Modelling Alzheimer's disease using human brain organoids: current progress and challenges

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

(2022) Wei Zhang et al.   Acta Pharmaceutica Sinica B

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

(2022) Emma Nichols et al.   Lancet Public Health

Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease

(2022) Qing Wang et al.   Neurology-Neuroimmunology & Neuroinflammation

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

(2022) Julia TCW et al.   CELL

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

(2021) Maa O. Quartey et al.   Scientific Reports

Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

(2021) Charles Arber et al.   Cell Reports

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

(2021) Paul S. Baxter et al.   Cell Reports

Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease

(2021) Jonathan D. Cherry et al.   Acta Neuropathologica Communications

Microglial activation and tau propagate jointly across Braak stages

(2021) Tharick A. Pascoal et al.   NATURE MEDICINE

The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects

(2021) Guini Song et al.   Frontiers in Cellular Neuroscience

Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

(2021) Feng-Chen Bi et al.   Translational Neurodegeneration

Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration

(2021) Dario Brunetti et al.   Biomedicines

Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

(2021) Kornélia Szebényi et al.   NATURE NEUROSCIENCE

Cerebral organoids transplantation improves neurological motor function in rat brain injury

(2020) Zhi Wang et al.   CNS Neuroscience & Therapeutics

Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches

(2020) Pi-Shan Sung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modeling medulloblastoma in vivo and with human cerebellar organoids

(2020) Claudio Ballabio et al.   Nature Communications

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

(2020) Swagata Ghatak et al.   MOLECULAR PSYCHIATRY

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

(2020) Lezanne Ooi et al.   NEUROSCIENTIST

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

(2020) Angélica María Sabogal-Guáqueta et al.   PROGRESS IN NEUROBIOLOGY

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

(2020) Sang Su Kwak et al.   Nature Communications

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Modeling and Targeting Alzheimer’s Disease With Organoids

(2020) Angelos Papaspyropoulos et al.   Frontiers in Pharmacology

In vitro Models of Neurodegenerative Diseases

(2020) Anna Slanzi et al.   Frontiers in Cell and Developmental Biology

The dynamics of biomarkers across the clinical spectrum of Alzheimer’s disease

(2020) Christoforos Hadjichrysanthou et al.   Alzheimers Research & Therapy

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

(2020) Yuriy Pomeshchik et al.   Stem Cell Reports

Human cerebral organoids establish subcortical projections in the mouse brain after transplantation

(2020) Xin Dong et al.   MOLECULAR PSYCHIATRY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease

(2020) Juan Yin et al.   ACS Biomaterials-Science & Engineering

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

(2019) Heesun Choi et al.   AGING CELL

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

(2019) Swagata Ghatak et al.   eLife

Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities

(2019) Juliana Minardi Nascimento et al.   Frontiers in Cell and Developmental Biology

Modeling cell-cell interactions in the brain using cerebral organoids

(2019) Bárbara Oliveira et al.   BRAIN RESEARCH

Human Stem Cell-derived Aggregates of Forebrain Astroglia Respond to Amyloid Beta Oligomers

(2019) Kyle Griffin et al.   TISSUE ENGINEERING PART A

Cerebral Organoids Repair Ischemic Stroke Brain Injury

(2019) Shu-Na Wang et al.   Translational Stroke Research

3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity

(2018) Christos Papadimitriou et al.   DEVELOPMENTAL CELL

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

(2018) Pavlos Alifragis et al.   Neural Regeneration Research

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells

(2018) Yuanwei Yan et al.   TISSUE ENGINEERING PART A

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

(2018) Philip W. Brownjohn et al.   Stem Cell Reports

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

(2018) Sonja Bergmann et al.   Nature Protocols

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

(2018) Serena Pavoni et al.   PLoS One

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(2017) Kazuyuki Takata et al.   IMMUNITY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells

(2017) Karin Lauschke et al.   STEM CELLS AND DEVELOPMENT

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation

(2016) Elsa Vera et al.   Cell Reports

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

UK research spend in 2008 and 2012: comparing stroke, cancer, coronary heart disease and dementia

(2015) R. Luengo-Fernandez et al.   BMJ Open

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

(2012) Masashi Kitazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

(2011) Anne Eckert et al.   Alzheimers Research & Therapy

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

(2010) S. M. Resnick et al.   NEUROLOGY

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variations in the neuropathology of familial Alzheimer’s disease

(2009) Claire Shepherd et al.   ACTA NEUROPATHOLOGICA

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY