Article
Multidisciplinary Sciences
Ami Shah, Madison Ratkowski, Alessandro Rosa, Paul Feinstein, Thomas Bozza
Summary: The study reveals that TAAR gene expression requires two cooperative cis-acting enhancers, deletion of either one or both elements can affect the expression of TAAR genes, and the similarity exists in the expression mechanisms between ORs and TAARs.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Guanglin Niu, Agnieszka Bak, Melanie Nusselt, Yue Zhang, Hubert Pausch, Tatiana Flisikowska, Angelika E. Schnieke, Krzysztof Flisikowski
Summary: This study confirms the importance of the p53/YAP1 network in the progression of osteosarcoma and identifies a significant association between YAP1 amplification and the progression of OS. The inactivation of YAP1 inhibits proliferation, migration, and invasion, indicating its role as a potential therapeutic target for p53-dependent osteosarcoma.
Article
Genetics & Heredity
Daniel Holoch, Michel Wassef, Cecilia Lovkvist, Dina Zielinski, Setareh Aflaki, Berangere Lombard, Tiphaine Hery, Damarys Loew, Martin Howard, Raphael Margueron
Summary: Epigenetic inheritance plays a role in maintaining cellular identities and transcriptional memory, particularly at Polycomb targets, depends on both histone modifications and the gene-regulatory network, varying with cellular context. Polycomb proteins are involved in regulating this type of epigenetic transcriptional memory during cell differentiation.
Article
Biochemistry & Molecular Biology
Swann Floc'hlay, Emily S. Wong, Bingqing Zhao, Rebecca R. Viales, Morgane Thomas-Chollier, Denis Thieffry, David A. Garfield, Eileen E. M. Furlong
Summary: Genetic variation (allelic imbalance) more frequently impacts gene expression, especially metabolic and environmental response genes. Allelic imbalance in cis-regulatory elements is common and highly heritable, but generally does not propagate to gene expression. Genetic variation affects RNA levels through mechanisms involving H3K4me3 or chromatin accessibility and H3K27ac.
Article
Multidisciplinary Sciences
Joseph L. Gage, Sujina Mali, Fionn McLoughlin, Merritt Khaipho-Burch, Brandon Monier, Julia Bailey-Serres, Richard D. Vierstra, Edward S. Buckler
Summary: The study found that rare variants in the 5' UTR can dysregulate maize protein abundance, and rare variants near the start codon of uORFs can repress or derepress mORF translation. Common variants that modify uORF start codons also disproportionately affect metabolic and whole-plant phenotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Anton J. M. Larsson, Christoph Ziegenhain, Michael Hagemann-Jensen, Bjorn Reinius, Tina Jacob, Tim Dalessandri, Gert-Jan Hendriks, Maria Kasper, Rickard Sandberg
Summary: This study investigates the relationship between monoallelic gene expression and transcriptional bursting based on single-cell RNA analysis, demonstrating that transcriptional bursting process can explain the amount of monoallelic expression. The burst frequency largely determines the frequency of monoallelic observations, while the burst size has minimal impact on monoallelic observations. The findings reinforce the idea that studies of allelic imbalance can be affected by the inherent noise in transcriptional bursting.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Samuel Valentini, Caterina Marchioretti, Alessandra Bisio, Annalisa Rossi, Sara Zaccara, Alessandro Romanel, Alberto Inga
Summary: This study identified SNPs that can mark allele-specific protein expression levels and potentially contribute to inter-individual variation in disease risk. Through experimental and computational approaches, 147 SNPs were identified, with 39 located in UTRs, suggesting their potential role in disease risk.
Article
Multidisciplinary Sciences
Kota Kitano, Atsuhito Yamagishi, Kengo Horie, Katsuhiko Nishimori, Nobuya Sato
Summary: Studies show that prairie voles display empathic responses and helping behavior by opening a door to assist conspecifics soaked in water. The distress of the conspecific is necessary for learning the door-opening behavior, and oxytocin plays a crucial role in the emergence of helping behavior.
