Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yongheng Fan, Xianming Wu, Sufang Han, Qi Zhang, Zheng Sun, Bing Chen, Xiaoyu Xue, Haipeng Zhang, Zhenni Chen, Man Yin, Zhifeng Xiao, Yannan Zhao, Jianwu Dai
Summary: This study used single-cell transcriptomics to investigate the cellular dynamic responses and heterogeneity in different regions below the lesion after spinal cord injury (SCI). The authors found that distal lumbar tissue cells were severely impacted, leading to degenerative microenvironments characterized by activated disease-associated microglia and oligodendrocytes as well as increased inhibitory interneurons following SCI. By implanting scaffold into the injury sites, the injury microenvironment could be improved through regulation of glial cells and fibroblasts, while spared lumbar tissues could be remodeled through reduction of inhibitory neuron proportion and improved phagocytosis and myelination.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Maximina H. Yun
Summary: Salamanders exhibit extreme regenerative abilities and extraordinary longevity, making them valuable models for studying organismal senescence and the interplay between regeneration and ageing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Benjamin Tajer, Aaron M. Savage, Jessica L. Whited
Summary: Regenerative ability varies greatly among different animal species, making it challenging to compare molecular processes. However, through analyzing the salamander limb blastema, which has been extensively studied for over 200 years and is supported by a wide range of molecular tools, researchers can gain valuable insights for comparing regenerative abilities and studying human limb regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Anatomy & Morphology
Laura E. Austin, Chloe Graham, Matthew K. Vickaryous
Summary: This study demonstrates that leopard geckos have the ability to undergo reactive neurogenesis, spontaneously replacing lost or damaged forebrain neurons. This ability is more taxonomically widespread and evolutionarily conserved than previously considered.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Youtong Huang, Greg Lemke
Summary: Recurrent seizures, which may contribute to the pathogenesis and cognitive decline of Alzheimer's disease, are common in early-stage AD and mouse models that overproduce amyloid beta. In a study of the APP/PS1 mouse model, it was found that the mutation of TAM receptor tyrosine kinase (RTK) Mer or its ligand Gas6 significantly increased the risk of early death, which was tied to violent seizures originating in the dentate gyrus of the hippocampus. TAM-deficient mice showed increased newborn DG neurons and excitatory synapses, coinciding with premature death and adult neurogenesis. In contrast, the incidence of lethal seizures was strongly anticorrelated with the deposition of dense-core amyloid plaques. These findings suggest that TAM-mediated phagocytosis influences synaptic connectivity in the hippocampus and that seizure-inducing amyloid beta polymers are present before the formation of dense-core plaques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Nishtha Ranawat, Ichiro Masai
Summary: Microglia are brain-resident macrophages that colonize specific brain regions during development, such as the retina. They use blood vessels as pathways and depend on neuronal differentiation for proper migration. Factors like IL34 also play a role in microglial precursor colonization of the retina.
Article
Immunology
Jian Zou, T. Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T. Crews, Leon G. Coleman
Summary: Adult hippocampal neurogenesis (AHN) is involved in learning and memory as well as regulation of mood. Binge ethanol reduces AHN, though the mechanism is unknown. Microglia promote neurogenesis through the secretion of pro-neurogenic extracellular vesicles (pn-EVs), but ethanol inhibits neurogenesis and causes secretion of proinflammatory EVs (EtOH-EVs), resulting in the loss of adult hippocampal neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hannah E. Walters, Konstantin E. Troyanovskiy, Alwin M. Graf, Maximina H. Yun
Summary: Salamanders are able to regenerate their limbs by modulating cellular plasticity and inducing cellular senescence, which can enhance muscle dedifferentiation and regeneration. Senescent cells promote myotube cell cycle re-entry and reversal of muscle identity through secreted factors, with the FGF-ERK signalling axis playing a critical role. This study highlights the beneficial role of cellular senescence in complex structure regeneration.
