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhang
Summary: This study used optogenetics to activate astrocytes and found that they can regulate blood-brain barrier functions and improve the treatment of ischemic stroke. Optogenetic-activated astrocytes reduced IgG leakage, gap formation of tight junction proteins, and matrix metallopeptidase 2 expression. In ischemic stroke, optogenetic-activated astrocytes protected neurons against apoptosis and improved neurobehavioral outcomes. Importantly, interleukin-10 derived from optogenetic-activated astrocytes protected blood-brain barrier integrity. Thus, this study provides a new therapeutic approach and target for acute ischemic stroke.
Article
Immunology
Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie, Kiran Bhaskar
Summary: The study revealed that genetic deletion of IL-10 exacerbates neuroinflammation and tau phosphorylation, leading to neurodegeneration. Loss of IL-10 activates microglia, enhances IL-6 expression, and results in increased phosphorylation of tau protein under acute systemic inflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Christos Tsitsipanis, Marianna Miliaraki, Elina Paflioti, Sofia Lazarioti, Nikolaos Moustakis, Konstantinos Ntotsikas, Athanasios Theofanopoulos, Stavroula Ilia, Antonis Vakis, Panagiotis Simos, Maria Venihaki
Summary: This study aimed to evaluate the value of inflammatory mediators in the assessment of acute TBI. The results showed that IL-6 and IL-10 were increased while IL-8 was decreased in adult patients with TBI. Higher levels of IL-6 and IL-10 were associated with more severe TBI, serious brain imaging findings, and unfavorable outcomes. Therefore, inflammatory molecular biomarkers may be valuable diagnostic and prognostic tools for TBI.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shervin Banitalebi, Nadia Skauli, Samuel Geiseler, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Summary: This study investigates the mechanisms of scar formation in the brain and finds pronounced changes in the astrocytic protein AQP4 in the infarct border zone, which may be related to the downregulation of the AQP4 isoform AQP4ex. These findings provide new insights into the molecular basis of scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Wladyslaw Lason, Danuta Jantas, Monika Leskiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: Ischemic stroke is a major cause of death and disability worldwide. In this context, vitamin D3 has emerged as a potential treatment adjunct, with its ability to interfere with key prosurvival pathways and show neuroprotective, anti-inflammatory, regenerative, and anti-aging properties. This narrative review discusses the biochemical mechanisms of stroke-related brain damage, the effects of vitamin D3 on diverse cell death signaling pathways, and the outcomes of experimental and clinical studies on its neuroprotective potential in ischemic stroke.
Review
Biochemistry & Molecular Biology
Ryszard Pluta, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: The article focuses on neuroinflammation in brain tissue after ischemia, particularly emphasizing ischemic stroke and potential treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Gavin Miles Lockard, Adam Alayli, Molly Monsour, Jonah Gordon, Samantha Schimmel, Bassel Elsayed, Cesar V. Borlongan
Summary: Stem cell transplantation has potential in stroke treatment, reducing infarction size and improving neurobehavioral performance. Interleukin-6 (IL-6), typically considered proinflammatory, can also have beneficial effects on the nervous system when upregulated or when stem cells are preconditioned.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Peter B. Sporns, Marco Hoehne, Lennart Meyer, Christos Krogias, Volker Puetz, Kolja M. Thierfelder, Marco Duering, Daniel Kaiser, Sonke Langner, Alex Brehm, Lukas T. Rotkopf, Wolfgang G. Kunz, Jens Fiehler, Walter Heindel, Peter Schramm, Heinz Wiendl, Heike Minnerup, Marios Nikos Psychogios, Andre Kemmling, Jens Minnerup
Summary: This study aimed to test a simple method of CT-based quantification of water uptake in ischemic tissue to identify stroke patients with symptom onset within 4.5 hours. The study found that using ROI measurements could accurately differentiate patients with stroke onset within and beyond 4.5 hours.
Article
Oncology
Beiping Miao, Andrea S. Bauer, Katrin Hufnagel, Yenan Wu, Marija Trajkovic-Arsic, Anna C. Pirona, Nathalia Giese, Jussi Taipale, Jens T. Siveke, Joerg D. Hoheisel, Smiths Lueong
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Neurosciences
Rebecca Sadler, Julia V. Cramer, Steffanie Heindl, Sarantos Kostidis, Dene Betz, Kielen R. Zuurbier, Bernd H. Northoff, Marieke Heijink, Mark P. Goldberg, Erik J. Plautz, Stefan Roth, Rainer Malik, Martin Dichgans, Lesca M. Holdt, Corinne Benakis, Martin Giera, Ann M. Stowe, Arthur Liesz
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Csaba Cserep, Balazs Posfai, Nikolett Lenart, Rebeka Fekete, Zsofia I. Laszlo, Zsolt Lele, Barbara Orsolits, Gabor Molnar, Steffanie Heindl, Anett D. Schwarcz, Katinka Ujvari, Zsuzsanna Kornyei, Krisztina Toth, Eszter Szabadits, Beata Sperlagh, Maria Baranyi, Laszlo Csiba, Tibor Hortobagyi, Zsofia Magloczky, Bernadett Martinecz, Gabor Szabo, Ferenc Erdelyi, Robert Szipocs, Michael M. Tamkun, Benno Gesierich, Marco Duering, Istvan Katona, Arthur Liesz, Gabor Tamas, Adam Denes
Article
Oncology
Mehdi Manoochehri, Yenan Wu, Nathalia A. Giese, Oliver Strobel, Stefanie Kutschmann, Florian Haller, Joerg D. Hoheisel, Evgeny A. Moskalev, Thilo Hackert, Andrea S. Bauer
MOLECULAR ONCOLOGY
(2020)
Article
Immunology
Stefan Roth, Jun Yang, Julia Cramer, Rainer Malik, Arthur Liesz
Summary: This study demonstrates that neuropsychiatric symptoms can be differentiated and specifically modulated independent of treating the primary lesion in stroke. Neutralizing systemic cytokines specifically ameliorated neuropsychiatric symptoms, indicating the importance of analyzing these symptoms for anti-inflammatory therapies in stroke.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D. Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S. Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Gross, Martin Dichgans, Veit Hornung, Arthur Liesz
Summary: T cell death after acute injury is mainly driven by monocyte-T cell interaction, leading to extrinsic T cell apoptosis through IL-1 beta secretion after sensing extracellular DNA. Pharmacological inhibition of this pathway can improve T cell survival and reduce infections.