Article
Biochemistry & Molecular Biology
Krzysztof Maria Wilczynski, Aleksandra Augusciak-Duma, Aleksandra Stasik, Lena Cichon, Alicja Kawalec, Malgorzata Janas-Kozik
Summary: Autism spectrum disorder is a complex neurodevelopmental disorder that affects social interactions, communication, and behavior. This study found that the balance between the expression levels of the CD38 gene and the oxytocinase gene plays a key role in the risk and clinical presentation of ASD.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Anthony Beucher, Irene Miguel-Escalada, Diego Balboa, Matias G. De Vas, Miguel Angel Maestro, Javier Garcia-Hurtado, Aina Bernal, Roser Gonzalez-Franco, Pierfrancesco Vargiu, Holger Heyn, Philippe Ravassard, Sagrario Ortega, Jorge Ferrer
Summary: This study reveals that HASTER plays a role in maintaining the normal concentration of HNF1A through positive and negative feedback loops. Mutations in Haster lead to silencing or overexpression of HNF1A in pancreatic beta cells, resulting in hyperglycemia. The HASTER-dependent negative feedback is essential for preventing inappropriate binding of HNF1A to genomic regions.
NATURE CELL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Junki Imaizumi, Shuhei Kamada, Miyu Taniguchi, Tatsuro Sugimoto, Takaaki Maeda, Ryosuke Arakaki, Shota Yamamoto, Aya Shirakawa, Ayuka Mineda, Atsuko Yoshida, Takeshi Iwasa, Takashi Kaji
Summary: Changes in oxytocin levels and oxytocin receptor mRNA expression were observed in rats with intrauterine undernutrition. These changes could potentially affect nutritional and metabolic regulation systems and contribute to the mechanisms underlying DOHaD.
Article
Multidisciplinary Sciences
Shangling Lou, Xiang Guo, Lian Liu, Yan Song, Lei Zhang, Yuanzhong Jiang, Lushui Zhang, Pengchuan Sun, Bao Liu, Shaofei Tong, Ningning Chen, Meng Liu, Han Zhang, Ruyun Liang, Xiaoqin Feng, Yudan Zheng, Huanhuan Liu, Michael J. Holdsworth, Jianquan Liu
Summary: A study found that allelic changes in the cis-regulatory elements WT box and W box in the promoter of a key transcription factor RAP2.12 in Arabidopsis thaliana are responsible for differentially regulating tolerance to drought and flooding. These two cis-elements are regulated by different transcription factors, resulting in differential accumulation of hypoxia-responsive transcripts. This gene promotes both drought and flooding adaptation through an adaptive mechanism that diversifies its regulation through noncoding alleles.
Article
Plant Sciences
Yuanyuan Fang, Dan Wang, Liang Xiao, Mingyang Quan, Weina Qi, Fangyuan Song, Jiaxuan Zhou, Xin Liu, Shitong Qin, Qingzhang Du, Qing Liu, Yousry A. El-Kassaby, Deqiang Zhang
Summary: In this study, a candidate gene PtoWRKY68 was identified through genome-wide association studies in Chinese white poplar, which is involved in drought response and adaptation. The two alleles of PtoWRKY68 are associated with different degrees of drought tolerance through regulation of ABA signaling pathway. This study provides insights into the genetic basis of drought tolerance in trees and facilitates molecular breeding for improving forest tree's drought tolerance.
Article
Plant Sciences
Zhiyan Gao, Xingyu Yang, Jinming Chen, Mark D. Rausher, Tao Shi
Summary: Cis- and trans-regulatory variations play distinct roles in lotus flower color evolution, with trans-regulatory mutations having a stronger impact on expression differences between species. In F1 hybrids, genes under cis-only and trans-only regulatory effects show different modes of inheritance, with additive and dominant inheritance respectively. The relative abundance of genes in different categories of regulatory divergence is associated with expression level and breadth constraints.
Article
Cell & Tissue Engineering
Pia A. Johansson, Per Ludvik Brattas, Christopher H. Douse, PingHsun Hsieh, Anita Adami, Julien Pontis, Daniela Grassi, Raquel Garza, Edoardo Sozzi, Rodrigo Cataldo, Marie E. Jonsson, Diahann A. M. Atacho, Karolina Pircs, Feride Eren, Yogita Sharma, Jenny Johansson, Alessandro Fiorenzano, Malin Parmar, Malin Fex, Didier Trono, Evan E. Eichler, Johan Jakobsson
Summary: Despite limited changes in protein-coding genes, the human forebrain has expanded in size and complexity compared to chimpanzees. This suggests that gene expression regulation, rather than genetic changes, plays a significant role in brain evolution. Researchers have identified a transcription factor called ZNF558 that is expressed in human forebrain neural progenitor cells but not in chimpanzees. ZNF558 functions in mitochondrial homeostasis and influences developmental timing during early human brain development. Its expression is controlled by a variable number tandem repeat, which is longer in chimpanzees and shows variability within the human population. This study provides mechanistic insights into how regulatory networks are established through structural variations, affecting human brain evolution.