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Immunology
Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M. D. Carneiro, Chang Y. Chung
Summary: Minocycline shows promising results in alleviating depressive-like behaviors induced by chronic mild stress, potentially by directly acting on microglia to reduce their phagocytic potential and reverse the pathogenic phagocytic potential of neurotoxic M1 microglia. This mechanism may help reduce negative phenotypes associated with reduced neurogenesis caused by exposure to chronic stress.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Chihena H. Banda, Makoto Shiraishi, Kohei Mitsui, Yoshimoto Okada, Kanako Danno, Ryohei Ishiura, Kaho Maemura, Chikafumi Chiba, Akira Mizoguchi, Kyoko Imanaka-Yoshida, Kazuaki Maruyama, Mitsunaga Narushima
Summary: Through the use of various imaging techniques, researchers have discovered a novel intraosseous lymphatic network in newts, rather than the traditional lymphatic heart, which plays a crucial role in their lymphatic circulation and limb regeneration. This study reveals the fundamental anatomical differences between the immune systems of urodeles and mammals and provides a new model for investigating lymphatics and regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Dimitrinka Atanasova, Nikolai Lazarov, Dimo S. Stoyanov, Radoslav H. Spassov, Anton B. Tonchev, Jana Tchekalarova
Summary: Agomelatine has anti-inflammatory and antidepressant effects, which can restore abnormal neuroglia activity in the model and partially restore suppressed neurogenesis.
Article
Multidisciplinary Sciences
Catarina R. Oliveira, Dunja Knapp, Ahmed Elewa, Tobias Gerber, Sandra G. Gonzalez Malagon, Phillip B. Gates, Hannah E. Walters, Andreas Petzold, Hernan Arce, Rodrigo C. Cordoba, Elaiyaraja Subramanian, Osvaldo Chara, Elly M. Tanaka, Andras Simon, Maximina H. Yun
Summary: Through single-cell RNAseq analysis, Tig1 has been identified as a central cell surface determinant of proximal identity in salamander limb regeneration. Its overexpression leads to regeneration defects in the distal elements and elicits proximal displacement of blastema cells, while its neutralisation blocks proximo-distal cell surface interactions.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Zoe Schmal, Ben Hammer, Andreas Mueller, Claudia E. Ruebe
Summary: Despite advances in hippocampus-sparing radiation therapy, radiation-induced injury to the neural stem cell compartment may impact neurocognitive functions. Low doses of ionizing radiation induced inflammatory responses in the hippocampus, with activated microglia and reactive astrocytes, suggesting a shift from neurogenesis to gliogenesis. These findings emphasize the importance of limiting radiation dose to preserve neurocognitive functions, particularly in the juvenile hippocampus.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Tiago Pinheiro, Magdalena Otrocka, Brinton Seashore-Ludlow, Vilma Rraklli, Johan Holmberg, Karin Forsberg-Nilsson, Andras Simon, Matthew Kirkham
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Daniel A. Berg, Yijing Su, Dennisse Jimenez-Cyrus, Aneek Patel, Nancy Huang, David Morizet, Stephanie Lee, Reeti Shah, Francisca Rojas Ringeling, Rajan Jain, Jonathan A. Epstein, Qing-Feng Wu, Stefan Canzar, Guo-Li Ming, Hongjun Song, Allison M. Bond
Article
Developmental Biology
Alberto Joven, Ahmed Elewa, Andras Simon
Correction
Multidisciplinary Sciences
Marketa Tesarova, Lucia Mancini, Andras Simon, Igor Adameyko, Marketa Kaucka, Ahmed Elewa, Gabriele Lanzafame, Yi Zhang, Dominika Kalasova, Bara Szarowska, Tomas Zikmund, Marie Novotna, Jozef Kaiser
SCIENTIFIC REPORTS
(2020)
Review
Neurosciences
Dimitri Ryczko, Andras Simon, Auke Jan Ijspeert
TRENDS IN NEUROSCIENCES
(2020)
Article
Biology