Review
Oncology
Fawaz N. Al-Shaheri, Mohamed S. S. Alhamdani, Andrea S. Bauer, Nathalia Giese, Markus W. Buechler, Thilo Hackert, Joerg D. Hoheisel
Summary: Pancreatic cancer is currently the most lethal tumor entity, with rising case numbers, and is expected to soon become the second most frequent cause of cancer-related death in the Western world. Blood-based diagnostics could be a crucial factor for improving this situation, and further research and development are needed.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
Lorenz A. Kapsner, Mikhail G. Zavgorodnij, Svetlana P. Majorova, Agnes Hotz-Wagenblatt, Oleg V. Kolychev, Igor N. Lebedev, Jorg D. Hoheisel, Arndt Hartmann, Andrea Bauer, Sebastian Mate, Hans-Ulrich Prokosch, Florian Haller, Evgeny A. Moskalev
Summary: Quantifying DNA methylation in neoplastic cells is crucial but prone to experimental biases. Correcting biases is more practical than optimizing experimental conditions. The software presented in this study effectively eliminates biases and represents a user-friendly tool for producing accurate epigenetic results.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biology
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J. MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Summary: Microbiota-derived SCFA play a critical role in promoting A beta deposition in Alzheimer's disease by modulating the microglial phenotype along the gut-brain axis.
Article
Multidisciplinary Sciences
Gemma Llovera, Kelsey Pinkham, Arthur Liesz
Summary: Stroke is a major cause of death and acquired adult disability in developed countries. Limited therapeutic options for stroke patients highlight the need for further research, particularly on pathophysiological pathways such as post-stroke inflammation, angiogenesis, neuronal plasticity, and regeneration. Experimental stroke models are essential for analyzing and evaluating new drug targets, but detailed standardized models are urgently needed.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Immunology
Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T. Nelson, Ann M. Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz
Summary: Stroke is a major cause of death and permanent disability globally, with current therapies limited to vascular recanalization in the acute phase. Neuroinflammation has emerged as a key focus in translational research, playing a crucial role in post-stroke recovery and neurodegeneration.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Axel Stang, Hauke Weilert, Michael J. Lipp, Karl J. Oldhafer, Joerg D. Hoheisel, Chaoyang Zhang, Andrea S. Bauer
Summary: Several cancer-related pathways were found to be affected by the deregulated miRNAs identified in blood samples from patients with colorectal cancer (CRC). The study revealed 179 CRC-associated miRNAs of differential abundance, with the majority specifically predicting metastatic CRC. Further confirmation is needed for the identified biomarker and therapeutic candidates in clinical relevance.
MOLECULAR ONCOLOGY
(2021)
Article
Virology
Matthias Neulinger-Munoz, Dominik Schaack, Svetlana P. Grekova, Andrea S. Bauer, Thomas Giese, Gabriel A. Salg, Elisa Espinet, Barbara Leuchs, Anette Heller, Juerg P. F. Nueesch, Miriam Schenk, Michael Volkmar, Nathalia A. Giese
Summary: Despite entering clinical trials, predicting the therapeutic success of oncolytic parvovirus H-1PV remains challenging. Research found that in pancreatic cancer cell lines, H-1PV caused a late global shutdown of innate immunity by co-regulatively inhibiting human endogenous retroviruses (HERVs) and interferon-stimulated genes (ISGs). The growth-inhibitory effect of H-1PV did not correlate with absolute ISG levels but with the power of suppression.
Article
Multidisciplinary Sciences
Gemma Llovera, Alba Simats, Arthur Liesz
Summary: Stroke ranks as the third leading cause of death in developed countries and is the leading cause of acquired adult disability. Current therapeutic options are limited, prompting extensive research into novel strategies to extend the treatment window. Recent investigations have focused on key pathophysiological pathways post-stroke and the reproducibility of experimental results, with a standardized mouse model proposed to address these issues.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Oncology
Yenan Wu, Lea Kroller, Beiping Miao, Henning Boekhoff, Andrea S. Bauer, Markus W. Buechler, Thilo Hackert, Nathalia A. Giese, Jussi Taipale, Jorg D. Hoheisel
Summary: High promoter methylation in pancreatic cancer does not always lead to gene silencing, but can sometimes enhance gene transcription. Transcription factor NFATc1 was identified to bind specifically to hypermethylated DNA motifs and trigger transcription, specifically affecting oncogenic gene ALDH1H3. The study reveals insights into the oncogenic role of transcription activation in PDAC promoted by DNA methylation, particularly through the regulation of NFATc1 on key genes like ALDH1A3.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