Article
Psychology, Developmental
Fiana Ni Ghralaigh, Ellen McCarthy, Daniel N. Murphy, Louise Gallagher, Lorna M. Lopez
Summary: This study evaluates the clinical utility of gene panels marketed for use in autism and finds that the diagnostic yields range from 0.22% to 10.02%. The gene selection for these panels also varies in relevance, measured as the overlap percentage with SFARI Gene, ranging from 15.15% to 100%. The study concludes that the current gene panels for autism have limited clinical utility and suggests that sequencing with greater coverage may be more appropriate.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Neurosciences
Yash Patel, Jean Shin, Christoph Abe, Ingrid Agartz, Clara Alloza, Dag Alnaes, Sonia Ambrogi, Linda A. Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Basgoze, Renata Basso Cupertino, Claiton H. D. Bau, Jochen Bauer, Sarah Baumeister, Fabio Bernardoni, Alessandro Bertolino, Caterina del Mar Bonnin, Daniel Brandeis, Silvia Brem, Jason Bruggemann, Robin Bulow, Juan R. Bustillo, Sara Calderoni, Rosa Calvo, Erick J. Canales-Rodriguez, Dara M. Cannon, Susanna Carmona, Vaughan J. Carr, Stanley V. Catts, Sneha Chenji, Qian Hui Chew, David Coghill, Colm G. Connolly, Annette Conzelmann, Alexander R. Craven, Benedicto Crespo-Facorro, Kathryn Cullen, Andreas Dahl, Udo Dannlowski, Christopher G. Davey, Christine Deruelle, Covadonga M. Diaz-Caneja, Katharina Dohm, Stefan Ehrlich, Jeffery Epstein, Tracy Erwin-Grabner, Lisa T. Eyler, Jennifer Fedor, Jacqueline Fitzgerald, William Foran, Judith M. Ford, Lydia Fortea, Paola Fuentes-Claramonte, Janice Fullerton, Lisa Furlong, Louise Gallagher, Bingchen Gao, Si Gao, Jose M. Goikolea, Ian Gotlib, Roberto Goya-Maldonado, Hans J. Grabe, Melissa Green, Eugenio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Jan Haavik, Tim Hahn, Ben J. Harrison, Walter Heindel, Frans Henskens, Dirk J. Heslenfeld, Eva Hilland, Pieter J. Hoekstra, Sarah Hohmann, Nathalie Holz, Fleur M. Howells, Jonathan C. Ipser, Neda Jahanshad, Babette Jakobi, Andreas Jansen, Joost Janssen, Rune Jonassen, Anna Kaiser, Vasiliy Kaleda, James Karantonis, Joseph A. King, Tilo Kircher, Peter Kochunov, Sheri-Michelle Koopowitz, Mikael Landen, Nils Inge Landro, Stephen Lawrie, Irina Lebedeva, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Daniel H. Mathalon, Colm McDonald, Andrew McIntosh, Susanne Meinert, Patricia T. Michie, Philip Mitchell, Ana Moreno-Alcazar, Bryan Mowry, Filippo Muratori, Leila Nabulsi, Igor Nenadic, Ruth O'Gorman Tuura, Jaap Oosterlaan, Bronwyn Overs, Christos Pantelis, Mara Parellada, Jose C. Pariente, Paul Pauli, Giulio Pergola, Francesco Maria Piarulli, Felipe Picon, Fabrizio Piras, Edith Pomarol-Clotet, Clara Pretus, Yann Quide, Joaquim Radua, J. Antoni Ramos-Quiroga, Paul E. Rasser, Andreas Reif, Alessandra Retico, Gloria Roberts, Susan Rossell, Diego Luiz Rovaris, Katya Rubia, Matthew Sacchet, Josep Salavert, Raymond Salvador, Salvador Sarro, Akira Sawa, Ulrich Schall, Rodney Scott, Pierluigi Selvaggi, Tim Silk, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Dan J. Stein, Olaf Steinstrater, Aleks Stolicyn, Yoichiro Takayanagi, Leanne Tamm, Maria Tavares, Alexander Teumer, Katharina Thiel, Sophia I. Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Michela Tosetti, Anne Uhlmann, Tamsyn Van Rheenen, Javier Vazquez-Bourgon, Meike W. Vernooij, Eduard Vieta, Oscar Vilarroya, Cynthia Weickert, Thomas Weickert, Lars T. Westlye, Heather Whalley, David Willinger, Alexandra Winter, Katharina Wittfeld, Tony T. Yang, Yuliya Yoncheva, Jende L. Zijlmans, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Christopher R. K. Ching, Ole A. Andreassen, Elena Pozzi, Dick Veltman, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, F. Xavier Castellanos, Zdenka Pausova, Paul Thompson, Tomas Paus
Summary: The study found that group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices across 11 cortical regions. These differences were associated with interregional profiles of prenatal cell-specific gene expression, implying that prenatal cell-specific processes may lead to deviations from typical brain development and vulnerability to mental illness. Additionally, genes coexpressed with radial glia and endothelial and mural cells were enriched with genes related to known pre/perinatal risk factors for psychosis, supporting a neurodevelopmental model of mental illness vulnerability.