Meng Xie, Pavel Gol'din, Anna Nele Herdina, Jordi Estefa, Ekaterina V. Medvedeva, Lei Li, Phillip T. Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, Lauren T. Shumate, Brian D. Metscher, Karl Grossschmidt, Shigeki Nishimori, Anastasia Akovantseva, Anna P. Usanova, Anastasiia D. Kurenkova, Anoop Kumar, Irene Linares Arregui, Paul Tafforeau, Kaj Fried, Mattias Carlstrom, Andras Simon, Christian Gasser, Henry M. Kronenberg, Murat Bastepe, Kimberly L. Cooper, Peter Timashev, Sophie Sanchez, Igor Adameyko, Anders Eriksson, Andrei S. Chagin
Article
Biochemical Research Methods
Tiago Pinheiro, Ivy Mayor, Steven Edwards, Alberto Joven, Christina G. Kantzer, Matthew Kirkham, Andras Simon
Summary: This study developed a tissue-clearing protocol, CUBIC-f, optimized for fragile brain samples, and demonstrated its effectiveness in quantifying neuronal cell density and characterizing neural progenitor cells. CUBIC-f was found suitable for preserving tissue integrity in embryonic mouse brains, larval, and adult salamander brains compared to traditional CUBIC and CLARITY protocols.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Allison M. Bond, Daniel A. Berg, Stephanie Lee, Alan S. Garcia-Epelboim, Vijay S. Adusumilli, Guo-li Ming, Hongjun Song
Article
Biochemistry & Molecular Biology
Marketa Kaucka, Bara Szarowska, Michaela Kavkova, Maria Eleni Kastriti, Polina Kameneva, Inga Schmidt, Lucie Peskova, Alberto Joven Araus, Andras Simon, Jozef Kaiser, Igor Adameyko
Summary: Melanocytes, pigmented cells primarily in the skin and hair follicles, have been found to play roles in hearing function and electrical conductivity in the heart, with their origin traced back to local innervation during embryonic development. This new knowledge may have implications for understanding the formation of extracutaneous melanoma in humans.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Weipang Chang, Andrea Pedroni, Maria Bertuzzi, Caghan Kizil, Andras Simon, Konstantinos Ampatzis
Summary: The study shows that physical exercise can activate neurogenesis in the spinal cord of adult zebrafish through cholinergic neurotransmission and a reduction of GABA(A) receptors. The researchers also found that functional recovery after spinal cord injury can be promoted by stimulating cholinergic receptors and interfering with GABAergic signaling. The findings suggest a model for activity-dependent neurogenesis in the adult zebrafish spinal cord during homeostasis and regeneration.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Catarina R. Oliveira, Dunja Knapp, Ahmed Elewa, Tobias Gerber, Sandra G. Gonzalez Malagon, Phillip B. Gates, Hannah E. Walters, Andreas Petzold, Hernan Arce, Rodrigo C. Cordoba, Elaiyaraja Subramanian, Osvaldo Chara, Elly M. Tanaka, Andras Simon, Maximina H. Yun
Summary: Through single-cell RNAseq analysis, Tig1 has been identified as a central cell surface determinant of proximal identity in salamander limb regeneration. Its overexpression leads to regeneration defects in the distal elements and elicits proximal displacement of blastema cells, while its neutralisation blocks proximo-distal cell surface interactions.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Neurosciences
Daniel A. Berg, Kyung-Ok Cho, Mi-Hyeon Jang
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Mario Yanakiev, Olivia Soper, Daniel A. Berg, Eunchai Kang
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual memory loss and declining cognitive and executive functions. The cause of AD is not well understood and there is no effective cure. Human brain organoids provide unique opportunities to study AD and its pathological components, filling the gap left by traditional model systems.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Editorial Material
Anesthesiology
Viola Neudecker, Jing Xu, Monica A. Thomas, Kristen K. Penberthy, Eunchai Kang, Daniel A. Berg, Alia M. I. O'Meara, Ansgar M. Brambrink, Cyrus David Mintz
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2023)
Article
Developmental Biology
Alberto Joven, Heng Wang, Tiago Pinheiro, L. Shahul Hameed, Laure Belnoue, Andras Simon
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)