BIOLOGICAL PSYCHIATRY
(2022)
Editorial Material
Psychiatry
L. Gallagher, J. McGrath
Summary: This special themed issue of the Irish Journal of Psychological Medicine focuses on autism spectrum disorders (ASD), addressing challenges with recognition, diagnosis, treatment, co-occurring conditions, and new research developments. The aim is to provide insights to better meet the needs of autistic individuals.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2022)
Meeting Abstract
Psychology, Developmental
Louise Gallagher, Evdokia Anagnostou
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Javier Contreras, Henriette Raventos, Michael Gill, Elizabeth Heron, Carol A. Mathews, Aiden Corvin
Summary: This study investigates the genetic variants associated with Tourette Syndrome (TS) in a Costa Rican family through whole-genome sequencing analysis. The researchers identified rare variants that were not present in controls and were linked with risk haplotypes in the family. These variants are enriched in pathways related to locomotion and signal transduction, suggesting their role in TS risk. The study highlights the importance of investigating both coding and non-coding variants in understanding the genetic basis of TS.
MOLECULAR PSYCHIATRY
(2022)
Article
Computer Science, Artificial Intelligence
Joana Vilela, Muhammad Asif, Ana Rita Marques, Joao Xavier Santos, Celia Rasga, Astrid Vicente, Hugo Martiniano
Summary: Personalized medicine is a concept that has gained increasing interest in recent years, but faces challenges in practical applications. This article describes an approach using Knowledge Graph Embedding (KGE) methods to reason over a biomedical Knowledge Graph (KG) and predict gene-disease associations, providing insights into the biology of Autism Spectrum Disorder (ASD).
Review
Clinical Neurology
Sven Bolte, Janina Neufeld, Peter B. Marschik, Zachary J. Williams, Louise Gallagher, Meng-Chuan Lai
Summary: There are qualitative and quantitative differences in health conditions between individuals of different birth-assigned sexes, gender identities, and gender experiences, which require personalized care. It is important to study the moderating and mediating effects of sex and gender factors on impairment, disability, wellbeing, and health, especially for neurodivergent individuals. Researchers have started to investigate the mechanisms through which sex and gender variables affect the manifestations of neurodevelopmental conditions.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Genetics & Heredity
Bethany Vibert, Patricia Segura, Louise Gallagher, Stelios Georgiades, Panagiota Pervanidou, Audrey Thurm, Lindsay Alexander, Evdokia Anagnostou, Yuta Aoki, Catherine S. Birken, Somer L. Bishop, Jessica Boi, Carmela Bravaccio, Helena Brentani, Paola Canevini, Alessandra Carta, Alice Charach, Antonella Costantino, Katherine T. Cost, Elaine A. Cravo, Jennifer Crosbie, Chiara Davico, Federica Donno, Junya Fujino, Alessandra Gabellone, Cristiane T. Geyer, Tomoya Hirota, Stephen Kanne, Makiko Kawashima, Elizabeth Kelley, Hosanna Kim, Young Shin Kim, So Hyun Kim, Daphne J. Korczak, Meng-Chuan Lai, Lucia Margari, Lucia Marzulli, Gabriele Masi, Luigi Mazzone, Jane McGrath, Suneeta Monga, Paola Morosini, Shinichiro Nakajima, Antonio Narzisi, Rob Nicolson, Aki Nikolaidis, Yoshihiro Noda, Kerri Nowell, Miriam Polizzi, Joana Portolese, Maria Pia Riccio, Manabu Saito, Ida Schwartz, Anish K. Simhal, Martina Siracusano, Stefano Sotgiu, Jacob Stroud, Fernando Sumiya, Yoshiyuki Tachibana, Nicole Takahashi, Riina Takahashi, Hiroki Tamon, Raffaella Tancredi, Benedetto Vitiello, Alessandro Zuddas, Bennett Leventhal, Kathleen Merikangas, Michael P. Milham, Adriana Di Martino
Summary: The study examined the impact of the COVID-19 pandemic on youth with autism spectrum disorder and related neurodevelopmental disorders, revealing heterogeneity in symptoms and access to services. The findings can inform recovery efforts and emphasize the importance of international data-sharing and collaborations in addressing the needs of vulnerable populations during crises.
Review
Psychiatry
Ciara J. Molloy, Ciara Quigley, Aine McNicholas, Linda Lisanti, Louise Gallagher
Summary: The heritability of intelligence or general cognitive ability is estimated to be 41% and 66% in children and adults, respectively. Rare copy number variants (ND-CNV) are associated with neurodevelopmental and neuropsychiatric conditions and can contribute to the variability in cognitive ability. This review examines the impact of ND-CNV on intelligence and cognitive function in both general population and clinical cohorts, and identifies genotype-specific cognitive phenotypes. The findings show that ND-CNV have cognitive impacts across different populations, but more studies and larger sample sizes are needed to determine ND-CNV-specific effects.
TRANSLATIONAL PSYCHIATRY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Siofra Heraty, Alexandra Lautarescu, David Belton, Alison Boyle, Pietro Cirrincione, Mary Doherty, Sarah Douglas, Jan Roderik Derk Plas, Katrien Van Den Bosch, Pierre Violland, Jerneja Tercon, Amber Ruigrok, Declan G. M. Murphy, Thomas Bourgeron, Christopher Chatham, Eva Loth, Bethany Oakley, Grainne M. Mcalonan, Tony Charman, Nicolaas Puts, Louise Gallagher, Emily J. H. Jones
Summary: A change in research culture is needed to improve the relationship between autistic people and the biomedical research community. Through participatory research, we can reject negative perceptions of autism and work towards a shared vision that embraces neurodiversity.
Review
Neurosciences
Ciara J. J. Molloy, Jennifer Cooke, Nicholas J. F. Gatford, Alejandro Rivera-Olvera, Sahar Avazzadeh, Judith R. R. Homberg, Joanes Grandjean, Cathy Fernandes, Sanbing Shen, Eva Loth, Deepak P. P. Srivastava, Louise Gallagher
Summary: This article reviews the multiple molecular pathways and cellular processes involved in the neurobiology of autism and other neurodevelopmental conditions. The focus is on synaptopathies, which are clinical conditions associated with rare genetic variants disrupting genes involved in synaptic biology. The NRXN-NLGN-SHANK pathway is discussed in detail, and insights from preclinical studies, cellular processes, neuroimaging, and clinical studies are presented. Despite challenges in translating preclinical research to human brain development and autism features, bridging the gap between preclinical and clinical studies is crucial for advancing targeted therapies for neurodevelopmental conditions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Psychiatry
Celia Rasga, Joao Xavier Santos, Catia Cafe, Alexandra Oliveira, Frederico Duque, Manuel Posada, Ana Nunes, Guiomar Oliveira, Astrid Moura Vicente
Summary: Accurate estimation of ASD prevalence is crucial for planning medical and educational resources for children. This study conducted a prevalence estimation in the Centro region of Portugal and found a higher prevalence in schools with Autism Units.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Joana Vilela, Hugo Martiniano, Ana Rita Marques, Joao Xavier Santos, Muhammad Asif, Celia Rasga, Guiomar Oliveira, Astrid Moura Vicente
Summary: This study investigates the biological processes affected by NS gene variants in individuals with Autism Spectrum Disorder (ASD) and the global networks connecting those processes. They identified ASD candidate genes and constructed a protein-protein interaction network to explore the pathological mechanisms of ASD. The results suggest disruptions in synaptic and neurotransmitter pathways, as well as other biological processes not typically associated with ASD.
Article
Psychiatry
K. Conlan, J. McGrath, M. Teeling, M. J. MacAvin, K. Bennett, L. Gallagher
Summary: This study examines the prescribing rates of antipsychotic drugs in the Irish pediatric and young adult population. The study also analyzes differences in prescribing rates based on age and sex. Findings reveal that a significant proportion of this population were prescribed antipsychotics, and there was an increase in co-prescribing of antidepressants.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Meeting Abstract
Medicine, General & Internal
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Nelson Freimer, Javier Contreras, Henriette Raventos, Carol A. Mathews, Elizabeth Heron, Michael Gill, Aiden Corvin
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
